The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Demorest, Zachary L ^a   Macduff, Donna A ^a,d   Brown, William L ^a   Morham, Scott G ^b   Parise, Leslie V ^c   Harris, Reuben S ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b Myriad Pharmaceuticals   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CALCIUM AND INTEGRIN BINDING PROTEIN 1; DEOXYRIBONUCLEASE; ENHANCED GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M; REGULATOR PROTEIN; RIBONUCLEASE; UNCLASSIFIED DRUG; AICDA (ACTIVATION INDUCED CYTIDINE DEAMINASE); AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CALCIUM BINDING PROTEIN; CIB1 PROTEIN, HUMAN; CYTIDINE DEAMINASE;

ANIMAL CELL; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE; CELL STRAIN HEK293; CHICKEN; CONTROLLED STUDY; GENE CONVERSION; GENE OVEREXPRESSION; GENE REARRANGEMENT; GENETIC RECOMBINATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN PROCESSING; SEQUENCE ANALYSIS; ANIMAL; CELL LINE; GENETICS; METABOLISM; MOUSE MUTANT; POLYMERASE CHAIN REACTION; PROTEIN BINDING; SOUTHERN BLOTTING;

MUS;

ANIMALS; BLOTTING, SOUTHERN; CALCIUM-BINDING PROTEINS; CELL LINE; CYTIDINE DEAMINASE; GENE CONVERSION; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULINS; IMMUNOPRECIPITATION; MICE; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; PROTEIN BINDING;

EID: 77955385274     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011660     Document Type: Article

References (53)

