Genetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight, or both

Physiological Genomics

Volumn 36, Issue 2, 2009, Pages 114-126

  Brockmann, Gudrun A ^a   Tsaih, Shirng Wern ^b   Neuschl, Christina ^a   Churchill, Gary A ^b   Li, Renhua ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b JACKSON LABORATORY   (United States)

Author keywords

Covariance analysis; Mouse; Pleiotropy; Quantitative biology; Systems genetics

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CONTROLLED STUDY; FEMALE; GENE LOCUS; HEREDITY; LEAN BODY WEIGHT; LIPID STORAGE; MALE; MOUSE; MUSCLE GROWTH; MUSCLE MASS; NONHUMAN; OBESITY; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SEX DIFFERENCE; STRUCTURAL EQUATION MODELING;

ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; BODY WEIGHTS AND MEASURES; FEMALE; MALE; MICE; MICE, INBRED STRAINS; MUSCLE, SKELETAL; OBESITY; PHENOTYPE; QUANTITATIVE TRAIT LOCI;

EID: 58649110845     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.90277.2008     Document Type: Article

References (34)

1. Borjeson M. The aetiology of obesity in children. Acta Paediatr Scand 65: 279-287, 1976.
2. Brockmann GA, Bevova MR. Using mouse models to dissect the genetics of obesity. Trends Genet 18: 367-376, 2002.
3. Brockmann GA, Karatayli E, Haley CS, Renne U, Rottmann O, Karle S. QTLs for pre- and postweaning body weight and body composition in selected mice. Mamm Genome 15: 1-15, 2004.
4. Brockmann GA, Kratzsch J, Haley CS, Renne U, Schwerin M, Karle S. Single QTL effects, epistasis, and pleiotropy account for two thirds of the phenotypic F2 variance of growth and obesity in DU6i x DBA/2 mice. Genome Res 10: 1941-1957, 2000.
5. Broman KW, Wu H Sen, Churchill GA. R/qtl: QTL mapping in experimental crosses. Bioinformatics 19: 889-890, 2003.
6. Bunger L, Herrendörfer G, Renne U. Results of long term selection for growth traits in laboratory mice. Proc 4th World Cong Genet Appl Livestock Production 13: 321-324, 1990.
7. Burnham KP, Anderson DR. Model Selection and Multimodel Inference. A Practical Information-Theoretic Approach. New York: Springer, 1998, p. 35-43.
8. Carlborg Ö, Brockmann GA, Haley C. Simultaneous mapping of epistatic QTL in DU6i × DBA/2. Mamm Genome 16: 481-494, 2005.
9. Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics 138: 963-971, 1994.
10. Churchill GA, Doerge RW. Naive application of permutation testing leads to inflated type I error rates. Genetics 178: 609-610, 2008.
11. Cocherham CC. An extension of the concept of partitioning heredity variance for analysis of covariance among relatives when epistasis is present. Genetics 39: 859-882, 1954.
12. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy M. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894, 2007.
13. Geller F, Reichwald K, Dempfle A, Illig T, Vollmert C, Herpertz F, Siffert W, Goldschmidt H, Siegfried W, Platzer M, Hess C, Gudermann T, Biebermann H, Wichmann HE, Schäfer H, Hinney A, Hebebrand J. Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. Am J Hum Genet 74: 572-581, 2004.
14. Hatcher L. A Step-by-Step Approach to Using the SAS System for Factor Analysis and Structural Equation Modeling (5th ed.). Cary, NC: SAS Institute, 2002, p. 141.
15. Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, Wichmann HE, Meitinger T, Hinney A, Hebebrand J, Koberwitz K, Christman MF. A common genetic variant 10 kb upstream of INSIG2 is associated with adult and childhood obesity. Science 312: 279-283, 2006.
16. Koeppen-Schomerus G, Wardle J, Plomin R. A genetic analysis of weight and overweight in 4-year-old twin pairs. Int J Obes Relat Metab Disord 25: 838-844, 2001.
17. Li R, Lyons MA, Wittenburg H, Paigen B, Churchill GA. Combining data from multiple inbred line crosses improves the power and resolution of quantitative trait loci mapping. Genetics 169: 1699-1709, 2005.
18. Li R, Svenson KL, Donahue LR, Peters LL, Churchill GA. Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels. Physiol Genomics 33: 26-32, 2008.
19. Li R, Tsaih SW, Shockley K, Stylianou IM, Wergedal J, Paigen B, Churchill GA. Structural model analysis of multiple quantitative traits. PLoS Genet 2: e114, 2006.
20. Lyon HN, Emilsson V, Hinney A, Heid IM, Nguyen TT, Scherag A, Pfeufer A, Meitinger T, Bronner G, Rief W, Vollmert C, Celedon JC, Wichmann HE, Hebebrand J, Hirschhorn JN. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet 3: e61, 2007.
21. Neuschl C, Brockmann GA, Knott SA. Multiple trait QTL mapping for body and organ weights in a cross between NMRI8 and DBA/2 mice. Genet Res 89: 47-59, 2007.
22. Pavlicev M, Kenney-Hunt JP, Norgard EA, Roseman CC, Wolf JB, Cheverud JM. Genetic variation in pleiotropy: differential epistasis as a source of variation in the allometric relationship between long bone lengths and body weight. Evolution 62: 199-213, 2008.
23. Perillo B, Ombra MN, Bertoni A, Cuozzo C, Saccetti S, Sasso A, Chiariotto L, Malorni A, Abbondanza C, Avedimento EV. DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science 319: 202-206, 2008.
24. Petros LM, Madeira R, Sargent E, Walker M, Petkov PM, Paigen K. Recombination activity is conserved regionally but not locally among mouse crosses. 7th Annual Complex Trait Consortium Conference, Montreal, Canada. Poster 35, 2008.
25. SAS. SAS User's Guide: Statistics. Cary, NC: SAS Institute, 1990.
26. Schüler L. Mouse strain Fzt:Du and its use as model in animal breeding research. Arch Tierz 28: 357-363, 1985.
27. Sen S, Churchill GA. A statistical framework for quantitative trait mapping. Genetics 159: 371-387, 2001.
28. Sheffield-Moore M, Urban RJ. An overview of the endocrinology of skeletal muscle. Trends Endocrinol Metab 15: 110-115, 2004.
29. Shen W, Liu H, Punyanitya M, Chen J, Heymsfield SB. Pediatric obesity phenotyping by magnetic resonance methods. Curr Opin Clin Nutr Metab Care 8: 595-601, 2005.
30. Stunkard A, Foch T, Hrubec Z. A twin study of human obesity. JAMA 256: 51-54, 1986.
31. Tanner JM. Fallacy of per-weight and per-surface area standards, and their relation to spurious correlation. J Appl Physiol 2: 1-15, 1949.
32. von Butler I, Pirchner F. Vergleich der Effizienz von Selektion innerhalb Familien und Massenselektion auf hohen Zuwachs in zwei verschiedenen Mäusepopulationen. Züchtungskunde 55: 241-246, 1983.
33. Wagner GP, Pavlicev M, Cheverud JM. The road to modularity. Nat Rev Genet 8: 921-931, 2007.
34. Wuschke S, Dahm S, Schmidt C, Joost HG, Al-Hasani H. A meta-analysis of quantitative trait loci associated with body weight and adiposity in mice. Int J Obes 31: 829-841, 2007.