메뉴 건너뛰기




Volumn 92, Issue 3, 2007, Pages 381-388

Chimeric T-cell receptors: New challenges for targeted immunotherapy in hematologic malignancies

Author keywords

Chimeric T cell receptor; Hematologic malignancy; Immunotherapy

Indexed keywords

ANTIGEN; CD19 ANTIGEN; CD20 ANTIGEN; CHIMERIC T CELL RECEPTOR; GANCICLOVIR; MONOCLONAL ANTIBODY; RITUXIMAB; T LYMPHOCYTE RECEPTOR; THYMIDINE KINASE; UNCLASSIFIED DRUG; CD30 ANTIGEN; CD33 ANTIGEN; DIFFERENTIATION ANTIGEN; HYBRID PROTEIN; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; TUMOR ANTIGEN;

EID: 34247582928     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.10873     Document Type: Review
Times cited : (28)

References (64)
  • 4
    • 0037350545 scopus 로고    scopus 로고
    • Immunotherapy: Past, present and future
    • Waldmann TA. Immunotherapy: past, present and future. Nat Med 2003;9:269-77.
    • (2003) Nat Med , vol.9 , pp. 269-277
    • Waldmann, T.A.1
  • 6
    • 1842562212 scopus 로고    scopus 로고
    • Tolerance and cancer: Mechanisms of tumor evasion and strategies for breaking tolerance
    • Mapara MY, Sykes M. Tolerance and cancer: mechanisms of tumor evasion and strategies for breaking tolerance. J Clin Oncol 2004;22: 1136-51.
    • (2004) J Clin Oncol , vol.22 , pp. 1136-1151
    • Mapara, M.Y.1    Sykes, M.2
  • 7
    • 33645023639 scopus 로고    scopus 로고
    • Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: The role of T regulatory cells
    • Taylor A, Verhagen J, Blaser K, Akdis M, Akdis CA. Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells. Immunology 2006;117:433-42.
    • (2006) Immunology , vol.117 , pp. 433-442
    • Taylor, A.1    Verhagen, J.2    Blaser, K.3    Akdis, M.4    Akdis, C.A.5
  • 8
    • 33645286546 scopus 로고    scopus 로고
    • T cells, tumour immunity and immunotherapy
    • Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol. 2006;6:295-307.
    • (2006) Nat Rev Immunol , vol.6 , pp. 295-307
    • Regulatory, Z.W.1
  • 9
    • 31644438021 scopus 로고    scopus 로고
    • Functional control of regulatory T cells and cancer immunotherapy
    • Wang RF. Functional control of regulatory T cells and cancer immunotherapy. Semin Cancer Biol 2006;16: 106-14.
    • (2006) Semin Cancer Biol , vol.16 , pp. 106-114
    • Wang, R.F.1
  • 11
    • 33646887376 scopus 로고    scopus 로고
    • Genotoxicity of retroviral integration in hematopoietic cells
    • Nienhuis AW, Dunbar CE, Sorrentino BP. Genotoxicity of retroviral integration in hematopoietic cells. Mol Ther 2006;13:1031-49.
    • (2006) Mol Ther , vol.13 , pp. 1031-1049
    • Nienhuis, A.W.1    Dunbar, C.E.2    Sorrentino, B.P.3
  • 12
    • 0036819779 scopus 로고    scopus 로고
    • Genetically engineered T-cells for adoptive immunotherapy
    • Pule M, Bollard CM, Heslop HE. Genetically engineered T-cells for adoptive immunotherapy. Curr Opin Mol Ther 2002;4:467-75.
    • (2002) Curr Opin Mol Ther , vol.4 , pp. 467-475
    • Pule, M.1    Bollard, C.M.2    Heslop, H.E.3
  • 14
    • 0242331180 scopus 로고    scopus 로고
    • Chimeric T-cell receptors for the targeting of cancer cells
    • Rossig C, Brenner MK. Chimeric T-cell receptors for the targeting of cancer cells. Acta Haematol 2003; 110: 154-9.