1. Di Noia JM, Neuberger MS (2007) Molecular mechanisms of antibody somatic hypermutation. Annu Rev Biochem 76: 1-22.
2. Longerich S, Basu U, Alt F, Storb U (2006) AID in somatic hypermutation and class switch recombination. Curr Opin Immunol 18: 164-174.
3. Neuberger MS (2008) Antibody diversification by somatic mutation: from Burnet onwards. Immunol Cell Biol 86: 124-132.
4. Petersen-Mahrt SK, Harris RS, Neuberger MS (2002) AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 418: 99-103.
5. Rada C, Di Noia JM, Neuberger MS (2004) Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol Cell 16: 163-171.
6. Di Noia J, Neuberger MS (2002) Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 419: 43-48.
7. Di Noia JM, Williams GT, Chan DT, Buerstedde JM, Baldwin GS, et al. (2007) Dependence of antibody gene diversification on uracil excision. J Exp Med 204: 3209-3219.
8. Rada C, Jarvis JM, Milstein C (2002) AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization. Proc Natl Acad Sci U S A 99: 7003-7008.
9. Barreto V, Reina-San-Martin B, Ramiro AR, McBride KM, Nussenzweig MC (2003) C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol Cell 12: 501-508.
10. Patenaude AM, Orthwein A, Hu Y, Campo VA, Kavli B, et al. (2009) Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nat Struct Mol Biol 16: 517-527.
11. Ito S, Nagaoka H, Shinkura R, Begum N, Muramatsu M, et al. (2004) Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1. Proc Natl Acad Sci U S A 101: 1975-1980.
12. Geisberger R, Rada C, Neuberger MS (2009) The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclearexport sequence. Proc Natl Acad Sci U S A 106: 6736-6741.
13. McBride KM, Barreto V, Ramiro AR, Stavropoulos P, Nussenzweig MC (2004) Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase. J Exp Med 199: 1235-1244.
14. Basu U, Chaudhuri J, Alpert C, Dutt S, Ranganath S, et al. (2005) The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature 438: 508-511.
15. Basu U, Wang Y, Alt FW (2008) Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase. Mol Cell 32: 285-291.
16. Chatterji M, Unniraman S, McBride KM, Schatz DG (2007) Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation. J Immunol 179: 5274-5280.
17. Cheng HL, Vuong BQ, Basu U, Franklin A, Schwer B, et al. (2009) Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A 106: 2717-2722.
18. Pasqualucci L, Kitaura Y, Gu H, Dalla-Favera R (2006) PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. Proc Natl Acad Sci U S A 103: 395-400.
19. Aoufouchi S, Faili A, Zober C, D'Orlando O, Weller S, et al. (2008) Proteasomal degradation restricts the nuclear lifespan of AID. J Exp Med 205: 1357-1368.
20. McBride KM, Gazumyan A, Woo EM, Schwickert TA, Chait BT, et al. (2008) Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med 205: 2585-2594.
21. Chaudhuri J, Khuong C, Alt FW (2004) Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature 430: 992-998.
22. Gentry HR, Singer AU, Betts L, Yang C, Ferrara JD, et al. (2005) Structural and biochemical characterization of CIB1 delineates a new family of EF-handcontaining proteins. J Biol Chem 280: 8407-8415.
23. Yuan W, Leisner TM, McFadden AW, Clark S, Hiller S, et al. (2006) CIB1 is essential for mouse spermatogenesis. Mol Cell Biol 26: 8507-8514.
24. Garrus JE, von Schwedler UK, Pornillos OW, Morham SG, Zavitz KH, et al. (2001) Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell 107: 55-65.
25. Wu X, Geraldes P, Platt JL, Cascalho M (2005) The double-edged sword of activation-induced cytidine deaminase. J Immunol 174: 934-941.
26. MacDuff DA, Neuberger MS, Harris RS (2006) MDM2 can interact with the Cterminus of AID but it is inessential for antibody diversification in DT40 B cells. Mol Immunol 43: 1099-1108.
27. Conticello SG, Ganesh K, Xue K, Lu M, Rada C, et al. (2008) Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol Cell 31: 474-484.
28. Bransteitter R, Pham P, Scharff MD, Goodman MF (2003) Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A 100: 4102-4107.
29. Chiu YL, Soros VB, Kreisberg JF, Stopak K, Yonemoto W, et al. (2005) Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells. Nature 435: 108-114.
30. Chiu YL, Witkowska HE, Hall SC, Santiago M, Soros VB, et al. (2006) Highmolecular-mass APOBEC3G complexes restrict Alu retrotransposition. Proc Natl Acad Sci U S A 103: 15588-15593.
31. Gallois-Montbrun S, Holmes RK, Swanson CM, Fernandez-Ocana M, Byers HL, et al. (2008) Comparison of cellular ribonucleoprotein complexes associated with the APOBEC3F and APOBEC3G antiviral proteins. J Virol 82: 5636-5642.
32. Gallois-Montbrun S, Kramer B, Swanson CM, Byers H, Lynham S, et al. (2007) Antiviral protein APOBEC3G localizes to ribonucleoprotein complexes found in P bodies and stress granules. J Virol 81: 2165-2178.
33. Kozak SL, Marin M, Rose KM, Bystrom C, Kabat D (2006) The anti-HIV-1 editing enzyme APOBEC3G binds HIV-1 RNA and messenger RNAs that shuttle between polysomes and stress granules. J Biol Chem 281: 29105-29119.
34. Arakawa H, Hauschild J, Buerstedde JM (2002) Requirement of the activationinduced deaminase (AID) gene for immunoglobulin gene conversion. Science 295: 1301-1306.
35. Harris RS, Sale JE, Petersen-Mahrt SK, Neuberger MS (2002) AID is essential for immunoglobulin V gene conversion in a cultured B cell line. Current Biology 12: 435-438.
36. MacDuff DA, Demorest ZL, Harris RS (2009) AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity. Nucleic Acids Res 37: 1854-1867.
37. Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, et al. (2000) Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102: 553-563.
38. Leisner TM, Liu M, Jaffer ZM, Chernoff J, Parise LV (2005) Essential role of CIB1 in regulating PAK1 activation and cell migration. J Cell Biol 170: 465-476.
39. Naik MU, Pham NT, Beebe K, Dai W, Naik UP (2010) Calcium-dependent inhibition of Polo-like kinase 3 activity by CIB1 in breast cancer cells. International Journal of Cancer In press.
40. Yoon KW, Cho JH, Lee JK, Kang YH, Chae JS, et al. (2009) CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1. Proc Natl Acad Sci U S A 106: 17389-17394.
41. Denofrio JC, Yuan W, Temple BR, Gentry HR, Parise LV (2008) Characterization of calcium- and integrin-binding protein 1 (CIB1) knockout platelets: potential compensation by CIB family members. Thromb Haemost 100: 847-856.
42. Esnault C, Millet J, Schwartz O, Heidmann T (2006) Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retroviruses. Nucleic Acids Res 34: 1522-1531.
43. Rosenberg BR, Papavasiliou FN (2007) Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection. Adv Immunol 94: 215-244.
44. Gourzi P, Leonova T, Papavasiliou FN (2007) Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB. J Exp Med 204: 259-265.
45. Stenglein MD, Burns MB, Li M, Lengyel J, Harris RS (2010) APOBEC3 proteins mediate the clearance of foreign DNA from human cells. Nat Struct Mol Biol 17: 222-229.
46. Bhutani N, Brady JJ, Damian M, Sacco A, Corbel SY, et al. (2009) Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature.
47. Popp C, Dean W, Feng S, Cokus SJ, Andrews S, et al. Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature.
48. Huang TT, Feinberg SL, Suryanarayanan S, Miyamoto S (2002) The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors. Mol Cell Biol 22: 5813-5825.
49. Bai Y, Soda Y, Izawa K, Tanabe T, Kang X, et al. (2003) Effective transduction and stable transgene expression in human blood cells by a third-generation lentiviral vector. Gene Ther 10: 1446-1457.
50. Naldini L, Blomer U, Gallay P, Ory D, Mulligan R, et al. (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272: 263-267.
51. Xu K, Ma H, McCown TJ, Verma IM, Kafri T (2001) Generation of a stable cell line producing high-titer self-inactivating lentiviral vectors. Mol Ther 3: 97-104.
52. Knuesel M, Wan Y, Xiao Z, Holinger E, Lowe N, et al. (2003) Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system. Mol Cell Proteomics 2: 1225-1233.
53. Naik UP, Patel PM, Parise LV (1997) Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J Biol Chem 272: 4651-4654.