Aging skeletal muscle mitochondria in the rat: Decreased uncoupling protein-3 content

American Journal of Physiology - Endocrinology and Metabolism

Volumn 281, Issue 5 44-5, 2001, Pages

  Kerner, Janos ^a,c   Turkaly, Peter J ^b   Minkler, Paul E ^c   Hoppel, Charles L ^b,c  

^a Education and Clinical Center ^*  (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

Aging; Carnitine; Carnitine palmitoyltransferase; Fuel utilization

Indexed keywords

ADENOSINE DIPHOSPHATE; CARBON 14; CARNITINE; CARNITINE PALMITOYLTRANSFERASE; CITRATE SYNTHASE; LACTATE DEHYDROGENASE; MITOCHONDRIAL ENZYME; SUCCINATE DEHYDROGENASE; UNCOUPLING PROTEIN 3;

AGED; AGING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ASSAY; FATTY ACID OXIDATION; IMMUNOBLOTTING; ISOTOPE LABELING; MALE; MUSCLE METABOLISM; MUSCLE MITOCHONDRION; MUSCLE STRENGTH; NONHUMAN; OXIDATIVE PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; SKELETAL MUSCLE;

EID: 0035204656     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2001.281.5.e1054     Document Type: Article

References (58)

1. Changes in uncoupling protein-2 and -3 expression in aging skeletal muscle, liver, and heart
2. Aging and acute exercise enhance free radical generation in rat skeletal muscle
3. Lactate dehydrogenase. UV-assay with pyruvate and NADH
4. Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat
5. Maximal metabolic rate and the balance of substrate utilization in aging
6. The physiology and biochemistry of skeletal muscle atrophy as a function of age
7. 2 max in identically trained young and old rats
8. The respiratory chain and oxidative phosphorylation
9. Regulation of mitochondrial respiration in senescence
10. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
11. Age-dependent decrease of carnitine content in muscle of mice and humans
12. Muscle specific up-regulation of rat UCP3 mRNA expression by long-term hindlimb unloading
13. Influence of age and dietary restriction on gastrocnemius electron transport system in mice
14. Uncoupling proteins: Do they have a role in body weight regulation?
15. Aging selectively decreases oxidative capacity in rat heart interfibrillar mitochondria
16. The interaction of aging and endurance exercise upon the mitochondrial function in skeletal muscle
17. Clean Western blots of membrane proteins after yeast heterologous expression following a shortened version of the method of Perini et al.
18. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
19. Bioenergetics in aging
20. Age-linked changes in the activity of enzymes of the tricarboxylate cycle and lipid oxidation, and of carnitine content, in muscles of the rat
21. Skeletal muscle atrophy in old rats: Differential changes in the three fiber types
22. Effect of voluntary exercise on longevity of rats
23. The action of digitonin on rat liver mitochondria
24. The malonyl-CoA-sensitive form of carnitine palmitoyltransferase is not localized exclusively in the outer membrane of rat liver mitochondria
25. Deficiency of reduced nicotinamide dinucleotide dehydrogenase component of complex I of mitochondrial electron transport
26. Coenzyme A and carnitine distribution in normal and ischemic hearts
27. The effect of electrical stimulation, fasting and anesthesia on the carnitine(s) and acylcarnitines of rat white and red skeletal muscle fibers
28. Populations of rat skeletal muscle mitochondria after exercise and immobilization
29. Glucose transporter content and enzymes of metabolism in nerve-repair grafted muscle of aging Fischer 344 rats
30. Muscle strength and speed of movement in relationship to age and muscle morphology
31. Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
32. A reference base and system for analysis of muscle constituents
33. Protein measurement with the Folin phenol reagent
34. Ageing and exercise performance
35. Prolonged recovery and reduced adaptation in aged rat muscle following eccentric exercise
36. Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Demonstration of the presence of malonyl-CoA in nonhepatic tissues of the rat
37. Mitochondrial metabolism and substrate competition in the aging Fischer rat heart
38. Quantification of carnitine, acetylcarnitine, and total carnitine in tissues by high-performance liquid chromatography: The effect of exercise on carnitine homeostasis in man
39. Malonyl-CoA binding site and overt carnitine palmitoyltransferase activity reside on the opposite sides of the outer mitochondrial membrane
40. Carnitine palmitoyl transferase-I activity in the aging mouse heart
41. Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from cardiac muscle
42. Changes in skeletal muscle with aging: Effects of exercise training
43. Bioenergetics in the aging Fischer 344 rat: Effects of exercise and food restriction
44. Fat and carbohydrate metabolism during exercise in elderly and young subjects
45. Identical responses of fast muscle to sustained activity by low-frequency stimulation in young and aging rats
46. Effects of fat availability on acetyl-CoA and acetylcarnitine metabolism in rat skeletal muscle
47. Skeletal muscle lipid peroxidation in exercised and food-restricted rats during aging
48. Muscle adaptations to hindlimb suspension in mature and old Fischer 344 rats
49. Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages
50. Changes in speed of contraction and ATPase activity in striated muscle during old age
51. Carnitine palmitoyltransferase in bovine fetal heart mitochondria
52. Age-related decrease in respiratory muscle mitochondrial function in rats
53. Changes in volume densities of mitochondria in rat skeletal muscle after chronic hypoxia
54. The effect of increasing exercise intensity on fuel selection: Free carnitine a key regulator
55. Energy metabolism in uncoupling protein 3 gene knockout mice
56. Influence of electrical stimulation on a fast-twitch muscle in aging rats
57. Maintenance of the adaptation of skeletal muscle mitochondria to exercise in old rats
58. Nutritional influences on aging of Fischer 344 rats. I. Physical, metabolic, and longevity characteristics