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Volumn 5, Issue 4, 2010, Pages

Topoisomerase iia binding domains of adenomatous polyposis coli influence cell cycle progression and aneuploidy

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; APC PROTEIN; BETA CATENIN; DNA TOPOISOMERASE (ATP HYDROLYSING); ISOENZYME; TOPOISOMERASE IIALPHA; TOPOISOMERASE IIBETA; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; DNA TOPOISOMERASE II ALPHA; TUMOR ANTIGEN;

EID: 77956310444     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009994     Document Type: Article
Times cited : (7)

References (53)
  • 1
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler KW, Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87: 159-170.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 3
    • 0027688022 scopus 로고
    • Congenital genetic instability in colorectal carcinomas
    • Svendsen LB (1993) Congenital genetic instability in colorectal carcinomas. Dan Med Bull 40: 546-556.
    • (1993) Dan Med Bull , vol.40 , pp. 546-556
    • Svendsen, L.B.1
  • 4
    • 0023907929 scopus 로고
    • DNA aneuploidy and cell proliferation in familial adenomatous polyposis
    • Quirke P, Dixon MF, Day DW, Fozard JB, Talbot IC, et al. (1988) DNA aneuploidy and cell proliferation in familial adenomatous polyposis. Gut 29: 603-607.
    • (1988) Gut , vol.29 , pp. 603-607
    • Quirke, P.1    Dixon, M.F.2    Day, D.W.3    Fozard, J.B.4    Talbot, I.C.5
  • 5
    • 0030978351 scopus 로고    scopus 로고
    • B-catenin is a target for the ubiquitin-proteasome pathway
    • Aberle H, Bauer A, Stappert J, Kispert A, Kemler R (1997) b-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16: 3797-3804.
    • (1997) EMBO J , vol.16 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 6
    • 0032562603 scopus 로고    scopus 로고
    • Functional interaction of an axin homolog, conductin, with beta- catenin, APC, and GSK3beta
    • Behrens J, Jerchow BA, Wurtele M, Grimm J, Asbrand C, et al. (1998) Functional interaction of an axin homolog, conductin, with beta- catenin, APC, and GSK3beta. Science 280: 596-599.
    • (1998) Science , vol.280 , pp. 596-599
    • Behrens, J.1    Jerchow, B.A.2    Wurtele, M.3    Grimm, J.4    Asbrand, C.5
  • 7
    • 0032492954 scopus 로고    scopus 로고
    • Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
    • Hart MJ, de los Santos R, Albert IN, Rubinfeld B, Polakis P (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr Biol 8: 573-581.
    • (1998) Curr Biol , vol.8 , pp. 573-581
    • Hart, M.J.1    de los Santos, R.2    Albert, I.N.3    Rubinfeld, B.4    Polakis, P.5
  • 8
    • 0032473355 scopus 로고    scopus 로고
    • Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta- dependent phosphorylation of beta-catenin
    • Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, et al. (1998) Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta- dependent phosphorylation of beta-catenin. EMBO J 17: 1371-1384.
    • (1998) EMBO J , vol.17 , pp. 1371-1384
    • Ikeda, S.1    Kishida, S.2    Yamamoto, H.3    Murai, H.4    Koyama, S.5
  • 9
    • 0031813650 scopus 로고    scopus 로고
    • Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level
    • Nakamura T, Hamada F, Ishidate T, Anai K, Kawahara K, et al. (1998) Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. Genes Cells 3: 395-403.
    • (1998) Genes Cells , vol.3 , pp. 395-403
    • Nakamura, T.1    Hamada, F.2    Ishidate, T.3    Anai, K.4    Kawahara, K.5
  • 10
    • 35648988947 scopus 로고    scopus 로고
    • Adenomatous polyposis coli (APC): A multifunctional tumor suppressor gene
    • Aoki K, Taketo MM (2007) Adenomatous polyposis coli (APC): a multifunctional tumor suppressor gene. J Cell Sci 120: 3327-3335.
