메뉴 건너뛰기




Volumn 45, Issue 1, 2006, Pages 19-28

Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2)

Author keywords

Antioxidant enzymes; Dietary antioxidants; Glutathione; Malondialdehyde; Oxidative stress; Polyphenols; Reactive oxygen species

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; BENZOIC ACID DERIVATIVE; BROXURIDINE; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; DIAMINOBENZOIC ACID; DICHLOROFLUORESCEIN; FLAVONOL DERIVATIVE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; QUERCETIN; REACTIVE OXYGEN METABOLITE; RUTOSIDE; UNCLASSIFIED DRUG;

EID: 32344433333     PISSN: 14366207     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00394-005-0558-7     Document Type: Article
Times cited : (227)

References (51)
  • 1
    • 0031721802 scopus 로고    scopus 로고
    • Polyphenols: Chemistry, dietary sources, metabolism and nutritional significance
    • Bravo L (1998) Polyphenols: chemistry, dietary sources, metabolism and nutritional significance. Nutr Rev 56:317-333
    • (1998) Nutr Rev , vol.56 , pp. 317-333
    • Bravo, L.1
  • 2
    • 0030021661 scopus 로고    scopus 로고
    • Potential health effects of the dietary flavonol quercetin
    • Hertog MGL, Holland PCH (1996) Potential health effects of the dietary flavonol quercetin. Eur J Clin Nutr 50:63-71
    • (1996) Eur J Clin Nutr , vol.50 , pp. 63-71
    • Hertog, M.G.L.1    Holland, P.C.H.2
  • 3
    • 0033136307 scopus 로고    scopus 로고
    • The flavonoids, myricetin, quercetin and rutin, protect against cholestan-3β:5α:6β-triol - Induced toxicity in Chinese hamster ovary cells in vitro
    • Aherne SA, O'Brien NM (1999) The flavonoids, myricetin, quercetin and rutin, protect against cholestan-3β:5α:6β-triol - induced toxicity in Chinese hamster ovary cells in vitro. Nutr Res 19:749-760
    • (1999) Nutr Res , vol.19 , pp. 749-760
    • Aherne, S.A.1    O'Brien, N.M.2
  • 4
    • 21544460696 scopus 로고    scopus 로고
    • Biological properties of plant flavonoids: An overview
    • Middelton E (1996) Biological properties of plant flavonoids: an overview. Int J Pharmacol 34:344-348
    • (1996) Int J Pharmacol , vol.34 , pp. 344-348
    • Middelton, E.1
  • 5
    • 0025041309 scopus 로고
    • Structure activity relationship of polymethoxyflavones and other flavonoids as inhibitors of non-enzymatic lipid peroxidation
    • Mora A, Paya M, Rios JL, Alcaraz MJ (1990) Structure activity relationship of polymethoxyflavones and other flavonoids as inhibitors of non-enzymatic lipid peroxidation. Biochem Pharmacol 40:793-797
    • (1990) Biochem Pharmacol , vol.40 , pp. 793-797
    • Mora, A.1    Paya, M.2    Rios, J.L.3    Alcaraz, M.J.4
  • 7
    • 0029867672 scopus 로고    scopus 로고
    • Flavonoids - Chemistry, metabolism, cardioprotective effects and dietary sources
    • Cook NC, Samman S (1996) Flavonoids - chemistry, metabolism, cardioprotective effects and dietary sources. J Nutr Biochem 7:66-76
    • (1996) J Nutr Biochem , vol.7 , pp. 66-76
    • Cook, N.C.1    Samman, S.2
  • 8
    • 0037157039 scopus 로고    scopus 로고
    • 2 during interaction of phenolic compounds with cell culture media
    • 2 during interaction of phenolic compounds with cell culture media. J Agric Food Chem 50:3156-3160
    • (2002) J Agric Food Chem , vol.50 , pp. 3156-3160
    • Lapidot, T.1    Walker, M.D.2    Kanner, J.3
  • 9
    • 0035003101 scopus 로고    scopus 로고
