Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems

Molecular Therapy

Volumn 13, Issue 4, 2006, Pages 786-794

  Hama, Susumu ^a,b   Akita, Hidetaka ^a,b   Ito, Rie ^a   Mizuguchi, Hiroyuki ^c   Hayakawa, Takao ^d   Harashima, Hideyoshi ^a,b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^d PHARMACEUTICALS AND MEDICAL DEVICES AGENCY   (Japan)

Author keywords

Adenovirus; Gene vector; Intracellular trafficking; Lipoplex; Nonviral vector; Quantification

Indexed keywords

LIPOFECTAMINE; LIPOPLEX;

ADENOVIRUS; ADENOVIRUS VECTOR; ARTICLE; CELL NUCLEUS; CELL NUCLEUS TRANSPLANTATION; CONTROLLED STUDY; CYTOSOL; ENDOSOME; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; INTRACELLULAR TRANSPORT; LYSOSOME; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; THREE DIMENSIONAL IMAGING; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; CELL LINE, TUMOR; CELL NUCLEUS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; ENDOSOMES; GENE EXPRESSION REGULATION, VIRAL; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC VECTORS; HUMANS; KINETICS; LIPIDS; LIPOSOMES; LUCIFERASES; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; TRANSCRIPTION, GENETIC; TRANSFECTION;

ADENOVIRIDAE;

EID: 33645528583     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.10.007     Document Type: Article

References (47)