    • (2003) Acta Haematol , vol.110 , pp. 154-159
    • Rossig, C.1    Brenner, M.K.2
  • 15
    • 3042772669 scopus 로고    scopus 로고
    • Genetic modification of T lymphocytes for adoptive immunotherapy
    • Rossig C, Brenner MK. Genetic modification of T lymphocytes for adoptive immunotherapy. Mol Ther 2004;10:5-18.
    • (2004) Mol Ther , vol.10 , pp. 5-18
    • Rossig, C.1    Brenner, M.K.2
  • 16
    • 22944467854 scopus 로고    scopus 로고
    • Current status of genetic modification of T cells for cancer treatment
    • Dotti G, Heslop HE. Current status of genetic modification of T cells for cancer treatment. Cytotherapy 2005; 7:262-72.
    • (2005) Cytotherapy , vol.7 , pp. 262-272
    • Dotti, G.1    Heslop, H.E.2
  • 17
    • 0029924619 scopus 로고    scopus 로고
    • Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virusspecific T lymphocytes
    • Heslop HE, Ng CY, Li C, Smith CA, Loftin SK, Krance RA, et al. Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virusspecific T lymphocytes. Nat Med 1996;2:551-5.
    • (1996) Nat Med , vol.2 , pp. 551-555
    • Heslop, H.E.1    Ng, C.Y.2    Li, C.3    Smith, C.A.4    Loftin, S.K.5    Krance, R.A.6
  • 18
    • 0032170108 scopus 로고    scopus 로고
    • Infusion of cytotoxic T cells for the prevention and treatment of Epstein-arr virus-induced lymphoma in allogeneic transplant recipients
    • Rooney CM, Smith CA, Ng CY, Loftin SK, Sixbey JW, Gan Y, et al. Infusion of cytotoxic T cells for the prevention and treatment of Epstein-arr virus-induced lymphoma in allogeneic transplant recipients. Blood 1998;92:1549-55.
    • (1998) Blood , vol.92 , pp. 1549-1555
    • Rooney, C.M.1    Smith, C.A.2    Ng, C.Y.3    Loftin, S.K.4    Sixbey, J.W.5    Gan, Y.6
  • 19
    • 0242285681 scopus 로고    scopus 로고
    • Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines
    • Peggs KS, Verfuerth S, Pizzey A, Khan N, Guiver M, Moss PA, et al. Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines. Lancet 2003;362:1375-7.
    • (2003) Lancet , vol.362 , pp. 1375-1377
    • Peggs, K.S.1    Verfuerth, S.2    Pizzey, A.3    Khan, N.4    Guiver, M.5    Moss, P.A.6
  • 20
    • 0036624737 scopus 로고    scopus 로고
    • Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy
    • Einsele H, Roosnek E, Rufer N, Sinzger C, Riegler S, Loffler J, et al. Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood 2002; 99:3916-22.
    • (2002) Blood , vol.99 , pp. 3916-3922
    • Einsele, H.1    Roosnek, E.2    Rufer, N.3    Sinzger, C.4    Riegler, S.5    Loffler, J.6
  • 21
    • 4644280313 scopus 로고    scopus 로고
    • Novel strategies for cancer therapy: The potential of genetically modified T lymphocytes
    • Riviere I, Sadelain M, Brentjens RJ. Novel strategies for cancer therapy: the potential of genetically modified T lymphocytes. Curr Hematol Rep 2004;3:290-7.
    • (2004) Curr Hematol Rep , vol.3 , pp. 290-297
    • Riviere, I.1    Sadelain, M.2    Brentjens, R.J.3
  • 22
    • 0027471898 scopus 로고
    • Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors
    • Eshhar Z, Waks T, Gross G, Schindler DG. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci USA 1993;90:720-4.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 720-724
    • Eshhar, Z.1    Waks, T.2    Gross, G.3    Schindler, D.G.4
  • 23
    • 17044378252 scopus 로고    scopus 로고
    • Redirected primary T cells harboring a chimeric receptor require co-stimulation for their antigen-specific activation
    • Friedmann-Morvinski D, Bendavid A, Waks T, Schindler D, Eshhar Z. Redirected primary T cells harboring a chimeric receptor require co-stimulation for their antigen-specific activation. Blood 2005;105:3087-93.
