IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects

Endocrinology

Volumn 151, Issue 8, 2010, Pages 3752-3763

  Cleveland Donovan, Kelly ^a   Maile, Laura A ^b   Tsiaras, William G ^a   Tchkonia, Tamara ^c   Kirkland, James L ^c   Boney, Charlotte M ^a  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CYCLIN D1; DNA; GLYCOGEN SYNTHASE KINASE 3; INSULIN RECEPTOR SUBSTRATE 1; LENTIVIRUS VECTOR; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; RICTOR PROTEIN; S6 KINASE; SERINE; SHORT HAIRPIN RNA; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; THREONINE; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL CYCLE REGULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRAABDOMINAL FAT; OBESITY; OMENTUM; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SUBCUTANEOUS FAT;

3T3-L1 CELLS; ADIPOCYTES, WHITE; ADULT; ANIMALS; CELL CULTURE TECHNIQUES; CELL CYCLE; CELLS, CULTURED; DOWN-REGULATION; ENZYME ACTIVATION; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTRA-ABDOMINAL FAT; MALE; MICE; MIDDLE AGED; OBESITY; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT;

EID: 77954917625     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0043     Document Type: Article

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