-
1
-
-
0027401203
-
Mutations in Cu/Zn superoxide dismutase gene are associated withfamilial amyotrophic lateral sclerosis
-
Rosen, D. R.; Siddique, T.; Patterson, D.; Figlewicz, D. A.; Sapp, P.; Hentati, A.; Donaldson, D.; Goto, J.; O'Regan, J. P.; Deng, H. X. Mutations in Cu/Zn superoxide dismutase gene are associated withfamilial amyotrophic lateral sclerosis. Nature, 1993, 362, 59-62.
-
(1993)
Nature
, vol.362
, pp. 59-62
-
-
Rosen, D.R.1
Siddique, T.2
Patterson, D.3
Figlewicz, D.A.4
Sapp, P.5
Hentati, A.6
Donaldson, D.7
Goto, J.8
O'Regan, J.P.9
Deng, H.X.10
-
2
-
-
41149180753
-
TDP-43mutations in familial and sporadic amyotrophic lateral sclerosis
-
Sreedharan, J.; Blair, I. P.; Tripathi, V. B.; Hu, X.; Vance, C.; Rogelj, B.; Ackerley, S.; Durnall, J. C.; Williams, K. L.; Buratti, E.; Baralle, F.; de Belleroche, J.; Mitchell, J. D.; Leigh, P. N.; AlChalabi, A.; Miller, C. C.; Nicholson, G.; Shaw, C. E. TDP-43mutations in familial and sporadic amyotrophic lateral sclerosis. Science, 2008, 319 (5870), 1668-1672.
-
(2008)
Science
, vol.319
, Issue.5870
, pp. 1668-1672
-
-
Sreedharan, J.1
Blair, I.P.2
Tripathi, V.B.3
Hu, X.4
Vance, C.5
Rogelj, B.6
Ackerley, S.7
Durnall, J.C.8
Williams, K.L.9
Buratti, E.10
Baralle, F.11
de Belleroche, J.12
Mitchell, J.D.13
Leigh, P.N.14
Alchalabi, A.15
Miller, C.C.16
Nicholson, G.17
Shaw, C.E.18
-
3
-
-
61349162349
-
Mutations in FUS, anRNA processing protein, cause familial amyotrophic lateralsclerosis type 6
-
Vance, C.; Rogelj, B.; Hortobagyi, T.; De Vos, K. J.; Nishimura, A. L.; Sreedharan, J.; Hu, X.; Smith, B.; Ruddy, D.; Wright, P.; Ganesalingam, J.; Williams, K. L.; Tripathi, V.; Al Saraj, S.; AlChalabi, A.; Leigh, P. N.; Blair, I. P.; Nicholson, G.; de Belleroche, J.; Gallo, J. M.; Miller, C. C.; Shaw, C. E. Mutations in FUS, anRNA processing protein, cause familial amyotrophic lateralsclerosis type 6. Science, 2009, 323(5918), 1208-1211.
-
(2009)
Science
, vol.323
, Issue.5918
, pp. 1208-1211
-
-
Vance, C.1
Rogelj, B.2
Hortobagyi, T.3
de Vos, K.J.4
Nishimura, A.L.5
Sreedharan, J.6
Hu, X.7
Smith, B.8
Ruddy, D.9
Wright, P.10
Ganesalingam, J.11
Williams, K.L.12
Tripathi, V.13
Al Saraj, S.14
Alchalabi, A.15
Leigh, P.N.16
Blair, I.P.17
Nicholson, G.18
de Belleroche, J.19
Gallo, J.M.20
Miller, C.C.21
Shaw, C.E.22
more..
-
4
-
-
61349156118
-
Mutations in the FUS/TLS gene on chromosome 16 cause familialamyotrophic lateral sclerosis
-
Kwiatkowski, T. J., Jr.; Bosco, D. A.; LeClerc, A. L.; Tamrazian, E.; Vanderburg, C. R.; Russ, C.; Davis, A.; Gilchrist, J.; Kasarskis, E. J.; Munsat, T.; Valdmanis, P.; Rouleau, G. A.; Hosler, B. A.; Cortelli, P.; de Jong, P. J.; Yoshinaga, Y.; Haines, J. L.; Pericak-Vance, M. A.; Yan, J.; Ticozzi, N.; Siddique, T.; McKenna-Yasek, D.; Sapp, P. C.; Horvitz, H. R.; Landers, J. E.; Brown, R. H. Jr. Mutations in the FUS/TLS gene on chromosome 16 cause familialamyotrophic lateral sclerosis. Science, 2009, 323(5918), 1205-1208.
-
(2009)
Science
, vol.323
, Issue.5918
, pp. 1205-1208
-
-
Kwiatkowski Jr., T.J.1
Bosco, D.A.2
Leclerc, A.L.3
Tamrazian, E.4
Vanderburg, C.R.5
Uss, C.6
Davis, A.7
Gilchrist, J.8
Kasarskis, E.J.9
Munsat, T.10
Valdmanis, P.11
Rouleau, G.A.12
Hosler, B.A.13
Cortelli, P.14
de Jong, P.J.15
Yoshinaga, Y.16
Haines, J.L.17
Pericak-Vance, M.A.18
Yan, J.19
Ticozzi, N.20
Siddique, T.21
McKenna-Yasek, D.22
Sapp, P.C.23
Horvitz, H.R.24
Landers, J.E.25
Brown Jr., R.H.26
more..
-
5
-
-
0028284779
-
Motorneuron degeneration in mice that express a human Cu, Znsuperoxide dismutase mutation
-
Gurney, M. E.; Pu, H.; Chiu, A. Y.; Dal Canto, M. C.; Polchow, C. Y.; Alexander, D. D.; Caliendo, J.; Hentati, A.; Kwon, Y. W.; Deng, H. X.; Chen, W.; Zhai, P.; Sufit, R. L.; Siddique, T. Motorneuron degeneration in mice that express a human Cu, Znsuperoxide dismutase mutation. Science, 1994, 264(5166), 1772-1775.
-
(1994)
Science
, vol.264
, Issue.5166
, pp. 1772-1775
-
-
Gurney, M.E.1
Pu, H.2
Chiu, A.Y.3
Dal Canto, M.C.4
Polchow, C.Y.5
Alexander, D.D.6
Caliendo, J.7
Hentati, A.8
Kwon, Y.W.9
Deng, H.X.10
Chen, W.11
Zhai, P.12
Sufit, R.L.13
Siddique, T.14
-
6
-
-
0028888945
-
Transgenic mice expressing an altered murine superoxidedismutase gene provide an animal model of amyotrophic lateralsclerosis
-
Ripps, M. E.; Huntley, G. W.; Hof, P. R.; Morrison, J. H.; Gordon, J. W. Transgenic mice expressing an altered murine superoxidedismutase gene provide an animal model of amyotrophic lateralsclerosis. Proc. Natl. Acad. Sci. USA, 1995, 92(3), 689-693.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, Issue.3
, pp. 689-693
-
-
Ripps, M.E.1
Huntley, G.W.2
Hof, P.R.3
Morrison, J.H.4
Gordon, J.W.5
-
7
-
-
0035194691
-
Disease mechanisms revealed bytranscription profiling in SOD1-G93A transgenic mouse spinalcord
-
Olsen, M. K.; Roberds, S. L.; Ellerbrock, B. R.; Fleck, T. J.; McKinley, D. K.; Gurney, M. E. Disease mechanisms revealed bytranscription profiling in SOD1-G93A transgenic mouse spinalcord. Ann. Neurol., 2001, 50(6), 730-740.