    • Tumor suppressor protein p53 mRNA and subcellular localization are altered by changes in cellular copper in human Hep G2 cells
    • Narayanan VS, Fitch CA, Levenson CW (2001) Tumor suppressor protein p53 mRNA and subcellular localization are altered by changes in cellular copper in human Hep G2 cells. J Nutr 131:1427-1432
    • (2001) J Nutr , vol.131 , pp. 1427-1432
    • Narayanan, V.S.1    Fitch, C.A.2    Levenson, C.W.3
  • 10
    • 0018718742 scopus 로고
    • Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line
    • Aden DP, Fogel A, Plotkin S, Damjanov I, Knowles BB (1979) Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature 286:615-616
    • (1979) Nature , vol.286 , pp. 615-616
    • Aden, D.P.1    Fogel, A.2    Plotkin, S.3    Damjanov, I.4    Knowles, B.B.5
  • 11
    • 0014978068 scopus 로고
    • An improved fluorometric assay for DNA
    • Hinegardner RT (1971) An improved fluorometric assay for DNA. Anal Biochem 39:197-201
    • (1971) Anal Biochem , vol.39 , pp. 197-201
    • Hinegardner, R.T.1
  • 12
    • 0000191753 scopus 로고
    • Lactate dehydrogenase. UV-method with pyruvate and NADH
    • Bergmeyer HV (ed) Weinheim: Verlag-Chemie
    • Vasault A (1987) Lactate dehydrogenase. UV-method with pyruvate and NADH. In: Bergmeyer HV (ed) Methods of enzymatic analysis. Weinheim: Verlag-Chemie, pp 118-133
    • (1987) Methods of Enzymatic Analysis , pp. 118-133
    • Vasault, A.1
  • 13
    • 85072164482 scopus 로고
    • Enzyme leakage as an indicator of cytotoxicity in culture cells
    • Tyson CA, Franzier JM (eds) New York: Academic press
    • Welder AA, Acosta D (1994) Enzyme leakage as an indicator of cytotoxicity in culture cells. In: Tyson CA, Franzier JM (eds) In vitro toxicity indicators: methods in toxicology. New York: Academic press, pp 46-49
    • (1994) In Vitro Toxicity Indicators: Methods in Toxicology , pp. 46-49
    • Welder, A.A.1    Acosta, D.2
  • 14
    • 0017064979 scopus 로고
    • A fluorometric method for determination of oxidised and reduced glutathione in tissues
    • Hissin PJ, Hilf R (1976) A fluorometric method for determination of oxidised and reduced glutathione in tissues. Anal Biochem 74:214-226
    • (1976) Anal Biochem , vol.74 , pp. 214-226
    • Hissin, P.J.1    Hilf, R.2
  • 15
    • 2042480725 scopus 로고    scopus 로고
    • Determination of malondialdehyde (MDA) by high-performance liquid chromatography as the 2,4-dinitrophenyl-hydrazine derivative. A marker for oxidative stress in cell cultures of human hepatoma HepG2
    • Mateos R, Goya L, Bravo L (2004) Determination of malondialdehyde (MDA) by high-performance liquid chromatography as the 2,4-dinitrophenyl-hydrazine derivative. A marker for oxidative stress in cell cultures of human hepatoma HepG2. J Chrom B 805:33-39
    • (2004) J Chrom B , vol.805 , pp. 33-39
    • Mateos, R.1    Goya, L.2    Bravo, L.3
  • 16
    • 0032820452 scopus 로고    scopus 로고
    • Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader
    • Wang H, Joseph JA (1999) Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Rad Biol Med 27:612-616
    • (1999) Free Rad Biol Med , vol.27 , pp. 612-616
    • Wang, H.1    Joseph, J.A.2
  • 17
    • 0000024076 scopus 로고
    • Catalase
    • Bergmeyer HV (ed) Weinheim: Verlag-Chemie
    • Aebi H (1987) Catalase. In: Bergmeyer HV (ed) Methods of enzymatic analysis. Weinheim: Verlag-Chemie, pp 273-282
    • (1987) Methods of Enzymatic Analysis , pp. 273-282
    • Aebi, H.1
  • 18
    • 0001528839 scopus 로고
