-
1
-
-
35648963790
-
Joint remodelling in inflammatory disease
-
G. Schett Joint remodelling in inflammatory disease Annals of the Rheumatic Diseases 66 Suppl. 3 2007 iii42 iii44
-
(2007)
Annals of the Rheumatic Diseases
, vol.66
, Issue.SUPPL. 3
-
-
Schett, G.1
-
2
-
-
0036853902
-
Osteoclasts are essential for TNF-alpha-mediated joint destruction
-
K. Redlich, S. Hayer, and R. Ricci Osteoclasts are essential for TNF-alpha-mediated joint destruction The Journal of Clinical Investigation 110 10 2002 1419 1427
-
(2002)
The Journal of Clinical Investigation
, vol.110
, Issue.10
, pp. 1419-1427
-
-
Redlich, K.1
Hayer, S.2
Ricci, R.3
-
3
-
-
0037673945
-
Osteoclast differentiation and activation
-
W.J. Boyle, W.S. Simonet, and D.L. Lacey Osteoclast differentiation and activation Nature 423 6937 2003 337 342
-
(2003)
Nature
, vol.423
, Issue.6937
, pp. 337-342
-
-
Boyle, W.J.1
Simonet, W.S.2
Lacey, D.L.3
-
4
-
-
66249096001
-
Cartilage homeostasis in health and rheumatic diseases
-
M.B. Goldring, and K.B. Marcu Cartilage homeostasis in health and rheumatic diseases Arthritis Research & Therapy 11 3 2009 224
-
(2009)
Arthritis Research & Therapy
, vol.11
, Issue.3
, pp. 224
-
-
Goldring, M.B.1
Marcu, K.B.2
-
5
-
-
0034523328
-
TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand
-
J. Lam, S. Takeshita, and J.E. Barker TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand The Journal of Clinical Investigation 106 12 2000 1481 1488
-
(2000)
The Journal of Clinical Investigation
, vol.106
, Issue.12
, pp. 1481-1488
-
-
Lam, J.1
Takeshita, S.2
Barker, J.E.3
-
6
-
-
0037371262
-
IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance
-
E. Lubberts, L. van den Bersselaar, and B. Oppers-Walgreen IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance Journal of Immunology 170 5 2003 2655 2662
-
(2003)
Journal of Immunology
, vol.170
, Issue.5
, pp. 2655-2662
-
-
Lubberts, E.1
Van Den Bersselaar, L.2
Oppers-Walgreen, B.3
-
7
-
-
33751521013
-
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
-
K. Sato, A. Suematsu, and K. Okamoto Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction The Journal of Experimental Medicine 203 12 2006 2673 2682
-
(2006)
The Journal of Experimental Medicine
, vol.203
, Issue.12
, pp. 2673-2682
-
-
Sato, K.1
Suematsu, A.2
Okamoto, K.3
-
9
-
-
34249720998
-
Cytokines in the pathogenesis of rheumatoid arthritis
-
I.B. McInnes, and G. Schett Cytokines in the pathogenesis of rheumatoid arthritis Nature Reviews. Immunology 7 6 2007 429 442
-
(2007)
Nature Reviews. Immunology
, vol.7
, Issue.6
, pp. 429-442
-
-
McInnes, I.B.1
Schett, G.2
-
10
-
-
33947583822
-
Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems
-
H. Takayanagi Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems Nature Reviews. Immunology 7 4 2007 292 304
-
(2007)
Nature Reviews. Immunology
, vol.7
, Issue.4
, pp. 292-304
-
-
Takayanagi, H.1
-
11
-
-
0034122050
-
Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor
-
E.M. Gravallese, C. Manning, and A. Tsay Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor Arthritis and Rheumatism 43 2 2000 250 258
-
(2000)
Arthritis and Rheumatism
, vol.43
, Issue.2
, pp. 250-258
-
-
Gravallese, E.M.1
Manning, C.2
Tsay, A.3
-
12
-
-
33947604810
-
