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Volumn 9, Issue 14, 2010, Pages 2938-2949

ATM regulates Mre11-dependent DNA end-degradation and microhomology- mediated end joining

Author keywords

ATM; DNA degradation; Double strand break repair; Microhomology mediated end joining; Mre11; MRN complex; PI 3 kinase like kinases

Indexed keywords

ATM PROTEIN; ENZYME INHIBITOR; ENZYME INHIBITOR MIRIN; EXONUCLEASE; MRE11 PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

EID: 77956819782     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.14.12363     Document Type: Article
Times cited : (59)

References (47)
  • 1
    • 11144357255 scopus 로고    scopus 로고
    • Cellular machineries for chromosomal DNA repair
    • Peterson CL, Cote J. Cellular machineries for chromosomal DNA repair. Genes Dev 2004; 18:602-16.
    • (2004) Genes Dev , vol.18 , pp. 602-616
    • Peterson, C.L.1    Cote, J.2
  • 2
    • 0035289717 scopus 로고    scopus 로고
    • Chromosomal stability and the DNA double-stranded break connection
    • van Gent DC, Hoeijmakers JH, Kanaar R. Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2001; 2:196-206.
    • (2001) Nat Rev Genet , vol.2 , pp. 196-206
    • Van Gent, D.C.1    Hoeijmakers, J.H.2    Kanaar, R.3
  • 3
    • 26244435498 scopus 로고    scopus 로고
    • Molecular pathology of ataxia telangiectasia
    • Taylor AM, Byrd PJ. Molecular pathology of ataxia telangiectasia. J Clin Pathol 2005; 58:1009-15.
    • (2005) J Clin Pathol , vol.58 , pp. 1009-1015
    • Taylor, A.M.1    Byrd, P.J.2
  • 4
    • 34247483506 scopus 로고    scopus 로고
    • ATM activation and DNA damage response
    • Lavin MF, Kozlov S. ATM activation and DNA damage response. Cell Cycle 2007; 6:931-42.
    • (2007) Cell Cycle , vol.6 , pp. 931-942
    • Lavin, M.F.1    Kozlov, S.2
  • 5
    • 0034162719 scopus 로고    scopus 로고
    • DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus
    • DiBiase SJ, Zeng ZC, Chen R, Hyslop T, Curran WJJr, Iliakis G. DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus. Cancer Res 2000; 60:1245-53.
    • (2000) Cancer Res , vol.60 , pp. 1245-1253
    • DiBiase, S.J.1    Zeng, Z.C.2    Chen, R.3    Hyslop, T.4    Curran Jr., W.J.5    Iliakis, G.6
  • 6
    • 0034234487 scopus 로고    scopus 로고
    • DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: Implications for Ku serving as an alignment factor in non-homologous DNA end joining
    • Feldmann E, Schmiemann V, Goedecke W, Reichenberger S, Pfeiffer P. DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining. Nucleic Acids Res 2000; 28:2585-96.
    • (2000) Nucleic Acids Res , vol.28 , pp. 2585-2596
    • Feldmann, E.1    Schmiemann, V.2    Goedecke, W.3    Reichenberger, S.4    Pfeiffer, P.5
  • 8
    • 15844385545 scopus 로고    scopus 로고
    • Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA
    • Liang F, Jasin M. Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA. J Biol Chem 1996; 271:14405-11.
    • (1996) J Biol Chem , vol.271 , pp. 14405-14411
    • Liang, F.1    Jasin, M.2
  • 10
    • 0037188898 scopus 로고    scopus 로고
    • Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations
    • Zhu C, Mills KD, Ferguson DO, Lee C, Manis J, Fleming J, et al. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell 2002; 109:811-21.
    • (2002) Cell , vol.109 , pp. 811-821
    • Zhu, C.1    Mills, K.D.2    Ferguson, D.O.3    Lee, C.4    Manis, J.5    Fleming, J.6
  • 11
    • 0035067494 scopus 로고    scopus 로고
    • Expression of ATM in ataxia telangiectasia fibroblasts rescues defects in DNA double-strand break repair in nuclear extracts
    • Li Y, Carty MP, Oakley GG, Seidman MM, Medvedovic M, Dixon K. Expression of ATM in ataxia telangiectasia fibroblasts rescues defects in DNA double-strand break repair in nuclear extracts. Environ Mol Mutagen 2001; 37:128-40.
