Glial cell line-derived neurotrophic factor-secreting genetically modified human bone marrow-derived mesenchymal stem cells promote recovery in a rat model of Parkinson's disease

Journal of Neuroscience Research

Volumn 88, Issue 12, 2010, Pages 2669-2681

  Glavaski Joksimovic, Aleksandra ^a   Virag, Tamas ^a,c   Mangatu, Thomas A ^a   McGrogan, Michael ^b   Wang, Xue Song ^a   Bohn, Martha C ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b SanBio Inc   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Dopamine; Gene therapy; Neurotrophic factor; Nigrostriatal system; Notch1

Indexed keywords

AMPHETAMINE; CYCLOSPORIN; CYCLOSPORIN A; DOPAMINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; NOTCH RECEPTOR; NOTCH1 RECEPTOR; OXIDOPAMINE; RECOMBINANT GREEN FLUORESCENT PROTEIN; RECOMBINANT PROTEIN; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; BRAIN DAMAGE; CELL REGENERATION; CONTROLLED STUDY; CONVALESCENCE; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; GENETIC TRANSFECTION; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; INTRACELLULAR MEMBRANE; LENTIVIRINAE; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NERVE FIBER; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECRETION; RAT; RENILLA; SIGNAL TRANSDUCTION; STEREOTAXIS; VIRAL GENE DELIVERY SYSTEM;

ADULT; ANIMALS; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CELL LINE; DISEASE MODELS, ANIMAL; GENETIC ENGINEERING; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GRAFT SURVIVAL; HUMANS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; NERVE REGENERATION; PARKINSONIAN DISORDERS; RATS; RATS, INBRED F344; RECOVERY OF FUNCTION; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HETEROLOGOUS; TRANSPLANTATION, HOMOLOGOUS;

EID: 77955478722     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22435     Document Type: Article

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