A phage display selected Fab fragment with MHC class i-restricted specificity for MAGE-A1 allows for retargeting of primary human T lymphocytes

Gene Therapy

Volumn 8, Issue 21, 2001, Pages 1601-1608

  Willemsen, R A ^a   Debets, R ^a   Hart, E ^a   Hoogenboom, H R ^b   Bolhuis, R L H ^a   Chames, P ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Chimeric receptor; Cytotoxic T lympocyte; Fab; MHC; T cellreceptor; Tumor rejection antigen

Indexed keywords

CD4 ANTIGEN DERIVATIVE; CHIMERIC PROTEIN; CYTOKINE; FC RECEPTOR; HLA A1 ANTIGEN; IMMUNOGLOBULIN F(AB) FRAGMENT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MELANOMA ANTIGEN 1; T LYMPHOCYTE RECEPTOR; TUMOR REJECTION ANTIGEN; UNCLASSIFIED DRUG;

ADOPTIVE IMMUNOTHERAPY; ANTIGEN SPECIFICITY; ARTICLE; CANCER; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; GENE THERAPY; HUMAN; HUMAN CELL; IN VITRO STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; PHAGE DISPLAY; PRIORITY JOURNAL; RETROVIRUS; TARGET CELL;

EPITOPES; GENE THERAPY; GENETIC VECTORS; HLA-A1 ANTIGEN; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOTHERAPY, ADOPTIVE; MELANOMA; NEOPLASM PROTEINS; PEPTIDE LIBRARY; RECEPTORS, IMMUNOLOGIC; RETROVIRIDAE; T-LYMPHOCYTES, CYTOTOXIC; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED;

UNIDENTIFIED RETROVIRUS;

EID: 0035186913     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301570     Document Type: Article

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