Development of miltefosine for the leishmaniases

Mini-Reviews in Medicinal Chemistry

Volumn 6, Issue 2, 2006, Pages 145-151

  Berman, Jo D ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Cutaneous leishmaniasis; Efficacy; Miltefosine; Tolerance; Visceral leishmaniasis

Indexed keywords

ALANINE AMINOTRANSFERASE; AMPHOTERICIN B; AMPHOTERICIN B LIPID COMPLEX; ANTIMONY DERIVATIVE; ASPARTATE AMINOTRANSFERASE; CREATININE; EDELFOSINE; ILMOFOSINE; MILTEFOSINE; PLACEBO;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANOREXIA; ANTIPROTOZOAL ACTIVITY; ARTHRALGIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHILL; CLINICAL TRIAL; CREATININE BLOOD LEVEL; DIARRHEA; DOSE RESPONSE; DRUG COST; DRUG EFFICACY; DRUG FATALITY; DRUG FEVER; DRUG HALF LIFE; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG TARGETING; DRUG TOLERABILITY; EYE TOXICITY; GASTROINTESTINAL SYMPTOM; HEART ARRHYTHMIA; HUMAN; HYPERAMYLASEMIA; LEISHMANIA DONOVANI; LEISHMANIASIS; LEUKOPENIA; MAXIMUM TOLERATED DOSE; MYALGIA; NAUSEA; NONHUMAN; PARASITE SURVIVAL; RIGOR; SKIN CANCER; SKIN LEISHMANIASIS; SKIN METASTASIS; THERAPY RESISTANCE; THROMBOCYTOPENIA; TREATMENT FAILURE; VISCERAL LEISHMANIASIS; VOMITING; WEIGHT REDUCTION;

ADULT; ANTIPROTOZOAL AGENTS; CHILD; CLINICAL TRIALS; DRUG DESIGN; HIV INFECTIONS; HUMANS; LEISHMANIASIS; PHOSPHORYLCHOLINE;

EID: 33646055156     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955706775475993     Document Type: Article

References (36)

