Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: The European male aging study

Journal of Clinical Endocrinology and Metabolism

Volumn 93, Issue 7, 2008, Pages 2737-2745

  Wu, Frederick C W ^a,j   Tajar, Abdelouahid ^a,j   Pye, Stephen R ^a,j   Silman, Alan J ^a,j   Finn, Joseph D ^a,j   O'Neill, Terence W ^a,j   Bartfai, Gyorgy ^b,j   Casanueva, Felipe ^c,j   Forti, Gianni ^d,j   Giwercman, Aleksander ^e,j   Huhtaniemi, Ilpo T ^f,j   Kula, Krzysztof ^g,j   Punab, Margus ^h,j   Boonen, Steven ^i,j   Vanderschueren, Dirk ^i,j   Petrone, Luisa ^j   Cilotti, Antonio ^j   Borghs, Herman ^j   Slowikowska Hilczer, Jolanta ^j   Walczak Jedrzejowska, Renata ^j   Steer, Philip ^j   Lee, David ^j   Ocampo, Marta ^j   Lage, Mary ^j   Földesi, Imre ^j   Fejes, Imre ^j   Korrovitz, Paul ^j   Jiang, Min ^j   more..

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF SZEGED   (Hungary)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^d UNIVERSITY OF FLORENCE   (Italy)

^e LUND UNIVERSITY HOSPITAL   (Sweden)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

^g MEDICAL UNIVERSITY OF LODZ   (Poland)

^h TARTU UNIVERSITY CLINICS   (Estonia)

ⁱ UNIVERSITY OF LEUVEN   (Belgium)

^j MANCHESTER ROYAL INFIRMARY   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; HORMONE; LUTEINIZING HORMONE; TESTOSTERONE;

ADULT; AGED; AGING; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; COHORT ANALYSIS; COMMUNITY; COMORBIDITY; EUROPEAN AMERICAN; HEALTH SURVEY; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; LIFESTYLE; MALE; MEN'S HEALTH; NEGATIVE FEEDBACK; OBESITY; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; STATISTICAL SIGNIFICANCE; TESTIS FUNCTION;

EID: 47549107694     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-1972     Document Type: Article

References (43)

