Programmed cell death regulation: Basic mechanisms and therapeutic opportunities

Leukemia

Volumn 14, Issue 8, 2000, Pages 1340-1344

  Johnson, D E ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bcl 2; Caspase; IAP; Mitochondria; TRAIL

Indexed keywords

CASPASE; CYTOCHROME C; INHIBITOR OF APOPTOSIS PROTEIN; REGULATOR PROTEIN;

APOPTOSIS; CANCER INHIBITION; CANCER RESEARCH; CELL DEATH; CELL PH; FEMALE; HUMAN; HUMAN CELL; MEDICAL SOCIETY; MITOCHONDRION; MOLECULAR BIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

EID: 0033906482     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401849     Document Type: Review

References (37)

1. Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification
2. The Mitochondrial FOF1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells
3. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
4. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
5. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
6. Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange
7. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria
8. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activitation of cell surface death receptors
9. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
10. Intereaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death
11. Interaction and regulation of subcellular localization of CED-4 by CED-9
12. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
13. Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation
14. Programmed cell death in the nematode C. elegans
15. Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
16. p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum
17. IAP family proteins - suppressors of apoptosis
18. A novel anti-apoptosis gene survivin, expressed in cancer and lymphoma
19. Survivin apoptosis: An interloper between cell death and cell proliferation in cancer
20. Cell cycle control of apoptosis and mitotic spindle checkpoint by survivin
21. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
22. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors
23. X-linked IAP is a direct inhibitor of cell-death proteases
24. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
25. A new internal-ribosome- entry-site motif potentiates XIAP-mediated cytoprotection
26. A single BIR domain of XIAP sufficient for inhibiting caspases
27. NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP
28. DAP-kinase participates in TNF-alpha-and Fas-induced apoptosis and its function requires the death domain
29. DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: Possible implications for role as tumor suppressor gene
30. Inhibition of virus-induced neuronal apoptosis by Bax
31. Conversion of Bcl-2 to a Bax-like death effector by caspases
32. Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: Evidence for a caspase-mediated, proteolytic inactivation of Bcl-2
33. Involvement of Bcl-2 cleavage in the acceleration of VP-16-induced U937 cell apoptosis
34. Modulation of cell death by Bcl-X(L) through caspase interaction
35. Death receptors: Signaling and modulation
36. Tumoricidal activity of tumor? necrosis factor-related apoptosis-inducing ligand in vivo
37. Safety and antitumor activity of recombinant soluble Apo2 ligand