    • (2001) Environ Mol Mutagen , vol.37 , pp. 128-140
    • Li, Y.1    Carty, M.P.2    Oakley, G.G.3    Seidman, M.M.4    Medvedovic, M.5    Dixon, K.6
  • 12
    • 0242468933 scopus 로고    scopus 로고
    • Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences
    • Ma JL, Kim EM, Haber JE, Lee SE. Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences. Mol Cell Biol 2003; 23:8820-8.
    • (2003) Mol Cell Biol , vol.23 , pp. 8820-8828
    • Ma, J.L.1    Kim, E.M.2    Haber, J.E.3    Lee, S.E.4
  • 13
    • 34548401682 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining
    • Lee K, Lee SE. Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining. Genetics 2007; 176:2003-14.
    • (2007) Genetics , vol.176 , pp. 2003-2014
    • Lee, K.1    Lee, S.E.2
  • 14
    • 0034612307 scopus 로고    scopus 로고
    • A mechanistic basis for Mre11-directed DNA joining at microhomologies
    • Paull TT, Gellert M. A mechanistic basis for Mre11-directed DNA joining at microhomologies. Proc Natl Acad Sci USA 2000; 97:6409-14.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6409-6414
    • Paull, T.T.1    Gellert, M.2
  • 16
    • 68249146431 scopus 로고    scopus 로고
    • Role of mammalian Mre11 in classical and alternative nonhomologous end joining
    • Xie A, Kwok A, Scully R. Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat Struct Mol Biol 2009; 16:814-8.
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 814-818
    • Xie, A.1    Kwok, A.2    Scully, R.3
  • 17
    • 34948899943 scopus 로고    scopus 로고
    • Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling and the chromatin template
    • Williams RS, Williams JS, Tainer JA. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling and the chromatin template. Biochem Cell Biol 2007; 85:509-20.
    • (2007) Biochem Cell Biol , vol.85 , pp. 509-520
    • Williams, R.S.1    Williams, J.S.2    Tainer, J.A.3
  • 18
    • 0032562595 scopus 로고    scopus 로고
    • In situ visualization of DNA double-strand break repair in human fibroblasts
    • Nelms BE, Maser RS, MacKay JF, Lagally MG, Petrini JH. In situ visualization of DNA double-strand break repair in human fibroblasts. Science 1998; 280:590-2.
    • (1998) Science , vol.280 , pp. 590-592
    • Nelms, B.E.1    Maser, R.S.2    MacKay, J.F.3    Lagally, M.G.4    Petrini, J.H.5
  • 19
    • 20744436198 scopus 로고    scopus 로고
    • ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
    • You Z, Chahwan C, Bailis J, Hunter T, Russell P. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol 2005; 25:5363-79.
    • (2005) Mol Cell Biol , vol.25 , pp. 5363-5379
    • You, Z.1    Chahwan, C.2    Bailis, J.3    Hunter, T.4    Russell, P.5
  • 20
    • 0034713466 scopus 로고    scopus 로고
    • ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
    • Wu X, Ranganathan V, Weisman DS, Heine WF, Ciccone DN, O'Neill TB, et al. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature 2000; 405:477-82.
    • (2000) Nature , vol.405 , pp. 477-482
    • Wu, X.1    Ranganathan, V.2    Weisman, D.S.3    Heine, W.F.4    Ciccone, D.N.5    O'Neill, T.B.6
  • 21
    • 0034611728 scopus 로고    scopus 로고
    • ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
    • Lim DS, Kim ST, Xu B, Maser RS, Lin J, Petrini JH, et al. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 2000; 404:613-7.
    • (2000) Nature , vol.404 , pp. 613-617
    • Lim, D.S.1    Kim, S.T.2    Xu, B.3    Maser, R.S.4    Lin, J.5    Petrini, J.H.6
  • 22
    • 33745005952 scopus 로고    scopus 로고
    • Signaling networks controlled by the MRN complex and MDC1 during early DNA damage responses
