Myocardial gene therapy

Nature

Volumn 415, Issue 6868, 2002, Pages 234-239

  Isner, Jeffrey M ^a  

^a Vasc Med and Cardiovasc Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CARDIOLOGY; DISEASES;

ANGIOGENIC GROWTH FACTOR; GENE THERAPY;

GENETIC ENGINEERING;

ANGIOGENIC FACTOR;

DISEASE;

ANGIOGENESIS; CLINICAL TRIAL; CORONARY ARTERY DISEASE; DRUG EFFECT; DRUG SAFETY; GENE EXPRESSION; GENE THERAPY; HEART FAILURE; HEART MUSCLE ISCHEMIA; HUMAN; NONHUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; REVIEW;

ANIMALS; CLINICAL TRIALS; CORONARY ARTERIOSCLEROSIS; GENE THERAPY; GENE TRANSFER TECHNIQUES; HEART FAILURE, CONGESTIVE; HUMANS; MYOCARDIAL ISCHEMIA;

EID: 0037049981     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/415234a     Document Type: Review

References (70)

1. Therapeutic angiogenesis: A single intra-arterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hindlimb model
2. Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease
3. 165
4. 165 following intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischaemia
5. 165 as sole therapy for myocardial ischaemia
6. Use of the rabbit artery to serially assess foreign protein secretion after site specific arterial gene transfer in vivo: Evidence that anatomic identification of successful gene transfer may underestimate the potential magnitude of transgene expression
7. Angiogenesis gene therapy: Phase I assessment of direct intramyocardial administration of an adenovirus vector expression VEGF 121 cDNA to individuals with clinically significant severe coronary artery disease
8. Adenovirus FGF angiogenic gene therapy (AGENT) trial
9. Direct gene transfer into mouse muscle in vivo
10. Increased expression of direct gene transfer into skeletal muscles observed after acute ischemic injury in rats
11. Direct myocardial transfection in two animal models: Evaluation of parameters affecting gene expression and percutaneous gene delivery
12. In vivo analysis of intramuscular gene transfer in human subjects studied by on-line ultrasound imaging
13. Intramyocardial gene therapy with naked DNA encoding vascular endothelial growth factor improves collateral flow to ischemic myocardium
14. Intraoperative multiplane transesophageal echocardiograpy for guiding direct myocardial gene transfer of vascular endothelial growth factor in patients with refractory, angina pectoris
15. An improved plasmid DNA expression vector for direct injection into skeletal muscle
16. Ultrasound enhances therapeutic gene expression in ischemic pig myocardium
17. Local delivery of naked plasmid DNA of P53 gene into rat balloon injured carotid artery using low voltage ultrasound with contrast microbubbles (optison): Development of novel non-viral transfection system into blood vessels
18. Differentiation of endothelium
19. Comparison of transmyocardial revascularization with medical therapy in patients with refractory angina
20. Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease: Preliminary clinical results
21. 121
22. Angiogenesis is induced in a rabbit model of hindlimb ischaemia by naked DNA encoding a HIF-1α/VP 16 hybrid transcription factor
23. Angiogenesis induced by adenovirus-mediated gene transfer of a hypoxia-inducible factor-1α/VP 16 hybrid in rabbit hindlimb ischaemia
24. Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electrochemical mapping in patients with chronic myocardial ischaemia
25. In vivo ventricular gene delivery of a β-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction
26. The genetic basis for cardiomyopathy: From mutation identification to mechanistic paradigms
27. Contribution of abnormal sarcoplasmic reti culum ATPase activity to systolic and diastolic dysfunction in human heart failure
28. Adenoviral gene transfer of SERCA2a improves left ventricular function in aortic-banded rats in transition to heart failure
29. Prospects for gene therapy for heart failure
30. 2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation
31. Adenoviral-mediated SERCA gene transfer into cardiac myocytes. How much is too much?
32. 2+-ATPase activity and cardiac myocyte contractility
33. Catecholamines, cardiac "β" adrenergic receptors and heart failure
34. Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary β2-adrenergic receptor gene delivery
35. Enhanced cardiac contractility after gene transfer of V2 vasopressin receptors in vivo by ultrasound-guided injection of transcoronary delivery
36. Preservation of β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction
37. Intracoronary delivery of adenovirus encoding adenylyl cyclase VI increases left ventricular function and cAMP-generating capacity
38. Toward antiapoptosis as a new treatment modality
39. Loss of gp 130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress
40. The bcl-2 gene product prevents programmed cell death of ventricular myocytes
41. Adenoviral gene transfer of activated PI 3-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro
42. Akt promotes survival of cardiomocytes in vitro and protects against ischaemia-reperfusion injury in mouse heart
43. Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart
44. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart
45. Tight control of exogenous SERCA expression is required to obtain acceleration of calcium transients with minimal cytotoxic effects in cardiac myocytes
46. Efficient and stable transduction of cardiomyocytes after intramyocardial injection or intracoronary perfusion with recombinant adeno-associated virus vectors
47. Adeno-associated viral vector-mediated vascular endothelial growth factor gene transfer induces neovascular formation in ischemic heart
48. The well-tempered vessel
49. Fibrillar collagen and remodeling of dilated canine left ventricle
50. Progression of heart failure: A role for interstitial fibrosis
51. Regional myocardial blood flow reserve impairment and metabolic changes suggesting myocardial ischaemia in patients with idiopathic dilated cardiomyopathy
52. 1HA
53. Formation of the coronary vasculature: A brief review
54. Knock out of VEGF in ventricular cardiomyocytes leads to increased embryonic lethality, and severe cardiac defects in surviving mice
55. Coronary collateral development in swine after coronary artery occlusion
56. Use of synchrotron radiation microangiography to assess development of small collateral arteries in a rat model of hindlimb ischaemia
57. Isolation of putative progenitor endothelial cells for angiogenesis
58. Gene therapy of endothelial progenitor cell for vascular development in severe ischemic disease
59. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
60. Ischaemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
61. 165 in patients with inoperable coronary disease
62. Evidence for circulating bone marrow-derived endothelial cells
63. Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation
64. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization
65. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischaemia
66. Tumor angiogenesis: Therapeutic implications
67. Autologous skeletal myoblast transplantation for ischemic cardiomyopathy: First clinical case
68. Translating cell transfer for cardiovascular disease to the bedside: A preclinical review and discussion of potential early trials
69. Regenerating functional myocardium: Improved performance after skeletal transplantation
70. Relieving exercise intolerance secondary to heart failure: Myoblast-mediated angiogenesis via VEGF delivery to ischemic skeletal muscle