-
1
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
10.1126/science.296.5573.1655, 12040186
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657. 10.1126/science.296.5573.1655, 12040186.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
2
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
10.1038/nrg1879, 16847462
-
Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006, 7:606-619. 10.1038/nrg1879, 16847462.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
3
-
-
16244393685
-
Signalling by PI3K isoforms: insights from gene-targeted mice
-
10.1016/j.tibs.2005.02.008, 15817396
-
Vanhaesebroeck B, Ali K, Bilancio A, Geering B, Foukas LC. Signalling by PI3K isoforms: insights from gene-targeted mice. Trends Biochem Sci 2005, 30:194-204. 10.1016/j.tibs.2005.02.008, 15817396.
-
(2005)
Trends Biochem Sci
, vol.30
, pp. 194-204
-
-
Vanhaesebroeck, B.1
Ali, K.2
Bilancio, A.3
Geering, B.4
Foukas, L.C.5
-
4
-
-
0030999696
-
STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor
-
10.1126/science.276.5317.1418, 9162009
-
Pfeffer LM, Mullersman JE, Pfeffer SR, Murti A, Shi W, Yang CH. STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor. Science 1997, 276:1418-1420. 10.1126/science.276.5317.1418, 9162009.
-
(1997)
Science
, vol.276
, pp. 1418-1420
-
-
Pfeffer, L.M.1
Mullersman, J.E.2
Pfeffer, S.R.3
Murti, A.4
Shi, W.5
Yang, C.H.6
-
5
-
-
49149086504
-
PTEN: a default gate-keeping tumor suppressor with a versatile tail
-
10.1038/cr.2008.83, 18626510
-
Wang X, Jiang X. PTEN: a default gate-keeping tumor suppressor with a versatile tail. Cell Res 2008, 18:807-816. 10.1038/cr.2008.83, 18626510.
-
(2008)
Cell Res
, vol.18
, pp. 807-816
-
-
Wang, X.1
Jiang, X.2
-
6
-
-
33646705667
-
Regulation of the PTEN phosphatase
-
10.1016/j.gene.2006.02.024, 16675164
-
Gericke A, Munson M, Ross AH. Regulation of the PTEN phosphatase. Gene 2006, 374:1-9. 10.1016/j.gene.2006.02.024, 16675164.
-
(2006)
Gene
, vol.374
, pp. 1-9
-
-
Gericke, A.1
Munson, M.2
Ross, A.H.3
-
7
-
-
69749083045
-
RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK
-
Brauer PM, Tyner AL. RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK. Cell Cycle 2009, 8:2728-2732.
-
(2009)
Cell Cycle
, vol.8
, pp. 2728-2732
-
-
Brauer, P.M.1
Tyner, A.L.2
-
8
-
-
0033582285
-
Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation
-
10.1073/pnas.96.2.429, 15153, 9892650
-
Beraud C, Henzel WJ, Baeuerle PA. Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation. Proc Natl Acad Sci USA 1999, 96:429-434. 10.1073/pnas.96.2.429, 15153, 9892650.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 429-434
-
-
Beraud, C.1
Henzel, W.J.2
Baeuerle, P.A.3
-
9
-
-
0033517190
-
NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
-
10.1038/43474, 10485711
-
Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 1999, 401:86-90. 10.1038/43474, 10485711.
-
(1999)
Nature
, vol.401
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
10
-
-
44849117768
-
Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK
-
10.1101/gad.1662308, 2418585, 18519641
-
Dan HC, Cooper MJ, Cogswell PC, Duncan JA, Ting JP, Baldwin AS. Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev 2008, 22:1490-1500. 10.1101/gad.1662308, 2418585, 18519641.
-
(2008)
Genes Dev
, vol.22
, pp. 1490-1500
-
-
Dan, H.C.1
Cooper, M.J.2
Cogswell, P.C.3
Duncan, J.A.4
Ting, J.P.5
Baldwin, A.S.6
-
11
-
-
58149395054
-
Phosphoinositide 3-kinases in cell migration
-
10.1042/BC20080079, 19055486
-
Cain RJ, Ridley AJ. Phosphoinositide 3-kinases in cell migration. Biol Cell 2009, 101:13-29. 10.1042/BC20080079, 19055486.