    • (2005) Blood , vol.105 , pp. 3087-3093
    • Friedmann-Morvinski, D.1    Bendavid, A.2    Waks, T.3    Schindler, D.4    Eshhar, Z.5
  • 24
    • 33645123690 scopus 로고    scopus 로고
    • Novel approaches to immunotherapy for B-cell malignancies
    • Brentjens RJ. Novel approaches to immunotherapy for B-cell malignancies. Curr Hematol Rep 2005;4:64-72.
    • (2005) Curr Hematol Rep , vol.4 , pp. 64-72
    • Brentjens, R.J.1
  • 25
    • 0037348324 scopus 로고    scopus 로고
    • Eradication or systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15
    • Brentjens RJ, Latouche JB, Santos E, Marti F, Gong MC, Lyddane C, et al. Eradication or systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15. Nat Med 2003; 9:279-86.
    • (2003) Nat Med , vol.9 , pp. 279-286
    • Brentjens, R.J.1    Latouche, J.B.2    Santos, E.3    Marti, F.4    Gong, M.C.5    Lyddane, C.6
  • 26
    • 0037441593 scopus 로고    scopus 로고
    • T-cell clones can be rendered specific for CD19: Toward the selective augmentation of the graft-versus-B-lineage leukemia effect
    • Cooper LJ, Topp MS, Serrano LM, Gonzalez S, Chang WC, Naranjo A, et al. T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B-lineage leukemia effect. Blood 2003;101:1637-44.
    • (2003) Blood , vol.101 , pp. 1637-1644
    • Cooper, L.J.1    Topp, M.S.2    Serrano, L.M.3    Gonzalez, S.4    Chang, W.C.5    Naranjo, A.6
  • 27
    • 13544273197 scopus 로고    scopus 로고
    • Enhanced antilymphoma efficacy of CD19-redirected influenza MP1-specific CTLs by co-transfer of T cells modified to present influenza MP1
    • Cooper LJ, Al-Kadhimi Z, Serrano LM, Pfeiffer T, Olivares S, Castro A, et al. Enhanced antilymphoma efficacy of CD19-redirected influenza MP1-specific CTLs by co-transfer of T cells modified to present influenza MP1. Blood 2005;105:1622-31.
    • (2005) Blood , vol.105 , pp. 1622-1631
    • Cooper, L.J.1    Al-Kadhimi, Z.2    Serrano, L.M.3    Pfeiffer, T.4    Olivares, S.5    Castro, A.6
  • 28
    • 33645514987 scopus 로고    scopus 로고
    • Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for post-transplantation adoptive immunotherapy
    • Serrano LM, Pfeiffer T, Olivares S, Numbenjapon T, Bennitt J, Kim D, et al Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for post-transplantation adoptive immunotherapy. Blood 2006;107:2643-52.
    • (2006) Blood , vol.107 , pp. 2643-2652
    • Serrano, L.M.1    Pfeiffer, T.2    Olivares, S.3    Numbenjapon, T.4    Bennitt, J.5    Kim, D.6
  • 29
    • 33646398347 scopus 로고    scopus 로고
    • Manufacturing of gene-modified cytotoxic T lymphocytes for autologous cellular therapy or lymphoma
    • Cooper LJ, Ausubel L, Gutierrez M, Stephan S, Shakeley R, Olivares S, et al. Manufacturing of gene-modified cytotoxic T lymphocytes for autologous cellular therapy or lymphoma. Cytotherapy 2006;8:105-17.
    • (2006) Cytotherapy , vol.8 , pp. 105-117
    • Cooper, L.J.1    Ausubel, L.2    Gutierrez, M.3    Stephan, S.4    Shakeley, R.5    Olivares, S.6
  • 31
    • 33644818955 scopus 로고    scopus 로고
    • Target antigen expression on a professional antigen-presenting cell induces superior proliferative antitumor T-cell responses via chimeric T-cell receptors
    • Rossig C, Bar A, Pscnerer S, Altvater B, Pule M, Rooney CM, et al. Target antigen expression on a professional antigen-presenting cell induces superior proliferative antitumor T-cell responses via chimeric T-cell receptors. J Immunother 2006;29: 21-31.
