Development of a Quantitative Model of Pregnane X Receptor (PXR) Mediated Xenobiotic Metabolizing Enzyme Induction

Bulletin of Mathematical Biology

Volumn 72, Issue 7, 2010, Pages 1799-1819

  Luke, Nicholas S ^a   DeVito, Michael J ^b   Shah, Imran ^c   El Masri, Hisham A ^c  

^a Technical State University   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Gene induction; Mathematical model; Nuclear receptors

Indexed keywords

CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; PREGNANE X RECEPTOR; STEROID RECEPTOR; XENOBIOTIC AGENT;

ARTICLE; BIOLOGICAL MODEL; COMPUTER SIMULATION; ENZYME INDUCTION; ENZYMOLOGY; HUMAN; LIVER; METABOLISM;

COMPUTER SIMULATION; CYTOCHROME P-450 CYP3A; ENZYME INDUCTION; HUMANS; LIVER; MODELS, BIOLOGICAL; RECEPTORS, STEROID; XENOBIOTICS;

EID: 77957359670     PISSN: 00928240     EISSN: 15229602     Source Type: Journal    
DOI: 10.1007/s11538-010-9508-5     Document Type: Article

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