Emerging roles of cysteine cathepsins in disease and their potential as drug targets
-
O. Vasiljeva, T. Reinheckel, and C. Peters Emerging roles of cysteine cathepsins in disease and their potential as drug targets Current Pharmaceutical Design 13 4 2007 387 403
-
(2007)
Current Pharmaceutical Design
, vol.13
, Issue.4
, pp. 387-403
-
-
Vasiljeva, O.1
Reinheckel, T.2
Peters, C.3
-
14
-
-
0033611467
-
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
-
Y.Y. Kong, H. Yoshida, and I. Sarosi OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis Nature 397 6717 1999 315 323
-
(1999)
Nature
, vol.397
, Issue.6717
, pp. 315-323
-
-
Kong, Y.Y.1
Yoshida, H.2
Sarosi, I.3
-
15
-
-
0032540319
-
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
-
D.L. Lacey, E. Timms, and H.L. Tan Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation Cell 93 2 1998 165 176
-
(1998)
Cell
, vol.93
, Issue.2
, pp. 165-176
-
-
Lacey, D.L.1
Timms, E.2
Tan, H.L.3
-
16
-
-
0031005576
-
Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
-
W.S. Simonet, D.L. Lacey, and C.R. Dunstan Osteoprotegerin: a novel secreted protein involved in the regulation of bone density Cell 89 2 1997 309 319
-
(1997)
Cell
, vol.89
, Issue.2
, pp. 309-319
-
-
Simonet, W.S.1
Lacey, D.L.2
Dunstan, C.R.3
-
17
-
-
0036792512
-
Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis
-
E. Romas, N.A. Sims, and D.K. Hards Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis The American Journal of Pathology 161 4 2002 1419 1427
-
(2002)
The American Journal of Pathology
, vol.161
, Issue.4
, pp. 1419-1427
-
-
Romas, E.1
Sims, N.A.2
Hards, D.K.3
-
18
-
-
12144289393
-
Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis
-
K. Redlich, B. Gortz, and S. Hayer Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis The American Journal of Pathology 164 2 2004 543 555
-
(2004)
The American Journal of Pathology
, vol.164
, Issue.2
, pp. 543-555
-
-
Redlich, K.1
Gortz, B.2
Hayer, S.3
-
19
-
-
20844434038
-
Additive bone-protective effects of anabolic treatment when used in conjunction with RANKL and tumor necrosis factor inhibition in two rat arthritis models
-
G. Schett, S. Middleton, and B. Bolon Additive bone-protective effects of anabolic treatment when used in conjunction with RANKL and tumor necrosis factor inhibition in two rat arthritis models Arthritis and Rheumatism 52 5 2005 1604 1611
-
(2005)
Arthritis and Rheumatism
, vol.52
, Issue.5
, pp. 1604-1611
-
-
Schett, G.1
Middleton, S.2
Bolon, B.3
-
20
-
-
0033581952
-
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
-
Y.Y. Kong, U. Feige, and I. Sarosi Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand Nature 402 6759 1999 304 309
-
(1999)
Nature
, vol.402
, Issue.6759
, pp. 304-309
-
-
Kong, Y.Y.1
Feige, U.2
Sarosi, I.3
-
21
-
-
0036710615
-
Duration of bone protection by a single osteoprotegerin injection in rats with adjuvant-induced arthritis
-
B. Bolon, G. Campagnuolo, and U. Feige Duration of bone protection by a single osteoprotegerin injection in rats with adjuvant-induced arthritis Cellular and Molecular Life Sciences 59 9 2002 1569 1576
-
(2002)
Cellular and Molecular Life Sciences
, vol.59
, Issue.9
, pp. 1569-1576
-
-
Bolon, B.1
Campagnuolo, G.2
Feige, U.3
-
22
-
-
69449086400
-
