Ivermectin-derived leishmanicidal compounds

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 2, 2009, Pages 496-502

  Santos, Anderson Rouge dos ^a   Falcão, Camila Alves Bandeira ^a   Muzitano, Michelle Frazão ^a,b   Kaiser, Carlos Roland ^a   Rossi Bergmann, Bartira ^a   Férézou, Jean Pierre ^c  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSIDADE ESTADUAL DO NORTE FLUMINENSE DARCY RIBEIRO   (Brazil)

^c LABORATOIRE DE SYNTHÈSE ORGANIQUE   (France)

Author keywords

Amastigotes; Avermectins; Ivermectin; Leishmania; Leishmanicidal activity; Ozonolysis; Promastigotes; Seco analogues

Indexed keywords

AMPHOTERICIN B; AVERMECTIN DERIVATIVE; BENZOFURAN DERIVATIVE; IVERMECTIN; MACROCYCLIC COMPOUND; STIBOGLUCONATE SODIUM;

AMASTIGOTE; ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONJUGATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; IC 50; LEISHMANIA; MOUSE; NONHUMAN; PROMASTIGOTE; STRUCTURE ACTIVITY RELATION;

LEISHMANIA AMAZONENSIS;

EID: 58749093729     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.12.003     Document Type: Article

References (18)

1. World Health Organization. http://www.who.int/leishmaniasis/en/ (2008); http://www.who.int/tdr/diseases/leish/default.htm (2008).
2. Croft S.L., and Coombs G.H. Trends Parasitol. 19 (2003) 502
3. Desjeux P. Comp. Immun. Microbiol. Infect. Dis. 27 (2004) 305
4. Croft S.L., Sundar S., and Fairlamb A.H. Clin. Microbiol. Rev. 19 (2006) 111
5. For an example:. Christensen D. Sci. News 162 (2003) 296
6. Omura S. Int. J. Antimicrob. Agent 31 (2008) 91
7. Rifaat L.K., Mohammad M.A., and Jawdat S.Z. Jpn. J. Med. Sci. Biol. 42 (1989) 51
8. Rasheid K.A., and Morsy T.A. J. Egypt Soc. Parasitol. 28 (1998) 207
9. Mrozik H., Eskola P., Arison B.H., Albers-Schönberg G., and Fisher M.H. J. Org. Chem. 47 (1982) 489
10. Chabala J.C., Mrozik H., Tolman R.L., Eskola P., Lusi A., Peterson L.H., Woods M.F., and Fisher M.H. J. Med. Chem. 23 (1980) 1134
11. Santos A.R., Ferreira M.L.G., Kaiser C.R., and Férézou J.-P. Eur. J. Org. Chem. (2005) 3348
12. For example, against mites, conjugated avermectin B1a exhibited only one-fifth of the natural product activity:. Pivnichny J.V., Arison B.H., Preiser F.A., Shim J.-S.K., and Mrozik H. J. Agric. Food Chem. 36 (1988) 826
13. Hanessian H., Dubé D., and Hodges P.J. J. Am. Chem. Soc. 109 (1987) 7063
14. Hanessian H., Ugolini A., Hodges P.J., and Dubé D. Tetrahedron Lett. 27 (1985) 2699
15. Boeck P., Falcão C.B., Leal P.V., Cechinel-Filho V., Torres-Santos E.C., Yunes R.A., and Rossi-Bergmann B. Bioorg. Med. Chem. 16 (2006) 1538
16. Muzitano M.F., Tinoco L.W., Guette C., Kaiser C.R., Rossi-Bergmann B., and Costa S.S. Phytochemistry 67 (2006) 2071
17. Bozue J.A., Parthasarathy N., Phillips L.R., Cote C.K., Fellows P.F., Mendelson I., Shafferman A., and Friedlander A.M. Microb. Pathog. 38 (2005) 1
18. Monteiro G.C.T.S., Hirata R., Andrade A.F.B., Mattos-Guaraldi A.L., and Nagao P.E. Int. J. Mol. Med. 13 (2004) 175