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Volumn 192, Issue 2, 2010, Pages 125-140

Low-shear modelled microgravity environment maintains morphology and differentiated functionality of primary porcine hepatocyte cultures

Author keywords

Differentiation; Integrin; Low fluid shear; Microgravity; Morphology, functional; Polarity; Three dimensional hepatocyte culture; Three dimensional liver cultures; Ultrastructure electron microscopy

Indexed keywords

ALPHA5 INTEGRIN; VERY LATE ACTIVATION ANTIGEN 5;

EID: 77954476804     PISSN: 14226405     EISSN: None     Source Type: Journal    
DOI: 10.1159/000308893     Document Type: Article
Times cited : (38)

References (72)
  • 1
    • 0036346357 scopus 로고    scopus 로고
    • Structural polarity and functional bile canaliculi in rat hepatocyte spheroids
    • Abu-Absi, S.F., J.R. Friend, L.K. Hansen, W.S. Hu (2002) Structural polarity and functional bile canaliculi in rat hepatocyte spheroids. Exp Cell Res 274: 56-67.
    • (2002) Exp Cell Res , vol.274 , pp. 56-67
    • Abu-Absi, S.F.1    Friend, J.R.2    Hansen, L.K.3    Hu, W.S.4
  • 2
    • 17644370659 scopus 로고    scopus 로고
    • Three-dimensional co-culture of hepatocytes and stellate cells
    • Abu-Absi, S.F., L.K. Hansen, W.S. Hu (2004) Three-dimensional co-culture of hepatocytes and stellate cells. Cytotechnology 45: 125-140.
    • (2004) Cytotechnology , vol.45 , pp. 125-140
    • Abu-Absi, S.F.1    Hansen, L.K.2    Hu, W.S.3
  • 3
    • 35648978998 scopus 로고    scopus 로고
    • Structure and mechanics of integrin-based cell adhesion
    • Arnaout, M.A., S. Goodman, J.P. Xiong (2007) Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol 19: 495-507.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 495-507
    • Arnaout, M.A.1    Goodman, S.2    Xiong, J.P.3
  • 4
    • 24044462685 scopus 로고    scopus 로고
    • Hepatocyte coculture, three-dimensional culture models and the extracellular matrix
    • Strain, A.J., Diehl, A.M. (eds): ed 1. London, Chapman & Hall
    • Auth, M.K.H., A. Ichihara (1998) Hepatocyte coculture, three-dimensional culture models and the extracellular matrix; in Strain, A.J., Diehl, A.M. (eds): Liver Growth and Repair, ed 1. London, Chapman & Hall, pp 465-481.
    • (1998) Liver Growth and Repair , pp. 465-481
    • Auth, M.K.H.1    Ichihara, A.2
  • 5
    • 0027409038 scopus 로고
    • Three-dimensional growth and differentiation of ovarian tumor cell line in high aspect rotating-wall vessel: Morphologic and embryologic considerations
    • Becker, J.L., T.L. Prewett, G.F. Spaulding, T.J. Goodwin (1993) Three-dimensional growth and differentiation of ovarian tumor cell line in high aspect rotating-wall vessel: morphologic and embryologic considerations. J Cell Biochem 51: 283-289.
    • (1993) J Cell Biochem , vol.51 , pp. 283-289
    • Becker, J.L.1    Prewett, T.L.2    Spaulding, G.F.3    Goodwin, T.J.4
  • 6
    • 0029852524 scopus 로고    scopus 로고
    • Effect of extracellular matrix topology on cell structure, function, and physiological responsiveness: Hepatocytes cultured in a sandwich configuration
    • Berthiaume, F., P.V. Moghe, M. Toner, M.L. Yarmush (1996) Effect of extracellular matrix topology on cell structure, function, and physiological responsiveness: hepatocytes cultured in a sandwich configuration. FASEB J 10: 1471-1484.
    • (1996) FASEB J , vol.10 , pp. 1471-1484
    • Berthiaume, F.1    Moghe, P.V.2    Toner, M.3    Yarmush, M.L.4
  • 7
    • 0032077407 scopus 로고    scopus 로고
    • Microfabrication of hepatocyte/fibroblast co-cultures: Role of homotypic cell interactions
    • Bhatia, S.N., U.J. Balis, M.L. Yarmush, M. Toner (1998a) Microfabrication of hepatocyte/fibroblast co-cultures: role of homotypic cell interactions. Biotechnol Prog 14: 378-387.
