The 2.4-Å crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin

Cellular and Molecular Life Sciences

Volumn 59, Issue 7, 2002, Pages 1223-1232

  Sauvage, E ^a   Kerff, F ^a   Fonze E ^a   Herman, R ^a   Schoot, B ^b,d   Marquette, J P ^b   Taburet, Y ^b   Prevost, D ^b   Dumas, J ^b   Leonard, G ^c   Stefanic, P ^a   Coyette, J ^a   Charlier, P ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b SANOFI   (France)

^c EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^d Galderma R and D   (France)

Author keywords

Benzylpenicillin; Enterococcus faecium; PBP5fm; Penicillin binding protein; Peptidoglycan synthesis; Resistance

Indexed keywords

AMINO ACID; ARGININE; ASPARTIC ACID; BETA LACTAM ANTIBIOTIC; MEMBRANE PROTEIN; PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 5FM; PENICILLIN G; PEPTIDOGLYCAN; UNCLASSIFIED DRUG; VALINE; BACTERIAL PROTEIN; CARBOXYPEPTIDASE TRANSPEPTIDASE; CARRIER PROTEIN; GLYCOSYLTRANSFERASE; PENICILLIN DERIVATIVE; PEPTIDYLTRANSFERASE;

ARTICLE; BACILLUS SUBTILIS; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENTEROCOCCUS FAECIUM; ENZYME ACTIVITY; NONHUMAN; PENICILLIN RESISTANCE; PROTEIN EXPRESSION; STAPHYLOCOCCUS AUREUS; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; GENETICS; MACROMOLECULE; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); ENTEROCOCCUS; ENTEROCOCCUS FAECIUM; INSERTION SEQUENCES; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; ENTEROCOCCUS FAECIUM; HEXOSYLTRANSFERASES; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; MUTATION; PENICILLIN G; PENICILLIN RESISTANCE; PENICILLIN-BINDING PROTEINS; PENICILLINS; PEPTIDYL TRANSFERASES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT;

EID: 0036628607     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-002-8500-0     Document Type: Article

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