-
(2001)
Ann. Neurol
, vol.50
, Issue.6
, pp. 730-740
-
-
Olsen, M.K.1
Roberds, S.L.2
Ellerbrock, B.R.3
Fleck, T.J.4
McKinley, D.K.5
Gurney, M.E.6
-
8
-
-
3042602991
-
Spinal cord molecular profilingprovides a better understanding of amyotrophic lateral sclerosispathogenesis
-
Malaspina, A.; de Belleroche, J. Spinal cord molecular profilingprovides a better understanding of amyotrophic lateral sclerosispathogenesis. Brain Res. Brain Res. Rev., 2004, 45(3), 213-229.
-
(2004)
Brain Res. Brain Res. Rev
, vol.45
, Issue.3
, pp. 213-229
-
-
Malaspina, A.1
de Belleroche, J.2
-
9
-
-
18744409323
-
Differentially expressed genes in sporadic amyotrophic lateralsclerosis spinal cords-screening by molecular indexing andsubsequent cDNA microarray analysis
-
Ishigaki, S.; Niwa, J.; Ando, Y.; Yoshihara, T.; Sawada, K.; Doyu, M.; Yamamoto, M.; Kato, K.; Yotsumoto, Y.; Sobue, G. Differentially expressed genes in sporadic amyotrophic lateralsclerosis spinal cords-screening by molecular indexing andsubsequent cDNA microarray analysis. FEBS Lett., 2002, 531(2), 354-358.
-
(2002)
FEBS Lett
, vol.531
, Issue.2
, pp. 354-358
-
-
Ishigaki, S.1
Niwa, J.2
Ando, Y.3
Yoshihara, T.4
Sawada, K.5
Doyu, M.6
Yamamoto, M.7
Kato, K.8
Yotsumoto, Y.9
Sobue, G.10
-
10
-
-
0036269810
-
Differential expression ofinflammation-and apoptosis-related genes in spinal cords of amutant SOD1 transgenic mouse model of familial amyotrophiclateral sclerosis
-
Yoshihara, T.; Ishigaki, S.; Yamamoto, M.; Liang, Y.; Niwa, J.; Takeuchi, H.; Doyu, M.; Sobue, G. Differential expression ofinflammation-and apoptosis-related genes in spinal cords of amutant SOD1 transgenic mouse model of familial amyotrophiclateral sclerosis. J. Neurochem., 2002, 80(1), 158-167.
-
(2002)
J. Neurochem
, vol.80
, Issue.1
, pp. 158-167
-
-
Yoshihara, T.1
Ishigaki, S.2
Yamamoto, M.3
Liang, Y.4
Niwa, J.5
Takeuchi, H.6
Doyu, M.7
Sobue, G.8
-
11
-
-
14544277978
-
Focus on deacetylation for the rapeutic benefit
-
Shabbeer, S.; Carducci, M. A. Focus on deacetylation for the rapeutic benefit. I Drugs, 2005, 8(2), 144-154.
-
(2005)
I Drugs
, vol.8
, Issue.2
, pp. 144-154
-
-
Shabbeer, S.1
Carducci, M.A.2
-
12
-
-
33746812188
-
Histone deacetylase enzymes as potentialdrug targets in cancer and parasitic diseases
-
Ouaissi, M.; Ouaissi, A. Histone deacetylase enzymes as potentialdrug targets in cancer and parasitic diseases. J. Biomed. Biotechnol., 2006, 2006(2), 13474.
-
(2006)
J. Biomed. Biotechnol
, vol.2006
, Issue.2
, pp. 13474
-
-
Ouaissi, M.1
Ouaissi, A.2
-
13
-
-
0013900616
-
RNA synthesis and histoneacetylation during the course of gene activation in lymphocytes
-
Pogo, B. G.; Allfrey, V. G.; Mirsky, A. E. RNA synthesis and histoneacetylation during the course of gene activation in lymphocytes. Proc. Natl. Acad. Sci. USA, 1966, 55(4), 805-812.
-
(1966)
Proc. Natl. Acad. Sci. USA
, vol.55
, Issue.4
, pp. 805-812
-
-
Pogo, B.G.1
Allfrey, V.G.2
Mirsky, A.E.3
-
14
-
-
0030798245
-
Histone acetylation in chromatin structure andtranscription
-
Grunstein, M. Histone acetylation in chromatin structure andtranscription. Nature, 1997, 389(6649), 349-352.
-
(1997)
Nature
, vol.389
, Issue.6649
, pp. 349-352
-
-
Grunstein, M.1
-
15
-
-
0034610367
-
Genomewide studies ofhistone deacetylase function in yeast
-
Bernstein, B. E.; Tong, J. K.; Schreiber, S. L. Genomewide studies ofhistone deacetylase function in yeast. Proc. Natl. Acad. Sci. USA, 2000, 97(25), 13708-13713.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, Issue.25
, pp. 13708-13713
-
-
Bernstein, B.E.1
Tong, J.K.2
Schreiber, S.L.3
-
16
-
-
0034676439
-
Deacetylation of p53modulates its effect on cell growth and apoptosis
-
Luo, J.; Su, F.; Chen, D.; Shiloh, A.; Gu, W. Deacetylation of p53modulates its effect on cell growth and apoptosis. Nature, 2000, 408(6810), 377-381.
-
(2000)
Nature
, vol.408
, Issue.6810
, pp. 377-381
-
-
Luo, J.1
Su, F.2
Chen, D.3
Shiloh, A.4
Gu, W.5
-
17
-
-
0035979737
-
Duration ofnuclear NF-kappaB action regulated by reversible acetylation
-
Chen, L.; Fischle, W.; Verdin, E.; Greene, W. C. Duration ofnuclear NF-kappaB action regulated by reversible acetylation. Science, 2001, 293(5535), 1653-1657.
-
(2001)
Science
, vol.293
, Issue.5535
, pp. 1653-1657
-
-
Chen, L.1
Fischle, W.2
Verdin, E.3
Greene, W.C.4
-
18
-
-
28044471827
-
Acetylation anddeacetylation of non-histone proteins
-
Glozak, M. A.; Sengupta, N.; Zhang, X.; Seto, E. Acetylation anddeacetylation of non-histone proteins. Gene, 2005, 363 15-23
-
(2005)
Gene
, vol.363
, pp. 15-23
-
-
Glozak, M.A.1
Sengupta, N.2
Zhang, X.3
Seto, E.4
-
19
-
-
33644946604
-
HATs and HDACs in neurodegeneration: Atale of disconcerted acetylation homeostasis
-
Saha, R. N.; Pahan, K. HATs and HDACs in neurodegeneration: atale of disconcerted acetylation homeostasis. Cell Death. Differ., 2006, 13(4), 539-550.
-
(2006)
Cell Death. Differ
, vol.13
, Issue.4
, pp. 539-550
-
-
Saha, R.N.1
Pahan, K.2
-
20
-
-
4143141116
-
Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy inneurological disorders
-
Rouaux, C.; Loeffler, J. P.; Boutillier, A. L. Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy inneurological disorders. Biochem. Pharmacol., 2004, 68(6), 1157-1164.
-
(2004)
Biochem. Pharmacol
, vol.68
, Issue.6
, pp. 1157-1164
-
-
Rouaux, C.1
Loeffler, J.P.2
Boutillier, A.L.3
-
21
-
-
0347624644
-
Critical loss of CBP/p300 histone acetylase activityby caspase-6 during neurodegeneration
-
Rouaux, C.; Jokic, N.; Mbebi, C.; Boutillier, S.; Loeffler, J. P.; Boutillier, A. L. Critical loss of CBP/p300 histone acetylase activityby caspase-6 during neurodegeneration. EMBO J., 2003, 22(24), 6537-6549.