-
(2009)
Biol Cell
, vol.101
, pp. 13-29
-
-
Cain, R.J.1
Ridley, A.J.2
-
12
-
-
33751431763
-
Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation
-
10.1016/j.cmet.2006.10.011, 17141631
-
Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portocarrero CP, Keister BA, Belka GK, Cho H, Rathmell JC, Thompson CB, Birnbaum MJ, Chodosh LA. Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell Metab 2006, 4:475-490. 10.1016/j.cmet.2006.10.011, 17141631.
-
(2006)
Cell Metab
, vol.4
, pp. 475-490
-
-
Boxer, R.B.1
Stairs, D.B.2
Dugan, K.D.3
Notarfrancesco, K.L.4
Portocarrero, C.P.5
Keister, B.A.6
Belka, G.K.7
Cho, H.8
Rathmell, J.C.9
Thompson, C.B.10
Birnbaum, M.J.11
Chodosh, L.A.12
-
13
-
-
0035008874
-
Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
-
10.1128/MCB.21.6.2203-2212.2001, 86854, 11238953
-
Hutchinson J, Jin J, Cardiff RD, Woodgett JR, Muller WJ. Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol 2001, 21:2203-2212. 10.1128/MCB.21.6.2203-2212.2001, 86854, 11238953.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2203-2212
-
-
Hutchinson, J.1
Jin, J.2
Cardiff, R.D.3
Woodgett, J.R.4
Muller, W.J.5
-
14
-
-
0142042372
-
Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation
-
10.1194/jlr.M300045-JLR200, 12700340
-
Schwertfeger KL, McManaman JL, Palmer CA, Neville MC, Anderson SM. Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation. J Lipid Res 2003, 44:1100-1112. 10.1194/jlr.M300045-JLR200, 12700340.
-
(2003)
J Lipid Res
, vol.44
, pp. 1100-1112
-
-
Schwertfeger, K.L.1
McManaman, J.L.2
Palmer, C.A.3
Neville, M.C.4
Anderson, S.M.5
-
15
-
-
0034987031
-
Mammary gland involution is delayed by activated Akt in transgenic mice
-
10.1210/me.15.6.867, 11376107
-
Schwertfeger KL, Richert MM, Anderson SM. Mammary gland involution is delayed by activated Akt in transgenic mice. Mol Endocrinol 2001, 15:867-881. 10.1210/me.15.6.867, 11376107.
-
(2001)
Mol Endocrinol
, vol.15
, pp. 867-881
-
-
Schwertfeger, K.L.1
Richert, M.M.2
Anderson, S.M.3
-
16
-
-
0037050234
-
Delayed mammary gland involution in MMTV-AKT1 transgenic mice
-
10.1038/sj.onc.1205052, 11803463
-
Ackler S, Ahmad S, Tobias C, Johnson MD, Glazer RI. Delayed mammary gland involution in MMTV-AKT1 transgenic mice. Oncogene 2002, 21:198-206. 10.1038/sj.onc.1205052, 11803463.
-
(2002)
Oncogene
, vol.21
, pp. 198-206
-
-
Ackler, S.1
Ahmad, S.2
Tobias, C.3
Johnson, M.D.4
Glazer, R.I.5
-
17
-
-
51449094934
-
Distinct roles of the three Akt isoforms in lactogenic differentiation and involution
-
10.1002/jcp.21518, 18561256
-
Maroulakou IG, Oemler W, Naber SP, Klebba I, Kuperwasser C, Tsichlis PN. Distinct roles of the three Akt isoforms in lactogenic differentiation and involution. J Cell Physiol 2008, 217:468-477. 10.1002/jcp.21518, 18561256.
