p66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 membrane recruitment

Molecular Endocrinology

Volumn 22, Issue 9, 2008, Pages 2162-2175

  Xi, Gang ^a   Shen, Xinchun ^a   Clemmons, David R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P52; PROTEIN P66; PROTEIN SH2; PROTEIN SHC; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; SMALL INTERFERING RNA; SOMATOMEDIN C;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BASE SEQUENCE; BINDING, COMPETITIVE; CELL MEMBRANE; CELL MOVEMENT; CELL PROLIFERATION; GRB2 ADAPTOR PROTEIN; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIPROTEIN COMPLEXES; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; RECEPTOR, IGF TYPE 1; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; SWINE;

EID: 50649099634     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2008-0079     Document Type: Article

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