    • (2006) J Immunother , vol.29 , pp. 21-31
    • Rossig, C.1    Bar, A.2    Pscnerer, S.3    Altvater, B.4    Pule, M.5    Rooney, C.M.6
  • 32
    • 27744566329 scopus 로고    scopus 로고
    • A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells
    • Pule MA, Straathof KC, Dotti G, Heslop HE, Rooney CM, Brenner MK. A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells. Mol Ther 2005; 12:933-41.
    • (2005) Mol Ther , vol.12 , pp. 933-941
    • Pule, M.A.1    Straathof, K.C.2    Dotti, G.3    Heslop, H.E.4    Rooney, C.M.5    Brenner, M.K.6
  • 33
    • 3042551216 scopus 로고    scopus 로고
    • Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia
    • Imai C, Mihara K, Andreansky M, Nicholson IC, Pui CH, Geiger TL, et al. Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia 2004; 18:676-84.
    • (2004) Leukemia , vol.18 , pp. 676-684
    • Imai, C.1    Mihara, K.2    Andreansky, M.3    Nicholson, I.C.4    Pui, C.H.5    Geiger, T.L.6
  • 34
    • 22044456688 scopus 로고    scopus 로고
    • Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells
    • Imai C, Iwamoto S, Campana D. Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells. Blood 2005;106:376-83.
    • (2005) Blood , vol.106 , pp. 376-383
    • Imai, C.1    Iwamoto, S.2    Campana, D.3
  • 35
    • 33747879963 scopus 로고    scopus 로고
    • Characterization of in vitro migratory properties of anti-CD19 chimeric receptor-redirected CIK cells for their potential use in B-ALL immunotherapy
    • Marin V, Dander E, Biagi E, Introna M, Fazio G, Biondi A, et al. Characterization of in vitro migratory properties of anti-CD19 chimeric receptor-redirected CIK cells for their potential use in B-ALL immunotherapy. Exp Hematol 2006; 34:1218-28.
    • (2006) Exp Hematol , vol.34 , pp. 1218-1228
    • Marin, V.1    Dander, E.2    Biagi, E.3    Introna, M.4    Fazio, G.5    Biondi, A.6
  • 36
    • 0038246383 scopus 로고    scopus 로고
    • Engineered CD20-specific primary human cytotoxic T lymphocytes for targeting B-cell malignancy
    • Jensen MC, Cooper LJ, Wu AM, Forman SJ, Raubitschek A Engineered CD20-specific primary human cytotoxic T lymphocytes for targeting B-cell malignancy. Cytotherapy 2003;5:131-8.
    • (2003) Cytotherapy , vol.5 , pp. 131-138
    • Jensen, M.C.1    Cooper, L.J.2    Wu, A.M.3    Forman, S.J.4    Raubitschek, A.5
  • 38
    • 12344276425 scopus 로고    scopus 로고
    • +leukemia cells by a natural killer cell line modified with a chimeric receptor
    • +leukemia cells by a natural killer cell line modified with a chimeric receptor. Leuk Res 2005; 29:301-6.
    • (2005) Leuk Res , vol.29 , pp. 301-306
    • Schirrmann, T.1    Pecher, G.2
  • 39
    • 0032721499 scopus 로고    scopus 로고
    • Characterization of a chimeric T-cell receptor with specificity for the Hodgkin's lymphoma-associated CD30 antigen
    • Hombach A, Heuser C, Sircar R, Tillmann T, Diehl V, Pohl C, et al. Characterization of a chimeric T-cell receptor with specificity for the Hodgkin's lymphoma-associated CD30 antigen. J Immunother 1999; 22:473-80.
    • (1999) J Immunother , vol.22 , pp. 473-480
    • Hombach, A.1    Heuser, C.2    Sircar, R.3    Tillmann, T.4    Diehl, V.5    Pohl, C.6
  • 42
    • 0035989039 scopus 로고    scopus 로고
    • A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy
    • Deeks SG, Wagner B, Anton PA, Mitsuyasu RT, Scadden DT, Huang C, et al. A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy. Mol Ther 2002;5:788-97.