-
(2003)
EMBO J
, vol.22
, Issue.24
, pp. 6537-6549
-
-
Rouaux, C.1
Jokic, N.2
Mbebi, C.3
Boutillier, S.4
Loeffler, J.P.5
Boutillier, A.L.6
-
22
-
-
0035504919
-
Polyglutamine expansion neurodegenerative disease
-
Fischbeck, K. H. Polyglutamine expansion neurodegenerative disease. Brain Res. Bull., 2001, 56(3-4), 161-163.
-
(2001)
Brain Res. Bull
, vol.56
, Issue.3-4
, pp. 161-163
-
-
Fischbeck, K.H.1
-
23
-
-
12944263711
-
The Huntington's disease protein interacts withp53 and CREB-binding protein and represses transcription
-
Steffan, J. S.; Kazantsev, A.; Spasic-Boskovic, O.; Greenwald, M.; Zhu, Y. Z.; Gohler, H.; Wanker, E. E.; Bates, G. P.; Housman, D. E.; Thompson, L. M. The Huntington's disease protein interacts withp53 and CREB-binding protein and represses transcription. Proc. Natl. Acad. Sci. USA, 2000, 97(12), 6763-6768.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, Issue.12
, pp. 6763-6768
-
-
Steffan, J.S.1
Kazantsev, A.2
Spasic-Boskovic, O.3
Greenwald, M.4
Zhu, Y.Z.5
Gohler, H.6
Wanker, E.E.7
Bates, G.P.8
Housman, D.E.9
Thompson, L.M.10
-
24
-
-
0034285017
-
CREB-binding protein sequestration by expanded polyglutamine
-
McCampbell, A.; Taylor, J. P.; Taye, A. A.; Robitschek, J.; Li, M.; Walcott, J.; Merry, D.; Chai, Y.; Paulson, H.; Sobue, G.; Fischbeck, K. H. CREB-binding protein sequestration by expandedpolyglutamine. Hum. Mol. Genet., 2000, 9(14), 2197-2202.
-
(2000)
Hum. Mol. Genet
, vol.9
, Issue.14
, pp. 2197-2202
-
-
McCampbell, A.1
Taylor, J.P.2
Taye, A.A.3
Robitschek, J.4
Li, M.5
Walcott, J.6
Merry, D.7
Chai, Y.8
Paulson, H.9
Sobue, G.10
Fischbeck, K.H.11
-
25
-
-
0037379709
-
Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5
-
Chawla, S.; Vanhoutte, P.; Arnold, F. J.; Huang, C. L.; Bading, H. Neuronal activity-dependent nucleocytoplasmic shuttling ofHDAC4 and HDAC5. J. Neurochem., 2003, 85(1), 151-159.
-
(2003)
J. Neurochem
, vol.85
, Issue.1
, pp. 151-159
-
-
Chawla, S.1
Vanhoutte, P.2
Arnold, F.J.3
Huang, C.L.4
Bading, H.5
-
26
-
-
0037067696
-
Cloning andfunctional characterization of HDAC11, a novel member of thehuman histone deacetylase family
-
Gao, L.; Cueto, M. A.; Asselbergs, F.; Atadja, P. Cloning andfunctional characterization of HDAC11, a novel member of thehuman histone deacetylase family. J. Biol. Chem., 2002, 277(28), 25748-25755.
-
(2002)
J. Biol. Chem
, vol.277
, Issue.28
, pp. 25748-25755
-
-
Gao, L.1
Cueto, M.A.2
Asselbergs, F.3
Atadja, P.4
-
27
-
-
1842578986
-
Molecular evolution ofthe histone deacetylase family: Functional implications ofphylogenetic analysis
-
Gregoretti, I. V.; Lee, Y. M.; Goodson, H. V. Molecular evolution ofthe histone deacetylase family: functional implications ofphylogenetic analysis. J. Mol. Biol., 2004, 338(1), 17-31.
-
(2004)
J. Mol. Biol
, vol.338
, Issue.1
, pp. 17-31
-
-
Gregoretti, I.V.1
Lee, Y.M.2
Goodson, H.V.3
-
28
-
-
34247130540
-
Distribution of histone deacetylases 1-11 in the ratbrain
-
Broide, R. S.; Redwine, J. M.; Aftahi, N.; Young, W.; Bloom, F. E.; Winrow, C. J. Distribution of histone deacetylases 1-11 in the ratbrain. J. Mol. Neurosci., 2007, 31(1), 47-58.
-
(2007)
J. Mol. Neurosci
, vol.31
, Issue.1
, pp. 47-58
-
-
Broide, R.S.1
Redwine, J.M.2
Aftahi, N.3
Young, W.4
Bloom, F.E.5
Winrow, C.J.6
-
29
-
-
0032582615
-
Neuronalapoptosis induced by histone deacetylase inhibitors
-
Salminen, A.; Tapiola, T.; Korhonen, P.; Suuronen, T. Neuronalapoptosis induced by histone deacetylase inhibitors. Brain Res. Mol. Brain Res., 1998, 61(1-2), 203-206.
-
(1998)
Brain Res. Mol. Brain Res
, vol.61
, Issue.1-2
, pp. 203-206
-
-
Salminen, A.1
Tapiola, T.2
Korhonen, P.3
Suuronen, T.4
-
30
-
-
68149159792
-
Analysis of neuroprotectiveeffects of valproic acid on primary motor neurons in monocultureor co-cultures with astrocytes or Schwann cells
-
Ragancokova, D.; Jahn, K.; Kotsiari, A.; Schlesinger, F.; Haastert, K.; Stangel, M.; Petri, S.; Krampfl, K. Analysis of neuroprotectiveeffects of valproic acid on primary motor neurons in monocultureor co-cultures with astrocytes or Schwann cells. Cell Mol. Neurobiol., 2009, 29(6-7), 1037-1043.
-
(2009)
Cell Mol. Neurobiol
, vol.29
, Issue.6-7
, pp. 1037-1043
-
-
Ragancokova, D.1
Jahn, K.2
Kotsiari, A.3
Schlesinger, F.4
Haastert, K.5
Stangel, M.6
Petri, S.7
Krampfl, K.8
-
31
-
-
63849206749
-
Histone deacetylaseinhibitors prevent p53-dependent and p53-independent Bax-mediated neuronal apoptosis through two distinct mechanisms
-
Uo, T.; Veenstra, T. D.; Morrison, R. S. Histone deacetylaseinhibitors prevent p53-dependent and p53-independent Bax-mediated neuronal apoptosis through two distinct mechanisms. J. Neurosci., 2009, 29(9), 2824-2832.
-
(2009)
J. Neurosci
, vol.29
, Issue.9
, pp. 2824-2832
-
-
Uo, T.1
Veenstra, T.D.2
Morrison, R.S.3
-
32
-
-
0842308109
-
Oxidative stress reduces histone deacetylase 2 activity andenhances IL-8 gene expression: Role of tyrosine nitration
-
Ito, K.; Hanazawa, T.; Tomita, K.; Barnes, P. J.; Adcock, I. M. Oxidative stress reduces histone deacetylase 2 activity andenhances IL-8 gene expression: role of tyrosine nitration. Biochem. Biophys. Res. Commun., 2004, 315(1), 240-245.
-
(2004)
Biochem. Biophys. Res. Commun
, vol.315
, Issue.1
, pp. 240-245
-
-
Ito, K.1
Hanazawa, T.2
Tomita, K.3
Barnes, P.J.4
Adcock, I.M.5
-
33
-
-
33749507982
-
Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors
-
Minetti, G. C.; Colussi, C.; Adami, R.; Serra, C.; Mozzetta, C.; Parente, V.; Fortuni, S.; Straino, S.; Sampaolesi, M.; Di Padova, M.; Illi, B.; Gallinari, P.; Steinkuhler, C.; Capogrossi, M. C.; Sartorelli, V.; Bottinelli, R.; Gaetano, C.; Puri, P. L. Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors. Nat. Med., 2006, 12(10), 1147-1150.
