The BLM helicase is necessary for normal DNA double-strand break repair

Cancer Research

Volumn 62, Issue 10, 2002, Pages 2766-2770

  Langland, Gregory ^a   Elliott, James ^a   Li, Yuling ^a   Creaney, Jenette ^a   Dixon, Kathleen ^a   Groden, Joanna ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; HELICASE;

ARTICLE; BLOOM SYNDROME; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; DNA STRUCTURE; GENE MUTATION; HUMAN; HUMAN CELL; MUTAGENESIS; MUTATION RATE; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATASES; BASE SEQUENCE; BLOOM SYNDROME; CELL LINE, TRANSFORMED; CELL-FREE SYSTEM; DNA HELICASES; DNA REPAIR; FEMALE; GENE DELETION; GENES, SUPPRESSOR; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PLASMIDS; RNA, TRANSFER;

EID: 0037093096     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Bloom's syndrome
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3. The Bloom's syndrome gene product is a 3′-5′ DNA helicase
4. DNA repair and the molecular mechanisms of Bloom's syndrome
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6. The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair
7. Joining of linear plasmid DNA is reduced and error-prone in Bloom's syndrome cells
8. Molecular mechanisms in DNA double-strand break repair
9. DNA double-strand breaks: Signaling, repair and the cancer connection
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11. Expression of ATM in ataxia telangiectasia fibroblasts rescues defects in DNA double-strand break repair in nuclear extracts
12. A shuttle vector plasmid for studying carcinogen-induced point mutations in mammalian cells
13. A mechanism for deletion formation in DNA by human cell extracts: The involvement of short sequence repeats
14. Sterility of Drosophila with mutations in the Bloom syndrome gene-complementation by Ku70
15. Functional interaction between Ku and the Wemer syndrome protein in DNA end processing
16. Qin a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
17. Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51
18. Possible association of BLM in decreasing DNA double strand breaks during DNA replication