-
1
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science 1956;123:309-14.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
2
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009;324:1029-33.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
4
-
-
38849182399
-
Application of PET/CT in the development of novel anticancer drugs
-
Boss DS, Olmos RV, Sinaasappel M, Beijnen JH, Schellens JH. Application of PET/CT in the development of novel anticancer drugs. Oncologist 2008;13:25-38.
-
(2008)
Oncologist
, vol.13
, pp. 25-38
-
-
Boss, D.S.1
Olmos, R.V.2
Sinaasappel, M.3
Beijnen, J.H.4
Schellens, J.H.5
-
5
-
-
46749121459
-
Causes and consequences of increased glucose metabolism of cancers
-
Gillies RJ, Robey I, Gatenby RA. Causes and consequences of increased glucose metabolism of cancers. J Nucl Med 2008;49 Suppl 2:24-42S.
-
(2008)
J Nucl Med
, vol.49
, Issue.SUPPL. 2
-
-
Gillies, R.J.1
Robey, I.2
Gatenby, R.A.3
-
6
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996;2:561-6.
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
7
-
-
0035960428
-
Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A phase I study
-
van Oosterom AT, Judson I, Verweij J, et al. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. Lancet 2001;358:1421-3.
-
(2001)
Lancet
, vol.358
, pp. 1421-1423
-
-
Van Oosterom, A.T.1
Judson, I.2
Verweij, J.3
-
8
-
-
0141486251
-
PDGF receptors as cancer drug targets
-
Pietras K, Sjoblom T, Rubin K, Heldin CH, Ostman A. PDGF receptors as cancer drug targets. Cancer Cell 2003;3:439-43.
-
(2003)
Cancer Cell
, vol.3
, pp. 439-443
-
-
Pietras, K.1
Sjoblom, T.2
Rubin, K.3
Heldin, C.H.4
Ostman, A.5
-
9
-
-
0041984595
-
18FDG-Positron emission tomography for the early prediction of response in advanced soft tissue sarcoma treated with imatinib mesylate (Glivec)
-
Stroobants S, Goeminne J, Seegers M, et al. 18FDG-Positron emission tomography for the early prediction of response in advanced soft tissue sarcoma treated with imatinib mesylate (Glivec). Eur J Cancer 2003;39:2012-20.
-
(2003)
Eur J Cancer
, vol.39
, pp. 2012-2020
-
-
Stroobants, S.1
Goeminne, J.2
Seegers, M.3
-
10
-
-
47749134584
-
The lessons of GIST-PET and PET/CT: A new paradigm for imaging
-
Van den Abbeele AD. The lessons of GIST-PET and PET/CT: a new paradigm for imaging. Oncologist 2008;13 Suppl 2:8-13.
-
(2008)
Oncologist
, vol.13
, Issue.SUPPL. 2
, pp. 8-13
-
-
Van Den Abbeele, A.D.1
-
11
-
-
5144225468
-
Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells
-
Gottschalk S, Anderson N, Hainz C, Eckhardt SG, Serkova NJ. Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells. Clin Cancer Res 2004;10:6661-8.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6661-6668
-
-
Gottschalk, S.1
Anderson, N.2
Hainz, C.3
Eckhardt, S.G.4
Serkova, N.J.5
-
12
-
-
0042763165
-
Increase in signal-to- noise ratio of >10,000 times in liquid-state NMR
-
Ardenkjaer-Larsen JH, Fridlund B, Gram A, et al. Increase in signal-to- noise ratio of >10,000 times in liquid-state NMR. Proc Natl Acad Sci U S A 2003;100:10158-63.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 10158-10163
-
-
Ardenkjaer-Larsen, J.H.1
Fridlund, B.2
Gram, A.3
-
14
-
-
35948970970
-
Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy
-
Day SE, Kettunen MI, Gallagher FA, et al. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy. Nat Med 2007;13:1382-7.
-
(2007)
Nat Med
, vol.13
, pp. 1382-1387
-
-
Day, S.E.1
Kettunen, M.I.2
Gallagher, F.A.3
-
15
-
-
76749161366
-
Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy
-
Ward CS, Venkatesh HS, Chaumeil MM, et al. Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. Cancer Res 2010;70:1296-305.
