Pharmacokinetic and pharmacodynamic considerations in gene therapy

Drug Discovery Today

Volumn 8, Issue 21, 2003, Pages 990-996

  Kamiya, Hiroyuki ^a   Akita, Hidetaka ^a   Harashima, Hideyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Biochemistry; Cell biology; Controlled nuclear disposition; Drug Discovery; Gene delivery system; Intracellular pharmacokinetics; Molecular Medicine; Non viral gene delivery; Pharmaceutical Science; Pharmacodynamics; Pharmacokinetics

Indexed keywords

2,3 DIOLEOYLOXYPROPYL 1 TRIMETHYLAMMONIUM BROMIDE; ARGININE DERIVATIVE; BETA GALACTOSIDASE; DRUG CARRIER; IMMUNOLIPOSOME; INSULIN RECEPTOR ANTIBODY; LIPID; LIPOFECTAMINE; MACROGOL; MONOCLONAL ANTIBODY; NAKED DNA; OCTAARGININE; PLASMID DNA; POLYETHYLENEIMINE; POLYLYSINE; POLYMER; STEARYLOCTAARGININE; UNCLASSIFIED DRUG;

BLOOD BRAIN BARRIER; BRAIN; DRUG DEGRADATION; DRUG DISTRIBUTION; DRUG TARGETING; ENDOCYTOSIS; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC TRANSCRIPTION; HUMAN; LIPID BILAYER; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; REPORTER GENE; REVIEW; TISSUE DISTRIBUTION; VIRAL GENE DELIVERY SYSTEM;

BRAIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GENE EXPRESSION; GENE THERAPY; HUMANS; INTRACELLULAR SPACE; NEOPLASMS; OLIGONUCLEOTIDES; PHARMACOLOGY; PLASMIDS; TISSUE DISTRIBUTION;

EID: 0344120637     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(03)02889-7     Document Type: Review

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