    • Glutathione reductase
    • Bergmeyer HV (ed) Weinheim: Verlag-Chemie
    • Goldberg DM, Spooner RJ (1987) Glutathione reductase. In: Bergmeyer HV (ed) Methods of enzymatic analysis. Weinheim: Verlag-Chemie, pp 258-265
    • (1987) Methods of Enzymatic Analysis , pp. 258-265
    • Goldberg, D.M.1    Spooner, R.J.2
  • 19
    • 0016287254 scopus 로고
    • An improved coupled test procedure for glutathione peroxidase
    • Gunzler WA, Kramers H, Flohe L (1974) An improved coupled test procedure for glutathione peroxidase. Klin Chem Klin Biochem 12:444
    • (1974) Klin Chem Klin Biochem , vol.12 , pp. 444
    • Gunzler, W.A.1    Kramers, H.2    Flohe, L.3
  • 20
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantification of microgram quantities of protein, utilizing the principle of protein-dye binding
    • Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein, utilizing the principle of protein-dye binding. Anal Biochem 72:248
    • (1976) Anal Biochem , vol.72 , pp. 248
    • Bradford, M.M.1
  • 22
    • 0033915810 scopus 로고    scopus 로고
    • Plant polyphenols in cancer and heart disease: Implications as nutritional antioxidants
    • Duthie GG, Duthie SJ, Kyle JAM (2000) Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants. Nutr Res Rev 13:79-106
    • (2000) Nutr Res Rev , vol.13 , pp. 79-106
    • Duthie, G.G.1    Duthie, S.J.2    Kyle, J.A.M.3
  • 23
    • 0028051495 scopus 로고
    • Quercetin exerts a preferential cytotoxic effect on active dividing colon carcinoma HT29 and Caco-2 cells
    • Agullo G, Gamet L, Besson C, Demigne C, Remesy C (1994) Quercetin exerts a preferential cytotoxic effect on active dividing colon carcinoma HT29 and Caco-2 cells. Cancer Lett 87:55-63
    • (1994) Cancer Lett , vol.87 , pp. 55-63
    • Agullo, G.1    Gamet, L.2    Besson, C.3    Demigne, C.4    Remesy, C.5
  • 25
    • 0032863640 scopus 로고    scopus 로고
    • Quercetin-induced apoptosis in colorectal tumor cells: Possible role of EGF receptor signaling
    • Richter M, Ebermann R, Marian B (1999) Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling. Nutr Cancer 34:88-99
    • (1999) Nutr Cancer , vol.34 , pp. 88-99
    • Richter, M.1    Ebermann, R.2    Marian, B.3
  • 27
    • 0030918017 scopus 로고    scopus 로고
    • The effect of dietary flavonoids on DNA damage (strand breaks and oxidized pyrimidines) and growth in human cells
    • Duthie SJ, Johnson W, Dobson VL (1997) The effect of dietary flavonoids on DNA damage (strand breaks and oxidized pyrimidines) and growth in human cells. Mutat Res 390:141-151
    • (1997) Mutat Res , vol.390 , pp. 141-151
    • Duthie, S.J.1    Johnson, W.2    Dobson, V.L.3
  • 28
    • 0031808308 scopus 로고    scopus 로고
    • Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes
    • Noroozi M, Angerson WJ, Lean MEJ (1998) Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes. Am J Clin Nutr 67:1210-1218
    • (1998) Am J Clin Nutr , vol.67 , pp. 1210-1218
    • Noroozi, M.1    Angerson, W.J.2    Lean, M.E.J.3
  • 30
    • 0030712279 scopus 로고    scopus 로고
    • Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells
    • Kang TB, Liang NC (1997) Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells. Biochem Pharmacol 54:1013-1018
    • (1997) Biochem Pharmacol , vol.54 , pp. 1013-1018
    • Kang, T.B.1    Liang, N.C.2
  • 31
    • 0029553449 scopus 로고
    • Quercetin, a bioflavonoid, inhibits the DNA synthesis of human leukemia cells