    • (1998) Biotechnol Prog , vol.14 , pp. 378-387
    • Bhatia, S.N.1    Balis, U.J.2    Yarmush, M.L.3    Toner, M.4
  • 8
    • 0031758047 scopus 로고    scopus 로고
    • Probing heterotypic cell interactions: Hepatocyte function in microfabricated co-cultures
    • Bhatia, S.N., U.J. Balis, M.L. Yarmush, M. Toner (1998b) Probing heterotypic cell interactions: hepatocyte function in microfabricated co-cultures. J Biomater Sci Polym Ed 9: 1137-1160.
    • (1998) J Biomater Sci Polym Ed , vol.9 , pp. 1137-1160
    • Bhatia, S.N.1    Balis, U.J.2    Yarmush, M.L.3    Toner, M.4
  • 9
    • 0032721936 scopus 로고    scopus 로고
    • Effect of cell-cell interactions in preservation of cellular phenotype: Cocultivation of hepatocytes and nonparenchymal cells
    • Bhatia, S.N., U.J. Balis, M.L. Yarmush, M. Toner (1999) Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells. FASEB J 13: 1883-1900.
    • (1999) FASEB J , vol.13 , pp. 1883-1900
    • Bhatia, S.N.1    Balis, U.J.2    Yarmush, M.L.3    Toner, M.4
  • 10
    • 34249005535 scopus 로고    scopus 로고
    • Real-time assessment of three-dimensional cell aggregation in rotating wall vessel bioreactors in vitro
    • DOI 10.1038/nprot.2006.311, PII NPROT.2006.311
    • Botta, G.P., P. Manley, S. Miller, P.I. Lelkes (2006) Real-time assessment of three-dimensional cell aggregation in rotating wall vessel bioreactors in vitro. Nat Protoc 1: 2116-2127. (Pubitemid 46778061)
    • (2006) Nature Protocols , vol.1 , Issue.4 , pp. 2116-2127
    • Botta, G.P.1    Manley, P.2    Miller, S.3    Lelkes, P.I.4
  • 11
    • 61949475114 scopus 로고    scopus 로고
    • Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function
    • Brophy, C.M., J.L. Luebke-Wheeler, B.P. Amiot, H. Khan, R.P. Remmel, P. Rinaldo, S.L. Nyberg (2009) Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function. Hepatology 49: 578-586
    • (2009) Hepatology , vol.49 , pp. 578-586
    • Brophy, C.M.1    Luebke-Wheeler, J.L.2    Amiot, B.P.3    Khan, H.4    Remmel, R.P.5    Rinaldo, P.6    Nyberg, S.L.7
  • 12
    • 64549117445 scopus 로고    scopus 로고
    • Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes
    • Chang, T.T., M. Hughes-Fulford (2009) Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes. Tissue Eng Part A 15: 559-567.
    • (2009) Tissue Eng Part A , vol.15 , pp. 559-567
    • Chang, T.T.1    Hughes-Fulford, M.2
  • 14
    • 0031915758 scopus 로고    scopus 로고
    • Expression of integrins during liver organogenesis in humans
    • Couvelard, A. (1998) Expression of integrins during liver organogenesis in humans. Hepatology 27: 839-847.
    • (1998) Hepatology , vol.27 , pp. 839-847
    • Couvelard, A.1
  • 15
    • 35348949492 scopus 로고    scopus 로고
    • Mass transfer and metabolic reactions in hepatocyte spheroids cultured in rotating wall gas-permeable membrane system
    • Curcio, E., S. Salerno, G. Barbieri, L. De Bartolo, E. Drioli, A. Bader (2007) Mass transfer and metabolic reactions in hepatocyte spheroids cultured in rotating wall gas-permeable membrane system. Biomaterials 28: 5487-5497.
    • (2007) Biomaterials , vol.28 , pp. 5487-5497
    • Curcio, E.1    Salerno, S.2    Barbieri, G.3    De Bartolo, L.4    Drioli, E.5    Bader, A.6
  • 16
    • 0035799693 scopus 로고    scopus 로고
    • The simulated microgravity environment maintains key metabolic functions and promotes aggregation of primary porcine hepatocytes
    • Dabos, KJ, L.J. Nelson, T.J. Bradnock, J.A. Parkinson, I.H. Sadler, P.C. Hayes, J.N. Plevris (2001) The simulated microgravity environment maintains key metabolic functions and promotes aggregation of primary porcine hepatocytes. Biochim Biophys Acta 1526: 119-130.
