Purple sweet potato color protects mouse liver against d-galactose-induced apoptosis via inhibiting caspase-3 activation and enhancing PI3K/Akt pathway

Food and Chemical Toxicology

Volumn 48, Issue 8-9, 2010, Pages 2500-2507

  Zhang, Zi Feng ^a   Lu, Jun ^a   Zheng, Yuan Lin ^a   Hu, Bin ^a   Fan, Shao Hua ^a   Wu, Dong Mei ^a   Zheng, Zi Hui ^b   Shan, Qun ^a   Liu, Chan Min ^a  

^a JIANGSU NORMAL UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Apoptosis; Caspase 3; Cell survival signaling; D gal; Mouse liver; PSPC

Indexed keywords

CASPASE 3; GALACTOSE; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT MEDICINAL PRODUCT; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P110; PURPLE SWEET POTATO COLOR; UNCLASSIFIED DRUG; CASPASE INHIBITOR; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; LIVER INJURY; LIVER PARENCHYMA; LIVER PROTECTION; LIVER SLICE; MALE; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; SWEET POTATO; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; LIVER; METABOLISM; PATHOLOGY; TOXICITY; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; ENZYME ACTIVATION; GALACTOSE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; IN SITU NICK-END LABELING; INDICATORS AND REAGENTS; IPOMOEA BATATAS; LIVER; MICE; PROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; CASPASE INHIBITORS; PHOSPHATIDYLINOSITOL 3-KINASES;

IPOMOEA BATATAS; MUS;

EID: 77955053050     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.06.023     Document Type: Article

References (52)