    • Uddin S, Choudhry MA (1995) Quercetin, a bioflavonoid, inhibits the DNA synthesis of human leukemia cells. Biochem Mol Bio Int 36:545-550
    • (1995) Biochem Mol Bio Int , vol.36 , pp. 545-550
    • Uddin, S.1    Choudhry, M.A.2
  • 32
    • 0030596107 scopus 로고    scopus 로고
    • Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells
    • Kuo SM (1996) Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett 110:41-48
    • (1996) Cancer Lett , vol.110 , pp. 41-48
    • Kuo, S.M.1
  • 34
    • 0027303188 scopus 로고
    • Genotoxicity of phenolic antioxidants
    • Brusick D (1993) Genotoxicity of phenolic antioxidants. Toxicol Ind Health 9:223-230
    • (1993) Toxicol Ind Health , vol.9 , pp. 223-230
    • Brusick, D.1
  • 37
    • 0031724702 scopus 로고    scopus 로고
    • The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells
    • Rodgers EH, Grant MH (1998) The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells. Chem Biol Interact 116:213-228
    • (1998) Chem Biol Interact , vol.116 , pp. 213-228
    • Rodgers, E.H.1    Grant, M.H.2
  • 38
    • 0036489186 scopus 로고    scopus 로고
    • Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter
    • Myhrstad MC, Carlsen H, Nordstrom O, Blomhoff R, Moskaug JO (2002) Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free Rad Biol Med 32:386-393
    • (2002) Free Rad Biol Med , vol.32 , pp. 386-393
    • Myhrstad, M.C.1    Carlsen, H.2    Nordstrom, O.3    Blomhoff, R.4    Moskaug, J.O.5
  • 39
    • 0038647564 scopus 로고    scopus 로고
    • Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2
    • Scharf G, Prustomersky S, Knasmuller S, Schulte-Hermann R, Huber WW (2003) Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2. Nutr Cancer 45:74-83
    • (2003) Nutr Cancer , vol.45 , pp. 74-83
    • Scharf, G.1    Prustomersky, S.2    Knasmuller, S.3    Schulte-Hermann, R.4    Huber, W.W.5
  • 40
    • 0034625677 scopus 로고    scopus 로고
    • Measurement of free and bound malondialdehyde in plasma by high-performance liquid chromatography as the 2,4-dinitrophenylhydrazine derivative
    • Pilz J, Meineke I, Gleiter CH (2000) Measurement of free and bound malondialdehyde in plasma by high-performance liquid chromatography as the 2,4-dinitrophenylhydrazine derivative. J Chrom B 742:315-325
    • (2000) J Chrom B , vol.742 , pp. 315-325
    • Pilz, J.1    Meineke, I.2    Gleiter, C.H.3
  • 41
    • 0031570760 scopus 로고    scopus 로고
    • Solid-phase extraction in malondialdehyde analysis
    • Suttnar J, Cermak J, Dyr E (1997) Solid-phase extraction in malondialdehyde analysis. Anal Biochem 249:20-23
    • (1997) Anal Biochem , vol.249 , pp. 20-23
    • Suttnar, J.1    Cermak, J.2    Dyr, E.3
  • 42
    • 0035835379 scopus 로고    scopus 로고
    • Influence of citrate and EDTA anticoagulants on plasma malondialdehyde concentrations estimated by high-performance liquid chromatography
    • Suttnar J, Masova L, Dyr E (2001) Influence of citrate and EDTA anticoagulants on plasma malondialdehyde concentrations estimated by high-performance liquid chromatography. J Chrom B 751:193-197
    • (2001) J Chrom B , vol.751 , pp. 193-197
    • Suttnar, J.1    Masova, L.2    Dyr, E.3
  • 43
    • 0027319939 scopus 로고
    • Measuring free radical reactions in vivo
    • Holley AE, Cheeseman KH (1993) Measuring free radical reactions in vivo. Br Med Bull 49:494-505
    • (1993) Br Med Bull , vol.49 , pp. 494-505
