A new method for evaluating the bitterness of medicines in development using a taste sensor and a disintegration testing apparatus

Chemical and Pharmaceutical Bulletin

Volumn 58, Issue 8, 2010, Pages 1009-1014

  Harada, Tsutomu ^a   Uchida, Takahiro ^b   Yoshida, Miyako ^b   Kobayashi, Yoshikazu ^c   Narazaki, Ryuichi ^a   Ohwaki, Takayuki ^a  

^a EISAI CO LTD   (Japan)

^b MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^c Intelligent Sensor Technology   (Japan)

Author keywords

Bitterness suppression; Disintegration testing apparatus; Orally disintegrating tablet; Propiverine hydrochloride; Taste masking agent; Taste sensor

Indexed keywords

PROPIVERINE;

ARTICLE; BITTER TASTE; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PALATABILITY; PREDICTION; SENSOR; TABLET DISINTEGRATION; TABLET FORMULATION; TASTE SENSOR;

ADMINISTRATION, ORAL; BENZILATES; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; DRUG EVALUATION, PRECLINICAL; HUMANS; MOUTH; PREDICTIVE VALUE OF TESTS; SALIVA; SOLUBILITY; SWEETENING AGENTS; TABLETS; TASTE;

EID: 77955386878     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.58.1009     Document Type: Article

References (35)

1. Uchida T., Miyanaga Y., Tanaka H., Wada K., Kurosaki S., Ohki T., Yoshida M., Matsuyama K., Chem. Pharm. Bull., 48, 1843-1845 (2000).
2. Uchida T., Kobayashi Y., Miyanaga Y., Toukubo R., Ikezaki H., Taniguchi A., Nishikata M., Matsuyama K., Chem. Pharm. Bull., 49, 1336-1339 (2001).
3. Miyanaga Y., Tanigake A., Nakamura T., Kobayashi Y., Ikezaki H., Taniguchi A., Matsuyama K., Uchida T., Int. J. Pharm., 248, 207-218 (2002).
4. Uchida T., Tanigake A., Miyanaga Y., Matsuyama K., Kunitomo M., Kobayashi Y., Ikezaki H., Taniguchi A., J. Pharm. Pharmacol., 55, 1479-1485 (2003).
5. Ishizaka T., Miyanaga Y., Mukai J., Asaka K., Nakai Y., Tsuji E., Uchida T., Chem. Pharm. Bull., 52, 943-948 (2004).
6. Anand V., Kataria M., Kukkar V., Saharan V., Choudhury K. P., Drug Discov. Today, 12, 257-265 (2007).
7. Kataoka M., Tokuyama E., Miyanaga Y., Uchida T., Int. J. Pharm., 351, 36-44 (2008).
8. Lorenz K. J., Reo P. J., Hendl O., Worthington H. J., Petrossian D. V., Int. J. Pharm., 367, 65-72 (2009).
9. Woertz K., Tissen C., Kleinebudde P., Breitkreutz J., J. Pharm. Biomed. Anal., 51, 497-506 (2010)
10. Takagi S., Toko K., Wada K., Yamada H., Toyoshima K., J. Pharm. Sci., 87, 552-555 (1998).
11. Takagi S., Toko K., Wada K., Ohki T., J. Pharm. Sci., 90, 2042-2048 (2001).
12. Nakamura T., Tanigake A., Miyanaga Y., Ogawa T., Akiyoshi T., Matsuyama K., Uchida T., Chem. Pharm. Bull., 50, 1589-1593 (2002).
13. Miyanaga Y., Kobayashi Y., Ikezaki H., Taniguchi A., Uchida T., Sensors Mater., 14, 455-465 (2002).
14. Hashimoto Y., Tanaka M., Kishimoto H., Shiozawa H., Hasegawa K., Matsuyama K., Uchida T., J. Pharm. Pharmacol., 54, 1323-1328 (2002).
15. Miyanaga Y., Inoue N., Ohnishi A., Fujisawa E., Yamaguchi M., Uchida T., Pharm. Res., 20, 1932-1938 (2003).
16. Ogawa T., Nakamura T., Tsuji E., Miyanaga Y., Nakagawa H., Hirabayashi H., Uchida T., Chem. Pharm. Bull., 52, 172-177 (2004).
17. Miyanaga Y., Mukai J., Mukai T., Odomi M., Uchida T., Chem. Pharm. Bull., 52, 490-493 (2004).
18. Zheng Y. J., Keeney P. M., Int. J. Pharm., 310, 118-124 (2006).
19. Tsuji E., Uchida T., Fukui A., Fujii R., Sunada H., Chem. Pharm. Bull., 54, 310-314 (2006).
20. Tokuyama E., Shibasaki T., Kawabe H., Mukai J., Okada S., Uchida T., Chem. Pharm. Bull., 54, 1288-1292 (2006).
21. Ishizaka T., Okada S., Takemoto E., Tokuyama E., Tsuji E., Mukai J., Uchida T., Chem. Pharm. Bull., 55, 1452-1457 (2007).
22. Hashimoto Y., Matsunaga C., Tokuyama E., Tsuji E., Uchida T., Okada H., Chem. Pharm. Bull., 55, 739-746 (2007).
23. Agresti C., Tu Z., Ng C., Yang Y., Liang F. J., Eur. J. Pharm. Biopharm., 70, 226-233 (2008).
24. Kobayashi Y., Hamada H., Yamaguchi Y., Ikezaki H., Toko K., IEEJ Trans., 4, 710-719 (2009).
25. Lelham C. N., Sundelöf O. L., Int. J. Pharm., 115, 103-111 (1995).
26. Katsuragi Y., Mitsui Y., Umeda T., Otsuji K., Yamasawa S., Kurihara K., Pharm. Res., 14, 720-724 (1997).
27. Harada T., Nakata H., PCT WO 03/074263.
28. Narazaki R., Harada T., Takami N., Kato Y., Ohwaki T., Chem. Pharm. Bull., 52, 704-707 (2004).
29. Harada T., Narazaki R., Nagira S., Ohwaki T., Aoki S., Iwamoto K., Chem. Pharm. Bull., 54, 1072-1075 (2006).
30. Harada T., Narazaki R., Ohwaki T., Uchida T., J. Drug Del. Sci. Tech., (2010), in press.
31. Anderson N. S., Campbell J. W., Harding M. M., Rees D. A., Samuel J. W. B., J. Mol. Biol., 45, 85-99 (1969).
32. Morris E. R., Rees D. A., Robinson G. O., J. Mol. Biol., 138, 349-362 (1980).
33. Ikeda S., Morris V. J., Nishinari K., Biomacromolecules, 2, 1331-1337 (2001).
34. Yuguchi Y., Thuy T. T. T., Urakawa H., Kajiwara K., Food Hydrocolloids, 16, 512-522 (2002).
35. De Ruiter G. A., Rudolph B., Trends Food Sci. Tech., 8, 389-395 (1997).