Antimalarial artemisinin analogs. Synthesis via chemoselective C-C bond formation and preliminary biological evaluation

Tetrahedron

Volumn 55, Issue 12, 1999, Pages 3625-3636

  O'Dowd, Hardwin ^a   Ploypradith, Poonsakdi ^a   Suji, Xie ^b   Shapiro, Theresa A ^b   Posner, Gary H ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antimalarial; Artemisinin; Chemoselective Carbonyl Additions; Peroxide Bond Stability; Trioxanes

Indexed keywords

ALDEHYDE; ARTEMISININ DERIVATIVE; CARBONYL DERIVATIVE; KETONE; LACTONE; ORGANOMETALLIC COMPOUND; PEROXIDE;

ANTIMALARIAL ACTIVITY; ARTICLE; CHEMICAL BOND; CHEMICAL REACTION; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; MOLECULAR STABILITY; PRIORITY JOURNAL; REACTION ANALYSIS;

EID: 0033583161     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(98)01170-3     Document Type: Article

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