    • (2007) J Cell Sci , vol.120 , pp. 3327-3335
    • Aoki, K.1    Taketo, M.M.2
  • 11
    • 12444336370 scopus 로고    scopus 로고
    • Zinc stabilizes adenomatous polyposis coli (APC) protein levels and induces cell cycle arrest in colon cancer cells
    • Jaiswal AS, Narayan S (2004) Zinc stabilizes adenomatous polyposis coli (APC) protein levels and induces cell cycle arrest in colon cancer cells. J Cell Biochem 93: 345-357.
    • (2004) J Cell Biochem , vol.93 , pp. 345-357
    • Jaiswal, A.S.1    Narayan, S.2
  • 12
    • 0038107468 scopus 로고    scopus 로고
    • Beta-catenin regulation during the cell cycle: Implications in G2/M and apoptosis
    • Olmeda D, Castel S, Vilaro S, Cano A (2003) Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis. Mol Biol Cell 14: 2844-2860.
    • (2003) Mol Biol Cell , vol.14 , pp. 2844-2860
    • Olmeda, D.1    Castel, S.2    Vilaro, S.3    Cano, A.4
  • 13
    • 0036725171 scopus 로고    scopus 로고
    • The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway
    • Heinen CD, Goss KH, Cornelius JR, Babcock GF, Knudsen ES, et al. (2002) The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway. Gastroenterology 123: 751-763.
    • (2002) Gastroenterology , vol.123 , pp. 751-763
    • Heinen, C.D.1    Goss, K.H.2    Cornelius, J.R.3    Babcock, G.F.4    Knudsen, E.S.5
  • 14
    • 0035067391 scopus 로고    scopus 로고
    • A role for the Adenomatous Polyposis Coli protein in chromosome segregation
    • Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, et al. (2001) A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat Cell Biol 3: 429-432.
    • (2001) Nat Cell Biol , vol.3 , pp. 429-432
    • Kaplan, K.B.1    Burds, A.A.2    Swedlow, J.R.3    Bekir, S.S.4    Sorger, P.K.5
  • 15
    • 0035070046 scopus 로고    scopus 로고
    • Mutations in the APC tumour suppressor gene cause chromosomal instability
    • Fodde R, Kuipers J, Rosenberg C, Smits R, Kielman M, et al. (2001) Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol 3: 433-438.
    • (2001) Nat Cell Biol , vol.3 , pp. 433-438
    • Fodde, R.1    Kuipers, J.2    Rosenberg, C.3    Smits, R.4    Kielman, M.5
  • 16
    • 0034688150 scopus 로고    scopus 로고
    • The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase
    • Ishidate T, Matsumine A, Toyoshima K, Akiyama T (2000) The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase. Oncogene 19: 365-372.
    • (2000) Oncogene , vol.19 , pp. 365-372
    • Ishidate, T.1    Matsumine, A.2    Toyoshima, K.3    Akiyama, T.4
  • 18
    • 57349182299 scopus 로고    scopus 로고
    • Interaction between tumor suppressor adenomatous polyposis coli and topoisomerase IIalpha: Implication for the G2/M transition
    • Wang Y, Azuma Y, Moore D, Osheroff N, Neufeld KL (2008) Interaction between tumor suppressor adenomatous polyposis coli and topoisomerase IIalpha: implication for the G2/M transition. Mol Biol Cell 19: 4076-4085.
    • (2008) Mol Biol Cell , vol.19 , pp. 4076-4085
    • Wang, Y.1    Azuma, Y.2    Moore, D.3    Osheroff, N.4    Neufeld, K.L.5
  • 19
    • 34548391416 scopus 로고    scopus 로고
    • DNA topoisomerase II, genotoxicity, and cancer
    • McClendon AK, Osheroff N (2007) DNA topoisomerase II, genotoxicity, and cancer. Mutat Res 623: 83-97.
    • (2007) Mutat Res , vol.623 , pp. 83-97
    • McClendon, A.K.1    Osheroff, N.2
  • 20
    • 0035227132 scopus 로고    scopus 로고
    • Topoisomerase II-catalyzed relaxation and catenation of plasmid DNA
    • Fortune JM, Osheroff N (2001) Topoisomerase II-catalyzed relaxation and catenation of plasmid DNA. Methods Mol Biol 95: 275-281.