    • Holley, A.E.1    Cheeseman, K.H.2
  • 44
    • 0026554428 scopus 로고
    • Evaluation of the probe 2′,′-dichlorofluorescein as an indicator of reactive oxygen species formation and oxidative stress
    • LeBel CP, Ishiropoulos H, Bondy SC (1992) Evaluation of the probe 2′,′-dichlorofluorescein as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 5:227-231
    • (1992) Chem Res Toxicol , vol.5 , pp. 227-231
    • Lebel, C.P.1    Ishiropoulos, H.2    Bondy, S.C.3
  • 45
    • 0029111799 scopus 로고
    • Oxidative stress by acute acetaminophen administration in mouse liver
    • Lores-Arnaiz S, Llesuy S, Cutrin JC, Boveris A (1995) Oxidative stress by acute acetaminophen administration in mouse liver. Free Rad Biol Med 19:303-310
    • (1995) Free Rad Biol Med , vol.19 , pp. 303-310
    • Lores-Arnaiz, S.1    Llesuy, S.2    Cutrin, J.C.3    Boveris, A.4
  • 46
    • 0036195961 scopus 로고    scopus 로고
    • The phytoestrogen Daidzein affects the antioxidant enzyme system of rat hepatoma H4IIE cells
    • Röhrdanz E, Ohler S, Tran-Thi Q-H, Kahl R (2002) The phytoestrogen Daidzein affects the antioxidant enzyme system of rat hepatoma H4IIE cells. J Nutr 132:370-375
    • (2002) J Nutr , vol.132 , pp. 370-375
    • Röhrdanz, E.1    Ohler, S.2    Tran-Thi, Q.-H.3    Kahl, R.4
  • 48
    • 0032775141 scopus 로고    scopus 로고
    • Antioxidative action of flavonoids, quercetin and catechin, mediated by the activation of glutathione peroxidase
    • Nagata H, Takekoshi S, Takagi T, Honma T, Watanabe K (1999) Antioxidative action of flavonoids, quercetin and catechin, mediated by the activation of glutathione peroxidase. Tokai J Exp Clin Med 24:1-11
    • (1999) Tokai J Exp Clin Med , vol.24 , pp. 1-11
    • Nagata, H.1    Takekoshi, S.2    Takagi, T.3    Honma, T.4    Watanabe, K.5
  • 49
    • 0001830957 scopus 로고    scopus 로고
    • Desirable versus harmful levels of intake of flavonoids and phenolic acids
    • Kumpulainen JT, Salonen JT (eds) Cambridge: Royal Society of Chemistry
    • Breinholt V (1999) Desirable versus harmful levels of intake of flavonoids and phenolic acids. In: Kumpulainen JT, Salonen JT (eds) Natural antioxidants in nutrition, health and disease. Cambridge: Royal Society of Chemistry, pp 93-105
    • (1999) Natural Antioxidants in Nutrition, Health and Disease , pp. 93-105
    • Breinholt, V.1
  • 50
    • 0036854702 scopus 로고    scopus 로고
    • The transcriptional activation of the human copper/zinc superoxide dismutase gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin through two different regulator sites, the antioxidant responsive element and xenobiotic responsive element
    • Park EY, Rho HM (2002) The transcriptional activation of the human copper/zinc superoxide dismutase gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin through two different regulator sites, the antioxidant responsive element and xenobiotic responsive element. Mol Cell Biochem 240:47-55
    • (2002) Mol Cell Biochem , vol.240 , pp. 47-55
    • Park, E.Y.1    Rho, H.M.2
  • 51
    • 0035578227 scopus 로고    scopus 로고
    • NF kappa B and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells
    • Zhou LZ, Johnson AP, Rando TA (2001) NF kappa B and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells. Free Rad Biol Med 31:1405-1416
    • (2001) Free Rad Biol Med , vol.31 , pp. 1405-1416
    • Zhou, L.Z.1    Johnson, A.P.2    Rando, T.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.