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Volumn 18, Issue 7, 2010, Pages 1383-1392

Fine-mapping of obesity-related quantitative trait loci in an F 9/10 advanced intercross line

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BREEDING; CHROMOSOME MAP; DISEASE MODEL; FEMALE; GENETIC EPISTASIS; GENETICS; GENOME; HYBRIDIZATION; MALE; METHODOLOGY; MOUSE; OBESITY; QUANTITATIVE TRAIT LOCUS; SEXUAL DEVELOPMENT; EPISTASIS; PROCEDURES;

EID: 77954144468     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2009.411     Document Type: Article
Times cited : (25)

References (50)
  • 2
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995;11:241-247.
    • (1995) Nat Genet , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 4
    • 0029089898 scopus 로고
    • The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7
    • Green ED, Maffei M, Braden VV et al. The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Res 1995;5:5-12.
    • (1995) Genome Res , vol.5 , pp. 5-12
    • Green, E.D.1    Maffei, M.2    Braden, V.V.3
  • 5
    • 0030006511 scopus 로고    scopus 로고
    • Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human
    • Chung WK, Power-Kehoe L, Chua M, Leibel RL. Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human. Genome Res 1996;6:431-438.
    • (1996) Genome Res , vol.6 , pp. 431-438
    • Chung, W.K.1    Power-Kehoe, L.2    Chua, M.3    Leibel, R.L.4
  • 6
    • 0030740803 scopus 로고    scopus 로고
    • Molecular screening of the human melanocortin-4 receptor gene: Identification of a missense variant showing no association with obesity, plasma glucose, or insulin
    • Gotoda T, Scott J, Aitman TJ. Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, or insulin. Diabetologia 1997;40:976-979.
    • (1997) Diabetologia , vol.40 , pp. 976-979
    • Gotoda, T.1    Scott, J.2    Aitman, T.J.3
  • 7
    • 0033772073 scopus 로고    scopus 로고
    • Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
    • Horikawa Y, Oda N, Cox NJ et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 2000;26:163-175.
    • (2000) Nat Genet , vol.26 , pp. 163-175
    • Horikawa, Y.1    Oda, N.2    Cox, N.J.3
  • 8
    • 15944371462 scopus 로고    scopus 로고
    • ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes
    • Abate N, Chandalia M, Satija P et al. ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes. Diabetes 2005;54: 1207-1213.
    • (2005) Diabetes , vol.54 , pp. 1207-1213
    • Abate, N.1    Chandalia, M.2    Satija, P.3
  • 9
    • 0347354997 scopus 로고    scopus 로고
    • The SLC6A14 gene shows evidence of association with obesity
    • Suviolahti E, Oksanen LJ, Ohman M et al. The SLC6A14 gene shows evidence of association with obesity. J Clin Invest 2003;112:1762-1772.
    • (2003) J Clin Invest , vol.112 , pp. 1762-1772
    • Suviolahti, E.1    Oksanen, L.J.2    Ohman, M.3
  • 10
    • 2642512097 scopus 로고    scopus 로고
    • GAD2 on chromosome 10p12 is a candidate gene for human obesity
    • Boutin P, Dina C, Vasseur F et al. GAD2 on chromosome 10p12 is a candidate gene for human obesity. PLoS Biol 2003;1:E68.
    • (2003) PLoS Biol , vol.1
    • Boutin, P.1    Dina, C.2    Vasseur, F.3
  • 12
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • Frayling TM, Timpson NJ, Weedon MN et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-894.
    • (2007) Science , vol.316 , pp. 889-894
    • Frayling, T.M.1    Timpson, N.J.2    Weedon, M.N.3
  • 13
    • 34547625955 scopus 로고    scopus 로고
    • Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    • Scuteri A, Sanna S, Chen WM et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007;3:e115.
    • (2007) PLoS Genet , vol.3
    • Scuteri, A.1    Sanna, S.2    Chen, W.M.3
  • 14
    • 36248986199 scopus 로고    scopus 로고
    • Association of single-nucleotide polymorphisms in MTMR9 gene with obesity
    • Yanagiya T, Tanabe A, Iida A et al. Association of single-nucleotide polymorphisms in MTMR9 gene with obesity. Hum Mol Genet 2007;16:3017-3026.
    • (2007) Hum Mol Genet , vol.16 , pp. 3017-3026
    • Yanagiya, T.1    Tanabe, A.2    Iida, A.3
  • 15
    • 33645825830 scopus 로고    scopus 로고
    • A common genetic variant is associated with adult and childhood obesity
    • Herbert A, Gerry N P, McQueen MB et al. A common genetic variant is associated with adult and childhood obesity. Science 2006;312:279-283.