-
(2010)
Cancer Res
, vol.70
, pp. 1296-1305
-
-
Ward, C.S.1
Venkatesh, H.S.2
Chaumeil, M.M.3
-
16
-
-
53549133145
-
Macromolecular dynamic contrast-enhanced (DCE)-MRI detects reduced vascular permeability in a prostate cancer bone metastasis model following anti-platelet-derived growth factor receptor (PDGFR) therapy, indicating a drop in vascular endothelial growth factor receptor (VEGFR) activation
-
Dafni H, Kim SJ, Bankson JA, Sankaranarayanapillai M, Ronen SM. Macromolecular dynamic contrast-enhanced (DCE)-MRI detects reduced vascular permeability in a prostate cancer bone metastasis model following anti-platelet-derived growth factor receptor (PDGFR) therapy, indicating a drop in vascular endothelial growth factor receptor (VEGFR) activation. Magn Reson Med 2008;60:822-33.
-
(2008)
Magn Reson Med
, vol.60
, pp. 822-833
-
-
Dafni, H.1
Kim, S.J.2
Bankson, J.A.3
Sankaranarayanapillai, M.4
Ronen, S.M.5
-
17
-
-
77649134950
-
13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI
-
13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI. Magn Reson Med 2010;63:582-91.
-
(2010)
Magn Reson Med
, vol.63
, pp. 582-591
-
-
Larson, P.E.1
Bok, R.2
Kerr, A.B.3
-
18
-
-
0242322622
-
Modulation of the pharmacokinetics of macromolecular contrast material by avidin chase: MRI, optical, and inductively coupled plasma mass spectrometry tracking of triply labeled albumin
-
Dafni H, Gilead A, Nevo N, Eilam R, Harmelin A, Neeman M. Modulation of the pharmacokinetics of macromolecular contrast material by avidin chase: MRI, optical, and inductively coupled plasma mass spectrometry tracking of triply labeled albumin. Magn Reson Med 2003;50:904-14.
-
(2003)
Magn Reson Med
, vol.50
, pp. 904-914
-
-
Dafni, H.1
Gilead, A.2
Nevo, N.3
Eilam, R.4
Harmelin, A.5
Neeman, M.6
-
19
-
-
0037112366
-
Overexpression of vascular endothelial growth factor 165 drives peritumor interstitial convection and induces lymphatic drain: Magnetic resonance imaging, confocal microscopy, and histological tracking of triple-labeled albumin
-
Dafni H, Israely T, Bhujwalla ZM, Benjamin LE, Neeman M. Overexpression of vascular endothelial growth factor 165 drives peritumor interstitial convection and induces lymphatic drain: magnetic resonance imaging, confocal microscopy, and histological tracking of triple-labeled albumin. Cancer Res 2002;62:6731-9.
-
(2002)
Cancer Res
, vol.62
, pp. 6731-6739
-
-
Dafni, H.1
Israely, T.2
Bhujwalla, Z.M.3
Benjamin, L.E.4
Neeman, M.5
-
20
-
-
0030223057
-
Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice
-
Pettaway CA, Pathak S, Greene G, et al. Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice. Clin Cancer Res 1996;2:1627-36.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 1627-1636
-
-
Pettaway, C.A.1
Pathak, S.2
Greene, G.3
-
24
-
-
0034905011
-
Salvianolic acid B attenuates VCAM-1 and ICAM-1 expression in TNF-α-treated human aortic endothelial cells
-
Chen YH, Lin SJ, Ku HH, et al. Salvianolic acid B attenuates VCAM-1 and ICAM-1 expression in TNF-α-treated human aortic endothelial cells. J Cell Biochem 2001;82:512-21.
-
(2001)
J Cell Biochem
, vol.82
, pp. 512-521
-
-
Chen, Y.H.1
Lin, S.J.2
Ku, H.H.3
-
25
-
-
0000191753
-
Lactate dehydrogenase. UV-method with pyruvate and NADH
-
Bergmeyer HU, editor. 3. Weinheim: Verlag Chemie
-
Vassault A. Lactate dehydrogenase. UV-method with pyruvate and NADH. In: Bergmeyer HU, editor. Methods of enzymatic analysis. 3. Weinheim: Verlag Chemie; 1983, p. 118-26.
-
(1983)
Methods of Enzymatic Analysis
, pp. 118-126
-
-
Vassault, A.1
-
26
-
-
0015888084
-
An improved cycling assay for nicotinamide adenine dinucleotide
-
Bernofsky C, Swan M. An improved cycling assay for nicotinamide adenine dinucleotide. Anal Biochem 1973;53:452-8.