1. Croft, S.L.; Seifert, K.; Duchene, M. Mol. Biochem. Parasitol., 2003, 126, 165.
2. Unger, C.; Eibl, H.; Lipids, 1991, 26, 1412.
3. Eibl, H.; Unger, C. Cancer Treat Rev., 1990, 17, 233.
4. Dummer, R.; Krasovec, M.; Roger, J.; Sindermann, H.; Burg, G. J. Am. Acad. Dermatol., 1993, 29, 963.
5. Verweij, J.; Planting, A.; van der Burg, M.; Stoter, G. J. Cancer Res. Clin. Oncol., 1992, 118, 606.
6. Smorenburg, C.H.; Seynaeve, C.; Bontenbal, M.; Planting, AS.; Sindermann, H.; Verweij, J. Anticancer Drugs, 2000, 11, 825.
7. Herrmann, H.O.; Gercken, G. Mol. Biochem. Parasitol., 1982, 5, 65.
8. Achterberg, V.; Gercken, G. Mol. Biochem. Parasitol., 1987, 26, 277.
9. Achterberg, V.; Gercken, G. Mol. Biochem. Parasitol., 1987, 23, 117
10. Croft, S.L.; Neal, R.A.; Pendergast, W.; Chan, J.H. Biochem. Pharmacol., 1987, 36, 2633.
11. Kuhlencord, A.; Maniera, T.; Eibl, H.; Unger, C. Antimicrob. Agents Chemother., 1992, 36, 1630.
12. Croft, S.L.; Snowdon, D.; Yardley, V. J. Antimicrob. Chemother., 1996, 38, 1041.
13. Sundar, S.; Rosenkaimer, F.; Makharia, M.K.; Goyal, A.K.; Mandal, A.K.; Voss, A.; Hilgard, P.; Murray, H.W. Lancet, 1998, 352, 1821.
14. Escobar, P.; Matu, S.; Marques, C.; Crot S.L. Acta Trop., 2002, 81, 151.
15. Santa-Rita, R.M.; Henriques-Pons, A.; Barbosa, H.S.; De Castro, S.L. J. Antimicrob. Chemother., 2004, 5, 704.
16. a) Azzouz S.; Maache M.; Garcia R.G.; Osuna A. Basic Clin. Pharmacol. Toxicol., 2005, 96, 60.
17. Schmidt-Ott, R.; Klenner, T.; Overath, P.; Aebischer, T. Trans. R. Soc. Trop. Med. Hyg., 1999, 93, 85.
18. Sundar, S.; Gupta, L.B.; Makharia, M.K.; Singh, M.K.; Voss, A.; Rosenkaimer, F.; Engel, J.; Murray, H.W. Ann. Trop. Med. Parasitol., 1999, 93, 589.
19. Jha, T.K.; Sundar, S.; Thakur, C.P.; Bachmann, P.; Karlywang, J.; Fischer, C.; Voss A.; Berman, J. N. Engl. J. Med., 1999, 341, 1795.
20. Sundar, S.; Jha, T.K.; Thakur, C.P.; Engel, J.; Sindermann, H.; Fischer, C.; Junge, K.; Bryceson, A.; Berman, J. N.Engl. J. Med., 2002, 347, 1739.
21. Sundar, S.; Jha, T.K.; Sindermann, H.; Junge, K.; Bachmann, P.; Berman, J. Pediatr. Infect. Dis. J., 2003; 22, 434.
22. Bhattacharya, S.K.; Jha, T.K.; Sundar, S.; Thakur, C.P.; Engel, J.; Sindermann, H.; Junge, K.; Karbwang, J.; Bryceson, A.D.; Berman, J.D. Clin. Infect. Dis., 2004, 38, 217.
23. R registration certificate for Miltefosine capsules 10 ing and 50 ing Issued by Drug Controller General India, 2002.
24. Sundar, S.; Makharia, A.; More, D.K.; Agrawal, G.; Voss, A.; Fischer, C.; Bachmann, P.; Murray, H.W. Clin. Infect. Dis., 2000, 31, 1110.
25. Sindermann, H.; Engel, K.R.; Fischer, C.; Bommer, W. Clin. Infect. Dis., 2004, 39, 1520.
26. Soto, J.; Toledo J.; Gutierrez, P.; Nicholls, R.S.; Padilla, J.; Engel, J.; Fischer, C.; Voss, A.; Berman, J. Clin. Infect. Dis., 2001, 33, E57.
27. Soto, J.; Arana, B.A.; Toledo, J.; Rizzo, N.; Vega, J.C.; Diaz, A.; Luz, M.; Gutierrez, P.; Arboleda, M.; Berman, J.D.; Junge, K., Engel, J.; Sindermann, H. Clin. Infect. Dis., 2004, 38, 1266.
28. Zufferey, R.; Mamoun, C.B. Mol. Biochem. Parasitol., 2002, 125, 127.
29. Jimenez-Lopez, J.M.; Carrasco, M.P.; Segovia, J.L.; Marco, C. Int. J. Biochem. Cell Biol., 2004, 36, 153.
30. van der Sanden, M.H.; Houweling, M.; Duijsings, D.; Vaandrager, A.B.; van Golde, L.M. Biochim. Biophys. Acta, 2004, 1636, 99.
31. Verma, N.K.; Dey, C.S. Antimicrob. Agents Chemother., 2004, 48, 3010.
32. Lira, R.; Contreras, L.M.; Rita, R.M.; Urbina, J.A. J. Antimicrob. Chemother., 2001, 47, 537.
33. Lux, H.; Heise, N.; Klenner, T.; Hart D.; Opperdoes, F.R. Mol. Biochem. Parasitol., 2000, 111, 1.
34. Seifert, K.; Matti, S.; Javier Perez-Victoria, F.; Castanys, S.; Gamarro, F.; Croft, S.L. Int. J. Antimicrob. Agents, 2003, 22, 380.
35. Perez-Victoria, F.J.; Castanys, S.; Gamarro, F. Antimicrob. Agents Chemother., 2003, 47, 2397.
36. de Castro, S.L.; Santa-Rita, R.M.; Urbina, J.A.; Croft, S.L. Min - Rev. Med. Chem., 2004, 4, 141.