Identification of quantitative trait loci affecting murine long bone length in a two-generation intercross of LG/J and SM/J Mice

Journal of Bone and Mineral Research

Volumn 23, Issue 6, 2008, Pages 887-895

  Norgard, Elizabeth A ^a,c   Roseman, Charles C ^b   Fawcett, Gloria L ^a   Pavličev, Mihaela ^a   Morgan, Clinton D ^a   Pletscher, L Susan ^a   Wang, Bing ^a   Cheverud, James M ^a  

^a WASHINGTON UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Genetic architecture; Long bone development; Quantitative genetics

Indexed keywords

ANIMAL TISSUE; ARTICLE; BODY SIZE; BONE DEVELOPMENT; BONE GROWTH; ENCHONDRAL OSSIFICATION; FEMALE; FEMUR; GENE INTERACTION; GENE MAPPING; GENE MUTATION; GENETIC EPISTASIS; HUMERUS; LONG BONE; MALE; MOUSE; NONHUMAN; PLEIOTROPY; QUANTITATIVE GENETICS; QUANTITATIVE TRAIT LOCUS; REGULATORY MECHANISM; SEX DIFFERENCE; TIBIA; ULNA;

ANIMALS; BONE AND BONES; CHROMOSOMES; EPISTASIS, GENETIC; FEMALE; MALE; MICE; QUANTITATIVE TRAIT LOCI;

EID: 44449110588     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.080210     Document Type: Article

References (43)

