Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis

Angewandte Chemie - International Edition

Volumn 44, Issue 30, 2005, Pages 4757-4760

  Gregory, Matthew A ^a   Petkovic, Hrvoje ^a   Lill, Rachel E ^a   Moss, Steven J ^a   Wilkinson, Barrie ^a   Gaisser, Sabine ^a   Leadlay, Peter F ^b   Sheridan, Rose M ^a  

^a BIOTICA TECHNOLOGY LTD   (United Kingdom)

^b Department of Biochemistry ^*  (United Kingdom)

Author keywords

Biosynthesis; Macrocycles; Mutasynthesis; Natural products; Polyketides

Indexed keywords

BACTERIA; GENES; STRUCTURE (COMPOSITION); SYNTHESIS (CHEMICAL);

MUTANTS; MUTASYNTHESIS; RAPAMYCIN;

PROTEINS;

LONG CHAIN FATTY ACID COENZYME A LIGASE; POLYKETIDE SYNTHASE; RAPAMYCIN;

ARTICLE; CATALYSIS; CHEMISTRY; CONFORMATION; GENETICS; METABOLISM; STEREOISOMERISM; STREPTOMYCES;

CATALYSIS; COENZYME A LIGASES; MOLECULAR CONFORMATION; POLYKETIDE SYNTHASES; SIROLIMUS; STEREOISOMERISM; STREPTOMYCES;

EID: 23044465228     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200462784     Document Type: Article

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