Synthesis and biological evaluation of indolyl bisphosphonates as anti-bone resorptive and anti-leishmanial agents

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 18, 2008, Pages 8482-8491

  Singh, Uma Sharan ^a   Shankar, Ravi ^a   Kumar, Avinash ^a   Trivedi, Ritu ^a   Chattopadhyay, Naibedya ^a   Shakya, Nishi ^a   Palne, Shraddha ^a   Gupta, Suman ^a   Hajela, K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Anti bone resorptive; Anti leishmanial activity; Apoptosis; Indolyl bisphosphonates

Indexed keywords

[1 (DIETHOXY PHOSPHORYL) 5 (6,7 DIHYDRO 5 THIA 12 AZADIBENZO[A,E] AZULEN 12 YL) PENTYL] PHOSPHONIC ACID DIETHYL ESTER; [1 (DIETHOXYPHOSPHORYL) 4 (6,7 DIHYDRO 5H BENZO[6,7]CYCLOHEPTA[1,2 B] INDOL 12 YL)PENTYL]PHOSPHONIC ACID DIETHYL ESTER; [1 (DIETHOXYPHOSPHORYL) 6 (6,7 DIHYDRO 5 THIA 12 AZADIBENZO[A,E]AZULEN 12 YL)HEXYL]PHOSPHONIC ACID DIETHYL ESTER; [1 (DIETHOXYPHOSPHORYL) 6 (6,7 DIHYDRO 5H BENZO[6,7]CYCLOHEPTA[1,2 B] INDOL 1 YL)HEXYL]PHOSPHONIC ACID DIETHYL ESTER; [1 (DIETHOXYPHOSPHORYL) 7 (6,7 DIHYDRO 5 THIA 12 AZADIBENZO[A,E]AZULEN 12 YLHEPTYL]PHOSPHONIC ACID DIETHYL ESTER; [2 (6,7 DIHYDRO 5 THIA 12 AZADIBENZO[A,E]AZULEN 12 YL) 1 HYDROXY 1 PHOSPHONOETHYL]PHOSPHONIC ACID; [3 (6,7 DIHYDRO 5 THIA 12 AZADIBENZO[A,E]AZULEN 12 YL) 1 HYDROXY 1 PHOSPHONOPROPYL]PHOSPHONIC ACID; ALENDRONIC ACID; ANTILEISHMANIAL AGENT; BISPHOSPHONIC ACID DERIVATIVE; COLONY STIMULATING FACTOR 1; INDOLE DERIVATIVE; OSTEOCLAST DIFFERENTIATION FACTOR; STIBOGLUCONATE SODIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG STRUCTURE; LEISHMANIA; LEISHMANIASIS; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; PROTON NUCLEAR MAGNETIC RESONANCE;

ALENDRONATE; ANIMALS; APOPTOSIS; BONE DENSITY CONSERVATION AGENTS; BONE RESORPTION; CELL PROLIFERATION; CELLS, CULTURED; DIPHOSPHONATES; INDOLES; LEISHMANIA; MICE; OSTEOCLASTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 51449109024     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.024     Document Type: Article

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