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Volumn 112, Issue 2, 2008, Pages 217-227

Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells

Author keywords

Breast cancer; PIK3CA; Somatic mutation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; EPIDERMAL GROWTH FACTOR; MATRIGEL; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PROTEIN KINASE B; PROTEIN P70;

EID: 53949099847     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10549-007-9847-6     Document Type: Article
Times cited : (56)

References (39)
  • 1
    • 0032929762 scopus 로고    scopus 로고
    • Signalling through phosphoinositide 3-kinases: The lipids take centre stage
    • 2
    • SJ Leevers B Vanhaesebroeck MD Waterfield 1999 Signalling through phosphoinositide 3-kinases: the lipids take centre stage Curr Opin Cell Biol 11 2 219 225
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 219-225
    • Leevers, S.J.1    Vanhaesebroeck, B.2    Waterfield, M.D.3
  • 2
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • 7
    • I Vivanco CL Sawyers 2002 The phosphatidylinositol 3-Kinase AKT pathway in human cancer Nat Rev Cancer 2 7 489 501
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 3
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • 12
    • AG Bader S Kang L Zhao PK Vogt 2005 Oncogenic PI3K deregulates transcription and translation Nat Rev Cancer 5 12 921 929
    • (2005) Nat Rev Cancer , vol.5 , pp. 921-929
    • Bader, A.G.1    Kang, S.2    Zhao, L.3    Vogt, P.K.4
  • 4
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • 5573
    • LC Cantley 2002 The phosphoinositide 3-kinase pathway Science 296 5573 1655 1657
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 10
    • 0033119702 scopus 로고    scopus 로고
    • Expression analysis of genes at 3q26-q27 involved in frequent amplification in squamous cell lung carcinoma
    • 4
    • A Racz N Brass D Heckel S Pahl K Remberger E Meese 1999 Expression analysis of genes at 3q26-q27 involved in frequent amplification in squamous cell lung carcinoma Eur J Cancer 35 4 641 646
    • (1999) Eur J Cancer , vol.35 , pp. 641-646
    • Racz, A.1    Brass, N.2    Heckel, D.3    Pahl, S.4    Remberger, K.5    Meese, E.6
  • 11
    • 0035872475 scopus 로고    scopus 로고
    • A simple specific pattern of chromosomal aberrations at early stages of head and neck squamous cell carcinomas: PIK3CA but not p63 gene as a likely target of 3q26-qter gains
    • 10
    • R Redon D Muller K Caulee K Wanherdrick J Abecassis S du Manoir 2001 A simple specific pattern of chromosomal aberrations at early stages of head and neck squamous cell carcinomas: PIK3CA but not p63 gene as a likely target of 3q26-qter gains Cancer Res 61 10 4122 4129
    • (2001) Cancer Res , vol.61 , pp. 4122-4129
    • Redon, R.1    Muller, D.2    Caulee, K.3    Wanherdrick, K.4    Abecassis, J.5    Du Manoir, S.6
  • 16
    • 20144387695 scopus 로고    scopus 로고
    • PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
    • 7
    • LH Saal K Holm M Maurer L Memeo T Su X Wang JS Yu PO Malmstrom M Mansukhani J Enoksson 2005 PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma Cancer Res 65 7 2554 2559
    • (2005) Cancer Res , vol.65 , pp. 2554-2559
    • Saal, L.H.1    Holm, K.2    Maurer, M.3    Memeo, L.4    Su, T.5    Wang, X.6    Yu, J.S.7    Malmstrom, P.O.8    Mansukhani, M.9    Enoksson, J.10
  • 19
    • 29444449785 scopus 로고    scopus 로고
    • The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
    • 51
    • JJ Zhao Z Liu L Wang E Shin MF Loda TM Roberts 2005 The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells Proc Natl Acad Sci USA 102 51 18443 18448
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18443-18448
    • Zhao, J.J.1    Liu, Z.2    Wang, L.3    Shin, E.4    Loda, M.F.5    Roberts, T.M.6
  • 20
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • 3
    • J Debnath SK Muthuswamy JS Brugge 2003 Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures Methods 30 3 256 268
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3
  • 21
    • 34247864012 scopus 로고    scopus 로고
    • Three-dimensional culture models of normal and malignant breast epithelial cells
    • 4
    • GY Lee PA Kenny EH Lee MJ Bissell 2007 Three-dimensional culture models of normal and malignant breast epithelial cells Nat Methods 4 4 359 365
    • (2007) Nat Methods , vol.4 , pp. 359-365
    • Lee, G.Y.1    Kenny, P.A.2    Lee, E.H.3    Bissell, M.J.4
  • 22
    • 22944463061 scopus 로고    scopus 로고
    • Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis
    • 4
    • KR Shaw CN Wrobel JS Brugge 2004 Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis J Mammary Gland Biol Neoplasia 9 4 297 310
    • (2004) J Mammary Gland Biol Neoplasia , vol.9 , pp. 297-310
    • Shaw, K.R.1    Wrobel, C.N.2    Brugge, J.S.3
  • 23
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • 1
    • D Hanahan RA Weinberg 2000 The hallmarks of cancer Cell 100 1 57 70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 24
    • 31944444234 scopus 로고    scopus 로고
    • Cancer-specific mutations in PIK3CA are oncogenic in vivo
    • 5
    • AG Bader S Kang PK Vogt 2006 Cancer-specific mutations in PIK3CA are oncogenic in vivo Proc Natl Acad Sci USA 103 5 1475 1479
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1475-1479
    • Bader, A.G.1    Kang, S.2    Vogt, P.K.3
  • 25
    • 14144252004 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
    • 3
    • S Kang AG Bader PK Vogt 2005 Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic Proc Natl Acad Sci USA 102 3 802 807
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 802-807
    • Kang, S.1    Bader, A.G.2    Vogt, P.K.3
  • 27
    • 34248369435 scopus 로고    scopus 로고
    • Rare cancer-specific mutations in PIK3CA show gain of function
    • 13
    • M Gymnopoulos MA Elsliger PK Vogt 2007 Rare cancer-specific mutations in PIK3CA show gain of function Proc Natl Acad Sci USA 104 13 5569 5574
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5569-5574
    • Gymnopoulos, M.1    Elsliger, M.A.2    Vogt, P.K.3
  • 28
    • 0242266916 scopus 로고    scopus 로고
    • Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner
    • 2
    • J Debnath SJ Walker JS Brugge 2003 Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner J Cell Biol 163 2 315 326
    • (2003) J Cell Biol , vol.163 , pp. 315-326
    • Debnath, J.1    Walker, S.J.2    Brugge, J.S.3
  • 29
    • 0037598679 scopus 로고    scopus 로고
    • The role of phosphatidylinositol 3'-kinase and its downstream signals in erbB-2-mediated transformation
    • 7
    • KM Woods Ignatoski DL Livant S Markwart NK Grewal SP Ethier 2003 The role of phosphatidylinositol 3'-kinase and its downstream signals in erbB-2-mediated transformation Mol Cancer Res 1 7 551 560
    • (2003) Mol Cancer Res , vol.1 , pp. 551-560
    • Woods Ignatoski, K.M.1    Livant, D.L.2    Markwart, S.3    Grewal, N.K.4    Ethier, S.P.5
  • 31
    • 0037229714 scopus 로고    scopus 로고
    • Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
    • 1
    • MJ Arboleda JF Lyons FF Kabbinavar MR Bray BE Snow R Ayala M Danino BY Karlan DJ Slamon 2003 Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells Cancer Res 63 1 196 206
    • (2003) Cancer Res , vol.63 , pp. 196-206
    • Arboleda, M.J.1    Lyons, J.F.2    Kabbinavar, F.F.3    Bray, M.R.4    Snow, B.E.5    Ayala, R.6    Danino, M.7    Karlan, B.Y.8    Slamon, D.J.9
  • 32
    • 0035496541 scopus 로고    scopus 로고
    • The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis
    • 4
    • SA Eccles 2001 The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis J Mammary Gland Biol Neoplasia 6 4 393 406
    • (2001) J Mammary Gland Biol Neoplasia , vol.6 , pp. 393-406
    • Eccles, S.A.1
  • 36
    • 16444382989 scopus 로고    scopus 로고
    • ErbB2 promotes Src synthesis and stability: Novel mechanisms of Src activation that confer breast cancer metastasis
    • 5
    • M Tan P Li KS Klos J Lu KH Lan Y Nagata D Fang T Jing D Yu 2005 ErbB2 promotes Src synthesis and stability: novel mechanisms of Src activation that confer breast cancer metastasis Cancer Res 65 5 1858 1867
    • (2005) Cancer Res , vol.65 , pp. 1858-1867
    • Tan, M.1    Li, P.2    Klos, K.S.3    Lu, J.4    Lan, K.H.5    Nagata, Y.6    Fang, D.7    Jing, T.8    Yu, D.9
  • 37
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
    • 4
    • J Luo BD Manning LC Cantley 2003 Targeting the PI3K-Akt pathway in human cancer: rationale and promise Cancer Cell 4 4 257 262
    • (2003) Cancer Cell , vol.4 , pp. 257-262
    • Luo, J.1    Manning, B.D.2    Cantley, L.C.3
  • 38
    • 2342632542 scopus 로고    scopus 로고
    • Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment
    • Pt 2
    • P Workman 2004 Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment Biochem Soc Trans 32 Pt 2 393 396
    • (2004) Biochem Soc Trans , vol.32 , pp. 393-396
    • Workman, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.