Safety of retroviral gene marking with a truncated NGF receptor [1]

Nature Medicine

Volumn 9, Issue 4, 2003, Pages 367-369

  Bonini, C ^a   Grez, M ^b   Traversari, C ^c   Ciceri, F ^a   Marktel, S ^a,d   Ferrari, G ^e   Dinauer, M ^f   Sadat, M ^f   Aiuti, A ^e   Deola, S ^e   Radrizzani, M ^c   Hagenbeek, A ^g   Apperley, J ^d   Ebeling, S ^g   Martens, A ^g   Kolb, H J ^h   Weber, M ^h   Lotti, F ^e   Grande, A ⁱ   Weissinger, E ^j   Bueren, J A ^k   Lamana, M ^k   Falkenburg, J H F ^l   Heemskerk, M H M ^l   Austin, T ^m   Kornblau, S ⁿ   Marini, F ⁿ   Benati, C ^c   Magnani, Z ^a   Cazzaniga, S ^a   Toma, S ^c   Gallo stampino, C ^c   Introna, M ^o   Slavin, S ^p   Greenberg, P D ^q   Bregni, M ^a   Mavilio, F ⁱ   Bordignon, C ^a,c   more..

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

^c MOLMED S P A   (Italy)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^f INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^h INSTITUTE OF EPIDEMIOLOGY   (Germany)

ⁱ UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^j HANNOVER MEDICAL SCHOOL   (Germany)

^k CIEMAT   (Spain)

^l LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^m StemCells Inc   (United States)

ⁿ UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^o Molec Immunohematology Laboratory   (Italy)

^p HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^q UNIVERSITY OF WASHINGTON   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; LENTIVIRUS VECTOR; LIGAND; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN RECEPTOR; RETROVIRUS VECTOR; THYMIDINE KINASE;

ADVERSE DRUG REACTION; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CANCER GROWTH; CELL DIFFERENTIATION; CELL GROWTH; CELL STIMULATION; CELL SURVIVAL; CELL TRANSFORMATION; CLINICAL TRIAL; DNA VECTOR; DOG; DRUG SAFETY; GENE EXPRESSION; GENE TRANSFER; GENOME; GRAFT VERSUS HOST REACTION; HOST CELL; HUMAN; IMMUNE DEFICIENCY; LETTER; LEUKEMIA CELL; MARKER GENE; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTO ONCOGENE; SFCMM 2 GENE VECTOR; SFCMM 3 GENE VECTOR; T LYMPHOCYTE; TRANSGENE; VIRAL GENE THERAPY;

ANIMALS; BONE MARROW TRANSPLANTATION; DOGS; GENES, VIRAL; GENETIC MARKERS; GENETIC VECTORS; HUMANS; LEUKEMIA; MICE; RATS; RECEPTOR, NERVE GROWTH FACTOR; RETROVIRIDAE; TRANSDUCTION, GENETIC;

CANIS FAMILIARIS; LENTIVIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0344511772     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0403-367     Document Type: Letter

References (5)

1. Li, Z. et al. Murine leukemia induced by retroviral gene marking. Science 296, 497 (2002).
2. Bordignon, C. & Bonini, C. A clinical protocol for gene transfer into peripheral blood lymphocytes for in vivo immunomodulation of donor anti-tumor immunity in patients affected by recurrent disease after allogeneic bone marrow transplantation. Hum. Gen. Ther. 2, 813-819 (1995).
3. Bonini, C. et al. HSV-TKgene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 276, 1719-1724 (1997).
4. Rosenberg, N. & Jolicoeur, P. Retroviral pathogenesis. in Retroviruses (eds. Coffin, I.M., Hughes, S.H. & Varmus, H.) 413-416 (Cold Spring Harbor Laboratory Press, New York, 1997).
5. Hacein-Bey-Abina, S. et al. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N. Engl. J. Med. 348, 255-256 (2003).