Abnormal DNA end-joining activity in human head and neck cancer

International Journal of Molecular Medicine

Volumn 17, Issue 5, 2006, Pages 917-924

  Shin, Ki Hyuk ^a,b   Kang, Mo K ^a,b   Kim, Reuben H ^a   Kameta, Ayako ^a   Baluda, Marcel A ^a,b   Park, No Hee ^a,b  

^a UCLA SCHOOL OF DENTISTRY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

DNA end joining; Double strand break repair; Genetic integrity; Head and neck squamous cell carcinoma

Indexed keywords

DNA; HYBRID PROTEIN; LUCIFERASE;

ARTICLE; BIOLOGICAL MODEL; CELL CULTURE; CELL LINE; CHEMISTRY; CYTOLOGY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA SEQUENCE; GENETIC TRANSFECTION; GENETICS; HEAD AND NECK TUMOR; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; KERATINOCYTE; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PLASMID; TUMOR CELL LINE; VIRUS CELL TRANSFORMATION;

BASE SEQUENCE; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL TRANSFORMATION, VIRAL; CELLS, CULTURED; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA, NEOPLASM; HEAD AND NECK NEOPLASMS; HUMAN PAPILLOMAVIRUS 16; HUMANS; KERATINOCYTES; LUCIFERASES; MODELS, GENETIC; MUTATION; PLASMIDS; RECOMBINANT FUSION PROTEINS; SEQUENCE ANALYSIS, DNA; TRANSFECTION;

EID: 33750603155     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.17.5.917     Document Type: Article

References (41)

