β-catenin regulation during the cell cycle: Implications in G2/M and apoptosis

Molecular Biology of the Cell

Volumn 14, Issue 7, 2003, Pages 2844-2860

  Olmeda, David ^a   Castel, Susanna ^b   Vilaró, Senén ^b   Cano, Amparo ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; WNT PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ADHESION; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CENTROSOME; COLON POLYPOSIS; CONTROLLED STUDY; CYTOPLASM; EPITHELIUM CELL; KERATINOCYTE; MITOSIS; MITOSIS INHIBITION; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; APOPTOSIS; BETA CATENIN; CELL ADHESION; CELL NUCLEUS; CELLS, CULTURED; CENTROSOME; CYTOSKELETAL PROTEINS; DOGS; FLOW CYTOMETRY; G2 PHASE; HUMANS; MICE; MICROSCOPY, CONFOCAL; MITOSIS; TRANS-ACTIVATORS;

ANIMALIA;

EID: 0038107468     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E03-01-0865     Document Type: Article

References (55)

1. Aberle, H., Schwartz, H., and Kemler, R. (1996). Cadherin-catenin complex: protein interactions and their implications for cadherin function. J. Cell Biochem. 61, 514-523.
2. Ahmed, Y., Hayashi, S., Levine, A., and Wieschaus, E. (1998). Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. Cell 93, 1171-1182.
3. Akong, K., Grevengoed, E., Price, M., McCartney, B., Hayden, M., DeNofrio, J., and Peifer, M. (2002a). Drosophila APC2 and APC1 play overlapping roles in Wingless signaling in the embryo and imaginal discs. Dev. Biol. 250, 91-100.
4. Akong, K., McCartney, B., and Peifer, M. (2002b). Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations. Dev. Biol. 250, 71-90.
5. Aoki, M., Sobek, V., Maslyar, D.J., Hecht, A., and Vogt, P.K. (2002). Oncogenic transformation by β-catenin: deletion analysis and characterization of selected target genes. Oncogene 21, 6983-6991.
6. Barth, A.I., Pollack, A.L., Altschuler, Y., Mostov, K.E., and Nelson, W.J. (1997). NH2-terminal deletion of β-catenin results in stable colocalization of mutant β-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion. J. Cell Biol. 136, 693-706.
7. Behrens, J., Jerchow, B.A., Wurtele, M., Grimm, J., Asbrand, C., Wirtz, R., Kuhl, M., Wedlich, D., and Birchmeier, W. (1998). Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β. Science 280, 596-599.
8. Bienz, M. (2002). The subcellular destinations of apc proteins. Nat. Rev. Mol. Cell. Biol. 3, 328-338.
9. Chan, S.K., and Struhl, G. (2002). Evidence that armadillo transduces Wingless by mediating nuclear export or cytosolic activation of pangolin. Cell 111, 265-280.
10. Cui, H., Dong, M., Sadhu, D., and Rosenberg, D. (2002). Suppression of kinesin expression disrupts adenomatous polyposis coli (APC) localization and affects β-catenin turnover in young adult mouse colon (YAMC) epithelial cells. Exp. Cell Res. 280, 12-23.
11. Damalas, A., Ben-Ze'ev, A., Simcha, I., Shtutman, M., Leal, J.F., Zhurinsky, J., Geiger, B., and Oren, M. (1999). Excess β-catenin promotes accumulation of transcriptionally active p53. EMBO J. 18, 3054-3063.
12. Damalas, A., Kahan, S., Shtutman, M., Ben-Ze'ev, A., and Oren, M. (2001). Deregulated β-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBO J. 20, 4912-4922.
13. Espada, J., Pérez-Moreno, M.A., Braga, V.M., Rodriguez-Viciana, P., and Cano, A. (1999). H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of β-catenin in epidermal keratinocytes. J. Cell Biol. 146, 967-980.
14. Fodde, R., et al. (2001). Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat. Cell Biol. 3, 433-438.