-
(2008)
J Cell Physiol
, vol.217
, pp. 468-477
-
-
Maroulakou, I.G.1
Oemler, W.2
Naber, S.P.3
Klebba, I.4
Kuperwasser, C.5
Tsichlis, P.N.6
-
18
-
-
67449136114
-
Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression
-
10.1158/0008-5472.CAN-08-4287, 19491266
-
Dillon RL, Marcotte R, Hennessy BT, Woodgett JR, Mills GB, Muller WJ. Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Cancer Res 2009, 69:5057-5064. 10.1158/0008-5472.CAN-08-4287, 19491266.
-
(2009)
Cancer Res
, vol.69
, pp. 5057-5064
-
-
Dillon, R.L.1
Marcotte, R.2
Hennessy, B.T.3
Woodgett, J.R.4
Mills, G.B.5
Muller, W.J.6
-
19
-
-
0038624395
-
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
-
10.1101/gad.1089403, 196068, 12782654
-
Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, Jacobs J, Sundararajan D, Chen WS, Crawford SE, Coleman KG, Hay N. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 2003, 17:1352-1365. 10.1101/gad.1089403, 196068, 12782654.
-
(2003)
Genes Dev
, vol.17
, pp. 1352-1365
-
-
Peng, X.D.1
Xu, P.Z.2
Chen, M.L.3
Hahn-Windgassen, A.4
Skeen, J.5
Jacobs, J.6
Sundararajan, D.7
Chen, W.S.8
Crawford, S.E.9
Coleman, K.G.10
Hay, N.11
-
20
-
-
27944446105
-
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
-
10.1016/j.molcel.2005.10.033, 16307918
-
Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 2005, 20:539-550. 10.1016/j.molcel.2005.10.033, 16307918.
-
(2005)
Mol Cell
, vol.20
, pp. 539-550
-
-
Yoeli-Lerner, M.1
Yiu, G.K.2
Rabinovitz, I.3
Erhardt, P.4
Jauliac, S.5
Toker, A.6
-
21
-
-
29144488505
-
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
-
10.1083/jcb.200505087, 2171329, 16365168
-
Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol 2005, 171:1023-1034. 10.1083/jcb.200505087, 2171329, 16365168.
-
(2005)
J Cell Biol
, vol.171
, pp. 1023-1034
-
-
Irie, H.Y.1
Pearline, R.V.2
Grueneberg, D.3
Hsia, M.4
Ravichandran, P.5
Kothari, N.6
Natesan, S.7
Brugge, J.S.8
-
22
-
-
17344372977
-
Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition
-
10.1038/ncb1242, 15793565
-
Abell K, Bilancio A, Clarkson RW, Tiffen PG, Altaparmakov AI, Burdon TG, Asano T, Vanhaesebroeck B, Watson CJ. Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition. Nat Cell Biol 2005, 7:392-398. 10.1038/ncb1242, 15793565.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 392-398
-
-
Abell, K.1
Bilancio, A.2
Clarkson, R.W.3
Tiffen, P.G.4
Altaparmakov, A.I.5
Burdon, T.G.6
Asano, T.7
Vanhaesebroeck, B.8
Watson, C.J.9
-
23
-
-
57149098047
-
Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation
-
10.1158/0008-5472.CAN-08-1539, 19047141
-
Renner O, Blanco-Aparicio C, Grassow M, Cañamero M, Leal JF, Carnero A. Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation. Cancer Res 2008, 68:9643-9653. 10.1158/0008-5472.CAN-08-1539, 19047141.
-
(2008)
Cancer Res
, vol.68
, pp. 9643-9653
-
-
Renner, O.1
Blanco-Aparicio, C.2
Grassow, M.3
Cañamero, M.4
Leal, J.F.5
Carnero, A.6
-
24
-
-
25444442081
-
The Jak/Stat pathway: a novel way to regulate PI3K activity
-
Abell K, Watson CJ. The Jak/Stat pathway: a novel way to regulate PI3K activity. Cell Cycle 2005, 4:897-900.