-
(1973)
Anal Biochem
, vol.53
, pp. 452-458
-
-
Bernofsky, C.1
Swan, M.2
-
27
-
-
10744227995
-
Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastases
-
Uehara H, Kim SJ, Karashima T, et al. Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastases. J Natl Cancer Inst 2003;95:458-70.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 458-470
-
-
Uehara, H.1
Kim, S.J.2
Karashima, T.3
-
28
-
-
33745271860
-
Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer
-
Kim SJ, Uehara H, Yazici S, et al. Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer. J Natl Cancer Inst 2006;98:783-93.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 783-793
-
-
Kim, S.J.1
Uehara, H.2
Yazici, S.3
-
29
-
-
57149092363
-
Neoadjuvant platelet derived growth factor receptor inhibitor therapy combined with docetaxel and androgen ablation for high risk localized prostate cancer
-
discussion 7
-
Mathew P, Pisters LL, Wood CG, et al. Neoadjuvant platelet derived growth factor receptor inhibitor therapy combined with docetaxel and androgen ablation for high risk localized prostate cancer. J Urol 2009;181:81-7; discussion 7.
-
(2009)
J Urol
, vol.181
, pp. 81-87
-
-
Mathew, P.1
Pisters, L.L.2
Wood, C.G.3
-
30
-
-
66149087361
-
The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism
-
Schroeder MA, Atherton HJ, Cochlin LE, Clarke K, Radda GK, Tyler DJ. The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism. Magn Reson Med 2009;61:1007-14.
-
(2009)
Magn Reson Med
, vol.61
, pp. 1007-1014
-
-
Schroeder, M.A.1
Atherton, H.J.2
Cochlin, L.E.3
Clarke, K.4
Radda, G.K.5
Tyler, D.J.6
-
31
-
-
34547746449
-
In vivo 13 carbon metabolic imaging at 3T with hyperpolarized 13C-1-pyruvate
-
Kohler SJ, Yen Y, Wolber J, et al. In vivo 13 carbon metabolic imaging at 3T with hyperpolarized 13C-1-pyruvate. Magn Reson Med 2007;58:65-9.
-
(2007)
Magn Reson Med
, vol.58
, pp. 65-69
-
-
Kohler, S.J.1
Yen, Y.2
Wolber, J.3
-
32
-
-
70350287827
-
In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized (13)C-pyruvate
-
Hu S, Chen AP, Zierhut ML, et al. In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized (13)C-pyruvate. Mol Imaging Biol 2009;11:399-407.
-
(2009)
Mol Imaging Biol
, vol.11
, pp. 399-407
-
-
Hu, S.1
Chen, A.P.2
Zierhut, M.L.3
-
35
-
-
66449129568
-
A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment
-
1 p following 82
-
Witney TH, Kettunen MI, Day SE, et al. A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment. Neoplasia 2009;11:574-82, 1 p following 82.
-
(2009)
Neoplasia
, vol.11
, pp. 574-582
-
-
Witney, T.H.1
Kettunen, M.I.2
Day, S.E.3
-
36
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-32.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
37
-
-
34547580590
-
HIF and c-Myc: Sibling rivals for control of cancer cell metabolism and proliferation
-
Gordan JD, Thompson CB, Simon MC. HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 2007;12:108-13.
-
(2007)
Cancer Cell
, vol.12
, pp. 108-113
-
-
Gordan, J.D.1
Thompson, C.B.2
Simon, M.C.3
-
38
-
-
62749124795
-
Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show?
-
Kaluz S, Kaluzova M, Liao SY, Lerman M, Stanbridge EJ. Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: a one transcription factor (HIF-1) show? Biochim Biophys Acta 2009;1795:162-72.
-
(2009)
Biochim Biophys Acta
, vol.1795
, pp. 162-172
-
-
Kaluz, S.1
Kaluzova, M.2
Liao, S.Y.3
Lerman, M.4
Stanbridge, E.J.5
-
39
-
-
4644313271
-
c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism
-
Knies-Bamforth UE, Fox SB, Poulsom R, Evan GI, Harris AL. c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. Cancer Res 2004;64:6563-70.
-
(2004)
Cancer Res
, vol.64
, pp. 6563-6570
-
-
Knies-Bamforth, U.E.1
Fox, S.B.2
Poulsom, R.3
Evan, G.I.4
Harris, A.L.5
-
40
-
-
0036792667
-
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
-
Baudino TA, McKay C, Pendeville-Samain H, et al. c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev 2002;16:2530-43.