1. 2003 Trends in aging - United States and worldwide. MMWR Morb Mortal Wkly Rep 52:101-104, 106
2. Oeppen J, Vaupel JW 2002 Demography: broken limits to life expectancy. Science 296:1029-1031
3. Sowers MR, La Pietra MT 1995 Menopause: its epidemiology and potential association with chronic diseases. Epidemiol Rev 17:287-302
4. Allan CA, McLachlan RI 2004 Age-related changes in testosterone and the role of replacement therapy in older men. Clin Endocrinol (Oxf) 60:653-670
5. Snyder PJ 2004 Hypogonadism in elderly men-what to do until the evidence comes. N Engl J Med 350:440-442
6. Kaufman JM, Vermeulen A 2005 The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 26:833-876
7. Liverman CT, Blazer DG eds 2004 Testosterone and aging clinical research directions. Washington, DC: Institute of Medicine of the National Academies
8. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM 2006 Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 91:1995-2010
9. Lee DM, O'Neill TW, Pye SR, Silman AJS, Finn JD, Pendleton N, Tajar A, Bartfai G, Casanueva F, Forti G, Giwercman A, Huhtaniemi IT, Kula K, Punab M, Boonen S, Vanderschueren D, Wu FCW, and the EMAS Group 2008 The European Male Ageing Study (EMAS): design, methods and recruitment. Int J Androl 31:1-4
10. Vermeulen A, Verdonck L, Kaufman JM 1999 A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84:3666-3672
11. Keenan DM, Takahashi PY, Liu PY, Roebuck PD, Nehra AX, Iranmanesh A, Veldhuis JD 2006 An ensemble model of the male gonadal axis: illustrative application in aging men. Endocrinology 147:2817-2828
12. Mendel CM 1989 The free hormone hypothesis: a physiologically based mathematical model. Endocr Rev 10:232-274
13. Kreft I, De Leeuwe J 1998 Introducing multilevel modelling. London: Sage Publications Ltd.
14. Litman HJ, Bhasin S, Link CL, Araujo AB, McKinlay JB 2006 Serum androgen levels in black, Hispanic, and white men. J Clin Endocrinol Metab 91:4326-4334
15. Liu PY, Beilin J, Meier C, Nguyen TV, Center JR, Leedman PJ, Seibel MJ, Eisman JA, Handelsman DJ 2007 Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: longitudinal analyses of two geographically separate regional cohorts. J Clin Endocrinol Metab 92:3599-3603
16. Ferrini RL, Barrett-Connor E 1998 Sex hormones and age: a cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men. Am J Epidemiol 147:750-754
17. van den Beld AW, de Jong FH, Grobbee DE, Pols HAP, Lamberts SWJ 2000 Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 85:3276-3282
18. Gray A, Feldman HA, McKinlay JB, Longcope C 1991 Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 73:1016-1025
19. Muller M, den Tonkelaar I, Thijssen JH, Grobbee DE, van der Schouw YT 2003 Endogenous sex hormones in men aged 40-80 years. Eur J Endocrinol 149:583-589
20. Orwoll E, Lambert LC, Marshall LM, Phipps K, Blank J, Barrett-Connor E, Cauley J, Ensrud K, Cummings S, for the Osteoporotic Fractures in Men (MrOS) Study Group 2005 Testosterone and estradiol among older men. J Clin Endocrinol Metab 91:1223-1225
21. Neaves WB, Johnson L, Porter JC, Parker Jr CR, Petty CS 1984 Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J Clin Endocrinol Metab 59:756-763
22. Wang X, Stocco DM 2005 The decline in testosterone biosynthesis during male aging: a consequence of multiple alterations. Mol Cell Endocrinol 238:1-7
23. Vermeulen A, Kaufman JM, Deslypere JP, Thomas G 1993 Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men. J Clin Endocrinol Metab 76:1140-1146
24. Phillips GB, Jing T, Heymsfield SB 2003 Relationships in men of sex hormones, insulin, adiposity, and risk factors for myocardial infarction. Metabolism 52:784-790
25. Pasquali R 2006 Obesity and androgens: facts and perspectives. Fertil Steril 85:1319-1340
26. Travison TG, Araujo AB, Kupelian V, O'Donnell AB, McKinlay JB 2007 The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men. J Clin Endocrinol Metab 92:549-555
27. Vermeulen A, Kaufman JM, Giagulli VA 1996 Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab 81:1821-1826
28. Kahn BB, Flier JS 2000 Obesity and insulin resistance. J Clin Invest 106:473-481
29. Plymate SR, Jones RE, Matej LA, Friedl KE 1988 Regulation of sex hormone binding globulin (SHBG) production in Hep G2 cells by insulin. Steroids 52:339-340
30. Porte Jr D, Baskin DG, Schwartz MW 2005 Insulin signaling in the central nervous system: a critical role in metabolic homeostasis and disease from C. elegans to humans. Diabetes 54:1264-1276
31. Pittas AG, Joseph NA, Greenberg AS 2004 Adipocytokines and insulin resistance. J Clin Endocrinol Metab 89:447-452
32. Pagotto U, Marsicano G, Cota D, Lutz B, Pasquali R 2006 The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev 27:73-100
33. Khaw KT, Barrett-Connor E 1992 Lower endogenous androgens predict central adiposity in men. Ann Epidemiol 2:675-682
34. Derby CA, Zilber S, Brambilla D, Morales KH, McKinlay JB 2006 Body mass index, waist circumference and waist to hip ratio and change in sex steroid hormones: the Massachusetts Male Ageing Study. Clin Endocrinol (Oxf) 65:125-131
35. Basaria S, Lieb 2nd J, Tang AM, DeWeese T, Carducci M, Eisenberger M, Dobs AS 2002 Long-term effects of androgen deprivation therapy in prostate cancer patients. Clin Endocrinol (Oxf) 56:779-786
36. Marin P 1995 Testosterone and regional fat distribution. Obes Res 3(Suppl 4):609S-612S
37. Liu PY, Pincus SM, Takahashi PY, Roebuck PD, Iranmanesh A, Keenan DM, Veldhuis JD 2006 Aging attenuates both the regularity and joint synchrony of LH and testosterone secretion in normal men: analyses via a model of graded GnRH receptor blockade. Am J Physiol Endocrinol Metab 290:E34-E41
38. Kapoor D, Jones TH 2005 Smoking and hormones in health and endocrine disorders. Eur J Endocrinol 152:491-499
39. Glinoer D 1997 The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev 18:404-433
40. Emanuele MA, Emanuele NV 1998 Alcohol's effects on male reproduction. Alcohol Health Res World 22:195-201
41. Travison TG, Araujo AB, O'Donnell AB, Kupelian V, McKinlay JB 2007 A population-level decline in serum testosterone levels in American men. J Clin Endocrinol Metab 92:196-202
42. Mohr BA, Bhasin S, Link CL, O'Donnell AB, McKinlay JB 2006 The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study. Eur J Endocrinol 155:443-452
43. Vermeulen A, Verdonck G 1992 Representativeness of a single point plasma testosterone level for the long term hormonal milieu in men. J Clin Endocrinol Metab 74:939-942