Crystal structures of covalent complexes of β-Lactam antibiotics with escherichia coli penicillin-binding protein 5: Toward an understanding of antibiotic specificity

Biochemistry

Volumn 49, Issue 37, 2010, Pages 8094-8104

  Nicola, George ^a,d   Tomberg, Joshua ^b   Pratt, R F ^c   Nicholas, Robert A ^b   Davies, Christopher ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c WESLEYAN UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CARBOXYLATION; COMPLEXATION; ESCHERICHIA COLI; PROTEINS;

BORONIC ACID; CEFOXITIN; CONFORMATIONAL CHANGE; COVALENT COMPLEX; DEACYLATION; ELECTRON DENSITIES; ELECTROSTATIC INTERACTIONS; LEAVING GROUPS; MOLECULAR LEVELS; MOLECULAR TARGETS; PENICILLIN- BINDING PROTEINS; PEPTIDOMIMETICS; SECOND ORDERS; SIDE CHAINS; WATER MOLECULE;

ACYLATION;

ARGININE; BETA LACTAM; BORONIC ACID DERIVATIVE; CARBOXYLIC ACID; CEFOXITIN; CLOXACILLIN; IMIPENEM; NITROGEN; PENICILLIN BINDING PROTEIN 5; PEPTIDOMIMETIC AGENT; ANTIINFECTIVE AGENT; PENICILLIN BINDING PROTEIN;

ACYLATION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ESCHERICHIA COLI; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; CHEMISTRY; ENZYMOLOGY; HYDROLYSIS; METABOLISM; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI;

ACYLATION; ANTI-BACTERIAL AGENTS; BETA-LACTAMS; CEFOXITIN; CLOXACILLIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HYDROLYSIS; IMIPENEM; PENICILLIN-BINDING PROTEINS;

EID: 77956563047     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100879m     Document Type: Article

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