1. Afaq F., Syed D.N., Malik A., Hadi N., Sarfaraz S., Kweon M.H., Khan N., Zaid M.A., Mukhtar H. Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis. J. Invest. Dermatol. 2007, 127:222-232.
2. Chandra J., Samali A., Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic. Biol. Med. 2000, 29:323-333.
3. Chang Y.C., Huang H.P., Hsu J.D., Yang S.F., Wang C.J. Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells. Toxicol. Appl. Pharmacol. 2005, 205:201-212.
4. Cho S.G., Choi E.J. Apoptotic signaling pathways: caspases and stress-activated protein kinases. J. Biochem. Mol. Biol. 2002, 35:24-27.
5. Cho J., Kang J.S., Long P.H., Jing J., Back Y., Chung K.S. Antioxidant and memory enhancing effects of purple sweet potato anthocyanin and cordyceps mushroom extract. Arch. Pharm. Res. 2003, 26:821-825.
6. Cory S., Huang D.C., Adams J.M. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003, 22:8590-8607.
7. Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91:231-239.
8. Elisia I., Kitts D.D. Anthocyanins inhibit peroxyl radical-induced apoptosis in Caco-2 cells. Mol. Cell Biochem. 2008, 312:139-145.
9. Fiers W., Beyaert R., Declercq W., Vandenabeele P. More than one way to die: apoptosis and necrosis and reactive oxygen damage. Oncogene 1999, 18:7719-7730.
10. Franke T.F., Hornik C.P., Segev L., Shostak G.A., Sugimoto C. PI3K/Akt and apoptosis: size matters. Oncogene 2003, 22:8983-8998.
11. Goda Y., Shimizu T., Kato Y., Nakamura M., Maitani T., Yamada T., Terahara N., Yamaguchi M. Two acylated anthocyanins from purple sweet potato. Phytochemistry 1997, 44:183-186.
12. Granado-Serrano A.B., Angeles Martín M., Goya L., Bravo L., Ramos S. Time-course regulation of survival pathways by epicatechin on HepG2 cells. J. Nutr. Biochem. 2009, 20:115-124.
13. Guicciardi M.E., Gores G.J. Apoptosis: a mechanism of acute and chronic liver injury. Gut 2005, 54:1024-1033.
14. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974, 249:7130-7139.
15. Hafeez B.B., Siddiqui I.A., Asim M., Malik A., Afaq F., Adhami V.M., Saleem M., Din M., Mukhtar H. A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-kappaB signaling. Cancer Res. 2008, 68:8564-8572.
16. Han Y.H., Kim S.Z., Kim S.H., Park W.H. Arsenic trioxide inhibits the growth of Calu-6 cells via inducing a G2 arrest of the cell cycle and apoptosis accompanied with the depletion of GSH. Cancer Lett. 2008, 18:40-55.
17. Harada K., Kano M., Takayanagi T., Yamakawa O., Ishikawa F. Absorption of acylated anthocyanins in rats and humans after ingesting an extract of Ipomoea batatas purple sweet potato tuber. Biosci. Biotechnol. Biochem. 2004, 68:1500-1507.
18. Higuchi M., Honda T., Proske R.J., Yeh E.T. Regulation of reactive oxygen species-induced apoptosis and necrosis by caspase 3-like proteases. Oncogene 1998, 17:2753-2760.
19. Ho S.C., Liu J.H., Wu R.Y. Establishment of the mimetic aging effect in mice caused by d-galactose. Biogerontology 2003, 4:15-18.
20. Jodynis-Liebert J., Matławska I., Bylka W., Murias M. Protective effect of Aquilegia vulgaris (L.) on APAP-induced oxidative stress in rats. J. Ethnopharmacol. 2005, 97:351-358.
21. Johnson D.E. Programmed cell death regulation: basic mechanisms and therapeutic opportunities. Leukemia 2000, 14:1340-1344.
22. Kano M., Takayanagi T., Harada K., Makino K., Ishikawa F. Antioxidative activity of anthocyanins from purple sweet potato, Ipomoea batatas cultivar ayamurasaki. Biosci. Biotechnol. Biochem. 2005, 69:979-988.
23. Koh S.H., Kim S.H., Kwon H., Park Y., Kim K.S., Song C.W., Kim J., Kim M.H., Yu H.J., Henkel J.S., Jung H.K. Epigallocatechin gallate protects nerve growth factor differentiated PC12 cells from oxidative-radical-stress-induced apoptosis through its effect on phosphoinositide 3-kinase/Akt and glycogen synthase kinase-3. Brain Res. Mol. Brain Res. 2003, 118:72-81.
24. Lee S.H., Park S.M., Park S.M., Park J.H., Shin D.Y., Kim G.Y., Ryu C.H., Shin S.C., Jung J.M., Kang H.S., Lee W.S., Choi Y.H. Induction of apoptosis in human leukemia U937 cells by anthocyanins through down-regulation of Bcl-2 and activation of caspases. Int. J. Oncol. 2009, 34:1077-1083.
25. Long J.G., Wang X.M., Gao H.X., Liu Z., Liu C.S., Miao M.Y., Cui X., Packer L., Liu J.K. d-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid. Biogerontology 2007, 8:373-381.
26. Lu J., Zheng Y.L., Luo L., Wu D.M., Sun D.X., Feng Y.J. Quercetin reverses d-galactose induced neurotoxicity in mouse brain. Behav. Brain Res. 2006, 171:251-260.
27. Lu J., Zheng Y.L., Wu D.M., Luo L., Sun D.X., Shan Q. Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by d-galactose. Biochem. Pharmacol. 2007, 74:1078-1090.
28. Mizumo Y., Ohta K. Regional distributions of thiobarbituric acid reactive products, activities of enzymes regulating the metabolism of oxygen free radicals, and some of the related enzymes in adult and aged rat brain. J. Neurochem. 1986, 46:1344-1352.