Tumor necrosis factor alpha and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis
-
G. Schett, M. Stolina, and D. Dwyer Tumor necrosis factor alpha and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis Arthritis and Rheumatism 60 9 2009 2644 2654
-
(2009)
Arthritis and Rheumatism
, vol.60
, Issue.9
, pp. 2644-2654
-
-
Schett, G.1
Stolina, M.2
Dwyer, D.3
-
23
-
-
0037869469
-
Effects of receptor activator of NFkappaB (RANK) signalling blockade on fracture healing
-
L.M. Flick, J.M. Weaver, and M. Ulrich-Vinther Effects of receptor activator of NFkappaB (RANK) signalling blockade on fracture healing Journal of Orthopaedic Research 21 4 2003 676 684
-
(2003)
Journal of Orthopaedic Research
, vol.21
, Issue.4
, pp. 676-684
-
-
Flick, L.M.1
Weaver, J.M.2
Ulrich-Vinther, M.3
-
24
-
-
77952531784
-
RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: Comparison with anti-TNFalpha or anti-IL-1 therapies
-
M. Stolina, G. Schett, and D. Dwyer RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFalpha or anti-IL-1 therapies Arthritis Research & Therapy 11 6 2009 R187
-
(2009)
Arthritis Research & Therapy
, vol.11
, Issue.6
, pp. 187
-
-
Stolina, M.1
Schett, G.2
Dwyer, D.3
-
25
-
-
33749009030
-
Mechanisms of disease: The link between RANKL and arthritic bone disease
-
G. Schett, S. Hayer, and J. Zwerina Mechanisms of disease: the link between RANKL and arthritic bone disease Nature Clinical Practice. Rheumatology 1 1 2005 47 54
-
(2005)
Nature Clinical Practice. Rheumatology
, vol.1
, Issue.1
, pp. 47-54
-
-
Schett, G.1
Hayer, S.2
Zwerina, J.3
-
27
-
-
0346837985
-
A phase i study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
-
J.J. Body, P. Greipp, and R.E. Coleman A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases Cancer 97 3 Suppl. 2003 887 892
-
(2003)
Cancer
, vol.97
, Issue.3 SUPPL.
, pp. 887-892
-
-
Body, J.J.1
Greipp, P.2
Coleman, R.E.3
-
28
-
-
33644849960
-
A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. 2004
-
P.J. Bekker, D.L. Holloway, and A.S. Rasmussen A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. 2004 Journal of Bone and Mineral Research 20 12 2005 2275 2282
-
(2005)
Journal of Bone and Mineral Research
, vol.20
, Issue.12
, pp. 2275-2282
-
-
Bekker, P.J.1
Holloway, D.L.2
Rasmussen, A.S.3
-
30
-
-
0030007961
-
Increased bone mass with pamidronate treatment in rheumatoid arthritis. Results of a three-year randomized, double-blind trial
-
F. Eggelmeijer, S.E. Papapoulos, and H.C. van Paassen Increased bone mass with pamidronate treatment in rheumatoid arthritis. Results of a three-year randomized, double-blind trial Arthritis and Rheumatism 39 3 1996 396 402
-
(1996)
Arthritis and Rheumatism
, vol.39
, Issue.3
, pp. 396-402
-
-
Eggelmeijer, F.1
Papapoulos, S.E.2
Van Paassen, H.C.3
-
31
-
-
0028059365
-
Double blind radiological assessment of continuous oral pamidronic acid in patients with rheumatoid arthritis
-
A. Maccagno, E. Di Giorgio, and E.J. Roldan Double blind radiological assessment of continuous oral pamidronic acid in patients with rheumatoid arthritis Scandinavian Journal of Rheumatology 23 4 1994 211 214
-
(1994)
Scandinavian Journal of Rheumatology
, vol.23
, Issue.4
, pp. 211-214
-
-
MacCagno, A.1
Di Giorgio, E.2
Roldan, E.J.3
-
32
-
-
0024544443
-
