Original CIN: Reviewing roles for APC in chromosome instability

Journal of Cell Biology

Volumn 181, Issue 5, 2008, Pages 719-726

  Rusan, Nasser M ^a   Peifer, Mark ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; T CELL FACTOR PROTEIN; WNT PROTEIN;

CANCER GROWTH; CENTROMERE; CENTROSOME; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; COLON CARCINOGENESIS; GENE MUTATION; HOMOZYGOSITY; HUMAN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SHORT SURVEY;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANEUPLOIDY; ANIMALS; CENTROMERE; CHROMOSOMES; CYTOKINESIS; GENE EXPRESSION REGULATION; GENES, APC; GENES, TUMOR SUPPRESSOR; HUMANS; KINETOCHORES; MICROTUBULES; MITOSIS; MODELS, BIOLOGICAL; PLOIDIES;

EID: 44649182871     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200802107     Document Type: Short Survey

References (43)

1. Ahmed, Y., A. Nouri, and E. Wieschaus. 2002. Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development. Development. 129:1751-1762.
2. Akong, K., E. Grevengoed, M. Price, B. McCartney, M. Hayden, J. DeNofrio, and M. Peifer. 2002. Drosophila APC2 and APC1 play overlapping roles in Wingless signaling in the embryo and imaginal discs. Dev. Biol. 250:91-100.
3. Albuquerque, C., C. Breukel, R. van der Luijt, P. Fidalgo, P. Lage, F.J. Slors, C.N. Leitao, R. Fodde, and R. Smits. 2002. The 'just-right' signaling model:APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade. Hum. Mol. Genet. 11:1549-1560.
4. Aoki, K., M. Aoki, M. Sugai, N. Harada, H. Miyoshi, T. Tsukamoto, T. Mizoshita, M. Tatematsu, H. Seno, T. Chiba, et al. 2007. Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells. Oncogene. 26:3511-3520.
5. Banks, J.D., and R. Heald. 2004. Adenomatous polyposis coli associates with the microtubule-destabilizing protein XMCAK. Curr. Biol. 14:2033-2038.
6. Cahill, D.P., C. Lengauer, J. Yu, G.J. Riggins, J.K. Willson, S.D. Markowitz, K.W. Kinzler, and B. Vogelstein. 1998. Mutations of mitotic checkpoint genes in human cancers. Nature. 392:300-303.
7. Caldwell, C.M., R.A. Green, and K.B. Kaplan. 2007. APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice. J. Cell Biol. 178:1109-1120.
8. Cardoso, J., L. Molenaar, R.X. de Menezes, M. van Leerdam, C. Rosenberg, G. Moslein, J. Sampson, H. Morreau, J.M. Boer, and R. Fodde. 2006. Chromosomal instability in MYH- and APC-mutant adenomatous polyps. Cancer Res. 66:2514-2519.
9. Clevers, H. 2006. Wnt/beta-catenin signaling in development and disease. Cell. 127:469-480.
10. Dikovskaya, D., D. Schiffmann, I.P. Newton, A. Oakley, K. Kroboth, O. Sansom, T.J. Jamieson, V. Meniel, A. Clarke, and I.S. Näthke. 2007. Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J. Cell Biol. 176:183-195.
11. Dobles, M., V. Liberal, M.L. Scott, R. Benezra, and P.K. Sorger. 2000. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell. 101:635-645.
12. Draviam, V.M., I. Shapiro, B. Aldridge, and P.K. Sorger. 2006. Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. EMBO J. 25:2814-2827.
13. Fodde, R., J. Kuipers, C. Rosenberg, R. Smits, M. Kielman, C. Gaspar, J.H. van Es, C. Breukel, J. Wiegant, R.H. Giles, and H. Clevers. 2001. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat. Cell Biol. 3:433-438.
14. Green, R.A., and K.B. Kaplan. 2003. Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC. J. Cell Biol. 163:949-961.
15. Green, R.A., R. Wollman, and K.B. Kaplan. 2005. APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment. Mol. Biol. Cell. 16:4609-4622.
16. Hadjihannas, M.V., M. Bruckner, B. Jerchow, W. Birchmeier, W. Dietmaier, and J. Behrens. 2006. Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer. Proc. Natl. Acad. Sci. USA. 103:10747-10752.
17. Haigis, K.M., J.G. Caya, M. Reichelderfer, and W.F. Dove. 2002. Intestinal adenomas can develop with a stable karyotype and stable microsatellites. Proc. Natl. Acad. Sci. USA. 99:8927-8931.
18. Hanks, S., K. Coleman, S. Reid, A. Plaja, H. Firth, D. Fitzpatrick, A. Kidd, K. Mehes, R. Nash, N. Robin, et al. 2004. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat. Genet. 36:1159-1161.
