Biosynthesis of rapamycin and its regulation: Past achievements and recent progress

Journal of Antibiotics

Volumn 63, Issue 8, 2010, Pages 434-441

  Park, Sung Ryeol ^a   Yoo, Young Ji ^a   Ban, Yeon Hee ^a   Yoon, Yeo Joon ^a  

^a Ewha Womans University   (South Korea)

Author keywords

biological activity; biosynthesis; rapamycin; regulation

Indexed keywords

32 DESMETHOXYRAPAMYCIN; 32 DESMETHYLRAPAMYCIN; 4 HYDROXYPROLYL 26 DEMETHOXYRAPAMYCIN; 4 HYDROXYPROLYLRAPAMYCIN; 4 THIARAPAMYCIN; 4,5 DIHYDROCYCLOHEX 1 ENE CARBOXYLIC ACID; 9 DEOXO 5 SULFOXYRAPAMYCIN; AMPHOTERICIN B; AP 23537; CANDICIDIN; CARBOXYLIC ACID; CYCLOSPORIN; DEFEROLIMUS; DEFOROLIMUS; EVEROLIMUS; ILS 920; MACROLIDE; NYSTATIN; PIPECOLIC ACID; POLYKETIDE; POLYKETIDE SYNTHASE; PROPYLRAPAMYCIN; RAPAMYCIN; RAPAMYCIN DERIVATIVE; STEROID; TACROLIMUS; TEMSIROLIMUS; UNCLASSIFIED DRUG; WAY 125286; WAY 24688; WYE 592;

ACUTE GRAFT REJECTION; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; BIOLOGICAL ACTIVITY; BIOSYNTHESIS; CANDIDIASIS; COMBINATORIAL CHEMISTRY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; GRAFT REJECTION; MUTAGENESIS; MYCOSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; STREPTOMYCES HYGROSCOPICUS; TUMOR;

BIOMEDICAL RESEARCH; BIOSYNTHETIC PATHWAYS; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; SIROLIMUS; STREPTOMYCES;

STREPTOMYCES HYGROSCOPICUS;

EID: 77956254341     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2010.71     Document Type: Review

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