    • (2001) Methods Mol Biol , vol.95 , pp. 275-281
    • Fortune, J.M.1    Osheroff, N.2
  • 21
    • 0034923502 scopus 로고    scopus 로고
    • DNA topoisomerases: Structure, function, and mechanism
    • Champoux JJ (2001) DNA topoisomerases: structure, function, and mechanism. Annu Rev Biochem 70: 369-413.
    • (2001) Annu Rev Biochem , vol.70 , pp. 369-413
    • Champoux, J.J.1
  • 22
    • 0030014783 scopus 로고    scopus 로고
    • DNA topoisomerases
    • Wang JC (1996) DNA topoisomerases. Annu Rev Biochem 65: 635-692.
    • (1996) Annu Rev Biochem , vol.65 , pp. 635-692
    • Wang, J.C.1
  • 24
    • 12444269092 scopus 로고    scopus 로고
    • Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase IIalpha
    • Akimitsu N, Adachi N, Hirai H, Hossain MS, Hamamoto H, et al. (2003) Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase IIalpha. Genes Cells 8: 393-402.
    • (2003) Genes Cells , vol.8 , pp. 393-402
    • Akimitsu, N.1    Adachi, N.2    Hirai, H.3    Hossain, M.S.4    Hamamoto, H.5
  • 26
    • 0032509551 scopus 로고    scopus 로고
    • Essential mitotic functions of DNA topoisomerase IIalpha are not adopted by topoisomerase IIbeta in human H69 cells
    • Grue P, Grasser A, Sehested M, Jensen PB, Uhse A, et al. (1998) Essential mitotic functions of DNA topoisomerase IIalpha are not adopted by topoisomerase IIbeta in human H69 cells. J Biol Chem 273: 33660-33666.
    • (1998) J Biol Chem , vol.273 , pp. 33660-33666
    • Grue, P.1    Grasser, A.2    Sehested, M.3    Jensen, P.B.4    Uhse, A.5
  • 27
    • 75349109588 scopus 로고    scopus 로고
    • Nuclear Functions of APC
    • Neufeld KL (2009) Nuclear Functions of APC. Adv Exp Med Biol 656: 13-29.
    • (2009) Adv Exp Med Biol , vol.656 , pp. 13-29
    • Neufeld, K.L.1
  • 28
    • 0035810054 scopus 로고    scopus 로고
    • Regulation of the G2/M transition by p53
    • Taylor WR, Stark GR (2001) Regulation of the G2/M transition by p53. Oncogene 20: 1803-1815.
    • (2001) Oncogene , vol.20 , pp. 1803-1815
    • Taylor, W.R.1    Stark, G.R.2
  • 29
    • 0001606206 scopus 로고
    • Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells
    • Wolf D, Rotter V (1985) Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells. Proc Natl Acad Sci U S A 82: 790-794.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 790-794
    • Wolf, D.1    Rotter, V.2
  • 30
    • 9444229370 scopus 로고    scopus 로고
    • Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line
    • Carpenter AJ, Porter AC (2004) Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line. Mol Biol Cell 15: 5700-5711.
    • (2004) Mol Biol Cell , vol.15 , pp. 5700-5711
    • Carpenter, A.J.1    Porter, A.C.2
  • 31
    • 0024353128 scopus 로고
    • Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of Pglycoprotein overexpression
    • Harker WG, Slade DL, Dalton WS, Meltzer PS, Trent JM (1989) Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of Pglycoprotein overexpression. Cancer Res 49: 4542-4549.
    • (1989) Cancer Res , vol.49 , pp. 4542-4549
    • Harker, W.G.1    Slade, D.L.2    Dalton, W.S.3    Meltzer, P.S.4    Trent, J.M.5
  • 32
    • 0028819988 scopus 로고
    • Selective use of an alternative stop codon and polyadenylation signal within intron sequences leads to a truncated topoisomerase II alpha messenger RNA and protein in human HL-60 leukemia cells selected for resistance to mitoxantrone
    • Harker WG, Slade DL, Parr RL, Holguin MH (1995) Selective use of an alternative stop codon and polyadenylation signal within intron sequences leads to a truncated topoisomerase II alpha messenger RNA and protein in human HL-60 leukemia cells selected for resistance to mitoxantrone. Cancer Res 55: 4962-4971.