    • (2001) Biochim Biophys Acta , vol.1526 , pp. 119-130
    • Dabos, K.J.1    Nelson, L.J.2    Bradnock, T.J.3    Parkinson, J.A.4    Sadler, I.H.5    Hayes, P.C.6    Plevris, J.N.7
  • 17
    • 46749145393 scopus 로고    scopus 로고
    • Which in vitro models could be best used to study hepatocyte polarity?
    • Decaens, C., M. Durand, B. Grosse, D. Cassio (2008) Which in vitro models could be best used to study hepatocyte polarity? Biol Cell 100: 387-398
    • (2008) Biol Cell , vol.100 , pp. 387-398
    • Decaens, C.1    Durand, M.2    Grosse, B.3    Cassio, D.4
  • 20
    • 34547929424 scopus 로고    scopus 로고
    • Designer self-assembling peptide scaffolds for 3-D tissue cell cultures and regenerative medicine
    • Gelain, F., A. Horii, S. Zhang (2007) Designer self-assembling peptide scaffolds for 3-D tissue cell cultures and regenerative medicine. Macromol Biosci 7: 544-551.
    • (2007) Macromol Biosci , vol.7 , pp. 544-551
    • Gelain, F.1    Horii, A.2    Zhang, S.3
  • 21
    • 0033551899 scopus 로고    scopus 로고
    • Integrin signaling
    • Giancotti, F.G., E. Ruoslahti (1999) Integrin signaling. Science 285: 1028-1032.
    • (1999) Science , vol.285 , pp. 1028-1032
    • Giancotti, F.G.1    Ruoslahti, E.2
  • 24
    • 67650999336 scopus 로고    scopus 로고
    • Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factorβ -induced apoptosis
    • Godoy, P., J.G. Hengstler, I. Ilkavets, C. Meyer, A. Bachmann, A. Müller, G. Tuschl, S.O. Mueller, S. Dooley (2009) Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factorβ -induced apoptosis. Hepatology 49: 2031-2043.
    • (2009) Hepatology , vol.49 , pp. 2031-2043
    • Godoy, P.1    Hengstler, J.G.2    Ilkavets, I.3    Meyer, C.4    Bachmann, A.5    Müller, A.6    Tuschl, G.7    Mueller, S.O.8    Dooley, S.9
  • 25
    • 0027530946 scopus 로고
    • Reduced shear stress: A major component in the ability of mammalian tissues to form three-dimensional assemblies in simulated microgravity
    • Goodwin, T.J., T.L. Prewett, D.A. Wolf, G.F. Spaulding (1993) Reduced shear stress: a major component in the ability of mammalian tissues to form three-dimensional assemblies in simulated microgravity. J Cell Biochem 51: 301-311.
    • (1993) J Cell Biochem , vol.51 , pp. 301-311
    • Goodwin, T.J.1    Prewett, T.L.2    Wolf, D.A.3    Spaulding, G.F.4
  • 26
    • 33644529130 scopus 로고    scopus 로고
    • Capturing complex 3D tissue physiology in vitro
    • Griffith, L.G., M.A. Swartz (2006) Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7: 211-224.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 211-224
    • Griffith, L.G.1    Swartz, M.A.2
  • 27
    • 0034807979 scopus 로고    scopus 로고
    • Optimized suspension culture: The rotating-wall vessel
    • Hammond, T.G., J.M. Hammond (2001) Optimized suspension culture: the rotating-wall vessel. Am J Physiol Renal Physiol 281: F12-F25.
    • (2001) Am J Physiol Renal Physiol , vol.281
    • Hammond, T.G.1    Hammond, J.M.2
  • 28
    • 0034715891 scopus 로고    scopus 로고
    • Multiple roles of integrins in cell motility
    • Holly, S.P., M.K. Larson, L.V. Parise (2000) Multiple roles of integrins in cell motility. Exp Cell Res 261: 69-74.