    • (2002) Mol Ther , vol.5 , pp. 788-797
    • Deeks, S.G.1    Wagner, B.2    Anton, P.A.3    Mitsuyasu, R.T.4    Scadden, D.T.5    Huang, C.6
  • 43
  • 45
    • 0033857630 scopus 로고    scopus 로고
    • An entirely humanized CD3 zeta-chain signaling receptor that directs peripheral blood T cells to specific lysis of carcinoembryonic antigenpositive tumor cells
    • Hombach A, Schneider C, Sent D, Koch D, Willemsen RA, et al. An entirely humanized CD3 zeta-chain signaling receptor that directs peripheral blood T cells to specific lysis of carcinoembryonic antigenpositive tumor cells. Int J Cancer 2000;88:115-20.
    • (2000) Int J Cancer , vol.88 , pp. 115-120
    • Hombach, A.1    Schneider, C.2    Sent, D.3    Koch, D.4    Willemsen, R.A.5
  • 46
    • 0032531091 scopus 로고    scopus 로고
    • Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product
    • Finney HM, Lawson AD, Bebbington CR, Weir AN. Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product. J Immunol 1998;161:2791-7.
    • (1998) J Immunol , vol.161 , pp. 2791-2797
    • Finney, H.M.1    Lawson, A.D.2    Bebbington, C.R.3    Weir, A.N.4
  • 47
    • 0031907541 scopus 로고    scopus 로고
    • Harnessing Syk family tyrosine kinases as signaling domains for chimeric single chain of the variable domain receptors: Optimal design for T cell activation
    • Fitzer-Attas CJ, Schindler DG, Waks T, Eshhar Z. Harnessing Syk family tyrosine kinases as signaling domains for chimeric single chain of the variable domain receptors: optimal design for T cell activation. J Immunol 1998;160:145-54.
    • (1998) J Immunol , vol.160 , pp. 145-154
    • Fitzer-Attas, C.J.1    Schindler, D.G.2    Waks, T.3    Eshhar, Z.4
  • 48
    • 0035889157 scopus 로고    scopus 로고
    • Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes
    • Geiger TL, Nguyen P, Leitenberg D, Flavell RA. Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes. Blood 2001;98:2364-71.
    • (2001) Blood , vol.98 , pp. 2364-2371
    • Geiger, T.L.1    Nguyen, P.2    Leitenberg, D.3    Flavell, R.A.4
  • 49
    • 33845985925 scopus 로고    scopus 로고
    • Efficiency of T cell receptor expression in dual specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex
    • Heemskerk MH, Hagedoorn RS, van der Hoorn MA, van der Veken LT, Hoogeboom M, Kester MG, et al. Efficiency of T cell receptor expression in dual specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex. Blood 2007;109:235-43.
    • (2007) Blood , vol.109 , pp. 235-243
    • Heemskerk, M.H.1    Hagedoorn, R.S.2    van der Hoorn, M.A.3    van der Veken, L.T.4    Hoogeboom, M.5    Kester, M.G.6
  • 50
    • 0348230938 scopus 로고    scopus 로고
    • +-T-cell responses by a chimeric antigen construct: Potential therapeutic vaccine for EBV-positive nasopharyngeal carcinoma
    • +-T-cell responses by a chimeric antigen construct: potential therapeutic vaccine for EBV-positive nasopharyngeal carcinoma. J Virol 2004;78:768-78.
    • (2004) J Virol , vol.78 , pp. 768-778
    • Taylor, G.S.1    Haigh, T.A.2    Gudgeon, N.H.3    Phelps, R.J.4    Lee, S.P.5    Steven, N.M.6
  • 51
    • 0037085804 scopus 로고    scopus 로고
    • Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: Potential for improved immunotherapy
    • Rossig C, Bollard CM, Nuchtern JG, Rooney CM, Brenner MK. Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy. Blood 2002;99:2009-16.