-
(2002)
Genes Dev
, vol.16
, pp. 2530-2543
-
-
Baudino, T.A.1
McKay, C.2
Pendeville-Samain, H.3
-
41
-
-
33748680731
-
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1β
-
Shchors K, Shchors E, Rostker F, LawlorER, Brown-Swigart L, Evan GI. The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1β. Genes Dev 2006;20:2527-38.
-
(2006)
Genes Dev
, vol.20
, pp. 2527-2538
-
-
Shchors, K.1
Shchors, E.2
Rostker, F.3
Lawlor, E.R.4
Brown-Swigart, L.5
Evan, G.I.6
-
42
-
-
34347402459
-
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
-
Yuneva M, Zamboni N, Oefner P, Sachidanandam R, Lazebnik Y. Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol 2007;178:93-105.
-
(2007)
J Cell Biol
, vol.178
, pp. 93-105
-
-
Yuneva, M.1
Zamboni, N.2
Oefner, P.3
Sachidanandam, R.4
Lazebnik, Y.5
-
43
-
-
57749088701
-
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
-
Wise DR, DeBerardinis RJ, Mancuso A, et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A 2008;105:18782-7.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 18782-18787
-
-
Wise, D.R.1
DeBerardinis, R.J.2
Mancuso, A.3
-
44
-
-
34548595378
-
Clinical applications of PET in brain tumors
-
Chen W. Clinical applications of PET in brain tumors. J Nucl Med 2007;48:1468-81.
-
(2007)
J Nucl Med
, vol.48
, pp. 1468-1481
-
-
Chen, W.1
-
45
-
-
77953616376
-
Positron emission tomography imaging of prostate cancer
-
Hong H, Zhang Y, Sun J, Cai W. Positron emission tomography imaging of prostate cancer. Amino Acids 2009;39:11-27.
-
(2009)
Amino Acids
, vol.39
, pp. 11-27
-
-
Hong, H.1
Zhang, Y.2
Sun, J.3
Cai, W.4
-
47
-
-
73949133557
-
Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors
-
Gallagher FA, Kettunen MI, Hu DE, et al. Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors. Proc Natl Acad Sci U S A 2009;106:19801-6.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 19801-19806
-
-
Gallagher, F.A.1
Kettunen, M.I.2
Hu, D.E.3
-
48
-
-
75849149496
-
13C magnetic resonance metabolic imaging: Application to brain tumors
-
13C magnetic resonance metabolic imaging: application to brain tumors. Neuro Oncol 2010;12:133-44.
-
(2010)
Neuro Oncol
, vol.12
, pp. 133-144
-
-
Park, I.1
Larson, P.E.2
Zierhut, M.L.3
-
49
-
-
54249093810
-
13C lactate, pyruvate, and alanine: Noninvasive biomarkers for prostate cancer detection and grading
-
13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. Cancer Res 2008;68:8607-15.
-
(2008)
Cancer Res
, vol.68
, pp. 8607-8615
-
-
Albers, M.J.1
Bok, R.2
Chen, A.P.3
-
50
-
-
0034306997
-
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
-
Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 2000;14:2501-14.
-
(2000)
Genes Dev
, vol.14
, pp. 2501-2514
-
-
Sears, R.1
Nuckolls, F.2
Haura, E.3
Taya, Y.4
Tamai, K.5
Nevins, J.R.6
-
51
-
-
10744230191
-
The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway
-
Iavarone C, Catania A, Marinissen MJ, et al. The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway. J Biol Chem 2003;278:50024-30.
-
(2003)
J Biol Chem
, vol.278
, pp. 50024-50030
-
-
Iavarone, C.1
Catania, A.2
Marinissen, M.J.3
-
52
-
-
35649014840
-
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
-
Kim JW, Gao P, Liu YC, Semenza GL, Dang CV. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 2007;27:7381-93.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 7381-7393
-
-
Kim, J.W.1
Gao, P.2
Liu, Y.C.3
Semenza, G.L.4
Dang, C.V.5
-
53
-
-
64749116346
-
c-Myc suppression of miR- 23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
-
Gao P, Tchernyshyov I, Chang TC, et al. c-Myc suppression of miR- 23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009;458:762-5.
-
(2009)
Nature
, vol.458
, pp. 762-765
-
-
Gao, P.1
Tchernyshyov, I.2
Chang, T.C.3
|