    • Kim JE, Minter-Dykhouse K, Chen J. Signaling networks controlled by the MRN complex and MDC1 during early DNA damage responses. Mol Carcinog 2006; 45:403-8.
    • (2006) Mol Carcinog , vol.45 , pp. 403-408
    • Kim, J.E.1    Minter-Dykhouse, K.2    Chen, J.3
  • 24
    • 0032508608 scopus 로고    scopus 로고
    • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
    • Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 1998; 281:1677-9.
    • (1998) Science , vol.281 , pp. 1677-1679
    • Canman, C.E.1    Lim, D.S.2    Cimprich, K.A.3    Taya, Y.4    Tamai, K.5    Sakaguchi, K.6
  • 25
    • 1842431822 scopus 로고    scopus 로고
    • Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
    • Lee JH, Paull TT. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 2004; 304:93-6.
    • (2004) Science , vol.304 , pp. 93-96
    • Lee, J.H.1    Paull, T.T.2
  • 26
    • 0142186242 scopus 로고    scopus 로고
    • The MRN complex: Coordinating and mediating the response to broken chromosomes
    • van den Bosch M, Bree RT, Lowndes NF. The MRN complex: coordinating and mediating the response to broken chromosomes. EMBO Rep 2003; 4:844-9.
    • (2003) EMBO Rep , vol.4 , pp. 844-849
    • Van Den Bosch, M.1    Bree, R.T.2    Lowndes, N.F.3
  • 27
    • 0037102708 scopus 로고    scopus 로고
    • Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism
    • Yuan SS, Chang HL, Hou MF, Chan TF, Kao YH, Wu YC, et al. Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism. Toxicology 2002; 177:123-30.
    • (2002) Toxicology , vol.177 , pp. 123-130
    • Yuan, S.S.1    Chang, H.L.2    Hou, M.F.3    Chan, T.F.4    Kao, Y.H.5    Wu, Y.C.6
  • 29
    • 60249099583 scopus 로고    scopus 로고
    • Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex
    • Garner KM, Pletnev AA, Eastman A. Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol 2009; 5:129-30.
    • (2009) Nat Chem Biol , vol.5 , pp. 129-130
    • Garner, K.M.1    Pletnev, A.A.2    Eastman, A.3
  • 31
    • 0032085295 scopus 로고    scopus 로고
    • The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
    • Paull TT, Gellert M. The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol Cell 1998; 1:969-79.
    • (1998) Mol Cell , vol.1 , pp. 969-979
    • Paull, T.T.1    Gellert, M.2
  • 32
    • 5144225797 scopus 로고    scopus 로고
    • DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining
    • Bentley J, Diggle CP, Harnden P, Knowles MA, Kiltie AE. DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining. Nucleic Acids Res 2004; 32:5249-59.
    • (2004) Nucleic Acids Res , vol.32 , pp. 5249-5259
    • Bentley, J.1    Diggle, C.P.2    Harnden, P.3    Knowles, M.A.4    Kiltie, A.E.5
  • 34
    • 30444458875 scopus 로고    scopus 로고
    • A model of oncogenic rearrangements: Differences between chromosomal translocation mechanisms and simple double-strand break repair
    • Weinstock DM, Elliott B, Jasin M. A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair. Blood 2006; 107:777-80.
    • (2006) Blood , vol.107 , pp. 777-780
    • Weinstock, D.M.1    Elliott, B.2    Jasin, M.3
  • 35
    • 37849023839 scopus 로고    scopus 로고
    • Distinctive differences in DNA double-strand break repair between normal urothelial and urothelial carcinoma cells
    • Windhofer F, Krause S, Hader C, Schulz WA, Florl AR. Distinctive differences in DNA double-strand break repair between normal urothelial and urothelial carcinoma cells. Mutat Res 2008; 638:56-65.
    • (2008) Mutat Res , vol.638 , pp. 56-65
    • Windhofer, F.1    Krause, S.2    Hader, C.3    Schulz, W.A.4    Florl, A.R.5
  • 36
    • 33745808783 scopus 로고    scopus 로고
    • Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement
    • Yoshimoto M, Joshua AM, Chilton-Macneill S, Bayani J, Selvarajah S, Evans AJ, et al. Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement. Neoplasia 2006; 8:465-9.