Clinical, biochemical, and radiographic effects of aminohydroxypropylidene bisphosphonate treatment in rheumatoid arthritis
-
S.H. Ralston, L. Hacking, and L. Willocks Clinical, biochemical, and radiographic effects of aminohydroxypropylidene bisphosphonate treatment in rheumatoid arthritis Annals of the Rheumatic Diseases 48 5 1989 396 399
-
(1989)
Annals of the Rheumatic Diseases
, vol.48
, Issue.5
, pp. 396-399
-
-
Ralston, S.H.1
Hacking, L.2
Willocks, L.3
-
33
-
-
43949139580
-
Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial
-
S.B. Cohen, R.K. Dore, and N.E. Lane Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial Arthritis and Rheumatism 58 5 2008 1299 1309
-
(2008)
Arthritis and Rheumatism
, vol.58
, Issue.5
, pp. 1299-1309
-
-
Cohen, S.B.1
Dore, R.K.2
Lane, N.E.3
-
34
-
-
25144448701
-
Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation
-
X. Li, P. Liu, and W. Liu Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation Nature Genetics 37 9 2005 945 952
-
(2005)
Nature Genetics
, vol.37
, Issue.9
, pp. 945-952
-
-
Li, X.1
Liu, P.2
Liu, W.3
-
35
-
-
21244480924
-
Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signalling
-
X. Li, Y. Zhang, and H. Kang Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signalling The Journal of Biological Chemistry 280 20 2005 19883 19887
-
(2005)
The Journal of Biological Chemistry
, vol.280
, Issue.20
, pp. 19883-19887
-
-
Li, X.1
Zhang, Y.2
Kang, H.3
-
36
-
-
33846949349
-
Dickkopf-1 is a master regulator of joint remodeling
-
D. Diarra, M. Stolina, and K. Polzer Dickkopf-1 is a master regulator of joint remodeling Nature Medicine 13 2 2007 156 163
-
(2007)
Nature Medicine
, vol.13
, Issue.2
, pp. 156-163
-
-
Diarra, D.1
Stolina, M.2
Polzer, K.3
-
37
-
-
77956156722
-
BHQ880, a novel anti-DKK1 neutralizing antibody, inhibits tumor-induced osteolytic bone disease
-
April 12-16 San Diego, California
-
Ettenberg S, Cong F, Shulok J, et al. BHQ880, a novel anti-DKK1 neutralizing antibody, inhibits tumor-induced osteolytic bone disease. American Association for Cancer Research Annual Meeting, April 12-16, 2008, San Diego, California.
-
(2008)
American Association for Cancer Research Annual Meeting
-
-
Ettenberg, S.1
Cong, F.2
Shulok, J.3
-
38
-
-
70949101564
-
Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo
-
H.Y. Choi, M. Dieckmann, J. Herz, and A. Niemeier Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo PLoS One 4 11 2009 e7930
-
(2009)
PLoS One
, vol.4
, Issue.11
, pp. 7930
-
-
Choi, H.Y.1
Dieckmann, M.2
Herz, J.3
Niemeier, A.4
-
39
-
-
13244298422
-
Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins
-
D.G. Winkler, M.S. Sutherland, and E. Ojala Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins The Journal of Biological Chemistry 280 4 2005 2498 2502
-
(2005)
The Journal of Biological Chemistry
, vol.280
, Issue.4
, pp. 2498-2502
-
-
Winkler, D.G.1
Sutherland, M.S.2
Ojala, E.3
-
40
-
-
22844445934
-
SOST is a ligand for LRP5/LRP6 and a Wnt signalling inhibitor
-
M. Semenov, K. Tamai, and X. He SOST is a ligand for LRP5/LRP6 and a Wnt signalling inhibitor The Journal of Biological Chemistry 280 29 2005 26770 26775
-
(2005)
The Journal of Biological Chemistry
, vol.280
, Issue.29
, pp. 26770-26775
-
-
Semenov, M.1
Tamai, K.2
He, X.3
-
41
-
-