-
(2005)
Cell Cycle
, vol.4
, pp. 897-900
-
-
Abell, K.1
Watson, C.J.2
-
25
-
-
0036738462
-
PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium
-
151121, 12235113
-
Dupont J, Renou JP, Shani M, Hennighausen L, LeRoith D. PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium. J Clin Invest 2002, 110:815-825. 151121, 12235113.
-
(2002)
J Clin Invest
, vol.110
, pp. 815-825
-
-
Dupont, J.1
Renou, J.P.2
Shani, M.3
Hennighausen, L.4
LeRoith, D.5
-
26
-
-
0036714806
-
Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland
-
Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H. Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development 2002, 129:4159-4170.
-
(2002)
Development
, vol.129
, pp. 4159-4170
-
-
Li, G.1
Robinson, G.W.2
Lesche, R.3
Martinez-Diaz, H.4
Jiang, Z.5
Rozengurt, N.6
Wagner, K.U.7
Wu, D.C.8
Lane, T.F.9
Liu, X.10
Hennighausen, L.11
Wu, H.12
-
27
-
-
66249146420
-
Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells
-
10.1158/0008-5472.CAN-08-1694, 19417140
-
Fournier MV, Fata JE, Martin KJ, Yaswen P, Bissell MJ. Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells. Cancer Res 2009, 69:4545-4552. 10.1158/0008-5472.CAN-08-1694, 19417140.
-
(2009)
Cancer Res
, vol.69
, pp. 4545-4552
-
-
Fournier, M.V.1
Fata, J.E.2
Martin, K.J.3
Yaswen, P.4
Bissell, M.J.5
-
28
-
-
0036231180
-
Requirement for IGF-I in epidermal growth factor-mediated cell cycle progression of mammary epithelial cells
-
10.1210/en.143.5.1872, 11956170
-
Stull MA, Richert MM, Loladze AV, Wood TL. Requirement for IGF-I in epidermal growth factor-mediated cell cycle progression of mammary epithelial cells. Endocrinology 2002, 143:1872-1879. 10.1210/en.143.5.1872, 11956170.
-
(2002)
Endocrinology
, vol.143
, pp. 1872-1879
-
-
Stull, M.A.1
Richert, M.M.2
Loladze, A.V.3
Wood, T.L.4
-
29
-
-
0033838808
-
The insulin-like growth factors (IGFs) and IGF binding proteins in postnatal development of murine mammary glands
-
10.1023/A:1009511131541, 10791766
-
Wood TL, Richert MM, Stull MA, Allar MA. The insulin-like growth factors (IGFs) and IGF binding proteins in postnatal development of murine mammary glands. J Mammary Gland Biol Neoplasia 2000, 5:31-42. 10.1023/A:1009511131541, 10791766.
-
(2000)
J Mammary Gland Biol Neoplasia
, vol.5
, pp. 31-42
-
-
Wood, T.L.1
Richert, M.M.2
Stull, M.A.3
Allar, M.A.4
-
30
-
-
67651174535
-
Insulin-like growth factor type 1 receptor and insulin receptor isoform expression and signaling in mammary epithelial cells
-
10.1210/en.2008-1473, 19406949
-
Rowzee AM, Ludwig DL, Wood TL. Insulin-like growth factor type 1 receptor and insulin receptor isoform expression and signaling in mammary epithelial cells. Endocrinology 2009, 150:3611-3619. 10.1210/en.2008-1473, 19406949.
-
(2009)
Endocrinology
, vol.150
, pp. 3611-3619
-
-
Rowzee, A.M.1
Ludwig, D.L.2
Wood, T.L.3
-
31
-
-
0029111934
-
Cyclin D1 provides a link between development and oncogenesis in the retina and breast
-
10.1016/0092-8674(95)90034-9, 7664341
-
Sicinski P, Donaher JL, Parker SB, Li T, Fazeli A, Gardner H, Haslam SZ, Bronson RT, Elledge SJ, Weinberg RA. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 1995, 82:621-630. 10.1016/0092-8674(95)90034-9, 7664341.