    • (2000) Exp Cell Res , vol.261 , pp. 69-74
    • Holly, S.P.1    Larson, M.K.2    Parise, L.V.3
  • 29
    • 0033025792 scopus 로고    scopus 로고
    • Receding cytochrome P450 activity in disassembling hepatocyte spheroids
    • Hsiao, C.C., J.R. Wu, F.J. Wu, W.J. Ko, R.P. Remmel, W.S. Hu (1999) Receding cytochrome P450 activity in disassembling hepatocyte spheroids. Tissue Eng 5: 207-221.
    • (1999) Tissue Eng , vol.5 , pp. 207-221
    • Hsiao, C.C.1    Wu, J.R.2    Wu, F.J.3    Ko, W.J.4    Remmel, R.P.5    Hu, W.S.6
  • 30
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • Hynes, R.O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110: 673-687.
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 31
    • 0032952039 scopus 로고    scopus 로고
    • How cells (might) sense microgravity
    • Ingber, D. (1999) How cells (might) sense microgravity. FASEB J 13(suppl): S3-S15.
    • (1999) FASEB J , vol.13 , Issue.SUPPL.
    • Ingber, D.1
  • 32
    • 33744488545 scopus 로고    scopus 로고
    • Cellular mechanotransduction: Putting all the pieces together again
    • Ingber, D.E. (2006) Cellular mechanotransduction: putting all the pieces together again. FASEB J 20: 811-827.
    • (2006) FASEB J , vol.20 , pp. 811-827
    • Ingber, D.E.1
  • 33
    • 0030899243 scopus 로고    scopus 로고
    • The use of microcarrier-roller bottle culture for largescale production of porcine hepatocytes
    • Jauregui, H.O., H. Naik, S. Santangini, D.M. Trenkler, C.J.P. Mullon (1997) The use of microcarrier-roller bottle culture for largescale production of porcine hepatocytes. Tissue Eng 3: 17-25.
    • (1997) Tissue Eng , vol.3 , pp. 17-25
    • Jauregui, H.O.1    Naik, H.2    Santangini, S.3    Trenkler, D.M.4    Mullon, C.J.P.5
  • 34
    • 0027533527 scopus 로고
    • Prospects for use of microgravity-based bioreactors to study three-dimensional host-tumor interactions in human neoplasia
    • Jessup, J.M., T.J. Goodwin, G. Spaulding (1993) Prospects for use of microgravity-based bioreactors to study three-dimensional host-tumor interactions in human neoplasia. J Cell Biochem 51: 290-300.
    • (1993) J Cell Biochem , vol.51 , pp. 290-300
    • Jessup, J.M.1    Goodwin, T.J.2    Spaulding, G.3
  • 36
    • 0026876760 scopus 로고
    • Combination of epidermal growth factor and insulin is required for multicellular spheroid formation of rat hepatocytes in primary culture
    • Kawaguchi, M., N. Koide, K. Sakaguchi, T. Shinji, T. Tsuji (1992) Combination of epidermal growth factor and insulin is required for multicellular spheroid formation of rat hepatocytes in primary culture. Acta Med Okayama 46: 195-201.
    • (1992) Acta Med Okayama , vol.46 , pp. 195-201
    • Kawaguchi, M.1    Koide, N.2    Sakaguchi, K.3    Shinji, T.4    Tsuji, T.5
  • 38
    • 70349466841 scopus 로고    scopus 로고
    • Oxygenmediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance
    • Kidambi, S., R.S. Yarmush, E. Novik, P. Chao, M.L. Yarmush, Y. Nahmias (2009) Oxygenmediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance. Proc Natl Acad Sci USA 106: 15714-15719.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 15714-15719
    • Kidambi, S.1    Yarmush, R.S.2    Novik, E.3    Chao, P.4    Yarmush, M.L.5    Nahmias, Y.6
  • 39
    • 0032404328 scopus 로고    scopus 로고
    • Development of biocompatible synthetic extracellular matrices for tissue engineering
    • Kim, B.-S., D.J. Mooney (1998) Development of biocompatible synthetic extracellular matrices for tissue engineering. TIBTECH 16: 224-230.