-
(2006)
Nat. Med
, vol.12
, Issue.10
, pp. 1147-1150
-
-
Minetti, G.C.1
Colussi, C.2
Adami, R.3
Serra, C.4
Mozzetta, C.5
Parente, V.6
Fortuni, S.7
Straino, S.8
Sampaolesi, M.9
Di Padova, M.10
Illi, B.11
Gallinari, P.12
Steinkuhler, C.13
Capogrossi, M.C.14
Sartorelli, V.15
Bottinelli, R.16
Gaetano, C.17
Puri, P.L.18
-
34
-
-
58049221125
-
HDAC2 blockade by nitric oxide andhistone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment
-
Colussi, C.; Mozzetta, C.; Gurtner, A.; Illi, B.; Rosati, J.; Straino, S.; Ragone, G.; Pescatori, M.; Zaccagnini, G.; Antonini, A.; Minetti, G.; Martelli, F.; Piaggio, G.; Gallinari, P.; Steinkuhler, C.; Clementi, E.; Dell'Aversana, C.; Altucci, L.; Mai, A.; Capogrossi, M. C.; Puri, P. L.; Gaetano, C. HDAC2 blockade by nitric oxide andhistone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment. Proc. Natl. Acad. Sci. USA, 2008, 105(49), 19183-19187.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, Issue.49
, pp. 19183-19187
-
-
Colussi, C.1
Mozzetta, C.2
Gurtner, A.3
Illi, B.4
Rosati, J.5
Straino, S.6
Ragone, G.7
Pescatori, M.8
Zaccagnini, G.9
Antonini, A.10
Minetti, G.11
Martelli, F.12
Piaggio, G.13
Gallinari, P.14
Steinkuhler, C.15
Clementi, E.16
Dell'Aversana, C.17
Altucci, L.18
Mai, A.19
Capogrossi, M.C.20
Puri, P.L.21
Gaetano, C.22
more..
-
35
-
-
34250183177
-
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
-
Pandey, U. B.; Nie, Z.; Batlevi, Y.; McCray, B. A.; Ritson, G. P.; Nedelsky, N. B.; Schwartz, S. L.; DiProspero, N. A.; Knight, M. A.; Schuldiner, O.; Padmanabhan, R.; Hild, M.; Berry, D. L.; Garza, D.; Hubbert, C. C.; Yao, T. P.; Baehrecke, E. H.; Taylor, J. P. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature, 2007, 447(7146), 859-863.
-
(2007)
Nature
, vol.447
, Issue.7146
, pp. 859-863
-
-
Pandey, U.B.1
Nie, Z.2
Batlevi, Y.3
McCray, B.A.4
Ritson, G.P.5
Nedelsky, N.B.6
Schwartz, S.L.7
Diprospero, N.A.8
Knight, M.A.9
Schuldiner, O.10
Padmanabhan, R.11
Hild, M.12
Berry, D.L.13
Garza, D.14
Hubbert, C.C.15
Yao, T.P.16
Baehrecke, E.H.17
Taylor, J.P.18
-
36
-
-
35948958216
-
HDAC6 atthe intersection of autophagy, the ubiquitin proteasome system and neurodegeneration
-
Pandey, U. B.; Batlevi, Y.; Baehrecke, E. H.; Taylor, J. P. HDAC6 atthe intersection of autophagy, the ubiquitin proteasome system and neurodegeneration. Autophagy, 2007, 3(6), 643-645.
-
(2007)
Autophagy
, vol.3
, Issue.6
, pp. 643-645
-
-
Pandey, U.B.1
Batlevi, Y.2
Baehrecke, E.H.3
Taylor, J.P.4
-
37
-
-
34047175919
-
Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington'sdisease by increasing tubulin acetylation
-
Dompierre, J. P.; Godin, J. D.; Charrin, B. C.; Cordelieres, F. P.; King, S. J.; Humbert, S.; Saudou, F. Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington'sdisease by increasing tubulin acetylation. J. Neurosci., 2007, 27(13), 3571-3583.
-
(2007)
J. Neurosci
, vol.27
, Issue.13
, pp. 3571-3583
-
-
Dompierre, J.P.1
Godin, J.D.2
Charrin, B.C.3
Cordelieres, F.P.4
King, S.J.5
Humbert, S.6
Saudou, F.7
-
38
-
-
73349143672
-
HDAC6 is atarget for protection and regeneration following injury in thenervous system
-
Rivieccio, M. A.; Brochier, C.; Willis, D. E.; Walker, B. A.; D'Annibale, M. A.; McLaughlin, K.; Siddiq, A.; Kozikowski, A. P.; Jaffrey, S. R.; Twiss, J. L.; Ratan, R. R.; Langley, B. HDAC6 is atarget for protection and regeneration following injury in thenervous system. Proc. Natl. Acad. Sci. USA, 2009, 106(46), 19599-19604.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, Issue.46
, pp. 19599-19604
-
-
Rivieccio, M.A.1
Brochier, C.2
Willis, D.E.3
Walker, B.A.4
D'Annibale, M.A.5
McLaughlin, K.6
Siddiq, A.7
Kozikowski, A.P.8
Jaffrey, S.R.9
Twiss, J.L.10
Ratan, R.R.11
Langley, B.12
-
39
-
-
75649135319
-
Knockdown of transactive response DNA-bindingprotein (TDP-43) downregulates histone deacetylase 6
-
Fiesel, F. C.; Voigt, A.; Weber, S. S.; Van den, H. C.; Waldenmaier, A.; Gorner, K.; Walter, M.; Anderson, M. L.; Kern, J. V.; Rasse, T. M.; Schmidt, T.; Springer, W.; Kirchner, R.; Bonin, M.; Neumann, M.; Baekelandt, V.; Alunni-Fabbroni, M.; Schulz, J. B.; Kahle, P. J. Knockdown of transactive response DNA-bindingprotein (TDP-43) downregulates histone deacetylase 6. EMBO J., 2010, 29(1), 209-221.
-
(2010)
EMBO J
, vol.29
, Issue.1
, pp. 209-221
-
-
Fiesel, F.C.1
Voigt, A.2
Weber, S.S.3
van Den, H.C.4
Waldenmaier, A.5
Gorner, K.6
Walter, M.7
Anderson, M.L.8
Kern, J.V.9
Rasse, T.M.10
Schmidt, T.11
Springer, W.12
Kirchner, R.13
Bonin, M.14
Neumann, M.15
Baekelandt, V.16
Alunni-Fabbroni, M.17
Schulz, J.B.18
Kahle, P.J.19
-
40
-
-
53249114029
-
Inhibition of specific HDACs andsirtuins suppresses pathogenesis in a Drosophila model ofHuntington's disease
-
Pallos, J.; Bodai, L.; Lukacsovich, T.; Purcell, J. M.; Steffan, J. S.; Thompson, L. M.; Marsh, J. L. Inhibition of specific HDACs andsirtuins suppresses pathogenesis in a Drosophila model ofHuntington's disease. Hum. Mol. Genet., 2008, 17(23), 3767-3775.
-
(2008)
Hum. Mol. Genet
, vol.17
, Issue.23
, pp. 3767-3775
-
-
Pallos, J.1
Bodai, L.2
Lukacsovich, T.3
Purcell, J.M.4
Steffan, J.S.5
Thompson, L.M.6
Marsh, J.L.7
-
41
-
-
26844518082
-
Intracellular trafficking of histonedeacetylase 4 regulates neuronal cell death
-
Bolger, T. A; Yao, T. P. Intracellular trafficking of histonedeacetylase 4 regulates neuronal cell death. J. Neurosci., 2005, 25(41), 9544-9553.