    • (2006) Science , vol.312 , pp. 279-283
    • Herbert, A.1    Gerry, N.P.2    McQueen, M.B.3
  • 17
    • 34249826350 scopus 로고    scopus 로고
    • Multiple-trait QTL mapping for body and organ weights in a cross between NMRI8 and DBA/2 mice
    • Neuschl C, Brockmann GA, Knott SA. Multiple-trait QTL mapping for body and organ weights in a cross between NMRI8 and DBA/2 mice. Genet Res 2007;89:47-59.
    • (2007) Genet Res , vol.89 , pp. 47-59
    • Neuschl, C.1    Brockmann, G.A.2    Knott, S.A.3
  • 18
    • 48749098611 scopus 로고    scopus 로고
    • Genetic architecture of adiposity and organ weight using combined generation QTL analysis
    • Fawcett GL, Roseman CC, Jarvis JP et al. Genetic architecture of adiposity and organ weight using combined generation QTL analysis. Obesity (Silver Spring) 2008;16:1861-1868.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 1861-1868
    • Fawcett, G.L.1    Roseman, C.C.2    Jarvis, J.P.3
  • 19
    • 44449110588 scopus 로고    scopus 로고
    • Identification of quantitative trait loci affecting murine long bone length in a two-generation intercross of LG/J and SM/J Mice
    • Norgard EA, Roseman CC, Fawcett GL et al. Identification of quantitative trait loci affecting murine long bone length in a two-generation intercross of LG/J and SM/J Mice. J Bone Miner Res 2008;23:887-895.
    • (2008) J Bone Miner Res , vol.23 , pp. 887-895
    • Norgard, E.A.1    Roseman, C.C.2    Fawcett, G.L.3
  • 20
    • 46249115442 scopus 로고    scopus 로고
    • Genome-wide analysis reveals a complex pattern of genomic imprinting in mice
    • Wolf JB, Cheverud JM, Roseman C, Hager R. Genome-wide analysis reveals a complex pattern of genomic imprinting in mice. PLoS Genet 2008;4:e1000091.
    • (2008) PLoS Genet , vol.4
    • Wolf, J.B.1    Cheverud, J.M.2    Roseman, C.3    Hager, R.4
  • 21
    • 58649110845 scopus 로고    scopus 로고
    • Genetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight, or both
    • Brockmann GA, Tsaih SW, Neuschl C, Churchill GA, Li R. Genetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight, or both. Physiol Genomics 2009;36:114-126.
    • (2009) Physiol Genomics , vol.36 , pp. 114-126
    • Brockmann, G.A.1    Tsaih, S.W.2    Neuschl, C.3    Churchill, G.A.4    Li, R.5
  • 22
    • 0035145192 scopus 로고    scopus 로고
    • Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice
    • Cheverud JM, Vaughn TT, Pletscher LS et al. Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice. Mamm Genome 2001;12:3-12.
    • (2001) Mamm Genome , vol.12 , pp. 3-12
    • Cheverud, J.M.1    Vaughn, T.T.2    Pletscher, L.S.3
  • 24
    • 20044390391 scopus 로고    scopus 로고
    • Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of obesity
    • Ehrich TH, Hrbek T, Kenney-Hunt JP et al. Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of obesity. Diabetes 2005;54:1863-1872.
    • (2005) Diabetes , vol.54 , pp. 1863-1872
    • Ehrich, T.H.1    Hrbek, T.2    Kenney-Hunt, J.P.3
  • 25
    • 24644458568 scopus 로고    scopus 로고
    • Genetic variation and correlation of dietary response in an advanced intercross mouse line produced from two divergent growth lines
    • Ehrich TH, Kenney-Hunt J P, Pletscher LS, Cheverud JM. Genetic variation and correlation of dietary response in an advanced intercross mouse line produced from two divergent growth lines. Genet Res 2005;85:211-222.
    • (2005) Genet Res , vol.85 , pp. 211-222
    • Ehrich, T.H.1    Kenney-Hunt, J.P.2    Pletscher, L.S.3    Cheverud, J.M.4
  • 26
    • 0033394504 scopus 로고    scopus 로고
    • Mapping quantitative trait loci for murine growth: A closer look at genetic architecture
    • Vaughn TT, Pletscher LS, Peripato A et al. Mapping quantitative trait loci for murine growth: a closer look at genetic architecture. Genet Res 1999;74:313-322.