    • (1995) Cancer Res , vol.55 , pp. 4962-4971
    • Harker, W.G.1    Slade, D.L.2    Parr, R.L.3    Holguin, M.H.4
  • 33
    • 0028985942 scopus 로고
    • Alterations in the topoisomerase II alpha gene, messenger RNA, and subcellular protein distribution as well as reduced expression of the DNA topoisomerase II beta enzyme in a mitoxantrone-resistant HL-60 human leukemia cell line
    • Harker WG, Slade DL, Parr RL, Feldhoff PW, Sullivan DM, et al. (1995) Alterations in the topoisomerase II alpha gene, messenger RNA, and subcellular protein distribution as well as reduced expression of the DNA topoisomerase II beta enzyme in a mitoxantrone-resistant HL-60 human leukemia cell line. Cancer Res 55: 1707-1716.
    • (1995) Cancer Res , vol.55 , pp. 1707-1716
    • Harker, W.G.1    Slade, D.L.2    Parr, R.L.3    Feldhoff, P.W.4    Sullivan, D.M.5
  • 34
    • 0025941508 scopus 로고
    • Mitoxantrone resistance in HL-60 leukemia cells: Reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II beta isoform
    • Harker WG, Slade DL, Drake FH, Parr RL (1991) Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II beta isoform. Biochemistry 30: 9953-9961.
    • (1991) Biochemistry , vol.30 , pp. 9953-9961
    • Harker, W.G.1    Slade, D.L.2    Drake, F.H.3    Parr, R.L.4
  • 35
  • 36
    • 0037416148 scopus 로고    scopus 로고
    • Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription
    • Rosin-Arbesfeld R, Cliffe A, Brabletz T, Bienz M (2003) Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription. Embo J 22: 1101-1113.
    • (2003) Embo J , vol.22 , pp. 1101-1113
    • Rosin-Arbesfeld, R.1    Cliffe, A.2    Brabletz, T.3    Bienz, M.4
  • 37
    • 44649182871 scopus 로고    scopus 로고
    • Original CIN: Reviewing roles for APC in chromosome instability
    • Rusan N, Peifer M (2008) Original CIN: reviewing roles for APC in chromosome instability. J Cell Biol 181: 719-726.
    • (2008) J Cell Biol , vol.181 , pp. 719-726
    • Rusan, N.1    Peifer, M.2
  • 38
    • 65649123738 scopus 로고    scopus 로고
    • Oncogenic Adenomatous Polyposis Coli Mutants Impair the Mitotic Checkpoint through Direct Interaction with Mad2
    • Zhang J, Neisa R, Mao Y (2009) Oncogenic Adenomatous Polyposis Coli Mutants Impair the Mitotic Checkpoint through Direct Interaction with Mad2. Mol Biol Cell 20: 2381-2388.
    • (2009) Mol Biol Cell , vol.20 , pp. 2381-2388
    • Zhang, J.1    Neisa, R.2    Mao, Y.3
  • 39
    • 0027965213 scopus 로고
    • Inhibition of DNA topoisomerase II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events
    • Ishida R, Sato M, Narita T, Utsumi KR, Nishimoto T, et al. (1994) Inhibition of DNA topoisomerase II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events. J Cell Biol 126: 1341-1351.
    • (1994) J Cell Biol , vol.126 , pp. 1341-1351
    • Ishida, R.1    Sato, M.2    Narita, T.3    Utsumi, K.R.4    Nishimoto, T.5
  • 40
    • 0028329736 scopus 로고
    • Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane; ADR-529] and ICRF-159 (Razoxane)
    • Gorbsky GJ (1994) Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane; ADR-529] and ICRF-159 (Razoxane). Cancer Res 54: 1042-1048.
    • (1994) Cancer Res , vol.54 , pp. 1042-1048
    • Gorbsky, G.J.1
  • 41
    • 43749123904 scopus 로고    scopus 로고
    • Hsp90- inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1
    • Sugimoto K, Sasaki M, Isobe Y, Tsutsui M, Suto H, et al. (2008) Hsp90- inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1. Oncogene 27: 3091-3101.