    • (2006) Neoplasia , vol.8 , pp. 465-469
    • Yoshimoto, M.1    Joshua, A.M.2    Chilton-Macneill, S.3    Bayani, J.4    Selvarajah, S.5    Evans, A.J.6
  • 37
    • 52949149420 scopus 로고    scopus 로고
    • Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair
    • Williams RS, Moncalian G, Williams JS, Yamada Y, Limbo O, Shin DS, et al. Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell 2008; 135:97-109.
    • (2008) Cell , vol.135 , pp. 97-109
    • Williams, R.S.1    Moncalian, G.2    Williams, J.S.3    Yamada, Y.4    Limbo, O.5    Shin, D.S.6
  • 38
    • 0037093096 scopus 로고    scopus 로고
    • The BLM helicase is necessary for normal DNA double-strand break repair
    • Langland G, Elliott J, Li Y, Creaney J, Dixon K, Groden J. The BLM helicase is necessary for normal DNA double-strand break repair. Cancer Res 2002; 62:2766-70.
    • (2002) Cancer Res , vol.62 , pp. 2766-2770
    • Langland, G.1    Elliott, J.2    Li, Y.3    Creaney, J.4    Dixon, K.5    Groden, J.6
  • 39
    • 11244280890 scopus 로고    scopus 로고
    • Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
    • Audebert M, Salles B, Calsou P. Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J Biol Chem 2004; 279:55117-26.
    • (2004) J Biol Chem , vol.279 , pp. 55117-55126
    • Audebert, M.1    Salles, B.2    Calsou, P.3
  • 40
    • 0032403914 scopus 로고    scopus 로고
    • Rejoining of DNA double-strand breaks in vitro by single-strand annealing
    • Gottlich B, Reichenberger S, Feldmann E, Pfeiffer P. Rejoining of DNA double-strand breaks in vitro by single-strand annealing. Eur J Biochem 1998; 258:387-95.
    • (1998) Eur J Biochem , vol.258 , pp. 387-395
    • Gottlich, B.1    Reichenberger, S.2    Feldmann, E.3    Pfeiffer, P.4
  • 41
    • 34547132093 scopus 로고    scopus 로고
    • Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination
    • Decottignies A. Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination. Genetics 2007; 176:1403-15.
    • (2007) Genetics , vol.176 , pp. 1403-1415
    • Decottignies, A.1
  • 42
    • 70349472553 scopus 로고    scopus 로고
    • Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair
    • Williams RS, Dodson GE, Limbo O, Yamada Y, Williams JS, Guenther G, et al. Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Cell 2009; 139:87-99.
    • (2009) Cell , vol.139 , pp. 87-99
    • Williams, R.S.1    Dodson, G.E.2    Limbo, O.3    Yamada, Y.4    Williams, J.S.5    Guenther, G.6
  • 43
    • 0037398027 scopus 로고    scopus 로고
    • Rad50/SMC proteins and ABC transporters: Unifying concepts from high-resolution structures
    • Hopfner KP, Tainer JA. Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures. Current Opinion in Structural Biology 2003; 13:249-55.
    • (2003) Current Opinion in Structural Biology , vol.13 , pp. 249-255
    • Hopfner, K.P.1    Tainer, J.A.2
  • 45
    • 38049187905 scopus 로고    scopus 로고
    • Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends
    • Guirouilh-Barbat J, Rass E, Plo I, Bertrand P, Lopez BS. Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends. Proc Natl Acad Sci USA 2007; 104:20902-7.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20902-20907
    • Guirouilh-Barbat, J.1    Rass, E.2    Plo, I.3    Bertrand, P.4    Lopez, B.S.5
  • 47
    • 34748863465 scopus 로고    scopus 로고
    • IgH class switching and translocations use a robust non-classical end-joining pathway
    • Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, et al. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 2007; 449:478-82.
    • (2007) Nature , vol.449 , pp. 478-482
    • Yan, C.T.1    Boboila, C.2    Souza, E.K.3    Franco, S.4    Hickernell, T.R.5    Murphy, M.6


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