22244474640
-
Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease
-
G.G. Loots, M. Kneissel, and H. Keller Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease Genome Research 15 7 2005 928 935
-
(2005)
Genome Research
, vol.15
, Issue.7
, pp. 928-935
-
-
Loots, G.G.1
Kneissel, M.2
Keller, H.3
-
42
-
-
10744221383
-
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
-
D.G. Winkler, M.K. Sutherland, and J.C. Geoghegan Osteocyte control of bone formation via sclerostin, a novel BMP antagonist The EMBO Journal 22 23 2003 6267 6276
-
(2003)
The EMBO Journal
, vol.22
, Issue.23
, pp. 6267-6276
-
-
Winkler, D.G.1
Sutherland, M.K.2
Geoghegan, J.C.3
-
43
-
-
44449099165
-
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
-
X. Li, M.S. Ominsky, and Q.T. Niu Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength Journal of Bone and Mineral Research 23 6 2008 860 869
-
(2008)
Journal of Bone and Mineral Research
, vol.23
, Issue.6
, pp. 860-869
-
-
Li, X.1
Ominsky, M.S.2
Niu, Q.T.3
-
44
-
-
0035089781
-
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein
-
M.E. Brunkow, J.C. Gardner, and J. Van Ness Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein American Journal of Human Genetics 68 3 2001 577 589
-
(2001)
American Journal of Human Genetics
, vol.68
, Issue.3
, pp. 577-589
-
-
Brunkow, M.E.1
Gardner, J.C.2
Van Ness, J.3
-
45
-
-
70350558488
-
Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis
-
H. Appel, G. Ruiz-Heiland, and J. Listing Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis Arthritis and Rheumatism 60 11 2009 3257 3262
-
(2009)
Arthritis and Rheumatism
, vol.60
, Issue.11
, pp. 3257-3262
-
-
Appel, H.1
Ruiz-Heiland, G.2
Listing, J.3
-
46
-
-
27744461726
-
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
-
K.E. Poole, R.L. van Bezooijen, and N. Loveridge Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation The FASEB Journal 19 13 2005 1842 1844
-
(2005)
The FASEB Journal
, vol.19
, Issue.13
, pp. 1842-1844
-
-
Poole, K.E.1
Van Bezooijen, R.L.2
Loveridge, N.3
-
47
-
-
26444464413
-
Wnt-mediated regulation of chondrocyte maturation: Modulation by TGF-beta
-
Y. Dong, H. Drissi, and M. Chen Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta Journal of Cellular Biochemistry 95 5 2005 1057 1068
-
(2005)
Journal of Cellular Biochemistry
, vol.95
, Issue.5
, pp. 1057-1068
-
-
Dong, Y.1
Drissi, H.2
Chen, M.3
-
48
-
-
46649107327
-
Inhibition of beta-catenin signalling causes defects in postnatal cartilage development
-
M. Chen, M. Zhu, and H. Awad Inhibition of beta-catenin signalling causes defects in postnatal cartilage development Journal of Cell Science 121 Pt 9 2008 1455 1465
-
(2008)
Journal of Cell Science
, vol.121
, Issue.PART 9
, pp. 1455-1465
-
-
Chen, M.1
Zhu, M.2
Awad, H.3
-
49
-
-
39749171039
-
Wnt/beta-catenin signalling stimulates matrix catabolic genes and activity in articular chondrocytes: Its possible role in joint degeneration
-
T. Yuasa, T. Otani, and T. Koike Wnt/beta-catenin signalling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration Laboratory Investigation 88 3 2008 264 274
-
(2008)
Laboratory Investigation
, vol.88
, Issue.3
, pp. 264-274
-
-
Yuasa, T.1
Otani, T.2
Koike, T.3
-
50
-
-
37149029397
-
Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice
