PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-I-stimulated AKT activation and vascular smooth muscle cell survival

Journal of Biological Chemistry

Volumn 285, Issue 38, 2010, Pages 29416-29424

  Shen, Xinchun ^a   Xi, Gang ^a   Radhakrishnan, Yashwanth ^a   Clemmons, David R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BLOOD VESSEL PROSTHESES; CELL DEATH; INSULIN; MUSCLE; PEPTIDES; PHOSPHORYLATION; SIGNALING;

AKT ACTIVATION; APOPTOSIS; INSULIN-LIKE GROWTH FACTOR-I; KINASE ACTIVITY; SCAFFOLD PROTEIN; SIGNALING COMPLEX; SRC HOMOLOGY 3 DOMAINS; UNDERLYING MECHANISM; VASCULAR SMOOTH MUSCLE CELLS;

EMPLOYMENT;

ALANINE; EPIDERMAL GROWTH FACTOR; FOCAL ADHESION KINASE 2; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROLINE; PROLINE RICH PROTEIN; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE SHP; SOMATOMEDIN C; THREONINE; DIFFERENTIATION ANTIGEN; IMMUNOGLOBULIN RECEPTOR; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE; SIRPA PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; AORTA MEDIA; APOPTOSIS; ARTICLE; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HYPERGLYCEMIA; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SRC HOMOLOGY DOMAIN; SWINE; VASCULAR SMOOTH MUSCLE; ANIMAL; BINDING SITE; CELL CULTURE; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOBLOTTING; IMMUNOPRECIPITATION; METABOLISM; NICK END LABELING; PHOSPHORYLATION; PROTEIN TRANSPORT; RNA INTERFERENCE;

ANIMALS; ANTIGENS, DIFFERENTIATION; BINDING SITES; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; GRB2 ADAPTOR PROTEIN; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN SITU NICK-END LABELING; INSULIN-LIKE GROWTH FACTOR I; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, IMMUNOLOGIC; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SWINE;

EID: 77956528144     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.155325     Document Type: Article

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