-
(1995)
Cell
, vol.82
, pp. 621-630
-
-
Sicinski, P.1
Donaher, J.L.2
Parker, S.B.3
Li, T.4
Fazeli, A.5
Gardner, H.6
Haslam, S.Z.7
Bronson, R.T.8
Elledge, S.J.9
Weinberg, R.A.10
-
32
-
-
0034740504
-
Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium
-
34596, 11359934
-
Brantley DM, Chen CL, Muraoka RS, Bushdid PB, Bradberry JL, Kittrell F, Medina D, Matrisian LM, Kerr LD, Yull FE. Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium. Mol Biol Cell 2001, 12:1445-1455. 34596, 11359934.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 1445-1455
-
-
Brantley, D.M.1
Chen, C.L.2
Muraoka, R.S.3
Bushdid, P.B.4
Bradberry, J.L.5
Kittrell, F.6
Medina, D.7
Matrisian, L.M.8
Kerr, L.D.9
Yull, F.E.10
-
33
-
-
2342527930
-
Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion
-
10.1158/0008-5472.CAN-03-3465, 15126356
-
Hutchinson JN, Jin J, Cardiff RD, Woodgett JR, Muller WJ. Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion. Cancer Res 2004, 64:3171-3178. 10.1158/0008-5472.CAN-03-3465, 15126356.
-
(2004)
Cancer Res
, vol.64
, pp. 3171-3178
-
-
Hutchinson, J.N.1
Jin, J.2
Cardiff, R.D.3
Woodgett, J.R.4
Muller, W.J.5
-
34
-
-
73349099030
-
MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells
-
10.1126/scisignal.2000356, 19825827
-
Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, Struhl K, Tsichlis PN. MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal 2009, 2:ra62. 10.1126/scisignal.2000356, 19825827.
-
(2009)
Sci Signal
, vol.2
-
-
Iliopoulos, D.1
Polytarchou, C.2
Hatziapostolou, M.3
Kottakis, F.4
Maroulakou, I.G.5
Struhl, K.6
Tsichlis, P.N.7
-
35
-
-
65849362115
-
Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3
-
10.1186/bcr2132, 2575543, 18700973
-
Young CD, Nolte EC, Lewis A, Serkova NJ, Anderson SM. Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3. Breast Cancer Res 2008, 10:R70. 10.1186/bcr2132, 2575543, 18700973.
-
(2008)
Breast Cancer Res
, vol.10
-
-
Young, C.D.1
Nolte, E.C.2
Lewis, A.3
Serkova, N.J.4
Anderson, S.M.5
-
36
-
-
2542451142
-
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice
-
10.1186/1471-2199-2-2, 29091, 11178110
-
Li Y, Podsypanina K, Liu X, Crane A, Tan LK, Parsons R, Varmus HE. Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice. BMC Mol Biol 2001, 2:2. 10.1186/1471-2199-2-2, 29091, 11178110.
-
(2001)
BMC Mol Biol
, vol.2
, pp. 2
-
-
Li, Y.1
Podsypanina, K.2
Liu, X.3
Crane, A.4
Tan, L.K.5
Parsons, R.6
Varmus, H.E.7
-
37
-
-
42049084166
-
Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis
-
10.1158/0008-5472.CAN-07-5727, 2752841, 18381417
-
Dourdin N, Schade B, Lesurf R, Hallett M, Munn RJ, Cardiff RD, Muller WJ. Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis. Cancer Res 2008, 68:2122-2131. 10.1158/0008-5472.CAN-07-5727, 2752841, 18381417.