1. Zelzer E, Olsen B 2003 The genetic basis for skeletal diseases. Nature 423:343-348.
2. Kenney-Hunt J, Vaughn T, Pletscher L, Peripato A, Routman E, Cothran K, Durand D, Norgard E, Perel C, Cheverud J 2006 Quantitative trait loci for body size components in mice. Mamm Genome 17:526-537.
3. Drake T, Hannani K, Kabo J, Villa V, Krass K, Lusis A 2001 Genetic loci influencing natural variations in femoral bone morphometry in mice. J Orthop Res 19:511-517.
4. Lang D, Sharkey N, Mack H, Vogler G, Vandenbergh D, Blizard D, Stout J, McClearn G 2005 Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res 20:88-99.
5. Christians J, Bingham V, Oliver F, Heath T, Keightley P 2003 Characterization of a QTL affecting skeletal size in mice. Mamm Genome 14:175-183.
6. Masinde G, Wergedal J, Davidson H, Mohan S, Li R, Li X, Baylink D 2003 Quantitative trait loci for periosteal circumference (PC): Identification of single loci and epistatic effects in F2 MRL/SJL mice. Bone 32:554-560.
7. Klingenberg C, Leamy L, Cheverud J 2004 Integration and modularity of quantitative trait locus effects on geometric shape in the mouse mandible. Genetics 166:1909-1921.
8. Cheverud J, Vaughn T, Pletscher L, Peripato A, Adams E, Erikson C, King-Ellison K 2001 Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice. Mamm Genome 12:3-12.
9. Yu H, Mohan S, Edderkaoui B, Masinde G, Davidson H, Wergedal J, Beamer W, Baylink D 2007 Detecting novel bone density and bone size quantitative trait loci using a cross of MRL/MpJ and CAST/EiJ inbred mice. Calcif Tissue Int 80:103-110.
10. Ishimori N, Li R, Walsh K, Korstanje R, Rollins J, Petkov P, Pletcher M, Wiltshire T, Donahue L, Rosen C, Beamer W, Churchill G, Paigen B 2006 Quantitative trait loci that determine BMD in C57BL/6J and 129S1/SvImJ inbred mice. J Bone Miner Res 21:105-112.
11. Klein R, Mitchell S, Phillips T, Belknap J, Orwoll E 1998 Quantitative trait loci affecting peak bone mineral density in mice. J Bone Miner Res 13:1648-1656.
12. Beamer W, Shultz K, Churchill G, Frankel W, Baylink D, Rosen C, Donahue L 1999 Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. Mamm Genome 10:1043-1049.
13. Robling A, Li J, Shultz K, Beamer W, Turner C 2003 Evidence for a skeletal mechanosensitivity gene on mouse chromosome 4. FASEB J 17:324-326.
14. Kesavan C, Mohan S, Srivastava A, Kapoor S, Wergedal J, Yu H, Baylink D 2006 Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ mice intercross. Bone 39:634-643.
15. Rubin C, Brandstrom H, Wright D, Kerje S, Gunnarsson U, Schutz K, Fredriksson R, Jensen P, Andersson L, Ohlsson C, Mallmin H, Larsson S, Kindmark A 2007 Quantitative trait loci for BMD and bone strength in an intercross between domestic and wildtype chickens. J Bone Miner Res 22:375-384.
16. Alam I, Sun Q, Liu L, Koller D, Fishburn T, Carr L, Econs M, Foroud T, Turner C 2006 Identification of a quantitative trait locus on rat chromosome 4 that is strongly linked to femoral neck structure and strength. Bone 39:93-99.
17. Volkman S, Galecki A, Burke D, Miller R, Goldstein S 2004 Quantitative trait loci that modulate femoral mechanical properties in a genetically heterogeneous mouse population. J Bone Miner Res 19:1497-1505.
18. Bower A, Lang D, Vogler G, Vandenbergh D, Blizard D, Stout J, McClearn G, Sharkey N 2006 QTL analysis of trabecular bone in BXD F2 and RI mice. J Bone Miner Res 21:1267-1275.
19. Bouxsein M, Uchiyama T, Rosen C, Shultz K, Donahue L, Turner C, Sen S, Churchill G, Muller R, Beamer W 2004 Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice. J Bone Miner Res 19:587-599.
20. Corva P, Horvat S, Medrano J 2001 Quantitative trait loci affecting growth in high growth (hg) mice. Mamm Genome 12:284-290.
21. Vaughn T, Pletscher L, Peripato A, King-Ellison K, Adams E, Erikson C, Cheverud J 1999 Mapping quantitative trait loci for murine growth: A closer look at genetic architecture. Genet Res 74:313-322.
22. Shultz K, Donahue L, Bouxsein ML, Baylink D, Rosen CJ, Beamer W 2003 Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral density. J Bone Miner Res 18:175-185.
23. Akai J, Kimura A, Hata R 1999 Transcriptional regulation of the human type I collagen alpha2 (COL1A2) gene by the combination of two dinucleotide repeats. Gene 239:65-73.
24. Lei S, Deng F, Dvornyk V, Liu M, Xiao S, Jiang D, Deng H 2005 The (GT)n polymorphism and haplotype of the COL1A2 gene, but not the (AAAG)n polymorphism of the PTHR1 gene, are associated with bone mineral density in Chinese. Hum Genet 116:200-207.
25. Drummond F, Mackrill J, O'Sullivan K, Daly M, Shanahan F, Molloy M 2006 CD38 is associated with premenopausal and postmenopausal bone mineral density and postmenopausal bone loss. J Bone Miner Metab 24:28-35.
26. Young N, Hallgrimsson B 2005 Serial homology and the evolution of mammalian limb covariation structure. Evolution Int J Org Evolution 59:2691-2704.
27. Cheverud J, Routman E, Duarte F, van Swinderen B, Cothran K, Perel C 1996 Quantitative Trait Loci for Murine Growth. Genetics 142:1305-1319.
28. Kramer M, Vaughn T, Pletscher L, King-Ellison K, Adams E, Erikson C, Cheverud J 1998 Genetic variation in body weight gain and composition in the intercross of Large (LG/J) and Small (SM/J) inbred strains of mice. Genet Mol Biol 21:211-218.
29. Goodale H 1938 A study of the inheritance of body weight in the albino mouse by selection. J Hered 29:101-112.
30. Goodale H 1941 Progress report on possibilities in progeny test breeding. Science 94:442-443.
31. MacArthur J 1944 Genetics of body size and related characters. I. Selection of small and large races of the laboratory mouse. Am Nat 78:142-157.
32. Darvasi A, Soller M 1995 Advanced intercross lines, an experimental population for fine genetic mapping. Genetics 141:1199-1207.
33. Lander E, Botstein D 1989 Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185-199.
34. Haley C, Knott S 1992 A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69:315-324.
35. Falconer D, Mackay T 1996 Introduction to Quantitative Genetics, 4th ed. Pearson Prentice Hall, Harlow, UK.
36. Chen L, Storey JD 2006 Relaxed significance criteria for linkage analysis. Genetics 173:2371-2381.
37. Knott S, Haley C 2000 Multitrait least squares for quantitative trait loci detection. Genetics 156:899-911.
38. Ammanamanchi S, Brattain M 2001 5-azaC treatment enhances expression of transforming growth factor-beta receptors through down-regulation of Sp3. J Biol Chem 276:32854-32859.
39. Coffer P, Kruijer W 1995 EGF receptor deletions define a region specifically mediating STAT transcription factor activation. Biochem Biophys Res Commun 210:74-81.
40. Katoh K, Nakanishi Y, Akimoto S, Yoshimura K, Takaqi M, Sakamoto M, Hirohasi S 2002 Correlation between laminin-5 gamma2 chain expression and epidermal growth factor receptor expression and its clinicophathological significance in squamous cell carcinoma of the tongue. Oncology 62:318-326.
41. de la Serna I, Roy K, Carlson K, Imbalzano A 2001 MyoD can induce cell cycle arrest but not muscle differentiation in the presence of dominant negative SWI/SNF chromatin remodeling enzymes. J Biol Chem 276:41486-41491.
42. Bergstrom D, Penn B, Strand A, Perry R, Rudnicki M, Tapscott S 2002 Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression. Mol Cell 9:587-600.
43. Atchley W, Xu S, Cowley D 1997 Altering Developmental Trajectories in Mice by Restricted Index Selection. Genetics 146:629-640.