-
R.J. Lories, J. Peeters, and A. Bakker Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice Arthritis and Rheumatism 56 12 2007 4095 4103
-
(2007)
Arthritis and Rheumatism
, vol.56
, Issue.12
, pp. 4095-4103
-
-
Lories, R.J.1
Peeters, J.2
Bakker, A.3
-
51
-
-
34547604106
-
Beta-catenin signalling plays a disparate role in different phases of fracture repair: Implications for therapy to improve bone healing
-
Y. Chen, H.C. Whetstone, and A.C. Lin Beta-catenin signalling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing PLoS Med 4 7 2007 e249
-
(2007)
PLoS Med
, vol.4
, Issue.7
, pp. 249
-
-
Chen, Y.1
Whetstone, H.C.2
Lin, A.C.3
-
52
-
-
43949145269
-
Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signalling after injury and in osteoarthritis
-
F. Dell'accio, C. De Bari, and N.M. Eltawil Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signalling after injury and in osteoarthritis Arthritis and Rheumatism 58 5 2008 1410 1421
-
(2008)
Arthritis and Rheumatism
, vol.58
, Issue.5
, pp. 1410-1421
-
-
Dell'Accio, F.1
De Bari, C.2
Eltawil, N.M.3
-
53
-
-
38749144432
-
Enhanced chondrogenesis and Wnt signalling in PTH-treated fractures
-
S. Kakar, T.A. Einhorn, and S. Vora Enhanced chondrogenesis and Wnt signalling in PTH-treated fractures Journal of Bone and Mineral Research 22 12 2007 1903 1912
-
(2007)
Journal of Bone and Mineral Research
, vol.22
, Issue.12
, pp. 1903-1912
-
-
Kakar, S.1
Einhorn, T.A.2
Vora, S.3
-
54
-
-
37549068912
-
Cathepsin K inhibitors: A novel target for osteoporosis therapy
-
S.A. Stoch, and J.A. Wagner Cathepsin K inhibitors: a novel target for osteoporosis therapy Clinical Pharmacology and Therapeutics 83 1 2008 172 176
-
(2008)
Clinical Pharmacology and Therapeutics
, vol.83
, Issue.1
, pp. 172-176
-
-
Stoch, S.A.1
Wagner, J.A.2
-
55
-
-
39749117421
-
Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice
-
U. Schurigt, K.M. Hummel, and P.K. Petrow Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice Arthritis and Rheumatism 58 2 2008 422 434
-
(2008)
Arthritis and Rheumatism
, vol.58
, Issue.2
, pp. 422-434
-
-
Schurigt, U.1
Hummel, K.M.2
Petrow, P.K.3
-
56
-
-
38849127573
-
Cathepsin K-dependent toll-like receptor 9 signalling revealed in experimental arthritis
-
M. Asagiri, T. Hirai, and T. Kunigami Cathepsin K-dependent toll-like receptor 9 signalling revealed in experimental arthritis Science 319 5863 2008 624 627
-
(2008)
Science
, vol.319
, Issue.5863
, pp. 624-627
-
-
Asagiri, M.1
Hirai, T.2
Kunigami, T.3
-
57
-
-
67149126908
-
Future therapeutic targets in osteoporosis
-
C. Deal Future therapeutic targets in osteoporosis Current Opinion in Rheumatology 21 4 2009 380 385
-
(2009)
Current Opinion in Rheumatology
, vol.21
, Issue.4
, pp. 380-385
-
-
Deal, C.1
-
58
-
-
35748943595
-
Effect of one year treatment with the cathepsin-K inhibitor, balicatib, on bone mineral density (BMD) in postmenopausal women with osteopenia/ osteoporosis
-
S. Adami, J. Supronik, and T. Hala Effect of one year treatment with the cathepsin-K inhibitor, balicatib, on bone mineral density (BMD) in postmenopausal women with osteopenia/osteoporosis Journal of Bone and Mineral Research 21 Suppl. 1 2006 Abstract 1085
-
(2006)
Journal of Bone and Mineral Research
