Inhibition of warfarin hydroxylation by major tanshinones of Danshen (Salvia miltiorrhiza) in the rat in vitro and in vivo

Phytomedicine

Volumn 17, Issue 3-4, 2010, Pages 219-226

  Wu, Windy W P ^a   Yeung, John H K ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

Danshen (Salvia miltiorrhiza); Rat; Tanshinones; Warfarin hydroxylation

Indexed keywords

3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; 4' HYDROXYWARFARIN; 6' HYDROXYWARFARIN; 7' HYDROXYWARFARIN; CRYPTOTANSHINONE; CYTOCHROME P450 1A1; CYTOCHROME P450 2C11; SALVIA MILTIORRHIZA EXTRACT; SALVIANOLIC ACID B; TANSHINONE; TANSHINONE I; TANSHINONE IIA; UNCLASSIFIED DRUG; WARFARIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG HYDROXYLATION; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SALVIA MILTIORRHIZA; SINGLE DRUG DOSE; STEADY STATE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DRUGS, CHINESE HERBAL; HERB-DRUG INTERACTIONS; HYDROXYLATION; MALE; METABOLIC DETOXICATION, DRUG; MICROSOMES, LIVER; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA; WARFARIN;

RATTUS; SALVIA MILTIORRHIZA;

EID: 75249097840     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.05.005     Document Type: Article

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