15. Gat, U., DasGupta, R., Degenstein, L., and Fuchs, E. (1998). De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated β-catenin in skin. Cell 95, 605-614.
16. Gounari, F. et al. (2002). Stabilization of β-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia. Oncogene 21, 4099-4107.
17. Gumbiner, B.M. (1995). Signal transduction of β-catenin. Curr. Opin. Cell Biol. 7, 634-640.
18. He, T.C., Sparks, A.B., Rago, C., Hermeking, H., Zawel, L., da Costa, L.T., Morin, P.J., Vogelstein, B., and Kinzler, K.W. (1998). Identification of c-MYC as a target of the APC pathway. Science 281, 1509-1512.
19. He, T.C., Chan, T.A., Vogelstein, B., and Kinzler, K.W. (1999). PPAR-delta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99, 335-345.
20. Hedgepeth, C.M., Conrad, L.J., Zhang, J., Huang, H.C., Lee, V.M., and Klein, P.S. (1997). Activation of the Wnt signaling pathway: a molecular mechanism for lithium action. Dev. Biol. 185, 82-91.
21. Imbert, A., Eelkema, R., Jordan, S., Feiner, H., and Cowin, P. (2001). Delta N89 β-catenin induces precocious development, differentiation, and neoplasia in mammary gland. J. Cell Biol. 153, 555-568.
22. Johnston, L.A., and Edgar, B.A. (1998). Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing. Nature 394, 82-84.
23. Kaplan, K.B., Burds, A.A., Swedlow, J.R., Bekir, S.S., Sorger, P.K., and Nathke, I.S. (2001). A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat. Cell Biol. 3, 429-432.
24. Kim, K., Pang, K.M., Evans, M., and Hay, E.D. (2000). Overexpression of β-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol. Biol. Cell 11, 3509-3523.
25. Korinek, V., Barker, N., Morin, P.J., van Wichen, D., de Weger, R., Kinzler, K.W., Vogelstein, B., and Clevers, H. (1997). Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/-colon carcinoma. Science 275, 1784-1787.
26. Lin, Y.M. et al. (2001). Identification of AF17 as a downstream gene of the β-catenin/T-cell factor pathway and its involvement in colorectal carcinogenesis. Cancer Res. 61, 6345-6349.
27. Liu, C., Kato, Y., Zhang, Z., Do, V.M., Yankner, B.A., and He, X. (1999). β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc. Natl. Acad. Sci. USA 96, 6273-6278.
28. Liu, J., Stevens, J., Rote, C.A., Yost, H.J., Hu, Y., Neufeld, K.L., White, R.L., and Matsunami, N. (2001). Siah-1 mediates a novel β-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol. Cell 7, 927-936.
29. Lozano, E., and Cano, A. (1998). Cadherin/catenin complexes in murine epidermal keratinocytes: E-cadherin complexes containing either β-catenin or plakoglobin contribute to stable cell-cell contacts. Cell Adhes. Commun. 6, 51-67.
30. McCartney, B.M., Dierick, H.A., Kirkpatrick, C., Moline, M.M., Baas, A., Peifer, M., and Bejsovec, A. (1999). Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. J. Cell Biol. 146, 1303-1318.
31. Mao, C.D., Hoang, P., and DiCorleto, P.E. (2001). Lithium inhibits cell cycle progression and induces stabilization of p53 in bovine aortic endothelial cells. J. Biol. Chem. 276, 26180-26188.
32. Matsuzawa, S.I., and Reed, J.C. (2001). Siah-1, SIP, and Ebi collaborate in a novel pathway for β-catenin degradation linked to p53 responses. Mol. Cell 7, 915-926.
33. Morin, P.J., Sparks, A.B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K.W. (1997). Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275, 1787-1790.
34. Muller, T., Bain, G., Wang, X., and Papkoff, J. (2002). Regulation of epithelial cell migration and tumor formation by β-catenin signaling. Exp. Cell Res. 280, 119-133.