-
(2005)
J. Neurosci
, vol.25
, Issue.41
, pp. 9544-9553
-
-
Bolger, T.A.1
Yao, T.P.2
-
42
-
-
58749097964
-
Variants of theelongator protein 3 (ELP3) gene are associated with motor neurondegeneration
-
Simpson, C. L.; Lemmens, R.; Miskiewicz, K.; Broom, W. J.; Hansen, V. K.; van Vught, P. W.; Landers, J. E.; Sapp, P.; Van Den, B. L.; Knight, J.; Neale, B. M.; Turner, M. R.; Veldink, J. H.; Ophoff, R. A.; Tripathi, V. B.; Beleza, A.; Shah, M. N.; Proitsi, P.; VanHoecke, A.; Carmeliet, P.; Horvitz, H. R.; Leigh, P. N.; Shaw, C. E.; van den Berg, L. H.; Sham, P. C.; Powell, J. F.; Verstreken, P.; Brown, R. H., Jr.; Robberecht, W.; Al Chalabi, A. Variants of theelongator protein 3 (ELP3) gene are associated with motor neurondegeneration. Hum. Mol. Genet., 2009, 18(3), 472-481.
-
(2009)
Hum. Mol. Genet
, vol.18
, Issue.3
, pp. 472-481
-
-
Simpson, C.L.1
Lemmens, R.2
Miskiewicz, K.3
Broom, W.J.4
Hansen, V.K.5
van Vught, P.W.6
Landers, J.E.7
Sapp, P.8
van Den, B.L.9
Knight, J.10
Neale, B.M.11
Turner, M.R.12
Veldink, J.H.13
Ophoff, R.A.14
Tripathi, V.B.15
Beleza, A.16
Shah, M.N.17
Proitsi, P.18
Vanhoecke, A.19
Carmeliet, P.20
Horvitz, H.R.21
Leigh, P.N.22
Shaw, C.E.23
van den Berg, L.H.24
Sham, P.C.25
Powell, J.F.26
Verstreken, P.27
Brown Jr., R.H.28
Robberecht, W.29
Al Chalabi, A.30
more..
-
43
-
-
59349089711
-
Elongator controls themigration and differentiation of cortical neurons throughacetylation of alpha-tubulin
-
Creppe, C.; Malinouskaya, L.; Volvert, M. L.; Gillard, M.; Close, P.; Malaise, O.; Laguesse, S.; Cornez, I.; Rahmouni, S.; Ormenese, S.; Belachew, S.; Malgrange, B.; Chapelle, J. P.; Siebenlist, U.; Moonen, G.; Chariot, A.; Nguyen, L. Elongator controls themigration and differentiation of cortical neurons throughacetylation of alpha-tubulin. Cell, 2009, 136(3), 551-564.
-
(2009)
Cell
, vol.136
, Issue.3
, pp. 551-564
-
-
Creppe, C.1
Malinouskaya, L.2
Volvert, M.L.3
Gillard, M.4
Close, P.5
Malaise, O.6
Laguesse, S.7
Cornez, I.8
Rahmouni, S.9
Ormenese, S.10
Belachew, S.11
Malgrange, B.12
Chapelle, J.P.13
Siebenlist, U.14
Moonen, G.15
Chariot, A.16
Nguyen, L.17
-
44
-
-
38149116286
-
Pulse inhibition of histone deacetylases inducescomplete resistance to oxidative death in cortical neurons withouttoxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cellcycle-independent neuroprotection
-
Langley, B.; D'Annibale, M. A.; Suh, K.; Ayoub, I.; Tolhurst, A.; Bastan, B.; Yang, L.; Ko, B.; Fisher, M.; Cho, S.; Beal, M. F.; Ratan, R. R. Pulse inhibition of histone deacetylases inducescomplete resistance to oxidative death in cortical neurons withouttoxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cellcycle-independent neuroprotection. J. Neurosci., 2008, 28(1), 163-176.
-
(2008)
J. Neurosci
, vol.28
, Issue.1
, pp. 163-176
-
-
Langley, B.1
D'Annibale, M.A.2
Suh, K.3
Ayoub, I.4
Tolhurst, A.5
Bastan, B.6
Yang, L.7
Ko, B.8
Fisher, M.9
Cho, S.10
Beal, M.F.11
Ratan, R.R.12
-
45
-
-
19944431703
-
Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease
-
Gardian, G.; Browne, S. E.; Choi, D. K.; Klivenyi, P.; Gregorio, J.; Kubilus, J. K.; Ryu, H.; Langley, B.; Ratan, R. R.; Ferrante, R. J.; Beal, M. F. Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease. J. Biol. Chem., 2005, 280(1), 556-563.
-
(2005)
J. Biol. Chem
, vol.280
, Issue.1
, pp. 556-563
-
-
Gardian, G.1
Browne, S.E.2
Choi, D.K.3
Klivenyi, P.4
Gregorio, J.5
Kubilus, J.K.6
Ryu, H.7
Langley, B.8
Ratan, R.R.9
Ferrante, R.J.10
Beal, M.F.11
-
46
-
-
67649619244
-
Putting the 'HAT' backon survival signalling: The promises and challenges of HDAC inhibition in the treatment of neurological conditions
-
Sleiman, S. F.; Basso, M.; Mahishi, L.; Kozikowski, A. P.; Donohoe, M. E.; Langley, B.; Ratan, R. R. Putting the 'HAT' backon survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions. Expert Opin. Investig. Drugs, 2009, 18(5), 573-584.
-
(2009)
Expert Opin. Investig. Drugs
, vol.18
, Issue.5
, pp. 573-584
-
-
Sleiman, S.F.1
Basso, M.2
Mahishi, L.3
Kozikowski, A.P.4
Donohoe, M.E.5
Langley, B.6
Ratan, R.R.7
-
47
-
-
20844438031
-
Remodeling chromatin and stress resistance in the central nervous system: Histone deacetylase inhibitors as novel and broadly effective neuroprotective agents
-
Langley, B.; Gensert, J. M.; Beal, M. F.; Ratan, R. R. Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents. Curr. Drug Targets CNS Neurol. Disord., 2005, 4(1), 41-50.
-
(2005)
Curr. Drug Targets CNS Neurol. Disord
, vol.4
, Issue.1
, pp. 41-50
-
-
Langley, B.1
Gensert, J.M.2
Beal, M.F.3
Ratan, R.R.4
-
48
-
-
20144385858
-
Sodium phenylbutyrate prolongs survivaland regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice
-
Ryu, H.; Smith, K.; Camelo, S. I.; Carreras, I.; Lee, J.; Iglesias, A. H.; Dangond, F.; Cormier, K. A.; Cudkowicz, M. E.; Brown, R. H., Jr.; Ferrante, R. J. Sodium phenylbutyrate prolongs survivaland regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice. J. Neurochem., 2005, 93(5), 1087-1098.
-
(2005)
J. Neurochem
, vol.93
, Issue.5
, pp. 1087-1098
-
-
Ryu, H.1
Smith, K.2
Camelo, S.I.3
Carreras, I.4
Lee, J.5
Iglesias, A.H.6
Dangond, F.7
Cormier, K.A.8
Cudkowicz, M.E.9
Brown Jr., R.H.10
Ferrante, R.J.11
-
49
-
-
0033579301
-
Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons
-
Riccio, A.; Ahn, S.; Davenport, C. M.; Blendy, J. A.; Ginty, D. D. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science, 1999, 286(5448), 2358-2361.