    • (1998) TIBTECH , vol.16 , pp. 224-230
    • Kim, B.-S.1    Mooney, D.J.2
  • 40
    • 37549052561 scopus 로고    scopus 로고
    • Oxygen transport and consumption by suspended cells in microgravity: A multiphase analysis
    • Kwon, O., S.B. Devarakonda, J.M. Sankovic, R.K. Banerjee (2008) Oxygen transport and consumption by suspended cells in microgravity: a multiphase analysis. Biotechnol Bioeng 99: 99-107.
    • (2008) Biotechnol Bioeng , vol.99 , pp. 99-107
    • Kwon, O.1    Devarakonda, S.B.2    Sankovic, J.M.3    Banerjee, R.K.4
  • 41
    • 34249654626 scopus 로고    scopus 로고
    • Collagen matrix deposition is dramatically enhanced in vitro when crowded with charged macromolecules: The biological relevance of the excluded volume effect
    • Lareu, R.R., K.H. Subramhanya, Y. Peng, P. Benny, C. Chen, Z. Wang, R. Rajagopalan, M. Raghunath (2007) Collagen matrix deposition is dramatically enhanced in vitro when crowded with charged macromolecules: the biological relevance of the excluded volume effect. FEBS Lett 581: 2709-2714.
    • (2007) FEBS Lett , vol.581 , pp. 2709-2714
    • Lareu, R.R.1    Subramhanya, K.H.2    Peng, Y.3    Benny, P.4    Chen, C.5    Wang, Z.6    Rajagopalan, R.7    Raghunath, M.8
  • 42
    • 33748328139 scopus 로고    scopus 로고
    • The matrix reorganized: Extracellular matrix remodeling and integrin signaling
    • Larsen, M., V.V. Artym, J.A. Green, K.M. Yamada (2006) The matrix reorganized: extracellular matrix remodeling and integrin signaling. Curr Opin Cell Biol 18: 463-471.
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 463-471
    • Larsen, M.1    Artym, V.V.2    Green, J.A.3    Yamada, K.M.4
  • 44
    • 0029004320 scopus 로고
    • Formation of porcine hepatocyte spheroids for use in a bioartificial liver
    • Lazar, A., M.V. Peshwa, F.J. Wu, C.M. Chi, F.B. Cerra, W.S. Hu (1995b) Formation of porcine hepatocyte spheroids for use in a bioartificial liver. Cell Transplant 4: 259-268.
    • (1995) Cell Transplant , vol.4 , pp. 259-268
    • Lazar, A.1    Peshwa, M.V.2    Wu, F.J.3    Chi, C.M.4    Cerra, F.B.5    Hu, W.S.6
  • 45
    • 58749093939 scopus 로고    scopus 로고
    • Recent advances in three-dimensional multicellular spheroid culture for biomedical research
    • Lin, R.Z., H.Y. Chang (2008) Recent advances in three-dimensional multicellular spheroid culture for biomedical research. Biotechnol J 3: 1172-1184.
    • (2008) Biotechnol J , vol.3 , pp. 1172-1184
    • Lin, R.Z.1    Chang, H.Y.2
  • 47
    • 23644448920 scopus 로고    scopus 로고
    • Bioreactors for tissue mass culture: Design, characterization, and recent advances
    • Martin, Y., P. Vermette (2005) Bioreactors for tissue mass culture: design, characterization, and recent advances. Biomaterials 26: 7481-7503.
    • (2005) Biomaterials , vol.26 , pp. 7481-7503
    • Martin, Y.1    Vermette, P.2
  • 48
    • 77049124474 scopus 로고    scopus 로고
    • Modelling tissues in 3D: The next future of pharmaco-toxicology and food research?
    • Mazzoleni, G., D. Di Lorenzo, N. Steimberg (2009) Modelling tissues in 3D: the next future of pharmaco-toxicology and food research? Genes Nutr 4: 13-22.
    • (2009) Genes Nutr , vol.4 , pp. 13-22
    • Mazzoleni, G.1    Di Lorenzo, D.2    Steimberg, N.3
  • 49
    • 0035149354 scopus 로고    scopus 로고
    • Histological organization in hepatocyte organoid cultures
    • Michalopoulos, G.K., W.C. Bowen, K. Mulè, D.B. Stolz (2001) Histological organization in hepatocyte organoid cultures. Am J Pathol 159: 1877-1887.