    • (1999) Genet Res , vol.74 , pp. 313-322
    • Vaughn, T.T.1    Pletscher, L.S.2    Peripato, A.3
  • 27
    • 9444270960 scopus 로고    scopus 로고
    • Quantitative trait loci for obesity-and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains
    • Cheverud JM, Ehrich TH, Hrbek T et al. Quantitative trait loci for obesity-and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes 2004;53:3328-3336.
    • (2004) Diabetes , vol.53 , pp. 3328-3336
    • Cheverud, J.M.1    Ehrich, T.H.2    Hrbek, T.3
  • 28
    • 33745206959 scopus 로고    scopus 로고
    • Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the inter-cross of SM/J and LG/J inbred mouse strains
    • Hrbek T, de Brito RA, Wang B, Pletscher LS, Cheverud JM. Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the inter-cross of SM/J and LG/J inbred mouse strains. Mamm Genome 2006;17:417-429.
    • (2006) Mamm Genome , vol.17 , pp. 417-429
    • Hrbek, T.1    De Brito, R.A.2    Wang, B.3    Pletscher, L.S.4    Cheverud, J.M.5
  • 29
    • 0028909487 scopus 로고
    • Epistasis and its contribution to genetic variance components
    • Cheverud JM, Routman EJ. Epistasis and its contribution to genetic variance components. Genetics 1995;139:1455-1461.
    • (1995) Genetics , vol.139 , pp. 1455-1461
    • Cheverud, J.M.1    Routman, E.J.2
  • 30
    • 0031715122 scopus 로고    scopus 로고
    • Genetic variation in body weight gain and composition in the intercross of Large (LG/J) and Small (SM/J) inbred strains of mice
    • Kramer M, Vaughn TT, Pletscher LS et al. Genetic variation in body weight gain and composition in the intercross of Large (LG/J) and Small (SM/J) inbred strains of mice. Genet Mol Biol 1998;21:211-218.
    • (1998) Genet Mol Biol , vol.21 , pp. 211-218
    • Kramer, M.1    Vaughn, T.T.2    Pletscher, L.S.3
  • 33
    • 0026470910 scopus 로고
    • Maximum likelihood mapping of quantitative trait loci using full-sib families
    • Knott SA, Haley CS. Maximum likelihood mapping of quantitative trait loci using full-sib families. Genetics 1992;132:1211-1222.
    • (1992) Genetics , vol.132 , pp. 1211-1222
    • Knott, S.A.1    Haley, C.S.2
  • 35
    • 33646942472 scopus 로고
    • A simple regression method for mapping quantitative trait loci in line crosses using flanking markers
    • Haley CS, Knott SA. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 1992;69:315-324.
    • (1992) Heredity , vol.69 , pp. 315-324
    • Haley, C.S.1    Knott, S.A.2
  • 36
    • 0034781050 scopus 로고    scopus 로고
    • A simple correction for multiple comparisons in interval mapping genome scans
    • Cheverud J. A simple correction for multiple comparisons in interval mapping genome scans. Heredity 2001;87:52-58.
    • (2001) Heredity , vol.87 , pp. 52-58
    • Cheverud, J.1
  • 37
    • 30744434862 scopus 로고    scopus 로고
    • Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix
    • Li J, Ji L. Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity 2005;95:221-227.
    • (2005) Heredity , vol.95 , pp. 221-227
    • Li, J.1    Ji, L.2
  • 38
    • 44449138056 scopus 로고    scopus 로고
    • Pleiotropic patterns of quantitative trait loci for 70 murine skeletal traits
    • Kenney-Hunt J P, Wang B, Norgard EA et al. Pleiotropic patterns of quantitative trait loci for 70 murine skeletal traits. Genetics 2008;178: 2275-2288.
    • (2008) Genetics , vol.178 , pp. 2275-2288
    • Kenney-Hunt, J.P.1    Wang, B.2    Norgard, E.A.3
  • 39
    • 41349102014 scopus 로고    scopus 로고
    • Pleiotropic scaling of gene effects and the 'cost of complexity'
    • Wagner G P, Kenney-Hunt J P, Pavlicev M et al. Pleiotropic scaling of gene effects and the 'cost of complexity'. Nature 2008;452:470-472.
    • (2008) Nature , vol.452 , pp. 470-472
    • Wagner, G.P.1    Kenney-Hunt, J.P.2    Pavlicev, M.3
  • 40
    • 67650447975 scopus 로고    scopus 로고
    • Epistasis and the evolutionary dynamics of measured genotypic values during simulated serial bottlenecks
    • Jarvis J P, Cheverud JM. Epistasis and the evolutionary dynamics of measured genotypic values during simulated serial bottlenecks. J Evol Biol 2009;22:1658-1668.
