Molecular screening of the human melancocortin-4 receptor gene: Identification of a missense variant showing no association with obesity, plasma glucose, or insulin

Diabetologia

Volumn 40, Issue 8, 1997, Pages 976-979

  Gotoda, T ^a   Scott, J ^a   Aitman, T J ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Agouti; Gene variant; Genetics; Hyperinsulinaemia; Molanocortin; Obesity; Receptor

Indexed keywords

GLUCOSE; INSULIN; MELANOCORTIN;

ADULT; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GENETICS; HUMAN; MAJOR CLINICAL STUDY; MALE; MOLECULAR BIOLOGY; MUTATION; OBESITY; PRIORITY JOURNAL;

ADULT; BASE SEQUENCE; BLOOD GLUCOSE; COHORT STUDIES; DNA; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENOTYPE; HUMANS; INSULIN; MALE; MIDDLE AGED; MUTATION; OBESITY, MORBID; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, PEPTIDE; SEQUENCE ANALYSIS, DNA; VARIATION (GENETICS);

EID: 0030740803     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050777     Document Type: Article

References (10)

1. Bouchard C (1996) The causes of obesity: advances in molecular biology but stagnation on the genetic front. Diabetologia 39: 1532-1533
2. Lu D, Willard D, Patel IR et al. (1994) Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor. Nature 371: 799-802
3. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD (1997) Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385: 165-168
4. Huszar D, Lynch CA, Fairchild-Huntress V et al. (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88: 131-141
5. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV (1996) Leptin: the tale of an obesity gene. Diabetes 45: 1455-1462
6. McKeigue PM, Shah B, Marmot MG (1991) Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet 337: 382-386
7. Gotoda T, Manning BS, Goldstone AP et al. (1997) Leptin receptor gene variation and obesity: lack of association in a white British male population. Hum Mol Genet 6: 869-876
8. Gantz I, Miwa H, Konda Y et al. (1993) Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J Biol Chem 268: 15174-15179
9. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD (1994) Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8: 1298-1308
10. Friedman JM (1997) The alphabet of weight control Nature 385: 119-120