PK/PD modelling and beyond: Impact on drug development

Pharmaceutical Research

Volumn 25, Issue 12, 2008, Pages 2720-2722

  Breimer, Douwe D ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Mechanism based PK PD models; New drug combinations; PK PD modeling in drug development; Systems pharmacology and therapeutics

Indexed keywords

CONFERENCE PAPER; DRUG DEVELOPMENT; MODEL; PHARMACODYNAMICS; PHARMACOKINETICS; PRIORITY JOURNAL; SYSTEMS BIOLOGY;

ANIMALS; DRUG DISCOVERY; HUMANS; MODELS, BIOLOGICAL; PHARMACOKINETICS; PHARMACOLOGY; SYSTEMS BIOLOGY;

EID: 57149126216     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9717-x     Document Type: Conference Paper

References (10)

1. M. Danhof et al. (editors). Proceedings: Measurement and Kinetics of In vivo Drug Effects. Advances in Simultaneous Pharmacokinetic/Pharmacodynamic Modelling. Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands, 1990, 1994, 1998, 2002, 2006.
2. D.D. Breimer M. Danhof 1997 Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The "Wooden Shoe" Paradigm Clin. Pharmacokin. 32 259 267
3. FDA. FDA report: innovation or stagnation. Challenge and opportunity on the critical path to new medical products. Food and Drug Administration, Rockville, 2004.
4. A. Cohen 2008 Pharmacokinetic and pharmacodynamic data to be derived from early-phase drug development. Designing informative human pharmacology studies Clin. Pharmacokin. 47 373 381
5. D.D. Breimer 1998 Future challenges for drug delivery research Adv. Drug Deliv. Rev. 33 265 268
6. L.B. Sheiner D.R. Stanski S. Vozeh R.D. Miller J. Ham 1979 Simultaneous modelling of pharmacokinetics and pharmacodynamics: application to D-tubocurarine Clin. Pharmacol. Ther. 25 358 371
7. M. Danhof J. de Jongh E.C.M. de Lange O. Della Pasqua B.A. Ploeger R.A. Voskuyl 2007 Mechanism-based pharmacokinetic-pharmacodynamic modelling: biophase distribution, receptor theory and dynamical systems analysis Annu. Rev. Pharmacol. Toxicol. 47 357 400
8. P.L. Chan N.H.G. Holford 2001 Drug treatment effects on disease progression Annu. Rev. Pharmacol. Toxicol. 41 625 659
9. H. Kitano 2002 Systems biology: a brief overview Science 295 1662 1664
10. D.M. Jonker S.A.G. Visser P.H. van der Graaf R.A. Voskuyl M. Danhof 2005 Towards a mechanism-based analysis of drug-drug interactions in vivo Pharmacol. Ther. 106 1 18