-
(2008)
Cancer Res
, vol.68
, pp. 2122-2131
-
-
Dourdin, N.1
Schade, B.2
Lesurf, R.3
Hallett, M.4
Munn, R.J.5
Cardiff, R.D.6
Muller, W.J.7
-
38
-
-
67650553421
-
PTEN deficiency in a luminal ErbB-2 mouse model results in dramatic acceleration of mammary tumorigenesis and metastasis
-
10.1074/jbc.M109.018937, 19435886
-
Schade B, Rao T, Dourdin N, Lesurf R, Hallett M, Cardiff RD, Muller WJ. PTEN deficiency in a luminal ErbB-2 mouse model results in dramatic acceleration of mammary tumorigenesis and metastasis. J Biol Chem 2009, 284:19018-19026. 10.1074/jbc.M109.018937, 19435886.
-
(2009)
J Biol Chem
, vol.284
, pp. 19018-19026
-
-
Schade, B.1
Rao, T.2
Dourdin, N.3
Lesurf, R.4
Hallett, M.5
Cardiff, R.D.6
Muller, W.J.7
-
39
-
-
70350510924
-
Pten in stromal fibroblasts suppresses mammary epithelial tumours
-
10.1038/nature08486, 19847259
-
Trimboli AJ, Cantemir-Stone CZ, Li F, Wallace JA, Merchant A, Creasap N, Thompson JC, Caserta E, Wang H, Chong JL, Naidu S, Wei G, Sharma SM, Stephens JA, Fernandez SA, Gurcan MN, Weinstein MB, Barsky SH, Yee L, Rosol TJ, Stromberg PC, Robinson ML, Pepin F, Hallett M, Park M, Ostrowski MC, Leone G. Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature 2009, 461:1084-1091. 10.1038/nature08486, 19847259.
-
(2009)
Nature
, vol.461
, pp. 1084-1091
-
-
Trimboli, A.J.1
Cantemir-Stone, C.Z.2
Li, F.3
Wallace, J.A.4
Merchant, A.5
Creasap, N.6
Thompson, J.C.7
Caserta, E.8
Wang, H.9
Chong, J.L.10
Naidu, S.11
Wei, G.12
Sharma, S.M.13
Stephens, J.A.14
Fernandez, S.A.15
Gurcan, M.N.16
Weinstein, M.B.17
Barsky, S.H.18
Yee, L.19
Rosol, T.J.20
Stromberg, P.C.21
Robinson, M.L.22
Pepin, F.23
Hallett, M.24
Park, M.25
Ostrowski, M.C.26
Leone, G.27
more..
-
40
-
-
0037096904
-
Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha
-
Zeng X, Xu H, Glazer RI. Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha. Cancer Res 2002, 62:3538-3543.
-
(2002)
Cancer Res
, vol.62
, pp. 3538-3543
-
-
Zeng, X.1
Xu, H.2
Glazer, R.I.3
-
41
-
-
38849185196
-
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE
-
10.1038/ncb1675, 18204440
-
Pinner S, Sahai E. PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. Nat Cell Biol 2008, 10:127-137. 10.1038/ncb1675, 18204440.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 127-137
-
-
Pinner, S.1
Sahai, E.2
-
42
-
-
6944235337
-
Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity
-
10.1158/1078-0432.CCR-04-0035, 15585641
-
deGraffenried LA, Friedrichs WE, Russell DH, Donzis EJ, Middleton AK, Silva JM, Roth RA, Hidalgo M. Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity. Clin Cancer Res 2004, 10:8059-8067. 10.1158/1078-0432.CCR-04-0035, 15585641.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8059-8067
-
-
deGraffenried, L.A.1
Friedrichs, W.E.2
Russell, D.H.3
Donzis, E.J.4
Middleton, A.K.5
Silva, J.M.6
Roth, R.A.7
Hidalgo, M.8
-
43
-
-
53949099847
-
Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells
-
10.1007/s10549-007-9847-6, 18074223
-
Zhang H, Liu G, Dziubinski M, Yang Z, Ethier SP, Wu G. Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells. Breast Cancer Res Treat 2008, 112:217-227. 10.1007/s10549-007-9847-6, 18074223.