    • (2009) J Evol Biol , vol.22 , pp. 1658-1668
    • Jarvis, J.P.1    Cheverud, J.M.2
  • 41
    • 33745186461 scopus 로고    scopus 로고
    • Quantitative trait loci for body size components in mice
    • Kenney-Hunt J P, Vaughn TT, Pletscher LS et al. Quantitative trait loci for body size components in mice. Mamm Genome 2006;17:526-537.
    • (2006) Mamm Genome , vol.17 , pp. 526-537
    • Kenney-Hunt, J.P.1    Vaughn, T.T.2    Pletscher, L.S.3
  • 42
    • 0002348364 scopus 로고
    • The power and deceit of QTL experiments: Lessons from comparative QTL studies
    • Beavis W. The power and deceit of QTL experiments: lessons from comparative QTL studies. Proc Corn Sorghum Ind Res Conf 1994;49: 250-266.
    • (1994) Proc Corn Sorghum Ind Res Conf , vol.49 , pp. 250-266
    • Beavis, W.1
  • 43
    • 33846519286 scopus 로고    scopus 로고
    • Fine mapping reveals sex bias in quantitative trait loci affecting growth, skeletal size and obesity-related traits on mouse chromosomes 2 and 11
    • Farber CR, Medrano J F. Fine mapping reveals sex bias in quantitative trait loci affecting growth, skeletal size and obesity-related traits on mouse chromosomes 2 and 11. Genetics 2007;175:349-360.
    • (2007) Genetics , vol.175 , pp. 349-360
    • Farber, C.R.1    Medrano, J.F.2
  • 44
    • 47249116535 scopus 로고    scopus 로고
    • Candidate genes for obesity revealed from a C57BL/6J x 129S1/SvlmJ intercross
    • Su Z, Korstanje R, Tsaih S-W, Paigen B. Candidate genes for obesity revealed from a C57BL/6J x 129S1/SvlmJ intercross. Int J Obes 2008;32:1180-1189.
    • (2008) Int J Obes , vol.32 , pp. 1180-1189
    • Su, Z.1    Korstanje, R.2    Tsaih, S.-W.3    Paigen, B.4
  • 45
    • 30744473697 scopus 로고    scopus 로고
    • Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci
    • Stylianou IM, Korstanje R, Li R et al. Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome 2006;17:22-36.
    • (2006) Mamm Genome , vol.17 , pp. 22-36
    • Stylianou, I.M.1    Korstanje, R.2    Li, R.3
  • 46
    • 2942525579 scopus 로고    scopus 로고
    • Characterization of epistasis influencing complex spontaneous obesity in the BSB model
    • Yi N, Diament A, Chiu S et al. Characterization of epistasis influencing complex spontaneous obesity in the BSB model. Genetics 2004;167: 399-409.
    • (2004) Genetics , vol.167 , pp. 399-409
    • Yi, N.1    Diament, A.2    Chiu, S.3
  • 47
    • 21644468069 scopus 로고    scopus 로고
    • Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice
    • Yi N, Chiu S, Allison DB, Fisler JS, Warden CH. Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice. J Lipid Res 2004;45:2063-2070.
    • (2004) J Lipid Res , vol.45 , pp. 2063-2070
    • Yi, N.1    Chiu, S.2    Allison, D.B.3    Fisler, J.S.4    Warden, C.H.5
  • 48
    • 33644949714 scopus 로고    scopus 로고
    • Bayesian analyses of multiple epistatic QTL models for body weight and body composition in mice
    • Yi N, Zinniel DK, Kim K et al. Bayesian analyses of multiple epistatic QTL models for body weight and body composition in mice. Genet Res 2006;87:45-60.
    • (2006) Genet Res , vol.87 , pp. 45-60
    • Yi, N.1    Zinniel, D.K.2    Kim, K.3
  • 49
    • 77950796058 scopus 로고    scopus 로고
    • Calpain-10 is a component of the obesity-related quantitative trait locus, Adip1
    • e-pub ahead of print 12 May 2009
    • Cheverud JM, Fawcett GL, Jarvis JP et al. Calpain-10 is a component of the obesity-related quantitative trait locus, Adip1. J Lipid Res 2009; e-pub ahead of print 12 May 2009.
    • (2009) J Lipid Res
    • Cheverud, J.M.1    Fawcett, G.L.2    Jarvis, J.P.3
  • 50
    • 21244473273 scopus 로고    scopus 로고
    • Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2
    • Jerez-Timaure NC, Eisen EJ, Pomp D. Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2. Physiol Genomics 2005;21:411-422
    • (2005) Physiol Genomics , vol.21 , pp. 411-422
    • Jerez-Timaure, N.C.1    Eisen, E.J.2    Pomp, D.3


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