    • (2001) Am J Pathol , vol.159 , pp. 1877-1887
    • Michalopoulos, G.K.1    Bowen, W.C.2    Mulè, K.3    Stolz, D.B.4
  • 50
    • 0032899212 scopus 로고    scopus 로고
    • Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor
    • Michalopoulos, G.K., W.C. Bowen, V.F. Zajac, D. Beer-Stolz, S. Watkins, V. Kostrubsky, S.C. Strom (1999) Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor. Hepatology 29: 90-100.
    • (1999) Hepatology , vol.29 , pp. 90-100
    • Michalopoulos, G.K.1    Bowen, W.C.2    Zajac, V.F.3    Beer-Stolz, D.4    Watkins, S.5    Kostrubsky, V.6    Strom, S.C.7
  • 52
    • 0032934277 scopus 로고    scopus 로고
    • Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells
    • Mitaka, T., F. Sato, T. Mizuguchi, T. Yokono, Y. Mochizuki (1999) Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells. Hepatology 29: 111-125.
    • (1999) Hepatology , vol.29 , pp. 111-125
    • Mitaka, T.1    Sato, F.2    Mizuguchi, T.3    Yokono, T.4    Mochizuki, Y.5
  • 53
    • 0342437102 scopus 로고    scopus 로고
    • Cell-cell interactions are essential for maintenance of hepatocyte function in collagen gel but not on matrigel
    • Moghe, P.V., R.N. Coger, M. Toner, M. Yarmush (1997) Cell-cell interactions are essential for maintenance of hepatocyte function in collagen gel but not on matrigel. Biotech Bioeng 56: 706-711.
    • (1997) Biotech Bioeng , vol.56 , pp. 706-711
    • Moghe, P.V.1    Coger, R.N.2    Toner, M.3    Yarmush, M.4
  • 55
    • 0036707818 scopus 로고    scopus 로고
    • Differential gene expression analysis during porcine hepatocyte spheroid formation
    • Narayanan, R.A., A. Rink, C.W. Beattie, W.S. Hu (2002) Differential gene expression analysis during porcine hepatocyte spheroid formation. Mamm Genome 13: 515-523.
    • (2002) Mamm Genome , vol.13 , pp. 515-523
    • Narayanan, R.A.1    Rink, A.2    Beattie, C.W.3    Hu, W.S.4
  • 56
    • 46149105454 scopus 로고    scopus 로고
    • The application of low shear modeled microgravity to 3-D cell biology and tissue engineering
    • Navran, S. (2008) The application of low shear modeled microgravity to 3-D cell biology and tissue engineering. Biotechnol Annu Rev 14: 275-296.
    • (2008) Biotechnol Annu Rev , vol.14 , pp. 275-296
    • Navran, S.1
  • 60
    • 0027692817 scopus 로고
    • Growth versus function in the three-dimensional culture of single and aggregated hepatocytes within collagen gels
    • Parsons-Wingerter, P.A., W.M. Saltzman (1993) Growth versus function in the three-dimensional culture of single and aggregated hepatocytes within collagen gels. Biotechnol Prog 9: 600-607.
    • (1993) Biotechnol Prog , vol.9 , pp. 600-607
    • Parsons-Wingerter, P.A.1    Saltzman, W.M.2
  • 61
    • 0029945884 scopus 로고    scopus 로고
    • Mechanistics of formation and ultrastructural evaluation of hepatocyte spheroids
    • Peshwa, M.V., F.J. Wu, H.L. Sharp, F.B. Cerra, W.S. Hu (1996) Mechanistics of formation and ultrastructural evaluation of hepatocyte spheroids. In Vitro Cell Dev Biol Anim 32: 197-203.
    • (1996) In Vitro Cell Dev Biol Anim , vol.32 , pp. 197-203
    • Peshwa, M.V.1    Wu, F.J.2    Sharp, H.L.3    Cerra, F.B.4    Hu, W.S.5
  • 62
    • 1542373992 scopus 로고    scopus 로고
    • Fibronectin matrix assembly regulatesα5β1 -mediated cell cohesion
    • Robinson, E.E., Foty R.A., Corbett S.A. (2004) Fibronectin matrix assembly regulatesα5β1 -mediated cell cohesion. Mol Biol Cell 15: 973-981.
    • (2004) Mol Biol Cell , vol.15 , pp. 973-981
    • Robinson, E.E.1    Foty, R.A.2    Corbett, S.A.3
  • 64
    • 0028341024 scopus 로고
    • Cell adhesion molecules in liver function and pattern formation
    • Stamatoglou, S.C., R.C. Hughes (1994) Cell adhesion molecules in liver function and pattern formation. FASEB J 8: 420-427.
