Physiological modeling of a proposed mechanism of enzyme induction by TCDD

Toxicology

Volumn 162, Issue 3, 2001, Pages 193-208

  Kohn, Michael C ^a   Walker, Nigel J ^a   Kim, Amy H ^a   Portier, Christopher J ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Enzyme induction; Gene expression kinetics; PBPK modeling; Pharmacodynamics; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CORN OIL; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; MESSENGER RNA; POLYADENYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DNA RESPONSIVE ELEMENT; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; KINETICS; NONHUMAN; PHARMACODYNAMICS; PHYSIOLOGY; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RAT; RIBOSOME; RNA STABILITY; RNA TRANSLATION;

ADIPOSE TISSUE; ALGORITHMS; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; DIOXINS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; GENE EXPRESSION REGULATION; KINETICS; LIVER; RATS; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN; TIME FACTORS;

ZEA MAYS;

EID: 0035926272     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(01)00363-8     Document Type: Article

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