    • (2002) Blood , vol.99 , pp. 2009-2016
    • Rossig, C.1    Bollard, C.M.2    Nuchtern, J.G.3    Rooney, C.M.4    Brenner, M.K.5
  • 52
    • 1842631467 scopus 로고    scopus 로고
    • Reprogramming of virus-specific T cells into leukemia-reactive T cells using T cell receptor gene transfer
    • Heemskerk MH, Hoogeboom M, Hagedoorn R, Kester MG, Willemze R, Falkenburg JH. Reprogramming of virus-specific T cells into leukemia-reactive T cells using T cell receptor gene transfer. J Exp Med 2004;199:885-94.
    • (2004) J Exp Med , vol.199 , pp. 885-894
    • Heemskerk, M.H.1    Hoogeboom, M.2    Hagedoorn, R.3    Kester, M.G.4    Willemze, R.5    Falkenburg, J.H.6
  • 55
    • 0347634456 scopus 로고    scopus 로고
    • Gene therapy insertional mutagenesis insights
    • Dave UP, Jenkins NA, Copeland NG. Gene therapy insertional mutagenesis insights. Science 2004; 303: 33.
    • (2004) Science , vol.303 , pp. 33
    • Dave, U.P.1    Jenkins, N.A.2    Copeland, N.G.3
  • 56
    • 10744233858 scopus 로고    scopus 로고
    • American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells
    • Kohn DB, Sadelain M, Dunbar C, Bodine D, Kiem HP, Candotti F, et al. American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells. Mol Ther 2003;8:180-7.
    • (2003) Mol Ther , vol.8 , pp. 180-187
    • Kohn, D.B.1    Sadelain, M.2    Dunbar, C.3    Bodine, D.4    Kiem, H.P.5    Candotti, F.6
  • 57
    • 0042738935 scopus 로고    scopus 로고
    • Occurrence of leukaemia following gene therapy of X-linked SCID
    • Kohn DB, Sadelain M, Glorioso JC. Occurrence of leukaemia following gene therapy of X-linked SCID. Nat Rev Cancer 2003;3:477-88.
    • (2003) Nat Rev Cancer , vol.3 , pp. 477-488
    • Kohn, D.B.1    Sadelain, M.2    Glorioso, J.C.3
  • 58
    • 13844281761 scopus 로고    scopus 로고
    • T cell suicide gene therapy to aid haematopoietic stem cell transplantation
    • Qasim W, Gaspar HB, Thrasher AJ. T cell suicide gene therapy to aid haematopoietic stem cell transplantation. Curr Gene Ther 2005;5:121-32.
    • (2005) Curr Gene Ther , vol.5 , pp. 121-132
    • Qasim, W.1    Gaspar, H.B.2    Thrasher, A.J.3
  • 60
    • 27744489220 scopus 로고    scopus 로고
    • Silencing and variegation of gammaretrovirus and lentivirus vectors
    • Ellis J. Silencing and variegation of gammaretrovirus and lentivirus vectors. Hum Gene Ther 2005;16:1241-6.
    • (2005) Hum Gene Ther , vol.16 , pp. 1241-1246
    • Ellis, J.1
  • 62
    • 6344278851 scopus 로고    scopus 로고
    • Innovative cell-based therapies in onco-hematology: What are the clinical facts?
    • Introna M, Barbui AM, Golay J, Rambaldi A. Innovative cell-based therapies in onco-hematology: what are the clinical facts? Haematologica 2004;89:1253-60.
    • (2004) Haematologica , vol.89 , pp. 1253-1260
    • Introna, M.1    Barbui, A.M.2    Golay, J.3    Rambaldi, A.4
  • 63
    • 0142259712 scopus 로고    scopus 로고
    • Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling
    • Rudd CE, Schneider H. Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nat Rev Immunol 2003;3:544-56.
    • (2003) Nat Rev Immunol , vol.3 , pp. 544-556
    • Rudd, C.E.1    Schneider, H.2
  • 64
    • 17644389199 scopus 로고    scopus 로고
    • Watts TH. TNF/TNFR family members in co-stimulation of T cell responses. Annu Rev Immunol 2005;23:23-68.
    • Watts TH. TNF/TNFR family members in co-stimulation of T cell responses. Annu Rev Immunol 2005;23:23-68.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.