, vol.21
, Issue.SUPPL. 1
-
-
Adami, S.1
Supronik, J.2
Hala, T.3
-
59
-
-
37549001539
-
Effect of three month treatment with the cathepsin-K inhibitor, balicatib, on biochemical markers of bone turnover in postmenopausal women: Evidence for uncoupling of bone resorption and bone formation
-
P. Papanastasiou, C. Ortmann, and M. Olson Effect of three month treatment with the cathepsin-K inhibitor, balicatib, on biochemical markers of bone turnover in postmenopausal women: evidence for uncoupling of bone resorption and bone formation Journal of Bone and Mineral Research 21 Suppl. 1 2006 Abstract 1223
-
(2006)
Journal of Bone and Mineral Research
, vol.21
, Issue.SUPPL. 1
-
-
Papanastasiou, P.1
Ortmann, C.2
Olson, M.3
-
60
-
-
67651180563
-
Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: Two double-blind, randomized, placebo-controlled phase i studies
-
S.A. Stoch, S. Zajic, and J. Stone Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: two double-blind, randomized, placebo-controlled phase I studies Clinical Pharmacology and Therapeutics 86 2 2009 175 182
-
(2009)
Clinical Pharmacology and Therapeutics
, vol.86
, Issue.2
, pp. 175-182
-
-
Stoch, S.A.1
Zajic, S.2
Stone, J.3
-
62
-
-
43049086357
-
Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity
-
S. Ohba, H. Kawaguchi, and F. Kugimiya Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity Developmental Cell 14 5 2008 689 699
-
(2008)
Developmental Cell
, vol.14
, Issue.5
, pp. 689-699
-
-
Ohba, S.1
Kawaguchi, H.2
Kugimiya, F.3
-
63
-
-
43049131846
-
Hedgehog signalling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression
-
K.K. Mak, Y. Bi, and C. Wan Hedgehog signalling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression Developmental Cell 14 5 2008 674 688
-
(2008)
Developmental Cell
, vol.14
, Issue.5
, pp. 674-688
-
-
Mak, K.K.1
Bi, Y.2
Wan, C.3
-
64
-
-
71549136203
-
Modulating hedgehog signalling can attenuate the severity of osteoarthritis
-
A.C. Lin, B.L. Seeto, and J.M. Bartoszko Modulating hedgehog signalling can attenuate the severity of osteoarthritis Nature Medicine 15 12 2009 1421 1425
-
(2009)
Nature Medicine
, vol.15
, Issue.12
, pp. 1421-1425
-
-
Lin, A.C.1
Seeto, B.L.2
Bartoszko, J.M.3
-
65
-
-
2942738996
-
The Hedgehog response network: Sensors, switches, and routers
-
L. Lum, and P.A. Beachy The Hedgehog response network: sensors, switches, and routers Science 304 5678 2004 1755 1759
-
(2004)
Science
, vol.304
, Issue.5678
, pp. 1755-1759
-
-
Lum, L.1
Beachy, P.A.2
-
66
-
-
32844470804
-
Repeated mechanical loading enhances the expression of Indian hedgehog in condylar cartilage
-
T.C. Ng, K.W. Chiu, A.B. Rabie, and U. Hagg Repeated mechanical loading enhances the expression of Indian hedgehog in condylar cartilage Frontiers in Bioscience 11 2006 943 948
-
(2006)
Frontiers in Bioscience
, vol.11
, pp. 943-948
-
-
Ng, T.C.1
Chiu, K.W.2
Rabie, A.B.3
Hagg, U.4
-
67
-
-
34447119750
-
Mechanisms of disease: Role of chondrocytes in the pathogenesis of osteoarthritis-structure, chaos and senescence
-
T. Aigner, S. Soder, and P.M. Gebhard Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis-structure, chaos and senescence Nature Clinical Practice. Rheumatology 3 7 2007 391 399
-
(2007)
Nature Clinical Practice. Rheumatology