    • (1994) FASEB J , vol.8 , pp. 420-427
    • Stamatoglou, S.C.1    Hughes, R.C.2
  • 65
    • 0025605733 scopus 로고
    • Localization of two fibronectin-binding glycoproteins in rat liver and primary hepatocytes. Co-distribution in vitro of integrin (α5β 1 ) and non-integrin (AGp110) receptors in cell-substratum adhesion sites
    • Stamatoglou, S.C., K.H. Sullivan, S. Johansson, P.M. Bayley, I.D. Burdett, R.C. Hughes (1990) Localization of two fibronectin-binding glycoproteins in rat liver and primary hepatocytes. Co-distribution in vitro of integrin (α5β 1 ) and non-integrin (AGp110) receptors in cell-substratum adhesion sites. J Cell Sci 97(pt 4): 595-606.
    • (1990) J Cell Sci , vol.97 , Issue.PART 4 , pp. 595-606
    • Stamatoglou, S.C.1    Sullivan, K.H.2    Johansson, S.3    Bayley, P.M.4    Burdett, I.D.5    Hughes, R.C.6
  • 66
    • 0033960094 scopus 로고    scopus 로고
    • Alternatives to liver transplantation: From hepatocyte transplantation to tissue-engineered organs
    • Review
    • Sundback, C.A., J.P. Vacanti (2000) Alternatives to liver transplantation: from hepatocyte transplantation to tissue-engineered organs. Gastroenterology 118: 438-442. Review.
    • (2000) Gastroenterology , vol.118 , pp. 438-442
    • Sundback, C.A.1    Vacanti, J.P.2
  • 68
    • 67650982782 scopus 로고    scopus 로고
    • Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: A valuable model for in vitro toxicity and drug-drug interaction studies
    • Tuschl, G., J. Hrach, Y. Walter, P.G. Hewitt, S.O. Mueller (2009) Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: a valuable model for in vitro toxicity and drug-drug interaction studies. Chem Biol Interact 181: 124-137.
    • (2009) Chem Biol Interact , vol.181 , pp. 124-137
    • Tuschl, G.1    Hrach, J.2    Walter, Y.3    Hewitt, P.G.4    Mueller, S.O.5
  • 69
    • 0035118470 scopus 로고    scopus 로고
    • The role of actin filaments and microtubules in hepatocyte spheroid self-assembly
    • Tzanakakis, E.S., K. Hansen, W.-S. Hu (2001) The role of actin filaments and microtubules in hepatocyte spheroid self-assembly. Cell Motil Cytoskelt 48: 175-189.
    • (2001) Cell Motil Cytoskelt , vol.48 , pp. 175-189
    • Tzanakakis, E.S.1    Hansen, K.2    Hu, W.-S.3
  • 70
    • 0031904597 scopus 로고    scopus 로고
    • Growing tissues in microgravity
    • Unsworth, B.R., P.I. Lelkes (1998) Growing tissues in microgravity. Nature Medicine 4: 901-907.
    • (1998) Nature Medicine , vol.4 , pp. 901-907
    • Unsworth, B.R.1    Lelkes, P.I.2
  • 71
    • 34547931078 scopus 로고    scopus 로고
    • Modeling tissue morphogenesis and cancer in 3D
    • Yamada, K.M., E. Cukierman (2007) Modeling tissue morphogenesis and cancer in 3D. Cell 130: 601-610.
    • (2007) Cell , vol.130 , pp. 601-610
    • Yamada, K.M.1    Cukierman, E.2
  • 72
    • 0030020408 scopus 로고    scopus 로고
    • Structural and functional features of bile canaliculi in adult rat hepatocyte spheroids
    • Yumoto, A.U., S. Watanabe, M. Hirose, T. Kitamura, Y. Yamaguchi, N. Sato (1996) Structural and functional features of bile canaliculi in adult rat hepatocyte spheroids. Liver 16: 61-66.
    • (1996) Liver , vol.16 , pp. 61-66
    • Yumoto, A.U.1    Watanabe, S.2    Hirose, M.3    Kitamura, T.4    Yamaguchi, Y.5    Sato, N.6


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