-
(2008)
Breast Cancer Res Treat
, vol.112
, pp. 217-227
-
-
Zhang, H.1
Liu, G.2
Dziubinski, M.3
Yang, Z.4
Ethier, S.P.5
Wu, G.6
-
44
-
-
68049117229
-
3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma
-
10.1158/0008-5472.CAN-09-0820, 19602588
-
Maurer M, Su T, Saal LH, Koujak S, Hopkins BD, Barkley CR, Wu J, Nandula S, Dutta B, Xie Y, Chin YR, Kim DI, Ferris JS, Gruvberger-Saal SK, Laakso M, Wang X, Memeo L, Rojtman A, Matos T, Yu JS, Cordon-Cardo C, Isola J, Terry MB, Toker A, Mills GB, Zhao JJ, Murty VV, Hibshoosh H, Parsons R. 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma. Cancer Res 2009, 69:6299-6306. 10.1158/0008-5472.CAN-09-0820, 19602588.
-
(2009)
Cancer Res
, vol.69
, pp. 6299-6306
-
-
Maurer, M.1
Su, T.2
Saal, L.H.3
Koujak, S.4
Hopkins, B.D.5
Barkley, C.R.6
Wu, J.7
Nandula, S.8
Dutta, B.9
Xie, Y.10
Chin, Y.R.11
Kim, D.I.12
Ferris, J.S.13
Gruvberger-Saal, S.K.14
Laakso, M.15
Wang, X.16
Memeo, L.17
Rojtman, A.18
Matos, T.19
Yu, J.S.20
Cordon-Cardo, C.21
Isola, J.22
Terry, M.B.23
Toker, A.24
Mills, G.B.25
Zhao, J.J.26
Murty, V.V.27
Hibshoosh, H.28
Parsons, R.29
more..
-
45
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
10.1038/nature05933, 17611497
-
Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, Hostetter G, Boguslawski S, Moses TY, Savage S, Uhlik M, Lin A, Du J, Qian YW, Zeckner DJ, Tucker-Kellogg G, Touchman J, Patel K, Mousses S, Bittner M, Schevitz R, Lai MH, Blanchard KL, Thomas JE. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 2007, 448:439-444. 10.1038/nature05933, 17611497.
-
(2007)
Nature
, vol.448
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.L.5
Robbins, C.M.6
Hostetter, G.7
Boguslawski, S.8
Moses, T.Y.9
Savage, S.10
Uhlik, M.11
Lin, A.12
Du, J.13
Qian, Y.W.14
Zeckner, D.J.15
Tucker-Kellogg, G.16
Touchman, J.17
Patel, K.18
Mousses, S.19
Bittner, M.20
Schevitz, R.21
Lai, M.H.22
Blanchard, K.L.23
Thomas, J.E.24
more..
-
46
-
-
11144357466
-
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
-
10.1016/S0092-8674(04)00302-2, 15084260
-
Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004, 117:225-237. 10.1016/S0092-8674(04)00302-2, 15084260.
-
(2004)
Cell
, vol.117
, pp. 225-237
-
-
Hu, M.C.1
Lee, D.F.2
Xia, W.3
Golfman, L.S.4
Ou-Yang, F.5
Yang, J.Y.6
Zou, Y.7
Bao, S.8
Hanada, N.9
Saso, H.10
Kobayashi, R.11
Hung, M.C.12
-
47
-
-
0242287934
-
Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo
-
10.1038/sj.gt.3302100, 14528320
-
Saito Y, Swanson X, Mhashilkar AM, Oida Y, Schrock R, Branch CD, Chada S, Zumstein L, Ramesh R. Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo. Gene Ther 2003, 10:1961-1969. 10.1038/sj.gt.3302100, 14528320.
-
(2003)
Gene Ther
, vol.10
, pp. 1961-1969
-
-
Saito, Y.1
Swanson, X.2
Mhashilkar, A.M.3
Oida, Y.4
Schrock, R.5
Branch, C.D.6
Chada, S.7
Zumstein, L.8
Ramesh, R.9
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