-
(1999)
Science
, vol.286
, Issue.5448
, pp. 2358-2361
-
-
Riccio, A.1
Ahn, S.2
Davenport, C.M.3
Blendy, J.A.4
Ginty, D.D.5
-
50
-
-
0037593888
-
Redox regulationof cAMP-responsive element-binding protein and induction of manganous superoxide dismutase in nerve growth factor-dependentcell survival
-
Bedogni, B.; Pani, G.; Colavitti, R.; Riccio, A.; Borrello, S.; Murphy, M.; Smith, R.; Eboli, M. L.; Galeotti, T. Redox regulationof cAMP-responsive element-binding protein and induction of manganous superoxide dismutase in nerve growth factor-dependentcell survival. J. Biol. Chem., 2003, 278(19), 16510-16519.
-
(2003)
J. Biol. Chem
, vol.278
, Issue.19
, pp. 16510-16519
-
-
Bedogni, B.1
Pani, G.2
Colavitti, R.3
Riccio, A.4
Borrello, S.5
Murphy, M.6
Smith, R.7
Eboli, M.L.8
Galeotti, T.9
-
51
-
-
0345561544
-
Tumor necrosis factorinduces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons
-
Tamatani, M.; Che, Y. H.; Matsuzaki, H.; Ogawa, S.; Okado, H.; Miyake, S.; Mizuno, T.; Tohyama, M. Tumor necrosis factorinduces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons. J. Biol. Chem., 1999, 274(13), 8531-8538.
-
(1999)
J. Biol. Chem
, vol.274
, Issue.13
, pp. 8531-8538
-
-
Tamatani, M.1
Che, Y.H.2
Matsuzaki, H.3
Ogawa, S.4
Okado, H.5
Miyake, S.6
Mizuno, T.7
Tohyama, M.8
-
52
-
-
0027318190
-
Bcl-2 inhibits death of centralneural cells induced by multiple agents
-
Zhong, L. T.; Sarafian, T.; Kane, D. J.; Charles, A. C.; Mah, S. P.; Edwards, R. H.; Bredesen, D. E. bcl-2 inhibits death of centralneural cells induced by multiple agents. Proc. Natl. Acad. Sci. USA, 1993, 90(10), 4533-4537.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, Issue.10
, pp. 4533-4537
-
-
Zhong, L.T.1
Sarafian, T.2
Kane, D.J.3
Charles, A.C.4
Mah, S.P.5
Edwards, R.H.6
Bredesen, D.E.7
-
53
-
-
0031057656
-
Bcl-2 gene family in the nervoussystem
-
Merry, D. E.; Korsmeyer, S. J. Bcl-2 gene family in the nervoussystem. Annu. Rev. Neurosci., 1997, 20, 245-267.
-
(1997)
Annu. Rev. Neurosci
, vol.20
, pp. 245-267
-
-
Merry, D.E.1
Korsmeyer, S.J.2
-
54
-
-
0141506887
-
Valproic acidincreases the SMN2 protein level: A well-known drug as a potentialtherapy for spinal muscular atrophy
-
Brichta, L.; Hofmann, Y.; Hahnen, E.; Siebzehnrubl, F. A.; Raschke, H.; Blumcke, I.; Eyupoglu, I. Y.; Wirth, B. Valproic acidincreases the SMN2 protein level: a well-known drug as a potentialtherapy for spinal muscular atrophy. Hum. Mol. Genet., 2003, 12(19), 2481-2489.
-
(2003)
Hum. Mol. Genet
, vol.12
, Issue.19
, pp. 2481-2489
-
-
Brichta, L.1
Hofmann, Y.2
Hahnen, E.3
Siebzehnrubl, F.A.4
Raschke, H.5
Blumcke, I.6
Eyupoglu, I.Y.7
Wirth, B.8
-
55
-
-
10844284615
-
Benefit of valproic acid insuppressing disease progression of ALS model mice
-
Sugai, F.; Yamamoto, Y.; Miyaguchi, K.; Zhou, Z.; Sumi, H.; Hamasaki, T.; Goto, M.; Sakoda, S. Benefit of valproic acid insuppressing disease progression of ALS model mice. Eur. J. Neurosci., 2004, 20(11), 3179-3183.
-
(2004)
Eur. J. Neurosci
, vol.20
, Issue.11
, pp. 3179-3183
-
-
Sugai, F.1
Yamamoto, Y.2
Miyaguchi, K.3
Zhou, Z.4
Sumi, H.5
Hamasaki, T.6
Goto, M.7
Sakoda, S.8
-
56
-
-
33747083488
-
Valproate may improvestrength and function in patients with type III/IV spinal muscleatrophy
-
Weihl, C. C.; Connolly, A. M.; Pestronk, A. Valproate may improvestrength and function in patients with type III/IV spinal muscleatrophy. Neurology, 2006, 67(3), 500-501.
-
(2006)
Neurology
, vol.67
, Issue.3
, pp. 500-501
-
-
Weihl, C.C.1
Connolly, A.M.2
Pestronk, A.3
-
57
-
-
34250612194
-
Sodium valproate exerts neuroprotective effects invivo through CREB-binding protein-dependent mechanisms butdoes not improve survival in an amyotrophic lateral sclerosismouse model
-
Rouaux, C.; Panteleeva, I.; Rene, F.; Gonzalez de Aguilar, J. L.; Echaniz-Laguna, A.; Dupuis, L.; Menger, Y.; Boutillier, A. L.; Loeffler, J. P. Sodium valproate exerts neuroprotective effects invivo through CREB-binding protein-dependent mechanisms butdoes not improve survival in an amyotrophic lateral sclerosismouse model. J. Neurosci., 2007, 27(21), 5535-5545.
-
(2007)
J. Neurosci
, vol.27
, Issue.21
, pp. 5535-5545
-
-
Rouaux, C.1
Panteleeva, I.2
Rene, F.3
Gonzalez de Aguilar, J.L.4
Echaniz-Laguna, A.5
Dupuis, L.6
Menger, Y.7
Boutillier, A.L.8
Loeffler, J.P.9
-
58
-
-
41549136422
-
Paths of convergence: Sirtuins in aging and neurodegeneration
-
Gan, L.; Mucke, L. Paths of convergence: sirtuins in aging and neurodegeneration. Neuron, 2008, 58(1), 10-14.
-
(2008)
Neuron
, vol.58
, Issue.1
, pp. 10-14
-
-
Gan, L.1
Mucke, L.2
-
59
-
-
53249130741
-
Therapeutic application ofhistone deacetylase inhibitors for central nervous system disorders
-
Kazantsev, A. G.; Thompson, L. M. Therapeutic application ofhistone deacetylase inhibitors for central nervous system disorders. Nat. Rev. Drug Discov., 2008, 7(10), 854-868.
-
(2008)
Nat. Rev. Drug Discov
, vol.7
, Issue.10
, pp. 854-868
-
-
Kazantsev, A.G.1
Thompson, L.M.2
-
60
-
-
43749121572
-
Therapeutic role ofsirtuins in neurodegenerative disease
-
Outeiro, T. F.; Marques, O.; Kazantsev, A. Therapeutic role ofsirtuins in neurodegenerative disease. Biochim. Biophys. Acta, 2008, 1782(6), 363-369.
-
(2008)
Biochim. Biophys. Acta
, vol.1782
, Issue.6
, pp. 363-369
-
-
Outeiro, T.F.1
Marques, O.2
Kazantsev, A.3
-
61
-
-
0035913903
-
A. hSIR2(SIRT1) functions as anNAD-dependent p53 deacetylase
-
Vaziri, H.; Dessain, S. K.; Ng, E. E.; Imai, S. I.; Frye, R. A.; Pandita, T. K.; Guarente, L.; Weinberg, R. A. hSIR2(SIRT1) functions as anNAD-dependent p53 deacetylase. Cell, 2001, 107(2), 149-159.