1. C.M. Lai Y.K. Lai P.E. Rakoczy Adenovirus and adeno-associated virus vectors DNA Cell Biol. 21 2002 895-913
2. J. Yoshida et. al. Human gene therapy for malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) by in vivo transduction with human interferon beta gene using cationic liposomes Hum. Gene Ther. 15 2004 77-86
3. T. Friedmann R. Roblin Gene therapy for human genetic disease? Science 175 1972 949-955
4. R. Dinser et. al. Comparison of long-term transgene expression after non-viral and adenoviral gene transfer into primary articular chondrocytes Histochem. Cell Biol. 116 2001 69-77
5. Y.K. Oh et. al. Polyethylenimine-mediated cellular uptake, nucleus trafficking and expression of cytokine plasmid DNA Gene Ther. 9 2002 1627-1632
6. R. Tachibana et. al. Quantitative analysis of correlation between number of nuclear plasmids and gene expression activity after transfection with cationic liposomes Pharm. Res. 19 2002 377-381
7. R. Tachibana H. Harashima Y. Shinohara H. Kiwada Quantitative studies on the nuclear transport of plasmid DNA and gene expression employing nonviral vectors Adv. Drug Delivery Rev. 52 2001 219-226
8. H. Akita R. Ito I.A. Khalil S. Futaki H. Harashima Quantitative three-dimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivery system using confocal laser scanning microscopy Mol. Ther. 9 2004 443-451
9. T. Masuda H. Akita H. Harashima Evaluation of nuclear transfer and transcription of plasmid DNA condensed with protamine by microinjection: the use of a nuclear transfer score FEBS Lett. 579 2005 2143-2148
10. Moriguchi, R., et al. (in press). Non-linear pharmacodynamics in a non-viral gene delivery system: Positive non-linear relationship between dose and transfection efficiency. J. Controlled Release.
11. L.C. Trotman N. Mosberger M. Fornerod R.P. Stidwill U.F. Greber Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1 Nat. Cell Biol. 3 2001 1092-1100
12. P.L. Leopold et. al. Fluorescent virions: Dynamic tracking of the pathway of adenoviral gene transfer vectors in living cells Hum. Gene Ther. 9 1998 367-378
13. N. Miyazawa et. al. Fiber swap between adenovirus subgroups B and C alters intracellular trafficking of adenovirus gene transfer vectors J. Virol. 73 1999 6056-6065
14. M.Y. Nakano U.F. Greber Quantitative microscopy of fluorescent adenovirus entry J. Struct. Biol. 129 2000 57-68
15. O. Meier U.F. Greber Adenovirus endocytosis J. Gene Med 5 2003 451-462
16. U.F. Greber M. Willetts P. Webster A. Helenius Stepwise dismantling of adenovirus 2 during entry into cells Cell 75 1993 477-486
17. M.J. Varga C. Weibull E. Everitt Infectious entry pathway of adenovirus type 2 J. Virol. 65 1991 6061-6070
18. N. Imelli O. Meier K. Boucke S. Hemmi U.F. Greber Cholesterol is required for endocytosis and endosomal escape of adenovirus type 2 J. Virol. 78 2004 3089-3098
19. O. Meier et. al. Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptake J. Cell Biol. 158 2002 1119-1131
20. M. Amyere et. al. Constitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C Mol. Biol. Cell. 11 2000 3453-3467
21. N. Araki M.T. Johnson J.A. Swanson A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages J. Cell Biol. 135 1996 1249-1260
22. E. Li D. Stupack R. Klemke D.A. Cheresh G.R. Nemerow Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase J. Virol. 72 1998 2055-2061
23. X. Zhou L. Huang DNA transfection mediated by cationic liposomes containing lipopolylysine: Characterization and mechanism of action Biochim. Biophys. Acta 1189 1994 195-203
24. I.S. Zuhorn R. Kalicharan D. Hoekstra Lipoplex-mediated transfection of mammalian cells occurs through the cholesterol-dependent clathrin-mediated pathway of endocytosis J. Biol. Chem. 277 2002 18021-18028
25. C. Goncalves et. al. Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependent pathway impair the transfection efficiency of human hepatocarcinoma cells Mol. Ther. 10 2004 373-385
26. J.S. Wadia R.V. Stan S.F. Dowdy Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis Nat. Med. 10 2004 310-315
27. N. Joshee D.R. Bastola P.W. Cheng Transferrin-facilitated lipofection gene delivery strategy: Characterization of the transfection complexes and intracellular trafficking Hum. Gene Ther. 13 2002 1991-2004
28. J. Zabner A.J. Fasbender T. Moninger K.A. Poellinger M.J. Welsh Cellular and molecular barriers to gene transfer by a cationic lipid J. Biol. Chem. 270 1995 18997-19007
29. S.D. Conner S.L. Schmid Regulated portals of entry into the cell Nature 422 2003 37-44
30. L.K. Medina-Kauwe Endocytosis of adenovirus and adenovirus capsid proteins Adv. Drug Delivery Rev. 55 2003 1485-1496
31. C.M. Wiethoff H. Wodrich L. Gerace G.R. Nemerow Adenovirus protein VI mediates membrane disruption following capsid disassembly J. Virol. 79 2005 1992-2000
32. O. Boussif et. al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine Proc. Natl. Acad. Sci. USA 92 1995 7297-7301
33. A.L. Bailey P.R. Cullis Membrane fusion with cationic liposomes: Effects of target membrane lipid composition Biochemistry 36 1997 1628-1634
34. R. Wattiaux M. Jadot M.T. Warnier-Pirotte S. Wattiaux-De Coninck Cationic lipids destabilize lysosomal membrane in vitro FEBS Lett. 417 1997 199-202
35. G. Daum Lipids of mitochondria Biochim. Biophys. Acta 822 1985 1-42
36. M. Suomalainen M.Y. Nakano K. Boucke S. Keller U.F. Greber Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus EMBO J. 20 2001 1310-1319
37. M. Suomalainen et. al. Microtubule-dependent plus- and minus end-directed motilities are competing processes for nuclear targeting of adenovirus J. Cell Biol. 144 1999 657-672
38. U.F. Greber et. al. The role of the nuclear pore complex in adenovirus DNA entry EMBO J. 16 1997 5998-6007
39. T. Bieber W. Meissner S. Kostin A. Niemann H.P. Elsasser Intracellular route and transcriptional competence of polyethylenimine-DNA complexes J. Controlled Release 82 2002 441-454
40. H. Pollard et. al. Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells J. Biol. Chem. 273 1998 7507-7511
41. L. Hatfield P. Hearing Redundant enhancements in the adenovirus type 5 inverted terminal repeat promote bidirectional transcription in vitro and are important for virus growth in vivo Virology 184 1991 265-276
42. J.N. Fredman J.A. Engler Adenovirus precursor to terminal protein interacts with the nuclear matrix in vivo and in vitro J. Virol. 67 1993 3384-3395
43. C. Endter T. Dobner Cell transformation by human adenoviruses Curr. Top. Microbiol. Immunol. 273 2004 163-214
44. B. Tauber T. Dobner Adenovirus early E4 genes in viral oncogenesis Oncogene 20 2001 7847-7854
45. P.A. Sharp C. Moore J.L. Haverty The infectivity of adenovirus 5 DNA-protein complex Virology 75 1976 442-456
46. C.M. Varga et. al. Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes Gene Ther. 12 2005 1023-1032
47. H. Mizuguchi et. al. A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob Gene Ther. 8 2001 730-735