35. Munemitsu, S., Albert, I., Souza, B., Rubinfeld, B., and Polakis, P. (1995). Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl. Acad. Sci. USA 92, 3046-3050.
36. Munemitsu, S., Albert, I., Rubinfeld, B., and Polakis, P. (1996). Deletion of an amino-terminal sequence stabilizes β-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein. Mol. Cell. Biol. 16, 4088-4094.
37. Nakamura, M., Zhou, X.Z., and Lu, K.P. (2001). Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization. Curr. Biol. 11, 1062-1067.
38. Nathke, I.S., Adams, C.L., Polakis, P., Sellin, J.H., and Nelson, W.J. (1996). The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J. Cell Biol. 134, 165-179.
39. Navarro, P., Gomez, M., Pizarro, A., Gamallo, C., Quintanilla, M., and Cano, A. (1991). A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis. J. Cell Biol. 115, 517-533.
40. Orford, K., Orford, C.C., and Byers, S.W. (1999). Exogenous expression of β-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest. J. Cell Biol. 146, 855-868.
41. Peifer, M. (1997). β-catenin as oncogene: the smoking gun. Science 275, 1752-1753.
42. Polakis, P. (1999). The oncogenic activation of β-catenin. Curr. Opin. Genet. Dev. 9, 15-21.
43. Reinacher-Schick, A., and Gumbiner, B.M. (2001). Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the β-catenin destruction complex in polarized epithelial cells. J. Cell Biol. 152, 491-502.
44. Rubinfeld, B., Souza, B., Albert, I., Muller, O., Chamberlain, S.H., Masiarz, F.R., Munemitsu, S., and Polakis, P. (1993). Association of the APC gene product with β-catenin. Science 262, 1731-1744.
45. Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C., Munemitsu, S., and Polakis, P. (1996). Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly. Science 272, 1023-1026.
46. Rubinfeld, B., Albert, I., Porfiri, E., Munemitsu, S., and Polakis, P. (1997). Loss of β-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene. Cancer Res. 57, 4624-4630.
47. Sharma, S., Schwarte-Waldhoff, I. Oberhuber, H., and Schafer, R. (1993). Functional interaction of wild-type and mutant p53 transfected into human tumor cell lines carrying activated ras genes. Cell Growth Differ. 4, 861-869.
48. Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D'Amico, M., Pestell, R, and Ben-Ze'ev, A. (1999). The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway. Proc. Natl. Acad. Sci. USA 96, 5522-5527.
49. Tetsu, O., and McCormick, F. (1999). β-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 422-426.
50. Tighe, A., Johnson, V.L., Albertella, M., and Taylor, S.S. (2001). Aneuploid colon cancer cells have a robust spindle checkpoint. EMBO Rep. 2, 609-614.
51. Willert, K., and Nusse, R. (1998). β-catenin: a key mediator of Wnt signaling. Curr. Opin. Genet. Dev. 8, 95-102.
52. Wong, M.H., Rubinfeld, B., and Gordon, J.L. (1998). Effects of forced expression of an NH2-terminal truncated β-catenin on mouse intestinal epithelial homeostasis. J. Cell Biol. 141, 765-777.
53. Young, C.S., Kitamura, M., Hardy, S., and Kitajewski, J. (1998). Wnt-1 induces growth, cytosolic β-catenin, and Tcf/Lef transcriptional activation in Rat-1 fibroblasts. Mol. Cell. Biol. 18, 2474-2485.
54. Yuspa, S.H., Morgan, D., Lichti, U., Spangler, E.F., Michael, D., Kilkenny, A., and Hennings, H. (1986). Cultivation and characterization of cells derived from mouse skin papillomas induced by an initiation-promotion protocol. Carcinogenesis 7, 949-958.
55. Zhang, F., White, R.L., and Neufeld, K.L. (2001). Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein. Mol. Cell. Biol. 21, 8143-8156.