-
(2001)
Cell
, vol.107
, Issue.2
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Ng, E.E.3
Imai, S.I.4
Frye, R.A.5
Pandita, T.K.6
Guarente, L.7
Weinberg, R.8
-
62
-
-
12144286529
-
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis
-
Cohen, H. Y.; Lavu, S.; Bitterman, K. J.; Hekking, B.; Imahiyerobo, T. A.; Miller, C.; Frye, R.; Ploegh, H.; Kessler, B. M.; Sinclair, D. A. Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol. Cell, 2004, 13(5), 627-638.
-
(2004)
Mol. Cell
, vol.13
, Issue.5
, pp. 627-638
-
-
Cohen, H.Y.1
Lavu, S.2
Bitterman, K.J.3
Hekking, B.4
Imahiyerobo, T.A.5
Miller, C.6
Frye, R.7
Ploegh, H.8
Kessler, B.M.9
Sinclair, D.A.10
-
63
-
-
36249016246
-
A therapeutic role forsirtuins in diseases of aging?
-
Westphal, C. H.; Dipp, M. A.; Guarente, L. A therapeutic role forsirtuins in diseases of aging? Trends Biochem. Sci., 2007, 32(12), 555-560.
-
(2007)
Trends Biochem. Sci
, vol.32
, Issue.12
, pp. 555-560
-
-
Westphal, C.H.1
Dipp, M.A.2
Guarente, L.3
-
64
-
-
0141526319
-
Differential regulation of the Sir2 histone deacetylase gene family by inhibitors of class I and II histone deacetylases
-
Kyrylenko, S.; Kyrylenko, O.; Suuronen, T.; Salminen, A. Differential regulation of the Sir2 histone deacetylase gene family by inhibitors of class I and II histone deacetylases. Cell Mol. LifeSci., 2003, 60(9), 1990-1997.
-
(2003)
Cell Mol. LifeSci
, vol.60
, Issue.9
, pp. 1990-1997
-
-
Kyrylenko, S.1
Kyrylenko, O.2
Suuronen, T.3
Salminen, A.4
-
65
-
-
0033214237
-
The SIR2/3/4 complexand SIR2 alone promote longevity in Saccharomyces cerevisiae bytwo different mechanisms
-
Kaeberlein, M.; McVey, M.; Guarente, L. The SIR2/3/4 complexand SIR2 alone promote longevity in Saccharomyces cerevisiae bytwo different mechanisms. Genes Dev., 1999, 13(19), 2570-2580.
-
(1999)
Genes Dev
, vol.13
, Issue.19
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
66
-
-
34447308268
-
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer'sdisease and amyotrophic lateral sclerosis
-
Kim, D.; Nguyen, M. D.; Dobbin, M. M.; Fischer, A.; Sananbenesi, F.; Rodgers, J. T.; Delalle, I.; Baur, J. A.; Sui, G.; Armour, S. M.; Puigserver, P.; Sinclair, D. A.; Tsai, L. H. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer'sdisease and amyotrophic lateral sclerosis. EMBO J., 2007, 26(13), 3169-3179.
-
(2007)
EMBO J
, vol.26
, Issue.13
, pp. 3169-3179
-
-
Kim, D.1
Nguyen, M.D.2
Dobbin, M.M.3
Fischer, A.4
Sananbenesi, F.5
Rodgers, J.T.6
Delalle, I.7
Baur, J.A.8
Sui, G.9
Armour, S.M.10
Puigserver, P.11
Sinclair, D.A.12
Tsai, L.H.13
-
67
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducingthe SIRT1 deacetylase
-
Cohen, H. Y.; Miller, C.; Bitterman, K. J.; Wall, N. R.; Hekking, B.; Kessler, B.; Howitz, K. T.; Gorospe, M.; de Cabo, R.; Sinclair, D. A. Calorie restriction promotes mammalian cell survival by inducingthe SIRT1 deacetylase. Science, 2004, 305(5682), 390-392.
-
(2004)
Science
, vol.305
, Issue.5682
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
Wall, N.R.4
Hekking, B.5
Kessler, B.6
Howitz, K.T.7
Gorospe, M.8
de Cabo, R.9
Sinclair, D.A.10
-
68
-
-
0033606410
-
No benefit of dietary restriction ondisease onset or progression in amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase mutant mice
-
Pedersen, W. A.; Mattson, M. P. No benefit of dietary restriction ondisease onset or progression in amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase mutant mice. Brain Res., 1999, 833(1), 117-120.
-
(1999)
Brain Res
, vol.833
, Issue.1
, pp. 117-120
-
-
Pedersen, W.A.1
Mattson, M.P.2
-
69
-
-
14544282413
-
Nutrient control of glucose homeostasis through acomplex of PGC-1alpha and SIRT1
-
Rodgers, J. T.; Lerin, C.; Haas, W.; Gygi, S. P.; Spiegelman, B. M.; Puigserver, P. Nutrient control of glucose homeostasis through acomplex of PGC-1alpha and SIRT1. Nature, 2005, 434(7029), 113-118.
-
(2005)
Nature
, vol.434
, Issue.7029
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
Puigserver, P.6
-
70
-
-
33845399894
-
Resveratrolimproves mitochondrial function and protects against metabolicdisease by activating SIRT1 and PGC-1alpha
-
Lagouge, M.; Argmann, C.; Gerhart-Hines, Z.; Meziane, H.; Lerin, C.; Daussin, F.; Messadeq, N.; Milne, J.; Lambert, P.; Elliott, P.; Geny, B.; Laakso, M., Puigserver, P.; Auwerx, J. Resveratrolimproves mitochondrial function and protects against metabolicdisease by activating SIRT1 and PGC-1alpha. Cell, 2006, 127(6), 1109-1122.
-
(2006)
Cell
, vol.127
, Issue.6
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
Geny, B.11
Laakso, M.12
Puigserver, P.13
Auwerx, J.14
-
71
-
-
34547914840
-
Sirtuins: The 'magnificent seven', function, metabolism and longevity
-
Dali-Youcef, N.; Lagouge, M.; Froelich, S.; Koehl, C.; Schoonjans, K.; Auwerx, J. Sirtuins: the 'magnificent seven', function, metabolism and longevity. Ann. Med., 2007, 39(5), 335-345.
-
(2007)
Ann. Med
, vol.39
, Issue.5
, pp. 335-345
-
-
Dali-Youcef, N.1
Lagouge, M.2
Froelich, S.3
Koehl, C.4
Schoonjans, K.5
Auwerx, J.6
-
72
-
-
33244486764
-
Sirt1 regulates insulinsecretion by repressing UCP2 in pancreatic beta cells
-
Bordone, L.; Motta, M. C.; Picard, F.; Robinson, A.; Jhala, U. S.; Apfeld, J.; McDonagh, T.; Lemieux, M.; McBurney, M.; Szilvasi, A., Easlon, E. J.; Lin, S. J., Guarente, L. Sirt1 regulates insulinsecretion by repressing UCP2 in pancreatic beta cells. PLoS Biol., 2006, 4(2), e31.
-
(2006)
PLoS Biol
, vol.4
, Issue.2
-
-
Bordone, L.1
Motta, M.C.2
Picard, F.3
Robinson, A.4
Jhala, U.S.5
Apfeld, J.6
McDonagh, T.7
Lemieux, M.8
McBurney, M.9
Szilvasi, A.10
Easlon, E.J.11
Lin, S.J.12
Guarente, L.13
-
73
-
-
58149339917
-
Opposingeffects of sirtuins on neuronal survival: SIRT1-mediatedneuroprotection is independent of its deacetylase activity
-
Pfister, J. A.; Ma, C.; Morrison, B. E.; D'Mello, S. R. Opposingeffects of sirtuins on neuronal survival: SIRT1-mediatedneuroprotection is independent of its deacetylase activity. PLoSOne, 2008, 3(12), e4090.