1. Khanna KK and Jackson SP: DNA double strand breaks: signaling, repair and the cancer connection. Nat Genet 27: 247-254, 2001.
2. Smith GC and Jackson SP: The DNA-dependent protein kinase. Genes Dev 13: 916-934, 1999.
3. Haber JE: Partners and pathways repairing a double-strand break. Trends Genet 16: 259-264, 2000.
4. Schar P: Spontaneous DNA damage, genomic instability, and cancer - when DNA replication escapes control. Cell 104: 329-332, 2001.
5. Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA and Alt FW: The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci USA 97: 6630-6633, 2000.
6. Zhu C, Bogue MA, Lim DS, Hasty P and Roth DB: Ku80- deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 86: 379-389, 1996.
7. Gu Y, Jin S, Gao Y, Weaver DT and Alt FW: Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity and inability to support V(D)J recombination. Proc Natl Acad Sci USA 94: 8076-8081, 1997.
8. Karanjawala ZE, Grawunder U, Hsieh CL and Liber MR: The nonhomologous DNA end-joining pathway is important for chromosome stability in primary fibroblasts. Curr Biol 9: 1501-1504, 1999.
9. Lim DS, Vogel H, Willerford DM, Sands AT, Platt KA and Hasty P: Analysis of ku80-mutant mice and cells with deficient levels of p53. Mol Cell Biol 20: 3772-3780, 2000.
10. Difilippantonio MJ, Zhu J, Chen HT, Meffre E, Nussenzweig MC, Max EE, Ried T and Nussenzweig A: DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 404: 510-514, 2000.
11. Park N-H, Min B-M, Li S-L, Huang MZ, Cherrick HM and Doniger J: Immortalization of normal human oral keratinocytes with type 16 human papillomavirus. Carcinogenesis 12: 1627-1631, 1991.
12. Shin K-H, Min B-M, Cherrick HM and Park N-H: Combined effects of human papillomavirus-18 and N-methyl-N′-nitro-N-nitrosoguanidine on the transformation of normal human oral keratinocytes. Mol Carcinogen 9: 76-86, 1994.
13. Shin K-H, Tannyhill RJ, Liu X and Park N-H: Oncogenic transformation of HPV-immortalized human oral keratinocytes is associated with the genetic instability of cells. Oncogene 12: 1089-1096, 1996.
14. Liu X, Han S, Baluda MA and Park N-H: HPV-16 oncogenes E6 and E7 are mutagenic in normal human oral keratinocytes. Oncogene 14: 2347-2353, 1997.
15. Rey O, Lee S and Park N-H: Impaired nucleotide excision repair in UV-irradiated human oral keratinocytes immortalized with type 16 human papillomavirus genome. Oncogene 18: 6997-7001, 1999.
16. Oda D, Bigler L, Mao EJ and Disteche CM: Chromosomal abnormalities in HPV-16-immortalized oral epithelial cells. Carcinogenesis 17: 2003-2008, 1996.
17. Solinas-Toldo S, Dürst M and Lichter P: Specific chromosomal imbalances in human papillomavirus-transfected cells during progression toward immortality. Proc Natl Acad Sci USA 94: 3854-3859, 1997.
18. Steenbergen RD, Hermsen MA, Walboomers JM, Meijer GA, Baak JP, Meijer CJ and Snijders PJ: Non-random allelic losses at 3p, 11p and 13q during HPV-mediated immortalization and concomitant loss of terminal differentiation of human keratinocytes. Int J Cancer 76: 412-417, 1998.
19. Matthews CP, Shera KA and McDougall JK: Genomic changes and HPV type in cervical carcinoma. Proc Soc Exp Biol Med 223: 316-321, 2000.
20. Sherwood JB, Shivapurkar N, Lin WM, Ashfaq R, Miller DS, Gazdar AF and Muller CY: Chromosome 4 deletions are frequent in invasive cervical cancer and differ between histologic variants. Gynecol Oncol 79: 90-96, 2000.
21. Chuaqui R, Silva M and Emmert-Buck M: Allelic deletion mapping on chromosome 6q and X chromosome inactivation clonality patterns in cervical intraepithelial neoplasia and invasive carcinoma. Gynecol Oncol 80: 364-371, 2001.
22. Kang MK, Shin K-H, Yip FK and Park N-H: Normal human oral keratinocytes demonstrate abnormal DNA end joining activity during replicative senescence. Mech Ageing Dev 126: 475-479, 2005.
23. Shin K-H, Ahn JH, Kang MK, Lim PK, Yip FK, Baluda MA and Park NH: HPV-16 E6 oncoprotein impairs the fidelity of DNA end-joining via p53-dependent and -independent pathways. Int J Oncol 28: 209-215, 2006.
24. Shin K-H, Kang MK, Dicterow E, Kameta A, Baluda MA and Park N-H: Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity. Clin Cancer Res 10: 2551-2560, 2004.
25. Bentley J, Diggle CP, Harnden P, Knowles MA and Kiltie AE: DNA double-strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining. Nucleic Acids Res 32: 5249-5259, 2004.
26. Kanaar R, Hoeijmakers JH and van Gent DC: Molecular mechanisms of DNA double-strand break repair. Trends Cell Biol 8: 483-489, 1998.
27. Oberosler P, Hloch P, Ramsperger U and Stahl H: p53- catalyzed annealing of complementary single-stranded nucleic acids. EMBO J 12: 2389-2396, 1993.
28. Lee S, Elenbaas B, Levine A and Griffith J: p53 and its 14 kDa C-terminal domain recognize primary DNA-damage in the form of insertion/deletion mismatches. Cell 81: 1013-1020, 1995.
29. Bakalkin G, Selivanova G, Yakovleva T, Kiseleva E, Kashuba E, Magnusson K, Szekely L, Klein G, Terenius L and Wiman K: p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain. Nucleic Acid Res 23: 362-369, 1995.
30. Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM, Chaudhuri J, Horner J, DePinho RA and Alt FW: Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature 404: 897-900, 2000.
31. Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, Manis JP, Horner J, DePinho RA and Alt FW: DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell 5: 993-1002, 2000.
32. Yang T, Namba H, Hara T, Takmura N, Nagayama Y, Fukata S, Ishikawa N, Kuma K, Ito K and Yamashita S: p53 induced by ionizing radiation mediates DNA end-jointing activity, but not apoptosis of thyroid cells. Oncogene 14: 1511-1519, 1997.
33. Tang W, Willers H and Powell SN: p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts. Cancer Res 59: 2562-2565, 1999.
34. Lin Y, Waldman BC and Waldman AS: Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-alpha, a chemical inhibitor of p53. DNA Repair 2: 1-11, 2003.
35. Min B-M, Baek JH, Shin K-H, Gujuluva CN, Cherrick HM and Park N-H: Inactivation of the p53 gene by either mutation or HPV infection is extremely frequent in human oral squamous cell carcinoma cell lines. Eur J Cancer 30B: 338-345, 1994.
36. Li S-L, Kim MS, Cherrick HM and Park N-H: Low p53 level in immortal, non-tumorigenic oral keratinocytes harboring HPV-16 DNA. Eur J Cancer 28B: 129-134, 1992.
37. Mummenbrauer T, Janus F, Muller B, Wiesmuller L, Deppert W and Grosse F: p53 protein exhibits 3′-to-5′ exonuclease activity. Cell 85: 1089-1099, 1996.
38. Huang P: Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein: Oncogene 17: 261-270, 1998.
39. Lilling G, Elena N, Sidi Y and Bakhanashvili M: p53-associated 3′→5′ exonuclease activity in nuclear and cytoplasmic compartments of cells. Oncogene 22: 233-245, 2003.
40. Guo W, Kang MK, Kim HJ and Park N-H: Immortalization of human oral keratinocytes is associated with elevation of telomerase activity and shortening of telomere length. Oncol Rep 5: 799-804, 1998. (Pubitemid 28270670)
41. Liu X, Nishitani J, McQuirter JL, Baluda MA and Park N-H: The temperature sensitive mutant p53-143ala extends in vitro life span, promotes errors in DNA replication and impairs DNA repair in normal human oral keratinocytes. Cell Mol Biol 47: 1169-1178, 2001.