19. Kaplan, K.B., A.A. Burds, J.R. Swedlow, S.S. Bekir, P.K. Sorger, and I.S. Nathke. 2001. A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat. Cell Biol. 3:429-432.
20. Kita, K., T. Wittmann, I.S. Näthke, and C.M. Waterman-Storer. 2006. Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. Mol. Biol. Cell. 17:2331-2345.
21. Kline-Smith, S.L., A. Khodjakov, P. Hergert, and C.E. Walczak. 2004. Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments. Mol. Biol. Cell. 15:1146-1159.
22. Lengauer, C., K.W. Kinzler, and B. Vogelstein. 1998. Genetic instabilities in human cancers. Nature. 396:643-649.
23. Liu, S.T., J.B. Rattner, S.A. Jablonski, and T.J. Yen. 2006. Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells. J. Cell Biol. 175:41-53.
24. Louie, R.K., S. Bahmanyar, K.A. Siemers, V. Votin, P. Chang, T. Stearns, W.J. Nelson, and A.I. Barth. 2004. Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes. J. Cell Sci. 117:1117-1128.
25. McCartney, B.M., M.H. Price, R.L. Webb, M.A. Hayden, L.M. Holot, M. Zhou, A. Bejsovec, and M. Peifer. 2006. Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. Development. 133:2407-2418.
26. Michel, L.S., V. Liberal, A. Chatterjee, R. Kirchwegger, B. Pasche, W. Gerald, M. Dobles, P.K. Sorger, V.V. Murty, and R. Benezra. 2001. MAD2 haploinsuffi ciency causes premature anaphase and chromosome instability in mammalian cells. Nature. 409:355-359.
27. Mimori-Kiyosue, Y., N. Shiina, and S. Tsukita. 2000. Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells. J. Cell Biol. 148:505-518.
28. Musacchio, A., and E.D. Salmon. 2007. The spindle-assembly checkpoint in space and time. Nat. Rev. Mol. Cell Biol. 8:379-393.
29. Näthke, I.S. 2004. The adenomatous polyposis coli protein:the Achilles heel of the gut epithelium. Annu. Rev. Cell Dev. Biol. 20:337-366.
30. Näthke, I.S., C.L. Adams, P. Polakis, J.H. Sellin, and W.J. Nelson. 1996. The Adenomatous Polyposis Coli (APC) tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J. Cell Biol. 134:165-180.
31. Pinsky, B.A., and S. Biggins. 2005. The spindle checkpoint: tension versus attachment. Trends Cell Biol. 15:486-493.
32. Polakis, P. 2007. The many ways of Wnt in cancer. Curr. Opin. Genet. Dev. 17:45-51.
33. Reya, T., and H. Clevers. 2005. Wnt signalling in stem cells and cancer. Nature. 434:843-850.
34. Sansom, O.J., V.S. Meniel, V. Muncan, T.J. Phesse, J.A. Wilkins, K.R. Reed, J.K. Vass, D. Athineos, H. Clevers, and A.R. Clarke. 2007. Myc deletion rescues Apc deficiency in the small intestine. Nature. 446:676-679.
35. Sieber, O.M., K. Heinimann, P. Gorman, H. Lamlum, M. Crabtree, C.A. Simpson, D. Davies, K. Neale, S.V. Hodgson, R.R. Roylance, et al. 2002. Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC. Proc. Natl. Acad. Sci. USA. 99:16910-16915.
36. Sihn, C.R., E.J. Suh, K.H. Lee, T.Y. K im, and S.H. Kim. 2003. p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells. Cancer Lett. 201:203-210.
37. Smits, R., M.F. K ielman, C. Breukel, C. Zurcher, K. Neufeld, S. Jagmohan-Changur, N. Hofland, J. van Dijk, R. White, W. Edelmann, et al. 1999. Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev. 13:1309-1321.
38. Tighe, A., V.L. Johnson, M. Albertella, and S.S. Taylor. 2001. Aneuploid colon cancer cells have a robust spindle checkpoint. EMBO Rep. 2:609-614.
39. Tighe, A., V.L. Johnson, and S.S. Taylor. 2004. Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability. J. Cell Sci. 117:6339-6353.
40. van de Wetering, M., E. Sancho, C. Verweij, W. de Lau, I. Oving, A. Hurlstone, K. van der Horn, E. Batlle, D. Coudreuse, A.P. Haramis, et al. 2002. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 111:241-250.
41. Wang, Z., J.M. Cummins, D. Shen, D.P. Cahill, P.V. Jallepalli, T.L. Wang, D.W. Parsons, G. Traverso, M. Awad, N. Silliman, et al. 2004. Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Res. 64:2998-3001.
42. Weaver, B.A., A.D. Silk, C. Montagna, P. Verdier-Pinard, and D.W. Cleveland. 2007. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell. 11:25-36.
43. Zhang, J., S. Ahmad, and Y. Mao. 2007. BubR1 and APC/EB1 cooperate to maintain metaphase chromosome alignment. J. Cell Biol. 178:773-784.