-
(2008)
PLoSOne
, vol.3
, Issue.12
-
-
Pfister, J.A.1
Ma, C.2
Morrison, B.E.3
D'Mello, S.R.4
-
74
-
-
4043165678
-
Increased nuclear NADbiosynthesis and SIRT1 activation prevent axonal degeneration
-
Araki, T.; Sasaki, Y.; Milbrandt, J. Increased nuclear NADbiosynthesis and SIRT1 activation prevent axonal degeneration. Science, 2004, 305(5686), 1010-1013.
-
(2004)
Science
, vol.305
, Issue.5686
, pp. 1010-1013
-
-
Araki, T.1
Sasaki, Y.2
Milbrandt, J.3
-
75
-
-
16844375290
-
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
-
Parker, J. A.; Arango, M.; Abderrahmane, S.; Lambert, E.; Tourette, C.; Catoire, H.; Neri, C. Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat. Genet., 2005, 37(4), 349-350.
-
(2005)
Nat. Genet
, vol.37
, Issue.4
, pp. 349-350
-
-
Parker, J.A.1
Arango, M.2
Abderrahmane, S.3
Lambert, E.4
Tourette, C.5
Catoire, H.6
Neri, C.7
-
76
-
-
64049092736
-
Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease
-
Julien, C.; Tremblay, C.; Emond, V.; Lebbadi, M.; Salem, N. Jr.; Bennett, D. A.; Calon, F. Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J. Neuropathol. Exp. Neurol., 2009, 68(1), 48-58.
-
(2009)
J. Neuropathol. Exp. Neurol
, vol.68
, Issue.1
, pp. 48-58
-
-
Julien, C.1
Tremblay, C.2
Emond, V.3
Lebbadi, M.4
Salem Jr., N.5
Bennett, D.A.6
Calon, F.7
-
77
-
-
45549096918
-
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
-
Li, Y.; Xu, W.; McBurney, M. W.; Longo, V. D. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab., 2008, 8(1), 38-48.
-
(2008)
Cell Metab
, vol.8
, Issue.1
, pp. 38-48
-
-
Li, Y.1
Xu, W.2
McBurney, M.W.3
Longo, V.D.4
-
78
-
-
5744248243
-
Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases
-
Ghosh, S.; Feany, M. B. Comparison of pathways controllingtoxicity in the eye and brain in Drosophila models of human neurodegenerative diseases. Hum. Mol. Genet., 2004, 13(18), 2011-2018.
-
(2004)
Hum. Mol. Genet
, vol.13
, Issue.18
, pp. 2011-2018
-
-
Ghosh, S.1
Feany, M.B.2
-
79
-
-
0037405043
-
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle
-
Dryden, S. C.; Nahhas, F. A.; Nowak, J. E.; Goustin, A. S.; Tainsky, M. A. Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol. Cell Biol., 2003, 23(9), 3173-3185.
-
(2003)
Mol. Cell Biol
, vol.23
, Issue.9
, pp. 3173-3185
-
-
Dryden, S.C.1
Nahhas, F.A.2
Nowak, J.E.3
Goustin, A.S.4
Tainsky, M.A.5
-
80
-
-
39149122568
-
Interphase nucleo-cytoplasmic shuttling andlocalization of SIRT2 during mitosis
-
North, B. J.; Verdin, E. Interphase nucleo-cytoplasmic shuttling andlocalization of SIRT2 during mitosis. PLoS One, 2007, 2(8), e784.
-
(2007)
PLoS One
, vol.2
, Issue.8
-
-
North, B.J.1
Verdin, E.2
-
81
-
-
34250848194
-
Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: A crucial role of tubulin deacetylation
-
Suzuki, K.; Koike, T. Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slowWallerian degeneration mice: a crucial role of tubulin deacetylation. Neuroscience, 2007, 147(3), 599-612.
-
(2007)
Neuroscience
, vol.147
, Issue.3
, pp. 599-612
-
-
Suzuki, K.1
Koike, T.2
-
82
-
-
34547599329
-
Sirtuin 2 inhibitors rescuealpha-synuclein-mediated toxicity in models of Parkinson's disease
-
Outeiro, T. F.; Kontopoulos, E.; Altmann, S. M.; Kufareva, I.; Strathearn, K. E.; Amore, A. M.; Volk, C. B.; Maxwell, M. M.; Rochet, J. C.; McLean, P. J.; Young, A. B.; Abagyan, R.; Feany, M. B.; Hyman, B. T.; Kazantsev, A. G. Sirtuin 2 inhibitors rescuealpha-synuclein-mediated toxicity in models of Parkinson's disease. Science, 2007, 317(5837), 516-519.
-
(2007)
Science
, vol.317
, Issue.5837
, pp. 516-519
-
-
Outeiro, T.F.1
Kontopoulos, E.2
Altmann, S.M.3
Kufareva, I.4
Strathearn, K.E.5
Amore, A.M.6
Volk, C.B.7
Maxwell, M.M.8
Rochet, J.C.9
McLean, P.J.10
Young, A.B.11
Abagyan, R.12
Feany, M.B.13
Hyman, B.T.14
Kazantsev, A.G.15
-
83
-
-
17144424946
-
SIRT3, a mitochondrialsirtuin deacetylase, regulates mitochondrial function andthermogenesis in brown adipocytes
-
Shi, T.; Wang, F.; Stieren, E.; Tong, Q. SIRT3, a mitochondrialsirtuin deacetylase, regulates mitochondrial function andthermogenesis in brown adipocytes. J. Biol. Chem., 2005, 280(14), 13560-13567.
-
(2005)
J. Biol. Chem
, vol.280
, Issue.14
, pp. 13560-13567
-
-
Shi, T.1
Wang, F.2
Stieren, E.3
Tong, Q.4
-
84
-
-
31044445366
-
Genomic instability and aging-likephenotype in the absence of mammalian SIRT6
-
Mostoslavsky, R.; Chua, K. F.; Lombard, D. B.; Pang, W. W.; Fischer, M. R.; Gellon, L.; Liu, P.; Mostoslavsky, G.; Franco, S.; Murphy, M. M.; Mills, K. D.; Patel, P.; Hsu, J. T.; Hong, A. L.; Ford, E.; Cheng, H. L.; Kennedy, C.; Nunez, N.; Bronson, R.; Frendewey, D.; Auerbach, W.; Valenzuela, D.; Karow, M.; Hottiger, M. O.; Hursting, S.; Barrett, J. C.; Guarente, L.; Mulligan, R.; Demple, B.; Yancopoulos, G. D.; Alt, F. W. Genomic instability and aging-likephenotype in the absence of mammalian SIRT6. Cell, 2006, 124(2), 315-329.
-
(2006)
Cell
, vol.124
, Issue.2
, pp. 315-329
-
-
Mostoslavsky, R.1
Chua, K.F.2
Lombard, D.B.3
Pang, W.W.4
Fischer, M.R.5
Gellon, L.6
Liu, P.7
Mostoslavsky, G.8
Franco, S.9
Murphy, M.M.10
Mills, K.D.11
Patel, P.12
Hsu, J.T.13
Hong, A.L.14
Ford, E.15
Cheng, H.L.16
Kennedy, C.17
Nunez, N.18
Bronson, R.19
Frendewey, D.20
Auerbach, W.21
Valenzuela, D.22
Karow, M.23
Hottiger, M.O.24
Hursting, S.25
Barrett, J.C.26
Guarente, L.27
Mulligan, R.28
Demple, B.29
Yancopoulos, G.D.30
Alt, F.W.31
more..
|