    • (2008) Oncogene , vol.27 , pp. 3091-3101
    • Sugimoto, K.1    Sasaki, M.2    Isobe, Y.3    Tsutsui, M.4    Suto, H.5
  • 43
    • 10644281068 scopus 로고    scopus 로고
    • Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration
    • Watanabe T, Wang S, Noritake J, Sato K, Fukata M, et al. (2004) Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell 7: 871-883.
    • (2004) Dev Cell , vol.7 , pp. 871-883
    • Watanabe, T.1    Wang, S.2    Noritake, J.3    Sato, K.4    Fukata, M.5
  • 44
    • 0030958484 scopus 로고    scopus 로고
    • Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints
    • Kingma PS, Greider CA, Osheroff N (1997) Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints. Biochemistry 36: 5934-5939.
    • (1997) Biochemistry , vol.36 , pp. 5934-5939
    • Kingma, P.S.1    Greider, C.A.2    Osheroff, N.3
  • 45
    • 0024519424 scopus 로고
    • Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae
    • Worland ST, Wang JC (1989) Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae. J Biol Chem 264: 4412-4416.
    • (1989) J Biol Chem , vol.264 , pp. 4412-4416
    • Worland, S.T.1    Wang, J.C.2
  • 46
    • 0035167598 scopus 로고    scopus 로고
    • Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein
    • Zhang F, White RL, Neufeld KL (2001) Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein. Mol Cell Biol 21: 8143-8156.
    • (2001) Mol Cell Biol , vol.21 , pp. 8143-8156
    • Zhang, F.1    White, R.L.2    Neufeld, K.L.3
  • 47
    • 0035859859 scopus 로고    scopus 로고
    • SMAD4 Mutations in Colorectal Cancer Probably Occur Before Chromosomal Instability, but After Divergence of the Microsatellite Instability Pathway
    • Woodford-Richens KL, Rowan AJ, Gorman P, Halford S, Bicknell DC, et al. (2001) SMAD4 Mutations in Colorectal Cancer Probably Occur Before Chromosomal Instability, but After Divergence of the Microsatellite Instability Pathway. Proc Natl Acad Sci USA 98: 9719-9723.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9719-9723
    • Woodford-Richens, K.L.1    Rowan, A.J.2    Gorman, P.3    Halford, S.4    Bicknell, D.C.5
  • 48
    • 0035956950 scopus 로고    scopus 로고
    • Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement
    • Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, et al. (2001) Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement. Proc Natl Acad Sci U S A 98: 2538-2543.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 2538-2543
    • Abdel-Rahman, W.M.1    Katsura, K.2    Rens, W.3    Gorman, P.A.4    Sheer, D.5
  • 50
    • 1242328236 scopus 로고    scopus 로고
    • NCI and NCBI's SKY/M-FISH and CGH Database
    • NCI and NCBI's SKY/M-FISH and CGH Database 2001: http://www.ncbi.nlm.nih.gov/sky/skyweb.cgi.
    • (2001)
  • 51
    • 0031004175 scopus 로고    scopus 로고
    • Genetic instability in colorectal cancers
    • Lengauer C, Kinzler KW, Vogelstein B (1997) Genetic instability in colorectal cancers. Nature 386: 623-627.
    • (1997) Nature , vol.386 , pp. 623-627
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 52
    • 0034724186 scopus 로고    scopus 로고
    • APC mutations in sporadic colorectal tumors: A mutational hotspot and interdependence of the two hits"
    • Rowan AJ, Lamlum H, Ilyas M, Wheeler J, Straub J, et al. (2000) APC mutations in sporadic colorectal tumors: A mutational hotspot and interdependence of the two hits". Proc Natl Acad Sci U S A 97: 3352-3357.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 3352-3357
    • Rowan, A.J.1    Lamlum, H.2    Ilyas, M.3    Wheeler, J.4    Straub, J.5
  • 53
    • 0035833319 scopus 로고    scopus 로고
    • Expression of the gutenriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2
    • Dang D, Mahatan C, Dang L, Agboola I, Yang V (2001) Expression of the gutenriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. Oncogene 20: 4884-4890.
    • (2001) Oncogene , vol.20 , pp. 4884-4890
    • Dang, D.1    Mahatan, C.2    Dang, L.3    Agboola, I.4    Yang, V.5


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