In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate

Molecular Imaging and Biology

Volumn 11, Issue 6, 2009, Pages 399-407

  Hu, Simon ^a   Chen, Albert P ^b   Zierhut, Matthew L ^a   Bok, Robert ^a   Yen, Yi Fen ^b   Schroeder, Marie A ^c   Hurd, Ralph E ^b   Nelson, Sarah J ^a   Kurhanewicz, John ^a   Vigneron, Daniel B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GE HEALTHCARE   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Alanine aminotransferase; Dynamic nuclear polarization (DNP); Fasted liver; Hyperpolarized carbon 13; Magnetic resonance spectroscopy spectroscopic imaging

Indexed keywords

ALANINE; ALANINE AMINOTRANSFERASE; LACTIC ACID; PYRUVIC ACID C 13; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; FEASIBILITY STUDY; HYPERPOLARIZATION; IN VIVO STUDY; LIVER METABOLISM; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POLARIZATION; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; THREE DIMENSIONAL IMAGING;

ALANINE; ANIMALS; CARBON ISOTOPES; FASTING; FEASIBILITY STUDIES; LACTIC ACID; LIVER; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, BIOLOGICAL; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 70350287827     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-009-0218-z     Document Type: Article

References (32)

1. 13C NMR spectroscopy of the brain. NMR Biomed 16:313-338
2. 13 C]-NMR spectroscopy of cerebral metabolism. NMR Biomed 16:339-357
3. Ross B, Lin A, Harris K et al (2003) Clinical experience with 13 MRS in vivo. NMR Biomed 16:358-369
4. Ardenkjaer-Larson JH, Fridlund B, Gram A et al (2003) Increase in signal-to-noise ration of > 10,000 times in liquid-state NMR. Proc Natl Acad Sci USA 100:10158-10163
5. Wolber J, Ellner F, Fridlund B et al (2004) Generating highly polarized nuclear spins in solution using dynamic nuclear polarization. Nucl Instr Meth Phys Res A 526:173-181
6. Golman K, Ardenkjaer-Larsen JH, Peterson JS et al (2003) Molecular imaging with endogenous substances. Proc Natl Acad Sci USA 100:10435-10439
7. 13C. Magn Reson Med 51:464-472
8. Golman K, Zandt R, Thaning M (2006) Real-time metabolic imaging. Proc Natl Acad Sci USA 103:11270-11275
9. 13C magnetic resonance imaging for in vivo tumor diagnosis. Cancer Res 66:10855-10860
10. 13C-1-pyruvate. Magn Reson Med 58:65-69
11. Chen AP, Albers MJ, Cunningham CH et al (2007) Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience. Magn Reson Med 58:1099-1106
12. 13C magnetic resonance imaging and spectroscopy. Nat Med 13:1382-1387, Erratum 13:1521
13. Brooks GA, Dubouchaud H, Brown M et al (1999) Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle. Proc Natl Acad Sci USA 96:1129-1134
14. Board M, Humm S, Newsholme E (1990) Maximum activities of key enzymes of glycolysis, glutaminolysis, pentose phosphate pathway and tricarboxylic acid cycle in normal, neoplastic and suppressed cells. Biochem J 265:503-509
15. DeBerardinis RJ, Lum JJ, Hatzivassiliou G et al (2008) The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7:11-20
16. 13 C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc Natl Acad Sci USA 104:19773-19777
17. Schroeder M, Cochlin L, Heather L et al (2008) In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance. Proc Natl Acad Sci USA 105:12051-12056
18. 13C. Acad Radiol 13:932-942
19. 13C MRSI studies. Magn Reson Imag 26:721-726
20. 13C-labelled bicarbonate. Nature 453:940-944
21. Gillies RJ, Raghunand N, Garcia-Martin M et al (2004) pH imaging: A review of pH measurement methods and applications in cancers. IEEE Eng Med Biol Mag 23:57-64
22. Reddy KR, Faust T (eds) (2006) The clinician's guide to liver disease, 1st edn. SLACK Incorporated, Thorofare
23. Derby K, Tropp J, Hawryszko C (1990) Design and evaluation of a novel dual-tuned resonator for spectroscopic imaging. J Mag Reson 86:645-651
24. 13C. J Magn Reson 187:357-362
25. Cunningham CH, Vigneron DB, Chen AP et al (2005) Design of flyback echo-planar readout gradients for magnetic resonance spectroscopic imaging. Mag Reson Med 54:1286-1289
26. Zhao L, Mulkern R, Tseng C-H et al (1996) Gradient-echo imaging considerations for hyperpolarized 129 Xe MR. J Magn Reson Series B 113:179-183
27. Nelson SJ (2001) Analysis of volume MRI and MR spectroscopic imaging data for the evaluation of patients with brain tumors. Mag Reson Med 46:228-239
28. Felig P (1973) The glucose-alanine cycle. Metab 22:179-207
29. 13C-labeled substrates by perfused liver from streptozotocin-diabetic and untreated rats. Biochem 26:563-572
30. Cohen SM (1987) 13 C NMR study of effects of fasting and diabetes on the metabolism of pyruvate in the tricarboxylic acid cycle and of the utilization of pyruvate and ethanol in lipogenesis in perfused rat liver. Biochem 26:581-589
31. 13C nuclear magnetic resonance methodology for in vivo studies. Magn Reson Med 3:24-32
32. Giboney PT (2005) Mildly elevated liver transaminase levels in the asymptomatic patient. Am Fam Physician 71:1105-1110