Expression of ATM in ataxia telangiectasia fibroblasts rescues defects in DNA double-strand break repair in nuclear extracts

Environmental and Molecular Mutagenesis

Volumn 37, Issue 2, 2001, Pages 128-140

  Li, Yuling ^a   Carty, Michael P ^a,c   Oakley, Gregory G ^a   Seidman, Michael M ^b   Medvedovic, Mario ^a   Dixon, Kathleen ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Ataxia telangiectasia; Deletion mutatian; Double strand break repair; Nuclear extracts; Plasmid vector

Indexed keywords

ATM PROTEIN; DNA; DOUBLE STRANDED DNA; ENDONUCLEASE; PROTEIN KINASE; TRANSFER RNA;

ARTICLE; ATAXIA TELANGIECTASIA; CANCER SUSCEPTIBILITY; CEREBELLUM DEGENERATION; CHROMOSOME BREAKAGE; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; FIBROBLAST; GENE EXPRESSION; GENETIC DISORDER; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; PLASMID; RADIOSENSITIVITY; SEQUENCE HOMOLOGY; WESTERN BLOTTING;

ATAXIA TELANGIECTASIA; BASE SEQUENCE; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; CELL NUCLEUS; DNA; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; FIBROBLASTS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0035067494     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.1020     Document Type: Article

References (49)

1. Defective recovery from potentially lethal damage in some human fibroblast cell strains
2. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
3. The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage
4. Chromosomal breakage syndromes
5. Common pathways for ultraviolet skin carcinogenesis in the repair and replication defective groups of xeroderma pigmentosum
6. Overexpression of the XPA repair gene increases resistance to ultraviolet radiation in human cells by selective repair of DNA damage
7. The role of genomic instability in human carcinogenesis
8. On the nature of a defect in cells from individuals with ataxia-telangiectasia
9. The repair of potentially lethal damage in X-irradiated cultures of normal and ataxia telangiectasia human fibroblasts
10. The use of recombinant DNA plasmids for the determination of DNA-repair and recombination in cultured māmmalian cells
11. Ataxia-telangiectasia: A human mutation giving high-frequency misrepair of DNA double-stranded scissions
12. Identification of defective illegitimate recombinational repair of oxidatively-induced DNA double-strand breaks in ataxia-telangiectasia cells
13. DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
14. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
15. Dose-rate effect on induction and repair rate of radiation-induced DNA double-strand breaks in a normal and an ataxia telangiectasia human fibroblast cell line
16. Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks
17. ATM-dependent phosphorylation of nibrin in response to radiation exposure
18. Ataxia-telangiectasia: Founder effect among North African Jews
19. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells
20. Nonhomologous DNA end joining in cell-free systems
21. Ku-dependent nonhomologous DNA end joining in Xenopus egg extracts
22. Radiosensitivity and oxidative signalling in ataxia telangiectasia: An update
23. ATM: The product of the gene mutated in ataxia-telangiectasia
24. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
25. Promotion of double-strand break repair by human nuclear extracts preferentially involves recombination with intact homologous DNA
26. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer
27. The rejoining of double-strand breaks in DNA by human cell extracts
28. Mutation of a mutL homolog in hereditary colon cancer
29. The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
30. The Mre 11 complex and ATM: Collaborating to navigate S phase
31. Ataxia telangiectasia: An investigation of the repair defect in the cell line AT5BIVA by plasmid reconstitution
32. Radiosensitive human tumour cell lines show misrepair of DNA termini
33. The ATM gene and protein: Possible roles in genome surveillance, checkpoint controls and cellular defence against oxidative stress
34. ATM: A mediator of multiple responses to genotoxic stress
35. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
36. A single ataxia telangiectasia gene with a product similar to PI-3 kinase
37. Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart
38. DNA-dependent protein kinase and related proteins
39. Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation
40. Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations
41. What has the cloning of the ATM gene told us about ataxia telangiectasia?
42. Leukemia and lymphoma in ataxia telangiectasia
43. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre1 l, and p95
44. Deficient recovery from potentially lethal radiation damage in ataxia telengiectasia and xeroderma pigmentosum
45. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
46. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
47. Cellular and molecular characteristics of an immortalized ataxia-telangiectasia (group AB) cell line
48. Recombinant ATM protein complements the cellular A-T phenotype