Pharmacophore modeling of substituted 1,2,4-trioxanes for quantitative prediction of their antimalarial activity

Journal of Chemical Information and Modeling

Volumn 50, Issue 8, 2010, Pages 1510-1520

  Gupta, Amit K ^a   Chakroborty, S ^a   Srivastava, Kumkum ^a   Puri, Sunil K ^a   Saxena, Anil K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN BONDS; HYDROPHOBICITY; MOLECULES;

ANTIMALARIAL ACTIVITY; ANTIMALARIAL AGENT; CLINICAL TRIAL; CORRELATION COEFFICIENT; PHARMACOPHORE MODELING; QUANTITATIVE PREDICTION; STRUCTURAL REQUIREMENTS; TEST SETS;

PHARMACODYNAMICS;

1,2,4 TRIOXANE; 1,2,4-TRIOXANE; ANTIMALARIAL AGENT; HETEROCYCLIC COMPOUND;

ARTICLE; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; HUMAN; MALARIA FALCIPARUM; PLASMODIUM FALCIPARUM; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTIMALARIALS; HETEROCYCLIC COMPOUNDS; HUMANS; MALARIA, FALCIPARUM; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956053752     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci100180e     Document Type: Article

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