Mutagenesis of the rapamycin producer Streptomyces hygroscopicus FC904

Journal of Antibiotics

Volumn 54, Issue 11, 2001, Pages 967-972

  Cheng, Y R ^a   Huang, J ^a   Qiang, H ^a   Lin, W L ^a   Demain, A L ^a  

^a Institute of Microbiology   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AGAR; AMINOGLYCOSIDE DERIVATIVE; CANDICIDIN; CHLORAMPHENICOL; ERYTHROMYCIN; GENTAMICIN; IMMUNOSUPPRESSIVE AGENT; KANAMYCIN; MACROLIDE; METHYLNITRONITROSOGUANIDINE; MITOMYCIN C; PENICILLIN G; RAPAMYCIN; STREPTOMYCIN; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CHINA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DILUTION; DRUG EXPOSURE; DRUG MANUFACTURE; DRUG STRUCTURE; FUNGUS CULTURE; FUNGUS MUTATION; FUNGUS SPORE; GENE THERAPY; MINIMUM INHIBITORY CONCENTRATION; MUTAGENICITY; NONHUMAN; OAT; PRIORITY JOURNAL; PROTOPLAST; SCREENING; SOIL; STREPTOMYCES HYGROSCOPICUS; SURVIVAL; TITRIMETRY; ULTRAVIOLET RADIATION;

STREPTOMYCES HYGROSCOPICUS;

EID: 0035210539     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.54.967     Document Type: Article

References (13)

1. Rapamycins: Antifungal, antitumor, antiproliferative, and immunosuppressive macrolides
2. Protein matchmaker may lead new gene therapy to the altar
3. Incorporation of acetate, propionate, and methionins into rapamycin by Streptomyces hygroscopicus
4. The immediate precursor of the nitrogen-containing ring of rapamycin is free pipecolic acid
5. The cyclohexane moiety of rapamycin is derived from shikimic acid in Streptomyces hygroscopicus
6. Carbon source nutrition of rapamycin biosynthesis in Streptomyces hygroscopicus
7. Phosphate, ammonium, magnesium and iron nutrition of Streptomyces hygroscopicus with respect to rapamycin biosynthesis
8. Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus
9. Exogenous shikimic acid stimulates rapamycin biosynthesis in Streptomyces hygroscopicus
10. Mutagenesis of Streptomyces spores by N-methyl-N′-nitro-N-nitrosoguanidine (NTG)
11. Gentamicin, Streptomycin
12. C. 7. Covalent and strand-breaking interactions with DNA