29. Oki T., Suda I., Terahara N., Sato M., Hatakeyama M. Determination of acylated anthocyanin in human urine after ingesting a purple-fleshed sweet potato beverage with various contents of anthocyanin by LC-ESI-MS/MS. Biosci. Biotechnol. Biochem. 2006, 70:2540-2543.
30. Palfi A., Bartha E., Copf L., Mark L., Gallyas F., Veres B., Kalman E., Pajor L., Toth K., Ohmacht R., Sumegi B. Alcohol-free red wine inhibits isoproterenol-induced cardiac remodeling in rats by the regulation of Akt1 and protein kinase Cα/βII. J. Nutr. Biochem. 2009, 20:418-425.
31. Pari L., Suresh A. Effect of grape (Vitis vinifera L.) leaf extract on alcohol induced oxidative stress in rats. Food Chem. Toxicol. 2008, 46:1627-1634.
32. Philpott M., Gould K.S., Lim C., Ferguson L.R. In situ and in vitro antioxidant activity of sweet potato anthocyanins. J. Agric. Food Chem. 2004, 52:1511-1513.
33. Pugazhenthi S., Nesterova A., Sable C., Heidenreich K.A., Boxer L.M., Heasley L.E., Reusch J.E. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J. Biol. Chem. 2000, 275:10761-10766.
34. Qiu F., Luo J., Yao S., Ma L., Kong L. Preparative isolation and purification of anthocyanins from purple sweet potato by high-speed counter-current chromatography. J. Sep. Sci. 2009, 32:2146-2151.
35. Ramana B.V., Kumar V.V., Krishna P.N., Kumar C.S., Reddy P.U.M., Raju T.N. Effect of quercetin on galactose-induced hyperglycaemic oxidative stress in hepatic and neuronal tissues of wistar rats. Acta Diabetol. 2006, 43:135-141.
36. Ramos A.M., Fernández C., Amrán D., Sancho P., de Blas E., Aller P. Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells. Blood 2005, 105:4013-4020.
37. Sha H., Ma Q., Jha R.K., Xu F., Wang L., Wang Z., Zhao Y., Fan F. Resveratrol ameliorates hepatic injury via the mitochondrial pathway in rats with severe acute pancreatitis. Eur. J. Pharmacol. 2008, 601:136-142.
38. Shih P.H., Yeh C.T., Yen G.C. Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells. Food Chem. Toxicol. 2005, 43:1557-1566.
39. Shih P.H., Yeh C.T., Yen G.C. Anthocyanins induce the activation of phase II enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis. J. Agric. Food Chem. 2007, 55:9427-9435.
40. Simon H.U., Haj-Yehia A., Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000, 5:415-418.
41. Suda I., Oki T., Masuda M., Nishiba Y., Furuta S., Matsugano K., Sugita K., Terahara N. Direct absorption of acylated anthocyanin in purple-fleshed sweet potato into rats. J. Agric. Food Chem. 2002, 50:1672-1676.
42. Suda I., Ishikawa F., Hatakeyama M., Miyawaki M., Kudo T., Hirano K., Ito A., Yamakawa O., Horiuchi S. Intake of purple sweet potato beverage affects on serum hepatic biomarker levels of healthy adult men with borderline hepatitis. Eur. J. Clin. Nutr. 2008, 62:60-67.
43. Terahara N., Konczak I., Ono H., Yoshimoto M., Yamakawa O. Characterization of acylated anthocyanins in callus induced from storage root of purple-fleshed sweet potato, Ipomoea batatas L. J. Biomed. Biotechnol. 2004, 5:279-286.
44. Tian Q., Konczak I., Schwartz S.J. Probing anthocyanin profiles in purple sweet potato cell Line (Ipomoea batatas LCv. Ayamurasaki) by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. J. Agric. Food Chem. 2005, 53:6503-6509.
45. Tsoyi K., Park H.B., Kim Y.M., Chung J.I., Shin S.C., Shim H.J., Lee W.S., Seo H.G., Lee J.H., Chang K.C., Kim H.J. Protective effect of anthocyanins from black soybean seed coats on UVB-induced apoptotic cell death in vitro and in vivo. J. Agric. Food Chem. 2008, 56:10600-10605.
46. Valcheva-Kuzmanova S., Marazova K., Krasnaliev I., Galunska B., Borisova P., Belcheva A. Effect of Aronia melanocarpa fruit juice on indomethacin-induced gastric mucosal damage and oxidative stress in rats. Exp. Toxicol. Pathol. 2005, 56:385-392.
47. Williams C.M., El Mohsen M.A., Vauzour D., Rendeiro C., Butler L.T., Ellis J.A., Whiteman M., Spencer J.P. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radic. Biol. Med. 2008, 45:295-305.
48. Xia M., Ling W., Zhu H., Ma J., Wang Q., Hou M., Tang Z., Guo H., Liu C., Ye Q. Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation. Atherosclerosis 2009, 202:41-47.
49. Xu X.H., Zhao T.Q. Effects of puerarin on d-galactose-induced memory deficits in mice. Acta Pharmacol. Sin. 2002, 23:587-590.
50. Yao R., Cooper G.M. Requirement for phosphatidyl-inositol-3 kinase in the prevention of apoptosis by the nerve growth factor. Science 1995, 267:2003-2006.
51. Yun J.M., Afaq F., Khan N., Mukhtar H. Delphinidin, an anthocyanidin in pigmented fruits and vegetables, induces apoptosis and cell cycle arrest in human colon cancer HCT116 cells. Mol. Carcinog. 2009, 48:260-270.
52. Zhang Z.F., Fan S.H., Zheng Y.L., Lu J., Wu D.M., Shan Q., Hu B. Purple sweet potato color attenuates oxidative stress and inflammatory response induced by d-galactose in mouse liver. Food Chem. Toxicol. 2009, 47:496-501.