, vol.3
, Issue.7
, pp. 391-399
-
-
Aigner, T.1
Soder, S.2
Gebhard, P.M.3
-
68
-
-
0033951768
-
FGFs, heparan sulfate and FGFRs: Complex interactions essential for development
-
D.M. Ornitz FGFs, heparan sulfate and FGFRs: complex interactions essential for development Bioessays 22 2 2000 108 112
-
(2000)
Bioessays
, vol.22
, Issue.2
, pp. 108-112
-
-
Ornitz, D.M.1
-
69
-
-
0036203355
-
Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18
-
Z. Liu, J. Xu, J.S. Colvin, and D.M. Ornitz Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18 Genes & Development 16 7 2002 859 869
-
(2002)
Genes & Development
, vol.16
, Issue.7
, pp. 859-869
-
-
Liu, Z.1
Xu, J.2
Colvin, J.S.3
Ornitz, D.M.4
-
70
-
-
0036671733
-
The IIIc alternative of Fgfr2 is a positive regulator of bone formation
-
V.P. Eswarakumar, E. Monsonego-Ornan, and M. Pines The IIIc alternative of Fgfr2 is a positive regulator of bone formation Development 129 16 2002 3783 3793
-
(2002)
Development
, vol.129
, Issue.16
, pp. 3783-3793
-
-
Eswarakumar, V.P.1
Monsonego-Ornan, E.2
Pines, M.3
-
71
-
-
0037097976
-
FGF signalling pathways in endochondral and intramembranous bone development and human genetic disease
-
D.M. Ornitz, and P.J. Marie FGF signalling pathways in endochondral and intramembranous bone development and human genetic disease Genes & Development 16 12 2002 1446 1465
-
(2002)
Genes & Development
, vol.16
, Issue.12
, pp. 1446-1465
-
-
Ornitz, D.M.1
Marie, P.J.2
-
72
-
-
0036246477
-
Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors
-
J.L. Ellsworth, J. Berry, and T. Bukowski Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors Osteoarthritis Cartilage 10 4 2002 308 320
-
(2002)
Osteoarthritis Cartilage
, vol.10
, Issue.4
, pp. 308-320
-
-
Ellsworth, J.L.1
Berry, J.2
Bukowski, T.3
-
73
-
-
20144378016
-
Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis
-
D. Davidson, A. Blanc, and D. Filion Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis The Journal of Biological Chemistry 280 21 2005 20509 20515
-
(2005)
The Journal of Biological Chemistry
, vol.280
, Issue.21
, pp. 20509-20515
-
-
Davidson, D.1
Blanc, A.2
Filion, D.3
-
74
-
-
0036205735
-
FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis
-
N. Ohbayashi, M. Shibayama, and Y. Kurotaki FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis Genes & Development 16 7 2002 870 879
-
(2002)
Genes & Development
, vol.16
, Issue.7
, pp. 870-879
-
-
Ohbayashi, N.1
Shibayama, M.2
Kurotaki, Y.3
-
75
-
-
73349132030
-
Involvement of fibroblast growth factor 18 in dedifferentiation of cultured human chondrocytes
-
H. Yamaoka, S. Nishizawa, and Y. Asawa Involvement of fibroblast growth factor 18 in dedifferentiation of cultured human chondrocytes Cell Proliferation 43 1 2010 67 76
-
(2010)
Cell Proliferation
, vol.43
, Issue.1
, pp. 67-76
-
-
Yamaoka, H.1
Nishizawa, S.2
Asawa, Y.3
-
76
-
-
20944443514
-
Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis
-
E.E. Moore, A.M. Bendele, and D.L. Thompson Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis Osteoarthritis Cartilage 13 7 2005 623 631
-
(2005)
Osteoarthritis Cartilage
, vol.13
, Issue.7
, pp. 623-631
-
-
Moore, E.E.1
Bendele, A.M.2
Thompson, D.L.3
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