Crystal structure of Escherichia coli penicillin-binding protein 5 bound to a tripeptide boronic acid inhibitor: A role for Ser-110 in deacylation

Biochemistry

Volumn 44, Issue 23, 2005, Pages 8207-8217

  Nicola, George ^a   Peddi, Sridhar ^b   Stefanova, Miglena ^b   Nicholas, Robert A ^c   Gutheil, William G ^b   Davies, Christopher ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CATALYSIS; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYMES; HYDROGEN BONDS; HYDROLYSIS; POLYPEPTIDES;

ANTIBIOTIC BINDING; BORONIC ACID; CATALYTIC MECHANISM; PENICILLIN-BINDING PROTEINS;

ESCHERICHIA COLI;

ALANINE CARBOXYPEPTIDASE; BORONIC ACID DERIVATIVE; BORONIC ACID INHIBITOR; CARBOXYPEPTIDASE; LYSINE; PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 5B; SERINE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DEACYLATION; DRUG BINDING; ESCHERICHIA COLI; HYDROGEN BOND; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SOLVATION; STRUCTURE ACTIVITY RELATION;

ACYLATION; AMINO ACID CHLOROMETHYL KETONES; BINDING SITES; BORONIC ACIDS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDYL PEPTIDASES; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; HYDROLYSIS; OLIGOPEPTIDES; PENICILLIN-BINDING PROTEINS; PHOSPHONIC ACIDS; SERINE; STREPTOCOCCUS PNEUMONIAE; STREPTOMYCES; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI;

EID: 20444369942     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0473004     Document Type: Article

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